Developmental biology:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Sunderland, Mass.
Sinauer
1988
|
| Edition: | 2. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XVI, 843 S. Ill., graph. Darst. |
| ISBN: | 0878932488 |
Staff View
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| 245 | 1 | 0 | |a Developmental biology |c Scott F. Gilbert |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Sunderland, Mass. |b Sinauer |c 1988 | |
| 300 | |a XVI, 843 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 500 | |a Literaturangaben | ||
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Record in the Search Index
| _version_ | 1809403378620432384 |
|---|---|
| adam_text |
Developmental
Biology Second Edition
SCOTT F JGILBERT
SWARTHMORE COLLEGE
sa Sinauer Associates, Inc • Publishers
Sunderland, Massachusetts
Contents
PREFACE xiv
I
PATTERNS
OF DEVELOPMENT
1 An introduction to animal development 3
Introduction 4
Principal features of
development 4
Our eukaryotic heritage 6
Development among the
unicellular eukaryotes 9
CONTROL OF DEVELOPMENTAL
MORPHOGENESIS IN
ACETABULARIA 9
DIFFERENTIATION IN THE
AMOEBOFLAGELLATE
NAEGLERIA 11
THE ORIGINS OF SEXUAL
REPRODUCTION 13
Colonial eukaryotes: The
evolution of
differentiation 17
THE VOLVOCALES 17
2 Fertilization? Beginning a new organism 29
Introduction 30
Structure of the gametes 30
SPERM 30
EGG 34
Recognition of sperm and egg:
Action at a distance 37
SPERM ATTRACTION 37
THE ACROSOME REACTION 38
Recognition of sperm and egg:
Contact of gametes 41
SPECIES-SPECIFIC RECOGNITION IN
SEA URCHINS 41
GAMETE BINDING IN
MAMMALS 44
Gamete fusion and prevention of
polyspermy 47
FUSION BETWEEN SPERM AND
OOCYTE CELL MEMBRANES 47
PREVENTION OF POLYSPERMY 50
Fusion of the genetic
material 56
Sidelights amp; Speculations:
Sex and death among
the Volvocales 20
THE SLIME MOLD
DICTYOSTELIUM 21
Developmental patterns among
metazoans 24
THE PORIFERA 24
PROTOSTOMES AND
DEUTEROSTOMES 25
Activation of egg metabolism 58
Sidelights amp; Speculations:
The nonequivalence of
mammalian pronuclei 59
EARLY RESPONSES 60
LATE RESPONSES 62
REARRANGEMENT OF EGG
CYTOPLASM 64
Sidelights amp; Speculations:
The biochemistry of egg
activation 64
Bilateral holoblastic cleavage 88
Rotational holoblastic
cleavage 89
COMPACTION 90
3 Cleavage: Creating multicellularity 73
Introduction 74 SEA URCHINS 77
Patterns of Embryonic AMPHIBIANS 81
Cleavage 75 Spiral holoblastic cleavage 83
Radial holoblastic cleavage 76 Sidelights amp; Speculations:
THE SEA CUCUMBER, SYNAPTA 76 Adaptation by modifying
embryonic cleavage 86
vii
Sidelights amp; Speculations:
The cell surface and the
mechanism of compaction 92
FORMATION OF THE INNER CELL
MASS 93
ESCAPE FROM THE ZONA
PELLUCIDA 95
Sidelights amp; Speculations:
Twins 96
Meroblastic cleavage types 98
DISCOIDAL CLEAVAGE 98
SUPERFICIAL CLEAVAGE 99
Mechanisms of Cleavage 102
Initiation of cleavage 102
The cytoskeletal mechanisms
of mitosis 104
The formation of new
membranes 106
Summary 108
4 Gastrulation: Reorganizing
Introduction: General features
of gastrulation 113
Sea urchin gastrulation 114
INGRESSION OF PRIMARY
MESENCHYME 114
FIRST STAGE OF ARCHENTERON
INVAGINATION 119
SECOND STAGE OF ARCHENTERON
INVAGINATION 120
Amphibian gastrulation 121
the embryonic cells 112
CELL MOVEMENTS DURING
AMPHIBIAN GASTRULATION:
AN OVERVIEW 122
POSITIONING OF THE
BLASTOPORE 124
CELL MOVEMENTS AND
CONSTRUCTION OF THE
ARCHENTERON 128
MIGRATION OF THE INVOLUTING
MESODERM 131
EPIBOLY OF THE ECTODERM 134
Gastrulation in birds 135
OVERVIEW OF AVIAN
GASTRULATION 135
MECHANISMS OF AVIAN
GASTRULATION 140
Gastrulation in mammals 142
Sidelights amp; Speculations:
The functions of the
chorion 146
5 Early vertebrate development: Neurulation and ectoderm 152
The vertebrate pattern
of development 153
Neurulation 155
The neural tube and the origins
of the central nervous
system 156
MECHANISM OF NEURAL TUBE
FORMATION 159
DIFFERENTIATION OF THE NEURAL
TUBE 161
Sidelights amp; Speculations:
The evolution of cerebral
development 167
DEVELOPMENT OF THE EYE 173
The neural crest and its
derivatives 176
MIGRATION PATHWAYS OF NEURAL
CREST CELLS 177
PLURIPOTENTIALITY OF NEURAL
CREST CELLS 183
The epidermis and the origin
of cutaneous structures 185
Sidelights amp; Speculations:
Teratology 187
Summary 192
PLURIPOTENTIAL STEM CELLS
AND HEMATOPOIETIC
MICROENVIRONMENTS 225
SITES OF HEMATOPOIESIS 230
Endoderm 232
Pharynx 232
The digestive tube and its
derivatives 234
LIVER, PANCREAS, AND
GALLBLADDER 235
THE RESPIRATORY TUBE 235
Sidelights amp; Speculations:
Teratocarcinoma 237
6 Early vertebrate development: Mesoderm and endoderm
Introduction 197
Mesoderm 197
Dorsal mesoderm: Differentiation
of somites 197
MYOGENESIS: DIFFERENTIATION OF
SKELETAL MUSCLE 201
OSTEOGENESIS: DEVELOPMENT OF
BONES 206
Lateral plate mesoderm 211
Sidelights amp; Speculations:
Isoforms 212
Formation of extraembryonic
membranes 212
Heart and circulatory
system 214
THE HEART 214
FORMATION OF BLOOD
VESSELS 216
REDIRECTING BLOOD FLOW IN THE
NEWBORN MAMMAL 220
Sidelights amp; Speculations:
Tumor-induced
angiogenesis 222
Development of blood cells 225
viii CONTENTS
II
MECHANISMS
OF CELLULAR
DIFFERENTIATION
7 Determination by cytoplasmic specification 245
Introduction 246
Preformation and epigenesis 247
The French teratologists 248
Cytoplasmic specification
in tunicate embryos 249
THE NATURE OF TUNICATE
MORPHOGENIC
DETERMINANTS 254'
Cytoplasmic localization
in mollusc embryos 255
Sidelights amp; Speculations:
Intracellular localization and
movements of morphogenic
determinants 256
THE POLAR LOBE 257
Determination in the nematode
Caenorhabditis elegans 261
Cytoplasmic localization of germ
cell determinants 264
GERM CELL DETERMINATION
IN NEMATODES 266
GERM CELL DETERMINATION
IN INSECTS 267
GERM CELL DETERMINATION
IN AMPHIBIANS 271
The genetics of cytoplasmic
determinants in
Drosophila 272
Summary 278
8 Progressive determination 282
Introduction 283
August Weismann: The germ-
plasm theory 283
Wilhelm Roux: Mosaic
development 284
Hans Driesch: Regulative
development 285
Sven Horstadius: Potency and
oocyte gradients 288
Hans Spemann: Progressive
determination of embryonic
cells 293
Hans Spemann and Hilde
Mangold: Primary embryonic
induction 297
Regional specificity of
induction 299
The mechanisms of primary
embryonic induction 301
INDUCTION OF MESODERMAL
SPECIFICITY BY
ENDODERM 302
INDUCTION INFLUENCES GENE
ACTIVITY 304
SEARCH FOR THE MESODERM
INDUCERS 306
The inducer as a diffusible
molecule 308
Competence and secondary
induction 309
9 Genomic equivalence and differential gene expression:
Embryological investigations 313
Introduction 314 Amphibian cloning: Restriction Sidelights amp; Speculations:
Genomic equivalence 314 of cell potency 320 Cloning 326
TRANSDETERMINATION 316 Amphibian cloning: Exceptions
METAPLASIA 318 to restriction 323
10 Genomic equivalence and differential gene expression:
Molecular investigations 330
Introduction 331
Molecular biology
techniques 331
NUCLEIC ACID
HYBRIDIZATION 331
GENE CLONING 333
Sidelights amp; Speculations:
Once the gene is
cloned 337
Differential gene expression 343
GENOMIC EQUIVALENCE 343
GENE STABILITY 344
EXCEPTIONS TO GENOME STABILITY:
CHANGES IN LYMPHOCYTE
GENES 345
Sidelights amp; Speculations:
Gene alterations 351
DIFFERENTIAL RNA SYNTHESIS 352
Summary 360
CONTENTS ix
11 Transcriptional regulation of gene expression:
Transcriptional changes during development 363
Introduction 364
Heterochromatin 365
PATERNAL HETEROCHROMATIN
IN MEALLY BUGS 365
MAMMALIAN X CHROMOSOME
INACTIVATION 366
Sidelights amp; Speculations:
The timing of X chromosome
inactivation 370
Amplified genes 371
AMPLIFICATION OF RIBOSOMAL
RNA GENES 371
MECHANISM OF RIBOSOMAL GENE
AMPLIFICATION 372
VISUALIZATION OF TRANSCRIPTION
FROM AMPLIFIED GENES 375
Sidelights amp; Speculations:
Molecular basis of rapid
ribosomal gene
transcription 375
DROSOPHILA CHORION GENES 376
Selective gene transcription 377
CHROMOSOMAL PUFFS AND
LAMPBRUSH
CHROMOSOMES 377
OVALBUMIN SYNTHESIS 380
GLOBIN GENE TRANSCRIPTION 382
A transcriptional regulator
protein: The control
of 5 S rRNA genes 385
CENTRAL PROMOTER
ELEMENT 385
TRANSCRIPTIONAL REGULATION
BY TFIIIA 385
TFIIIA BINDING AND
FUNCTION 386
Transcriptional control of
determination: The lineage
switch genes 388
Sidelights amp; Speculations:
The determination of vulval
cells in Caenorhabditis
elegans 391
Summary 392
12 Transcriptional regulation of gene expression:
The mechanism of differential gene transcription 396
Eukaryotic Protein-Encoding
Genes 397
Exons and Introns 397
Promoter structure and
function 401
TRANS-REGULATORY PROTEINS
BINDING TO PROMOTERS 403
Enhancer structure and
function 405 - -
TIME-SPECIFIC ENHANCERS 406
TISSUE-SPECIFIC ENHANCERS 407
HORMONE-RESPONSIVE
ENHANCERS 408
Transcription of immunoglobulin
light chain genes 412
Sidelights amp; Speculations:
Modular genes 415
DNA methylation 416
Sidelights amp; Speculations:
Probing methylation
sites 420
Eukaryotic Chromatin 420
Nucleosomes 420
Activating repressed
chromatin 423
ACCESSIBILITY TO TRANS-
REGULATORY FACTORS 423
DNASE HYPERSENSITIVE SITES 425
DNASE HYPERSENSITIVITY AND
METHYLATION PATTERN 426
REGULATION OF GENE
ACCESSIBILITY 426
Association of active DNA with
the nuclear matrix 429
ATTACHMENT OF ACTIVE
CHROMATIN TO A NUCLEAR
MATRIX 429
TOPOISOMERASES AND GENE
TRANSCRIPTION 431
Z-DNA AND HAIRPIN LOOPS 432
Summary 434
13 Control of development
Introduction 441
Heterogeneous nuclear
RNA 441
Complexity of nuclear and
messenger RNAs 443
Control of development by
nRNA processing 445
Sidelights amp; Speculations:
Mechanisms for specific
nuclear RNA processing 449
by RNA processing 440
Evidence for unprocessed
message precursors in the
nucleus 451
Creating alternative proteins from
the same gene: Differential
RNA processing in the
immune system 451
Differential RNA processing:
Generating new proteins in
different cells at different
times 454
ALTERNATIVE RNA PROCESSING
AND SEX DETERMINATION 455
Sidelights amp; Speculations:
The biochemistry of RNA
processing 456
Determining the 3' end
of the RNA 460
Transport out of the
nucleus 460
Summary 462
x CONTENTS
14 Translational and posttranslational regulation of developmental processes 465
Translational Regulation of
Development 466
Mechanisms of eukaryotic
translation 466
Translational control of
coordinated protein
synthesis: Hemoglobin
production 469
Selective degradation of
messenger RNA 472
Translational control of oocyte
messages 473
EVIDENCE FOR MATERNAL
REGULATION OF EARLY
DEVELOPMENT 473
STORED MESSENGER RNA 475
CHARACTERIZATION OF MATERNAL
MESSAGES 478
MECHANISMS FOR TRANSLATIONAL
CONTROL OF OOCYTE
MESSAGES 479
MATERNAL MRNA AND EMBRYONIC
CLEAVAGE 483
Sidelights amp; Speculations:
The activation of the
embryonic genome 484
Hormonal stabilization of specific
messenger RNAs 485
The widespread use of
translational regulation 485
Posttranslational Regulation of
Gene Expression 487
Activation of proteins by
posttranslational
mechanisms 488
Inactivation of proteins by
posttranslational
modifications 490
Subcellular localization of
proteins by posttranslational
modifications: Targeting
proteins for membranes and
lysosomes 492
Targeting proteins for the nucleus
and mitochondria 494
Supramolecular assembly 496
Collagen: An epitome of
posttranslational
regulation 497
CELL INTERACTIONS
IN DEVELOPMENT
15 The spatial ordering of cells: The roles of the cell surface 507
Introduction 508
Differential cell affinity 508
STATIONARY CULTURES 508
ROTARY CULTURES 511
SPECIFIC CELL AFFINITY CHANGES
AND MIGRATION IN SEA
URCHIN EMBRYOS 513
Modes of cellular migration 513
CHEMOTAXIS 513
HAPTOTAXIS 514
GALVANOTAXIS 515
CONTACT GUIDANCE 516
CONTACT INHIBITION OF
MOVEMENT 517
THERMODYNAMIC MODEL OF CELL
INTERACTIONS 518
IN VIVO EVIDENCE FOR THE
THERMODYNAMIC MODEL 519
The changing structure of the cell
surface 521
STRUCTURE OF THE CELL
MEMBRANE 521
CELL MEMBRANE CHANGES WITH
DEVELOPMENT 525
Sidelights amp; Speculations:
From protein to gene 528
Cell adhesion molecules 530
IDENTIFYING CELL ADHESION
MOLECULES 530
GENERAL CELL ADHESION
MOLECULES 532
MECHANISM OF N-CAM
BINDING 534
RESTRICTED CELL ADHESION
MOLECULES 535
SACCHARIDE-MEDIATED CELL
ADHESION 536
Morphogenesis by cell-substrate
interactions 539
THE EXTRACELLULAR MATRIX 539
EXTRACELLULAR
GLYCOPROTEINS 542
FIBRONECTIN RECEPTORS 544
IMPORTANCE OF THE
EXTRACELLULAR MATRIX TO
DIFFERENTIATION 546
Junctional modifications in
morphogenesis 547
CONTENTS xi
16 Proximate tissue interactions: Secondary induction 554
Introduction 555
Instructive and permissive
interactions 555
Intercellular coordination in
proximate interactions 556
Epitheliomesenchymal
interactions 560
REGIONAL SPECIFICITY OF
INDUCTION 560
GENETIC SPECIFICITY OF
INDUCTION 561
Sidelights amp; Speculations:
Development and
macroevolution 563
FORMATION OF PARENCHYMAL
ORGANS 564
COORDINATED DIFFERENTIATION
AND MORPHOGENESIS IN THE
PANCREAS 567
The nature of proximity in
epitheliomesenchymal
inductions 568
Mechanism of branching in the
formation of parenchymal
organs 573
Induction of plasma cells 575
MACROPHAGES AND HELPER
T CELLS 575
NONSPECIFIC LYMPHOCYTE
ADHERENCE 578
Sidelights amp; Speculations:
Crosslinking and
induction 579
Induction of the chick limb 581
17 Pattern formation 588
Introduction 589
Gradient models of positional
information 589
FRENCH FLAG MODEL 589
GRADIENTS IN HYDRA 592
Limb regeneration: The polar
coordinate model of
positional information 595
SALAMANDER LIMB
REGENERATION 595
POLAR COORDINATE MODEL 597
Pattern formation during limb
development: Specification of
the axes 599
THE LIMB FIELD 600
POLARIZATION ALONG THE LIMB
AXES 601
Sidelights amp; Speculations:
Retinoic acid and pattern
formation 606
Pattern formation in the nervous
system 607
MECHANISMS OF DIRECTING AXON
GROWTH 609
MECHANISMS OF SYNAPTIC
SPECIFICITY 616
Sidelights amp; Speculations:
Cell surface address markers
and lymphocyte
migration 622
DEVELOPMENT OF BEHAVIORS 622
Sidelights amp; Speculations:
Morphogenesis by specific cell
death 624
18 The genetics of pattern
Introduction 631
A summary of Drosophila ~~
development 631
Compartmentalization in insect
development 633
Mutations affecting the number
of segments 636
THE THREE TYPES OF
SEGMENTATION GENES 636
PARASEGMENTS AND THE SPATIAL
REGULATION OF GENE
EXPRESSION 636
formation in Drosophila 630
SEQUENTIAL EXPRESSION OF
— SEGMENTATION GENES 638
DEFINING THE SEQUENCE OF GENE
EXPRESSION 640
Specification of segment identity:
The homeotic genes 642
Regulation of the regulators (of
the regulators) 646
THE MOLECULAR BIOLOGY OF
PATTERN-FORMING GENES 648
THE HOMEOBOX 650
Sidelights amp; Speculations:
Evolution through homeotic
genes? 653
The specification of cells:
Positional information 654
Sidelights amp; Speculations:
Prepatterning of embryos:
How the zebras (and
Drosophilas) got their
stripes 655
19 Cell interactions at a distance: Hormones as mediators of development 662
Introduction 663
Metamorphosis:
The hormonal reactivation
of development 663
Amphibian metamorphosis 664
THE PHENOMENON OF AMPHIBIAN
METAMORPHOSIS 664
HORMONAL CONTROL
OF AMPHIBIAN
METAMORPHOSIS 665
MOLECULAR RESPONSES TO
THYROID HORMONES DURING
METAMORPHOSIS 672
Sidelights amp; Speculations:
Heterochrony 674
Metamorphosis in insects 678
EVERSION AND DIFFERENTIATION
OF THE IMAGINAL DISCS 678
REMODELING OF THE NERVOUS
SYSTEM 683
HORMONAL CONTROL OF INSECT
METAMORPHOSIS 683
Sidelights amp; Speculations:
Childhood's end: Signals to
initiate metamorphosis 686
xii CONTENTS
Multiple hormonal interactions in EMBRYONIC STAGE 688
mammary gland ADOLESCENCE 691
development 688 PREGNANCY 691
Sidelights amp; Speculations:
Puberty as a variation on the
theme of metamorphosis 692
20 Patterns of growth and oncogenesis 698
The Mathematics of Organismal The Physiology of Organ How cellular proto-oncogenes go
Growth 699 Growth 709 wrong 729
Growing pains: physical limits to Growth hormones and ONCOGENESIS BY MUTATION 729
growth 699 mitosis 709 ONCOGENESIS BY GENE
Isometric growth 701 Growth inhibitory factors 716 AMPLIFICATION 730
BROOKS'S LAW OF LINEAR Oncogenes and Cell ONCOGENESIS BY PROMOTER
GROWTH 701 Growth 719 INSERTION 730
THE EQUIANGULAR SPIRAL 701 Viral oncogenes 719 ONCOGENESIS BY CHROMOSOMAL
Allometric growth 704 Oncogenes and cellular REARRANGEMENT 731
Sidelights amp; Speculations: growth 721 Senescence 733
Evolution and allometry 708 GROWTH FACTOR MIMICS 721 Sidelights amp; Speculations:
GROWTH FACTOR RECEPTOR Mechanisms of
MIMICS 724 senescence 737
21 Sex determination 743
Introduction 744 Sidelights amp; Speculations: Secondary sex
Chromosomal sex determination Why are there males? 765 determination 754
in mammals 744 Environmental sex HORMONAL REGULATION OF THE
THE DEVELOPING GONADS 745 determination 766 SEXUAL PHENOTYPE 754
Control of mammalian sex TEMPERATURE-DEPENDENT SEX THE CENTRAL NERVOUS
determination: DETERMINATION IN SYSTEM 757
Y-chromosomal genes 748 REPTILES 766 Sidelights amp; Speculations:
Control of mammalian sex LOCATION-DEPENDENT SEX The development of sexual
determination: Autosomal DETERMINATION IN BONELLIA behaviors 759
genes 751 VIVIDIS AND CREPIDULA Chromosomal sex determination
A model of primary mammalian FORNICATA 767 in Drosophila 759
sex determination 753 Hermaphroditism 763
22 The saga of the germ line i 772
Introduction 773 Sidelights amp; Speculations: MATURATION OF THE OOCYTE
Germ cell formation 773 Big decisions: Mitosis!meiosis IN AMPHIBIANS 788
GERM CELL MIGRATION IN and sperm/egg 780 OOGENESIS IN MEROISTIC
AMPHIBIANS 773 Spermatogenesis 782 INSECTS 795
GERM CELL MIGRATION IN SPERMIOGENESIS 783 OOGENESIS IN HUMANS 798
MAMMALS 775 GENE EXPRESSION DURING SPERM Sidelights amp; Speculations:
GERM CELL MIGRATION IN BIRDS DEVELOPMENT 785 The maintenance and
AND REPTILES 776 Oogenesis 787 breaking of meiotic
MEIOSIS 777 OOGENIC MEIOSIS 787 arrest 803
Epilog: An essay on some unanswered problems 809
SOURCES FOR CHAPTER
OPENING QUOTATIONS 814
AUTHOR INDEX 816
SUBJECT INDEX 827
CONTENTS xiii |
| any_adam_object | 1 |
| author | Gilbert, Scott F. 1949- |
| author_GND | (DE-588)133098559 |
| author_facet | Gilbert, Scott F. 1949- |
| author_role | aut |
| author_sort | Gilbert, Scott F. 1949- |
| author_variant | s f g sf sfg |
| building | Verbundindex |
| bvnumber | BV002612563 |
| callnumber-first | Q - Science |
| callnumber-label | QL955 |
| callnumber-raw | QL955 |
| callnumber-search | QL955 |
| callnumber-sort | QL 3955 |
| callnumber-subject | QL - Zoology |
| classification_rvk | WX 6000 |
| ctrlnum | (OCoLC)246745030 (DE-599)BVBBV002612563 |
| dewey-full | 574.3 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.3 |
| dewey-search | 574.3 |
| dewey-sort | 3574.3 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 2. ed. |
| format | Book |
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| genre | 1\p (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV002612563 |
| illustrated | Illustrated |
| indexdate | 2024-09-06T00:12:10Z |
| institution | BVB |
| isbn | 0878932488 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-001679908 |
| oclc_num | 246745030 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-29 DE-29T DE-11 DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-29 DE-29T DE-11 DE-188 |
| physical | XVI, 843 S. Ill., graph. Darst. |
| publishDate | 1988 |
| publishDateSearch | 1988 |
| publishDateSort | 1988 |
| publisher | Sinauer |
| record_format | marc |
| spelling | Gilbert, Scott F. 1949- Verfasser (DE-588)133098559 aut Developmental biology Scott F. Gilbert 2. ed. Sunderland, Mass. Sinauer 1988 XVI, 843 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Embryologie Embryologie ram Ontwikkelingsbiologie gtt Embryology Entwicklungsphysiologie (DE-588)4152449-4 gnd rswk-swf Entwicklungsbiologie (DE-588)4152440-8 gnd rswk-swf Morphogenese (DE-588)4132460-2 gnd rswk-swf Ontogenie (DE-588)4043565-9 gnd rswk-swf Embryonalentwicklung (DE-588)4070792-1 gnd rswk-swf Embryologie (DE-588)4014562-1 gnd rswk-swf 1\p (DE-588)4123623-3 Lehrbuch gnd-content Entwicklungsbiologie (DE-588)4152440-8 s Morphogenese (DE-588)4132460-2 s Entwicklungsphysiologie (DE-588)4152449-4 s Embryologie (DE-588)4014562-1 s Ontogenie (DE-588)4043565-9 s 2\p DE-604 Embryonalentwicklung (DE-588)4070792-1 s 3\p DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001679908&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Gilbert, Scott F. 1949- Developmental biology Embryologie Embryologie ram Ontwikkelingsbiologie gtt Embryology Entwicklungsphysiologie (DE-588)4152449-4 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd Morphogenese (DE-588)4132460-2 gnd Ontogenie (DE-588)4043565-9 gnd Embryonalentwicklung (DE-588)4070792-1 gnd Embryologie (DE-588)4014562-1 gnd |
| subject_GND | (DE-588)4152449-4 (DE-588)4152440-8 (DE-588)4132460-2 (DE-588)4043565-9 (DE-588)4070792-1 (DE-588)4014562-1 (DE-588)4123623-3 |
| title | Developmental biology |
| title_auth | Developmental biology |
| title_exact_search | Developmental biology |
| title_full | Developmental biology Scott F. Gilbert |
| title_fullStr | Developmental biology Scott F. Gilbert |
| title_full_unstemmed | Developmental biology Scott F. Gilbert |
| title_short | Developmental biology |
| title_sort | developmental biology |
| topic | Embryologie Embryologie ram Ontwikkelingsbiologie gtt Embryology Entwicklungsphysiologie (DE-588)4152449-4 gnd Entwicklungsbiologie (DE-588)4152440-8 gnd Morphogenese (DE-588)4132460-2 gnd Ontogenie (DE-588)4043565-9 gnd Embryonalentwicklung (DE-588)4070792-1 gnd Embryologie (DE-588)4014562-1 gnd |
| topic_facet | Embryologie Ontwikkelingsbiologie Embryology Entwicklungsphysiologie Entwicklungsbiologie Morphogenese Ontogenie Embryonalentwicklung Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001679908&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT gilbertscottf developmentalbiology |