Transition metal complexes as drugs and chemotherapeutic agents:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Dordrecht [u.a.]
Kluwer
1989
|
| Series: | Catalysis by metal complexes
11 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XI, 291 S. |
| ISBN: | 9027728283 |
Staff View
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| adam_text | TRANSITION METAL COMPLEXES AS DRUGS AND CHEMOTHERAPEUTIC AGENTS BY
NICHOLAS FARRELL THE UNIVERSITY OF VERMONT, BURLINGTON, VERMONT, U.S.A.
KLUWER ACADEMIC PUBLISHERS DORDRECHT/ BOSTON / LONDON CONTENTS PREFACE
XII INTRODUCTION 1 METALS IN MEDICINE 2 CHEMOTHERAPEUTIC AGENTS AND
DRUGS 4 MECHANISMS OF TOXICITY 4 METAL ACCUMULATION AND ACTIVATION 4
BIOCHEMICAL TARGETS FOR METAL COMPLEXES 5 SUMMARY 6 REFERENCES 6 CHAPTER
1. INTERACTION OF METAL COMPLEXES WITH DNA 8 1.1. DNA AND CONFORMATION
10 1.1.1. NUCLEASES AND DNA 14 1.2. EXPERIMENTAL METHODS FOR THE STUDY
OF CONFORMATIONAL CHANGES 16 1.2.1. ULTRAVIOLET SPECTROSCOPY 16 1.2.2.
CIRCULAR DICHROISM AND OPTICAL DISPERSION 16 1.2.3. NUCLEAR MAGNETIC
RESONANCE . 17 1.2.4. HYDRODYNAMIC AND LIGHT SCATTERING PROPERTIES 17
1.3. BINDING OF METAL COMPLEXES TO DNA 17 1.3.1. INTERCALATION 18
1.3.1.1. PLATINUM*TERPYRIDINE COMPLEXES 20 1.3.1.2.
METAL*(1,10-PHENANTHROLINE) COMPLEXES 22 1.3.1.3. PORPHYRINS AND
METALLOPORPHYRINS 24 1.3.1.4. INTERCALATORS AS DRUGS 25 1.3.1.5. REDOX
ACTIVITY OF METALLOINTERCALATORS 26 1.3.2. OUTER SPHERE BINDING 27
1.3.2.1. METAL*AMINE COMPLEXES 27 1.3.3. INNER SPHERE (COVALENT) BINDING
29 1.3.3.1. BINDING OF PLATINUM*AMINE COMPLEXES 30 VI CONTENTS 1.3.3.2.
PLATINUM*AMINE COMPLEXES AND INTERCALATORS 33 1.3.3.3. RESTRICTION
ENZYMES AND PLATINUM COMPLEXES 35 1.3.4. STRAND BREAKAGE 36 1.3.4.1.
COPPER*(1,10-PHENANTHROLINE) COMPLEXES 36 1.3.4.2.
COBALT*(1,10-PHENANTHROLINE) COMPLEXES 37 1.3.4.3.
IRON*EDTA*(DNA-BINDER) COMPLEXES 37 1.4. SUMMARY 40 REFERENCES 40
CHAPTER 2. PLATINUM*AMINE COMPLEXES AS ANTICANCER AGENTS 2.1. THE
DISCOVERY OF CISPLATIN AS AN ANTITUMOUR AGENT 46 2.2. CLINICAL
PROPERTIES OF CISPLATIN 49 2.3. DEVELOPMENT OF CISPLATIN ANALOGUES 54
2.3.1. CLINICAL TRIALS OF CISPLATIN ANALOGUES 58 2.4. BIOCHEMICAL
MECHANISM OF ACTION OF PLATINUM COM- PLEXES 59 2.4.1. BIOLOGICAL EFFECTS
IMPLYING DNA AS TARGET 60 2.4.2. BIOLOGICAL EFFECTS NOT INVOLVING DNA 62
2.5. SUMMARY 62 REFERENCES 63 CHAPTER 3. STRUCTURE*ACTIVITY
RELATIONSHIPS OF PLATINUM* AMINE COMPLEXES 67 3.1. THE REQUIREMENT FOR
NEUTRALITY 6 8 3.2. COMPLEXES OF PT(IV) 70 3.3. NATURE OF THE LEAVING
GROUP 72 3.3.1. BISPLATINUM COMPLEXES CONTAINING BRIDGING DICARBOXY-
LATES 74 3.3.2. SULFOXIDES AS LEAVING GROUPS 74 3.4. NATURE OF THE
NONLEAVING GROUP 76 3.4.1. STEREOSPECIFIC EFFECTS IN AMINE COMPLEXES 77
3.5. NOVEL AND TARGETED APPROACHES TO [PTX 2 (AM) 2 ] COM- PLEXES 80
3.5.1. TERNARY COMPLEXES 80 3.5.2. AMINES AS CARRIER LIGANDS 82 3.6.
QUANTITATIVE STRUCTURE*ACTIVITY RELATIONSHIPS 84 3.7. CHEMISTRY OF
PLATINUM*AMINE COMPLEXES 85 3.7.1. REACTIONS WITH BIOMOLECULES OTHER
THAN DNA 88 3.8. SUMMARY 90 REFERENCES 90 CONTENTS VII CHAPTER 4.
INTERACTIONS OF PLATINUM COMPLEXES WITH DNA COMPONENTS 95 4.1.
STRUCTURAL ASPECTS OF METAL*NUCLEOBASE BINDING 95 4.1.1. BINDING IN
SOLUTION 96 4.1.1.1. BASICITY AND PH 96 4.1.1.2. HARD*SOFT RELATIONSHIP
OF DONOR ATOM AND METAL ION 96 4.1.1.3. STERIC EFFECTS INCLUDING
HYDROGEN BONDING 97 4.1.1.4. BASE STACKING AND CHELATION 97 4.1.2.
BINDING OF PLATINUM COMPLEXES IN SOLUTION 97 4.2. REACTIVITY OF PLATINUM
METAL*BASE COMPLEXES 100 4.2.1. EFFECT OF METALLATION ON ACIDITY OF
NONCOORDINATED ATOMS 101 4.2.1.1. THEPLATINUM-N 7 ,O 6 CHELATE 102
4.2.2. EFFECT OF METALLATION ON C-H EXCHANGE 102 4.2.3. SUSCEPTIBILITY
TO OXIDATION OF METAL*BASE COMPLEXES 103 4.2.4. REACTIVITY OF NUCLEOSIDE
AND NUCLEOTIDE LINKAGES 104 4.2.5. REACTIVITY OF METAL*BASE COMPLEXES
TOWARD NUCLEO- PHILES 104 4.2.6. LINKAGE ISOMERIZATION 105 4.2.7.
ROTATION AROUND METAL*PURINE BONDS 106 4.3. SOLID STATE STRUCTURAL
STUDIES 106 4.4. STRUCTURAL STUDIES ON DI- AND OLIGONUCLEOTIDE COM-
PLEXES 110 4.4.1. STUDIES ON DINUCLEOTIDE COMPLEXES 110 4.4.2. STUDIES
ON TRINUCLEOTIDES 113 4.4.3. STUDIES ON OLIGONUCLEOTIDES 114 4.4.3.1.
STRUCTURAL STUDIES ON OLIGONUCLEOTIDES 115 4.5. PLATINUM ADDUCTS FROM
DNA DEGRADATION 117 4.6. ON THE MOLECULAR MECHANISM OF ANTITUMOUR ACTION
OF CISPLATIN 118 4.7. SUMMARY 121 REFERENCES 121 CHAPTER 5. THE
PLATINUM*PYRIMIDINE BLUES 127 5.1. PROPERTIES OF THE PLATINUM*PYRIMIDINE
BLUES 127 5.2. PLATINUM BLUES NOT DERIVED FROM PYRIMIDINES 128 5.3.
X-RAY STRUCTURE OF PLATINUM*PYRIMIDINE AND A- PYRIDONE BLUES 128 5.4.
FORMATION OF PLATINUM*PYRIMIDINE AND A-PYRIDONE BLUES 131 VIII CONTENTS
5.4.1. 5.4.2. 5.4.3. 5.5. 5.6. 5.7. MONOMENC COMPLEXES DIMERIC COMPLEXES
COMPLEXES OF PT(III) STUDIES OF CRYSTALLINE BLUES BIOLOGICAL STUDIES ON
PLATINUM*PYRIMIDINE BLUE PRE- CURSORS SUMMARY REFERENCES CHAPTER 6.
ANTITUMOUR ACTIVITY OF METAL COMPLEXES 6.1. 6.1.1. 6.1.2. 6.1.2.1.
6.1.3. 6.1.3.1. 6.2. 6.2.1. 6.2.2. 6.2.3. 6.2.4. 6.3. 6.4. 6.5. PLATINUM
GROUP METAL COMPLEXES PALLADIUM COMPLEXES RHODIUM COMPLEXES STUDIES ON
RHODIUM CARBOXYLATES RUTHENIUM COMPLEXES STUDIES ON RUTHENIUM*AMINE
COMPLEXES COPPER COMPLEXES BIS(THIOSEMICARBAZONE) COMPLEXES
THIOSEMICARBAZONE COMPLEXES NITROGEN CHELATES COPPER SALICYLATES SILVER
AND GOLD ORGANOMETALLIC COMPLEXES SUMMARY REFERENCES CHAPTER 7.
METAL-MEDIATED ANTIBIOTIC ACTION 7.1. 7.2. 7.3. 7.3.1. 7.3.2. 7.3.3.
7.4. 7.4.1. 7.4.2. 7.5. 7.5.1. 7.5.1.1. 7.5.2. 7.6. DISCOVERY AND
PHARMACOLOGY OF BLEOMYCIN STRUCTURE OF BLEOMYCIN AND ANALOGUES METAL
COMPLEXES OF BLEOMYCIN COPPER BLEOMYCIN COBALT BLEOMYCIN MANGANESE
BLEOMYCIN MECHANISM OF ACTION OF BLEOMYCIN DNA*BLEOMYCIN INTERACTIONS
IRON AND IRON*OXYGEN ADDUCTS OTHER METAL BINDING ANTIBIOTICS
ANTHRACYCLINES BIOCHEMICAL ASPECTS OF METAL*ANTHRACYCLINES STREPTONIGRIN
SUMMARY REFERENCES 131 133 136 138 138 139 139 142 143 144 144 145 147
150 151 151 153 155 155 157 160 163 163 168 168 169 170 171 171 172 172
173 173 175 176 177 178 179 179 CONTENTS CHAPTER 8. METALS, METAL
COMPLEXES, AND RADIATION 8.1. 8.2. 8.2.1. 8.3. 8.3.1. 8.3.2. 8.3.3.
8.3.3.1. 8.3.3.2. 8.3.4. 8.3.4.1. 8.3.5. 8.4. 8.4.1. 8.5. 8.6.
INTERACTION OF RADIATION AND BIOLOGICAL TISSUE CHEMICAL MODIFICATION OF
RADIATION DAMAGE OXYGEN MIMICS AND ELECTRON AFFINITY METAL COMPLEXES AS
RADIATION SENSITIZERS RADIOSENSITIZATION BY METAL SALTS COBALT*AMINE
COMPLEXES RADIOSENSITIZATION BY ELECTRON AFFINITY METAL*RADIOSENSITIZER
COMPLEXES METAL CHELATES POTENTIATION OF RADIATION DAMAGE BY
PLATINUM*AMINES. DIFFERENTIAL REPAIR PROCESSES MECHANISM OF ACTION OF
PLATINUM*AMINE COMPLEXES RADIOSENSITIZATION BY THIOL DEPLETION METAL
COMPLEXES AND RADIOPROTECTION METAL COMPLEXES AS RADIOPROTECTORS
ACTIVATION OF METAL COMPLEXES SUMMARY REFERENCES CHAPTER 9.
ANTIBACTERIAL EFFECTS OF METAL COMPLEXES 9.1. 9.1.1. 9.1.2. 9.2. 9.3.
9.4. 9.5. MERCURY AND SILVER SALTS AS ANTIBACTERIAL AGENTS MERCURY
SILVER ANTIBACTERIAL ACTIVITY OF CHELATING AGENTS AND METAL CHELATES
ANTIBACTERIAL ACTIVITY OF METAL*AMINE COMPLEXES REDOX ACTIVITY AND
ANTIBACTERIAL ACTIVITY SUMMARY REFERENCES CHAPTER 10. ANTIVIRAL AND
ANTIPARASITIC EFFECTS OF METAL COM- 10.1. 10.2. 10.2.1. 10.2.2. 10.2.3.
10.2.4. 10.2.5. 10.3 PLEXES ANTIVIRAL THERAPY CHELATING AGENTS AND METAL
COMPLEXES AS ANTIVIRAL AGENTS CHELATING AGENTS
METAL*(1,10-PHENANTHROLINE) COMPLEXES PLATINUM* AND PALLADIUM*AMINE
COMPLEXES ZINC COMPLEXES OTHER METAL COMPLEXES METAL COMPLEXES AS
ANTIPROTOZOAL AGENTS IX 183 183 187 188 190 190 192 193 193 196 197 198
200 201 201 202 203 204 208 209 209 211 214 217 219 219 220 222 222 225
225 226 226 228 229 230 X CONTENTS 10.3.1. METAL COMPLEXES IN
TRYPANOSOMIASIS 231 10.3.2. PLATINUM*AMINE COMPLEXES AS TRYPANOCIDES 232
10.3.3. OTHER METAL COMPLEXES 233 10.3.4. PORPHYRINS AND
METALLOPORPHYRINS AS TRYPANOCIDES. METAL SEQUESTRATION 234 10.3.5. METAL
COMPLEXES WITH TRYPANOCIDAL DRUGS. DUAL-FUNC- TION AGENTS 236 10.3.6.
METAL COMPLEXES IN AMERICAN TRYPANOSOMIASIS 238 10.4. SUMMARY 239
REFERENCES 239 CHAPTER 11 METAL COMPLEXES IN ARTHRITIS 243 11.1. GOLD
COMPLEXES IN THE TREATMENT OF RHEUMATOID ARTHRITIS 243 11.1.1. ACTIVITY
AND TOXICITY OF GOLD DRUGS 244 11.1.2. STRUCTURES OF GOLD COMPLEXES 245
11.1.3. CHEMISTRY AND BIOCHEMISTRY OF GOLD DRUGS 246 11.1.4. MECHANISM
OF ACTION OF GOLD DRUGS 247 11.2. COPPER IN ARTHRITIS 248 11.2.1. COPPER
COMPLEXES IN ARTHRITIS 249 11.2.2. COPPER BRACELETS 250 11.2.3.
COPPERAND D-PENICILLAMINE 250 11.2.4. MECHANISM OF ACTION OF COPPER
COMPLEXES 251 11.3. OTHER METALS 252 11.4. SUMMARY 252 REFERENCES 253
CHAPTER 12. MISCELLANEOUS USES OF METAL COMPLEXES 257 12.1. MERCURIAL
DIURETICS 257 12.2. NEUROMUSCULAR EFFECTS OF METAL COMPLEXES 259 12.3.
NITROPRUSSIDE AS VASODILATOR 261 12.3.1. ACTIVITY AND TOXICITY OF
NITROPRUSSIDE 261 12.3.2. MECHANISM OF ACTION OF NITROPRUSSIDE 262 12.4.
SUMMARY 263 REFERENCES 263 NAMES AND ABBREVIATIONS 266 GLOSSARY OF TERMS
AND DEFINITIONS 270 APPENDIX 1 274 CONTENTS XI APPENDIX 2 2 7 9 INDEX
OF SUBJECTS 281
|
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| id | DE-604.BV002461604 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-09T15:45:28Z |
| institution | BVB |
| isbn | 9027728283 |
| language | English |
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| publisher | Kluwer |
| record_format | marc |
| series | Catalysis by metal complexes |
| series2 | Catalysis by metal complexes |
| spelling | Farrell, Nicholas 1948- Verfasser (DE-588)17207181X aut Transition metal complexes as drugs and chemotherapeutic agents Nicholas Farrell Dordrecht [u.a.] Kluwer 1989 XI, 291 S. txt rdacontent n rdamedia nc rdacarrier Catalysis by metal complexes 11 Métaux de transition - Composés - Effets physiologiques Métaux de transition - Composés - Emploi en thérapeutique - Essais Metals pharmacokinetics Metals therapeutic use Transition metal complexes Physiological effect Transition metal complexes Therapeutic use Testing Arzneimittel (DE-588)4003115-9 gnd rswk-swf Übergangsmetallkomplexe (DE-588)4131837-7 gnd rswk-swf Pharmakologie (DE-588)4045687-0 gnd rswk-swf Chemotherapeutikum (DE-588)4009895-3 gnd rswk-swf Übergangsmetallkomplexe (DE-588)4131837-7 s Pharmakologie (DE-588)4045687-0 s DE-604 Chemotherapeutikum (DE-588)4009895-3 s Arzneimittel (DE-588)4003115-9 s Catalysis by metal complexes 11 (DE-604)BV001899776 11 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001591302&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Farrell, Nicholas 1948- Transition metal complexes as drugs and chemotherapeutic agents Catalysis by metal complexes Métaux de transition - Composés - Effets physiologiques Métaux de transition - Composés - Emploi en thérapeutique - Essais Metals pharmacokinetics Metals therapeutic use Transition metal complexes Physiological effect Transition metal complexes Therapeutic use Testing Arzneimittel (DE-588)4003115-9 gnd Übergangsmetallkomplexe (DE-588)4131837-7 gnd Pharmakologie (DE-588)4045687-0 gnd Chemotherapeutikum (DE-588)4009895-3 gnd |
| subject_GND | (DE-588)4003115-9 (DE-588)4131837-7 (DE-588)4045687-0 (DE-588)4009895-3 |
| title | Transition metal complexes as drugs and chemotherapeutic agents |
| title_auth | Transition metal complexes as drugs and chemotherapeutic agents |
| title_exact_search | Transition metal complexes as drugs and chemotherapeutic agents |
| title_full | Transition metal complexes as drugs and chemotherapeutic agents Nicholas Farrell |
| title_fullStr | Transition metal complexes as drugs and chemotherapeutic agents Nicholas Farrell |
| title_full_unstemmed | Transition metal complexes as drugs and chemotherapeutic agents Nicholas Farrell |
| title_short | Transition metal complexes as drugs and chemotherapeutic agents |
| title_sort | transition metal complexes as drugs and chemotherapeutic agents |
| topic | Métaux de transition - Composés - Effets physiologiques Métaux de transition - Composés - Emploi en thérapeutique - Essais Metals pharmacokinetics Metals therapeutic use Transition metal complexes Physiological effect Transition metal complexes Therapeutic use Testing Arzneimittel (DE-588)4003115-9 gnd Übergangsmetallkomplexe (DE-588)4131837-7 gnd Pharmakologie (DE-588)4045687-0 gnd Chemotherapeutikum (DE-588)4009895-3 gnd |
| topic_facet | Métaux de transition - Composés - Effets physiologiques Métaux de transition - Composés - Emploi en thérapeutique - Essais Metals pharmacokinetics Metals therapeutic use Transition metal complexes Physiological effect Transition metal complexes Therapeutic use Testing Arzneimittel Übergangsmetallkomplexe Pharmakologie Chemotherapeutikum |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001591302&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV001899776 |
| work_keys_str_mv | AT farrellnicholas transitionmetalcomplexesasdrugsandchemotherapeuticagents |