The acridines: their preparation, physical, chemical and biological properties and uses
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
London
Arnold
1966
|
| Edition: | 2. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 604 S. graph. Darst. 24 cm |
Staff View
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Record in the Search Index
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| adam_text | THE ACRIDINES
Their Preparation
Physical, Chemical and Biological
Properties and Uses
Second Edition
ADRIEN ALBERT
D Sc (London); Ph D Medicine (London); B Sc (Sydney); FRIC, Professor
of Medical Chemistry, John Curtin School of Medical Research, The Australian
National University, Canberra Fellow of the Australian Academy of Science
London: EDWARD ARNOLD (PUBLISHERS) LTD
Contents
Page
The numbering of the acridine ring Front end paper
Preface v
Notes on numbering the acridine ring xi
PART I: PREPARATIVE METHODS
CHAPTER
1 Interconversion of acridines, acridones, and acridans 3
2 Synthesis of acridones and 9-chloroacridines by ring-closure of
diphenylamine-2-carboxylic acids 29
3 The preparation of diphenylamine-2-carboxylic acids (phenylan-
thranilic acids) as starting material for the reactions of Chapter 2 56
4 Synthesis of acridines by ring-closure of diphenylamine-2-alde-
hydes, and -2-ketones 78
5 Synthesis of acridines Ifrom diphenylamine and organic acids
Preparation of diphenylamines 91
6 Synthesis of acridines from wz-phenylenediamine(s) and formic
acid 103
7 Synthesis of acridans from aromatic amines and aldehydes, or from
their derivatives 114
8 Miscellaneous syntheses of acridones, acridines, and acridans 131
9 How to choose a suitable preparative method Hints on the mani
pulation and purification of acridines 143
PART II: PHYSICAL PROPERTIES
10 Surface Activity and Association Ionization Dipole Moments 155
11 Spectra Fluorescence and phosphorescence 176
PART III: CHEMICAL PROPERTIES
12 Chemical properties of acridines (excluding aminoacridines) 233
Alkyl-, aryl-, halogeno-, alkoxy-, hydroxy-, nitro-, and cyano-
acridines 245
Acridine-aldehydes, -ketones, -carboxylic acids, -sulphonic
acids, -arsonic acids, and -stibonic acids; also their derivatives 266
Nitrogen-oxides, thio-ethers, seleno-ethers 269
Benzacridines 274
13 Aminoacridines with no C-substituent 284
Aminacrine, Proflavine, Acridine Orange
X Contents
CHAPTER Page
14 Aminoacridines bearing C-substituents
Ethacridine ( Rivanol ), Entozon , Mepacrine (Quinacrine,
Atebrin ), Aminoacrichine, Azacrin , AcraniV 308
Acridine Yellow, Benzoflavine, Chrysaniline, Flaveosin, Phos-
phine, Rheonine
15 Quaternary acridines 330
Acriflavine, Euflavine, Trypaflavin , Diamond Phosphine and
other quaternized dyes
16 Acridans, and other hydroacridines 350
Tacrine (tetrahydro-aminacrine) Carbazons, Carbazims
17 Acridones, thio- and seleno-acridones, tetrahydroacridones 371
18 Binuclear acridines
Biacridyls, biacridylidenes, biacridanyls, Luzigenin, Biacridonyls 391
PART IV: BIOLOGICAL PROPERTIES AND USES
19 The utilization of acridines in clinical medicine
General review Antibacterials Antimalarials 403
Anthelmintics Anti-immune substances 430
Analeptics, and Morphine antagonists 431
20 The connexion between antibacterial action and physicochemical 434
properties in the acridine series
21 The connexion between antimalarial action and chemical structure
in the acridine series Trypanocidal action 469
22 Complexes of acridines with nucleic acid Vital staining, antiviral
action, mutogenesis, antimitotic activity 493
23 Vertebrate pharmacology and toxicology of acridines Action on
enzymes Carcinogenicity and anticarcinogenicity 504
PART V: DYES AND REAGENTS
24 The utilization of acridines as pigments and dyestuffs 523
25 Other applications of acridines Analytical uses, Antioxidants and
corrosion inhibitors, Biochemical Reagents, Chemiluminescence,
Energy Cells, Industrial disinfection and preservation, Micro
scopical reagents, Photographic reagents 535
References 546
Subject Index 585
Index to preparations 603
Frontispiece Reproduction of Graebe and Caro s description of
acridine in Annalen (facing title page)
Plate Atomic models of the cations of 9-aminoacridine (left-
hand pair) and its 1-, 2-, 3-, 4-tetrahydro-analogue (right-hand
pair) (facing p 452)
|
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| dewey-ones | 661 - Technology of industrial chemicals |
| dewey-raw | 661.894 |
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| discipline | Chemie / Pharmazie Chemie |
| edition | 2. ed. |
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| indexdate | 2024-07-09T15:39:33Z |
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| language | English |
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| owner_facet | DE-91G DE-BY-TUM DE-355 DE-BY-UBR DE-19 DE-BY-UBM DE-83 DE-11 DE-210 |
| physical | 604 S. graph. Darst. 24 cm |
| psigel | TUB-nveb HUB-ZB011200707 |
| publishDate | 1966 |
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| publisher | Arnold |
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| spelling | Albert, Adrien 1907-1989 Verfasser (DE-588)1019608390 aut The acridines their preparation, physical, chemical and biological properties and uses 2. ed. London Arnold 1966 604 S. graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Acridine Acridines Acridinderivate (DE-588)4141307-6 gnd rswk-swf Acridane (DE-588)4134737-7 gnd rswk-swf Acridinonderivate (DE-588)4141311-8 gnd rswk-swf Acridinonderivate (DE-588)4141311-8 s DE-604 Acridane (DE-588)4134737-7 s Acridinderivate (DE-588)4141307-6 s HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001342988&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Albert, Adrien 1907-1989 The acridines their preparation, physical, chemical and biological properties and uses Acridine Acridines Acridinderivate (DE-588)4141307-6 gnd Acridane (DE-588)4134737-7 gnd Acridinonderivate (DE-588)4141311-8 gnd |
| subject_GND | (DE-588)4141307-6 (DE-588)4134737-7 (DE-588)4141311-8 |
| title | The acridines their preparation, physical, chemical and biological properties and uses |
| title_auth | The acridines their preparation, physical, chemical and biological properties and uses |
| title_exact_search | The acridines their preparation, physical, chemical and biological properties and uses |
| title_full | The acridines their preparation, physical, chemical and biological properties and uses |
| title_fullStr | The acridines their preparation, physical, chemical and biological properties and uses |
| title_full_unstemmed | The acridines their preparation, physical, chemical and biological properties and uses |
| title_short | The acridines |
| title_sort | the acridines their preparation physical chemical and biological properties and uses |
| title_sub | their preparation, physical, chemical and biological properties and uses |
| topic | Acridine Acridines Acridinderivate (DE-588)4141307-6 gnd Acridane (DE-588)4134737-7 gnd Acridinonderivate (DE-588)4141311-8 gnd |
| topic_facet | Acridine Acridines Acridinderivate Acridane Acridinonderivate |
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