Integration of mitochondrial function: [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.]
Saved in:
| Format: | Conference Proceeding Book |
|---|---|
| Language: | English |
| Published: |
New York u.a.
Plenum Pr.
1988
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIII, 664 S. Ill. |
| ISBN: | 0306429993 |
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Record in the Search Index
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| adam_text | INTEGRATION OF
MITOCHONDRIAL
FUNCTION
Edited by
John J Lemasters,
Charles R Hackenbrock,
and Ronald G Thurman
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
and
Hans V Westerhoff
National Institutes of Health
Bethesda, Maryland
PLENUM PRESS • NEW YORK AND LONDON
CONTENTS
Section I
DIFFUSIONAL INTEGRATION OF MITOCHONDRIAL FUNCTION
Oiffusional Integration of Mitochondrial Function: Lateral Diffusion
of Proteins in Energy Transduction
E C Slater 3
Diffusion and Collision in Cytochrome c-Mediated Electron Transport
Charles R Hackenbrock and Sharmila Shaila Gupte 15
Is Electron Transfer Mediated By Random Diffusion Alone?
S Ferguson-Miller, K Rajarathnam, 3 Hochman, and M Schindler 23
Role of Ubiquinone Diffusion in Mitochondrial Electron Transfer
G Lenaz, R Fato, C Castelluccio, M Degli Esposti,
C M Samworth, M Battino, and G Parenti Castelli 33
Physical Constraints on Lateral Diffusion and Ubiquinone-Mediated
Mitochondrial Electron Transport
Brad Chazotte and Charles R Hackenbrock 53
Inhibition of Bovine Heart Mitochondrial NADH-Ubiquinone Reductase
by Tinopal AN, A Cationic Benzoxazole
W Marshall Anderson and Deborah L Delinck-Gordon 63
Topographical Changes in Cytochrome c Oxidase in the Soluble and
Membrane-Bound Enzyme as Probed by Antibodies to Subunit V
and the_ Whole Enzyme
Jo A Freedman, Samuel H/P Chan, and P Nicholls 71
Multiple Forms of Cytochrome C Oxidase Observed in Heart Tissue,
Myocytes, and Mitochondria by Fourier Transform Infrared
Spectroscopy
Frank G Fiamingo, Ruth A Altschuld, and James O Alben 79
Functional Importance of Mitochondrial Cardiolipin in Yeast
Cytochrome c Oxidase Activity
A Trivedi, A V Wearring, S D Kohlwein, F Paltauf,
and E R Tustanoff 87
Lateral Diffusion of Mitochondrial FJFQATP Synthase: A Random
Collision Model For Proton Transier and ATP Synthesis
Sharmila Shaila Gupte and Charles R Hackenbrock 95
Section II
THERMODYNAMIC INTEGRATION
Thermodynamics and Control of Proton-Motive Free-Energy
Transduction
Hans V Westerhoff, Fernando Ferrer, and R Dean Astumian 105
The Mechanism of Uncoupling of Oxidative Phosphorylation
G F Azzone, Daniela Pietrobon, and S Luvisetto 121
Upper and Lower Limits of Charge, Proton, and ATP Stoichiometrics
of Oxidative Phosphorylation
Andrew D Beavis 135
ATP/2e~ Stoichiometries for the Coupling Sites of Mitochondrial
Oxidative Phosphorylation: Evaluation by Equilibrium and
Non-Equilibrium Thermodynamics
John J Lemasters, Jo A Freedman, Kenneth E Fleishman,
and Thomas L Dawson 155
Nonequilibrium Thermodynamics and Cellular Bioenergetics
Jorg W Stucki and Erwin Sigel 169
The Near-Equilibrium Thermodynamics Approach to Living Systems
William L Gitomer and Richard L Veech 177
The H+/e~ Forces and Stoichiometries of the Mitochondrial
Respiratory Chain
Guy Brown 197
Variation of Efficiency With Free Energy Dissipation in Theoretical
Models of Oxidative Phosphorylation and Cytochrome Oxidase
Davor Juretic, Richard W Hendler, and Hans V Westerhoff 205
Analysis of Mechanisms of Free Energy Coupling and Uncoupling by
Inhibitor Titrations
Daniela Pietrobon, Valeria Petronilli and G F Azzone 213
Section III
FLUX CONTROL AND STRUCTURAL REGULATION
Mechanisms Stabilizing the-Protonmotive Force in Respiring
Mitochondria ——-
Jerzy Duszynsky, Anna Zolkiewska, Krystyna Bogucka,
and Lech Wojtczak 223
Regulation of Respiration and Pyruvate Dehydrogenase in Isolated
Cardiac Myocytes and Hepatocytes
Richard G Hansford, Rafael Moreno-Sanchez and James Staddon 235
Control Analysis of Cellular Metabolism: Application to
Gluconeogenesis in Rat-Liver Cells
Albert K Groen and Joseph M Tager 2 t5
Mitochondrial Volume Control
Keith D Garlid 259
Organization of the Mitochondrial Matrix
Paul A Srere, Lindsey Inman, Zsolt Liposits, and Balazs Sumegi 279
X
Competition Between Electron Transfer and ATPase in Generating
Steady-State Protonmotive Force and Phosphorylation Potential
E Jack Davis and WIA Davis-van Thienen 289
Control of Respiration and ATP Hydrolysis in Uncoupled Mitochondria
Rafael Moreno-Sanchez, M Teresa Espinosa-Garcia,
and J Carlos Raya 297
Voltage-Dependent Channels Are Present in the Inner Membrane of
Mitochondria
M Catia Sorgato, Giovanna Lippe, Bernhard U Keller,
and Walte r Stuhmer 305
The Kinetics of Inorganic Phosphate Uptake and Utilization By Chick
Heart Mitochondria
Peter P Toth, Britton Chance, John E Sell, John F Holland,
Shelagh Ferguson-Miller, and Clarence H Suelter 313
Possible Role of Membrane-Enzyme Interactions in Activation of
Pyruvate Carboxylation and Decarboxylation in Mitochondria
Jan Zaleski, Malgorzata Zaleski, and Maria Erecinska 325
Duramycin Effects on Mitochondrial Structure and Function
Patricia M Sokolove, Mary Beth Kester, Patricia A Westphal,
Roderick Wierwille, and Karin Sikora-VanMeter 333
Mitochondrial Compartmentation of Branched Chain Amino Acid
Catabolism: Is The Aminotransferase A Mitochondrial Enzyme?
Susan M Hutson and Connie Mahar 341
Mitochondrial Lactate Dehydrogenase
E S Kline, R B Brandt, J E Laux and S E Spainhour 349
Lithium Ion Is a Competitive Inhibitor of the Na+ Selective Na+/H+
Antiporter from Mitochondria
Sati Nath and Keith Garlid 357
Section IV
IN SITU ASSESSMENT OF MITOCHONDRIAL FUNCTION
Mitochondrial Membrane Potential and pH Gradient in Hypoxic
Hepatocytesj Characteristics of The Neahypoxic State
Tak Yee Aw, Xiaoqi n Shan, Bo S Anderson, and Dean P Jones 367
Blebbing, Cytosolic Free Calcium, and Mitochondrial Membrane
Potential Following Toxic and Anoxic Injury in Hepatocytes
Brian Herman, Anna-Liisa Nieminen, Gregory J Gores,
and John J Lemasters 379
Physiological Significance of a New Adenine Nucleotide Transport
Mechanism in Liver Mitochondria
June R Aprille 393
Integration of Mitochondrial Function with High Aerobic Glycolysis in
Tumors: Role of Hexokinase Binding to the Outer Mitochondrial
Membrane
Richard A Nakashima, Marco G Paggi, Krishan K Arora,
and Peter L Petersen 405
xi
Cytosolic Free Calcium and Myocardial Cell Injury
E Murphy, C Steenbergen, A LeFurgey, M Lieberman,
and R E London 413
Relationships Between Extracellular pH, Intracellular pH and Cell
Injury During Chemical Hypoxia
Gregory 3 Gores, Anna-Liisa Nieminen, Thomas L Dawson,
Brian Herman, and John J Lemasters 421
Regulation of the Mitochondrial ATPase In Situ in Slow and Fast
Heart-Rate Hearts -
William Rouslin 429
The Role of Ionized Cytosolic Calcium ([Ca^+] j) in Acute and Chronic
Cell Injury
Benjamin F Trump, Mary W Smith, Patricia C Phelps,
Annette L Regec, and Irene K Berezesky 437
Succinate and Oxygen Dependence of Mitochondrial Function in
Neonatal Hepatocytes
Tak Yee Aw and Dean P Jones 445
Cyclic Nucleotides and Mitochondrial Functions at Birth
Daniele C Gautheron, Jane Comte, and Roger Meister 451
Simultaneous Determination of Proton Concentration in Two
Compartments
P J Thomas and J A Thomas 459
Tetraphenylphosphonium Ion Distribution in Human Fibroblasts as a
Function of In Vitro Aging
Michela Rugolo, Teresa Mastrocola, and Giorgio Lenaz 467
Section V
HORMONES AND CALCIUM
The Role of Calcium in the Control of Cell Function
Ernesto Carafoli 475
Hormonal Control of Ca^+-5ensitive Intramitochondrial Enzymes in
Mammalian Tissues
James G McCormack and Richard M Denton 487
Effect of Mitochondrial Ca^+ on Hepatic Aspartate Formation and
Gluconeogenic Flux
K F LaNoue, A Sterniczuk, T Strzelecki, S Hreniuk,
and R Scaduto, Jr 497
Glucagon Stimulation Of Mitochondrial Metabolism
Robert C Haynes, Jr 511
The Function of the Uncoupling Protein in the Intact Brown Fat Cell
David Nicholls and Eduardo Rial 517
Hormonal Regulation of the Hepatic 2-Oxoglutarate Dehydrogenase
Complex
Tarun B Patel and Hani M Rashed 527
xii
Ca -Dependent NAD(P)+-Induced Alterations In Membrane
Permeability of Rat Liver Mitochondria
Denise V Macedo, Valmir L Ferraz, Lucia Pereira-da-Silva,
and Anibal E Vercesi 535
Integrated Mitochondrial and Microsomal Regulation of Free Ca^+ in
Permeabilized Insulinoma Cells
Barbara E Corkey, Keith Tornheim, Jude T Deeney,
M Clay Glennon, Janice C Parker, Franz M Matschinsky,
Neil B Ruderman, and Marc Prentki 543
The Estimation of the In Vivo Mitochondrial Free Ca^+
Concentration
William L Gitomer and Richard L Veech 551
Section VI
INTERCELLULAR INTEGRATION OF ENERGY-LINKED METABOLISM
Metabolic Zonation of Carbohydrate Metabolism in the Liver
Kurt Jungermann 561
Acinar Compartmentation of Amino Acid and Ammonia Metabolism
and Its Functional Significance
Dieter Haussinger 581
Role of Mitochondria in Zone-Specific Toxicity to the Liver Lobule
Frederick C Kauffman, Mostafa Z Badr, Stephen A Belinsky,
Michael Whittaker, and Ronald G Thurman 591
Role of Calcium in Regulation of Hepatic Oxygen Uptake
Harumasa Yoshihara, Takakatsu Matsumura, Roger Jeffs,
Frederick C Kauffman, John J Lemasters, Meina Liang,
and Ronald G Thurman 605
Heterogeneity of Energy Metabolism in the Kidney
Lazaro J Mandel 617
Metabolic Key to Hypoxia Tolerance: Loss of Regulatory Links
Between the Electron Transfer System and Glycolysis
P * Hochachka 623
Glucagon Actions in Perfused Liver Are Oxygen Dependent
Zenro Kizaki and Ronald G Thurman 629
Microzonation of Metabolism Associated with Mitochondrial
Distribution in Cells
Dean P Jones and Tak Yee Aw 637
Contributors 643
Index 653
xiii
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| spelling | Integration of mitochondrial function [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.] ed. by John J. Lemasters ... New York u.a. Plenum Pr. 1988 XIII, 664 S. Ill. txt rdacontent n rdamedia nc rdacarrier Mitochondrium (DE-588)4124939-2 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1987 Chapel Hill NC gnd-content Mitochondrium (DE-588)4124939-2 s DE-604 Lemasters, John J. Sonstige oth International Conference on Integration of Mitochondrial Function 1987 Chapel Hill, NC Sonstige (DE-588)3003121-7 oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001326831&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Integration of mitochondrial function [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.] Mitochondrium (DE-588)4124939-2 gnd |
| subject_GND | (DE-588)4124939-2 (DE-588)1071861417 |
| title | Integration of mitochondrial function [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.] |
| title_auth | Integration of mitochondrial function [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.] |
| title_exact_search | Integration of mitochondrial function [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.] |
| title_full | Integration of mitochondrial function [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.] ed. by John J. Lemasters ... |
| title_fullStr | Integration of mitochondrial function [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.] ed. by John J. Lemasters ... |
| title_full_unstemmed | Integration of mitochondrial function [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.] ed. by John J. Lemasters ... |
| title_short | Integration of mitochondrial function |
| title_sort | integration of mitochondrial function proceedings of an international conference on integration of mitochondrial function held june 4 7 1987 in chapel hill n c |
| title_sub | [proceedings of an International Conference on Integration of Mitochondrial Function, held June 4 - 7, 1987, in Chapel Hill, N.C.] |
| topic | Mitochondrium (DE-588)4124939-2 gnd |
| topic_facet | Mitochondrium Konferenzschrift 1987 Chapel Hill NC |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001326831&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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