Modern drug research: paths to better and safer drugs
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York u.a.
Dekker
1989
|
| Series: | Medicinal research
12 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 507 S. |
| ISBN: | 0824779029 |
Staff View
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Record in the Search Index
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| adam_text | MODERN DRUG RESEARCH PATHS TO BETTER AND SAFER DRUGS EDITED BY . YVONNE
CONNOLLY MARTIN COMPUTER-ASSISTED MOLECULAR DESIGN PROJECT;
PHARMACEUTICAL PRODUCTS DIVISION ABBOTT LABORATORIES ABBOTT PARK,
ILLINOIS EBERHARD KUTTER DEPARTMENT OF RESEARCH AND DEVELOPMENT
BOEHRINGER INGELHEIM KG INGELHEIM, FEDERAL REPUBLIC OF GERMANY VOLKHARD
AUSTEL DEPARTMENT OF CHEMISTRY DR. KARL THOMAE GMBH BIBERBACH, FEDERAL
REPUBLIC OF GERMANY MARCEL DEKKER, INC. NEW YORK AND BASEL CONTENTS
ABOUT THE SERIES - GARY L. GRUNEWALD V PREFACE VII CONTRIBUTORS XV
CHAPTER 1 DRUG ACTION AND RECEPTOR THEORY 1 I. FUNCTIONAL AND STRUCTURAL
ASPECTS OF ORGANISMS 1 II. INTERACTION OF DRUGS WITH RECEPTORS AND
ENZYMES 8 III. SIGNAL TRANSDUCTION 19 IV. CONCLUSIONS 31 REFERENCES 33
CHAPTER 2 PROGRESS IN MOLECULAR PHARMACOLOGY AND BIOCHEMISTRY AS A LINK
BETWEEN DISEASES AND NEW DRUGS FOR THEIR TREATMENT 35 I. INTRODUCTION 35
II. CARDIOVASCULAR DISEASES: ATHEROSCLEROSIS 37 III. DISEASES OF THE
CENTRAL NERVOUS SYSTEM 39 IV. VIRAL INFECTIONS 47 V. IMMUNOLOGICAL
DISEASES 53 VI. CANCER 59 VII. OUTLOOK 71 REFERENCES 72 CHAPTER 3
PRINCIPLES OF PHARMACOKINETICS AND DRUG METABOLISM 77 I. THE
AVAILABILITY OF THE DRUG AT ITS SITES OF ACTION 77 II. PHYSIOLOGICAL
CONSIDERATIONS IN PHARMACOKINETICS 93 XI XII CONTENTS III.
BIOTRANSFORMATION OF XENOBIOTICS 118 IV. THE ROLE OF PHARMACOKINETICS
AND BIOTRANSFORMATION IN THE DEVELOPMENT OF BETTER AND SAFER DRUGS 146
REFERENCES 158 CHAPTER 4 THEORETICAL BASIS OF MEDICINAL CHEMISTRY:
STRUCTURE-ACTIVITY RELATIONSHIPS AND THREE- DIMENSIONAL STRUCTURES OF
SMALL AND MACROMOLECULES 161 I. FORCES WITH WHICH A BIOLOGICAL
MACROMOLECULE BINDS A SMALL MOLECULE 162 II. STRUCTURE-ACTIVITY
RELATIONSHIPS (SAR S) IN TERMS OF SUB-STRUCTURAL FEATURES 171 III. QSAR:
CORRELATION BETWEEN PHYSICAL PROPERTIES AND BIOLOGICAL POTENCY 176 IV.
THE ANALYSIS OF THREE-DIMENSIONAL PROPERTY- ACTIVITY RELATIONSHIPS TO
MAP BINDING SITES ON BIOMACROMOLECULES 190 V. STRUCTURE OF THE
BIOLOGICAL MACROMOLECULE- DRUG COMPLEX 201 VI. SUMMARY AND OUTLOOK 212
REFERENCES 213 CHAPTER 5 THE IMPORTANCE OF BIOTECHNOLOGY FOR THE
DISCOVERY OF BETTER AND SAFER DRUGS 217 I. INTRODUCTION 217 II.
PRODUCTION OF HUMAN PROTEINS, THE FIRST GENERATION OF NEW DRUGS FROM
RECOMBINANT DNA 218 III. NATURAL PROTEINS AS LEADS FOR STRUCTURALLY
MODIFIED PROTEINS: THE SECOND GENERATION OF PRODUCTS FROM BIOTECHNOLOGY
233 IV. EXAMINATION OF THE STRUCTURE AND FUNCTION OF PROTEINS AS TOOLS
FOR THE EVALUATION OF PATHOLOGICAL PROCESSES: THE THIRD GENERATION OF
PRODUCTS FROM BIOTECHNOLOGY 236 V. SUMMARY 239 REFERENCES 240 CHAPTER 6
THE MEDICINAL CHEMIST S APPROACH 243 I. GENERAL ASPECTS 243 II.
PROCEDURES THAT LEAD TO BETTER AND SAFER DRUGS 250 CONTENTS XIII III.
SUMMARY AND OUTLOOK 303 REFERENCES 306 CHAPTER 7 EVALUATION OF THE
THERAPEUTIC POTENTIAL OF NEW COMPOUNDS 309 I. INTRODUCTION 309 II.
PHARMACOLOGY AND MICROBIOLOGY AS LINKS BETWEEN BIOCHEMISTRY AND THERAPY
310 III. ETHICAL CONSIDERATIONS ON ANIMAL EXPERIMENTS 313 IV. STAGES OF
BIOLOGICAL TESTING 314 V. BASIC CONSIDERATIONS FOR TEST PROCEDURES 316
VI. EXPLORATIVE PHARMACOLOGICAL OR MICROBIOLOGICAL INVESTIGATIONS 318
VII. PROFILING OF SELECTED COMPOUNDS 330 VIII. EXTRAPOLATION OF RESULTS
FROM ANIMAL EXPERIMENTS INTO HUMAN THERAPY 348 REFERENCES 350 CHAPTER 8
SAFETY EVALUATION OF NEW DRUGS 355 I. INTRODUCTORY REMARKS 355 II.
ANIMAL WELFARE 356 III. PREREQUISITES TO TOXICOLOGICAL STUDIES 358 IV.
VETERINARY CARE OF ANIMALS IN TOXICOLOGY 361 V. TOXICOLOGICAL STUDIES IN
LABORATORY ANIMALS 362 VI. TEST PARAMETERS IN TOXICOLOGICAL STUDIES 381
VII. EVALUATION OF TOXICITY STUDIES 384 VIII. TOXICOLOGY OF
BIOTECHNOLOGICAL PRODUCTS 389 IX. EXPENDITURE IN TOXICOLOGY 392 X.
SUMMARY 394 REFERENCES 395 CHAPTER 9 THE CONTRIBUTION OF PHARMACEUTICS
TO IMPROVEMENTS IN DRUG THERAPY 401 I. GENERAL ASPECTS OF PHARMACEUTICS
IN DRUG DEVELOPMENT 401 II. PRINCIPAL WORKING AREAS IN PHARMACEUTICAL
RESEARCH 406 III. SPECIFIC EXAMPLES OF NEW DRUG DELIVERY SYSTEMS 421 IV.
OUTLOOK FOR THE CONTRIBUTION OF PHARMACEUTICS TO DRUG DEVELOPMENT 434
REFERENCES 439 XIV CONTENTS CHAPTER 10 SEARCH FOR BETTER AND SAFER
DRUGS: IMPACT OF EXTERNAL FACTORS - THE SOCIAL, FINANCIAL, AND 441
WORKING ENVIRONMENT I. DRUG THERAPY AND PUBLIC OPINION 442 II. DRUG
RESEARCH AND FINANCIAL CONSTRAINTS 448 III. WORKING CLIMATE FOR
INNOVATIVE DRUG RESEARCH 458 REFERENCES 468 ABBREVIATIONS 469 INDEX 471
|
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| callnumber-raw | RS420 |
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| dewey-full | 615/.1 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.1 |
| dewey-search | 615/.1 |
| dewey-sort | 3615 11 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Book |
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| indexdate | 2024-07-09T15:39:09Z |
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| isbn | 0824779029 |
| language | English |
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| publishDate | 1989 |
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| spelling | Modern drug research paths to better and safer drugs ed. by Yvonne Connolly Martin ... New York u.a. Dekker 1989 XVI, 507 S. txt rdacontent n rdamedia nc rdacarrier Medicinal research 12 Médicaments Médicaments - Design - Recherche Médicaments - Essais (Technologie) Recherche Drugs Design Research Drugs Testing Research Pharmaceutical Preparations Research Arzneimittelforschung (DE-588)4003120-2 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Arzneimittelentwicklung (DE-588)4143176-5 s DE-604 Arzneimittelforschung (DE-588)4003120-2 s Martin, Yvonne C. Sonstige oth Medicinal research 12 (DE-604)BV000662231 12 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001326231&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Modern drug research paths to better and safer drugs Medicinal research Médicaments Médicaments - Design - Recherche Médicaments - Essais (Technologie) Recherche Drugs Design Research Drugs Testing Research Pharmaceutical Preparations Research Arzneimittelforschung (DE-588)4003120-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| subject_GND | (DE-588)4003120-2 (DE-588)4143176-5 (DE-588)4143413-4 |
| title | Modern drug research paths to better and safer drugs |
| title_auth | Modern drug research paths to better and safer drugs |
| title_exact_search | Modern drug research paths to better and safer drugs |
| title_full | Modern drug research paths to better and safer drugs ed. by Yvonne Connolly Martin ... |
| title_fullStr | Modern drug research paths to better and safer drugs ed. by Yvonne Connolly Martin ... |
| title_full_unstemmed | Modern drug research paths to better and safer drugs ed. by Yvonne Connolly Martin ... |
| title_short | Modern drug research |
| title_sort | modern drug research paths to better and safer drugs |
| title_sub | paths to better and safer drugs |
| topic | Médicaments Médicaments - Design - Recherche Médicaments - Essais (Technologie) Recherche Drugs Design Research Drugs Testing Research Pharmaceutical Preparations Research Arzneimittelforschung (DE-588)4003120-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| topic_facet | Médicaments Médicaments - Design - Recherche Médicaments - Essais (Technologie) Recherche Drugs Design Research Drugs Testing Research Pharmaceutical Preparations Research Arzneimittelforschung Arzneimittelentwicklung Aufsatzsammlung |
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