Principles of microbiology:
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Format: | Buch |
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Mosby
1985
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adam_text | PRINCIPLES OF MICROBIOLOGY
ALICE LORRAINESMITH
AB,MD,FCAP,FACP
Professor of Pathology, The University of Texas Health Science
Center at Dallas, Texas; formerly Assistant Professor of Microbiology,
Department of Nursing, Dominican College and St Joseph s Hospital,
Houston, Texas
TENTH EDITION
With 475 illustrations and 4 color plates
II
TIMES MIRROR/MOSBY
COLLEGE PUBLISHING
ST LOUIS TORONTO SANTA CLARA 1985
CONTENTSINBRIEF
MODULEONE
MICROBIOLOGY: PRELUDE AND PRIMER
1 Definition and dimensions of microbiology, 2
2 Milestones of progress, 9
3 The bacterial cell: form and substance, 27
4 Biologic attributes of bacteria: sustenance and growth, 47
5 Biologic activities of bacteria: metabolism, 60
6 Biologic attributes of bacteria: genetics, 78
7 Classification of bacteria, 106
Laboratory survey of module one, 124
Evaluation for module one, 128
MODULETWO
MICROBES: PROCEDURES FOR STUDY
8 Visualization of microbes, 140
9 Cultivation, 156
10 Laboratory identification, 171
11 Specimen collection, 182
Laboratory survey of module two, 191
Evaluation forjnodule two, 198
MODULETHREE
MICROBES: PRECLUSION OF DISEASE
12 Physical agents in sterilization, 208
13 Chemicals as antimicrobial agents, 218
14 Chemical agents therapeutic for microbial diseases, 233
15 Practical technics, 265
Laboratory survey of module three, 280
Evaluation for module three, 283
xii Contents in brief
MODULEFOUR
MICROBES: PRODUCTION OF INFECTION
16 Role in disease, 290
17 The body s defense, 310
18 Immunologic concepts, 330
19 Immunologic disorders, including allergy, 361
20 Immunologic testing, 395
21 Immunizing biologicals, 419
22 Immunizing schedules, 438
Laboratory survey of module four, 452
Evaluation for module four, 460
MODULEFIVE
MICROBES: PATHOGENS AND PARASITES
23 Pyogenic cocci, 478
24 Neisseriae, 507
25 Enteric bacilli and vibrios, 527
26 Small gram-negative rods, 554
27 Anaerobes, 571
28 Corynebacteria and actinomycetes, 587
29 Acid-fast mycobacteria, 598
30 Spirochetes and spirals, 615
31 Miscellaneous microbes, 632
32 Rickettsias and chlamydiae, 647
33 Viruses, 667
34 Viral diseases, 703
-35 __Fungi: medical mycology, 754
36 Protozoa: medical parasitology, 788
37 Metazoa: medical helminthology, 820
Laboratory survey of module five, 854
Evaluation for module five, 861
MODULESIX
MICROBES: PUBLIC WELFARE
38 Microbes everywhere, 886
39 Microbiology of water, 896
40 Microbiology of food, 907
Laboratory survey of module six, 921
Evaluation for module six, 925
Glossary, CI
Color plates, 426
DETAILEDCONTENTS
MODULE ONE
MICROBIOLOGY: PRELUDE AND PRIMER
1 Definition and Dimensions of Microbiology, 2
Definition, 2
Dimensions, 2
Biologic classification, 2
Naming of microbes, 6
2 Milestones of Progress, 9
Early events in microbiology, 9
Emergence of germ theory of disease, 9
Applications of microscopy to study of microbes, 9
Discovery of vaccination, 11
Start of epidemiologic approach to infection, 12
Achievements of Louis Pasteur, 12
Discover) of antisepsis, 13
Contributions of Robert Koch, 14
Early events in immunology, 15
Controversial nineteenth century theories, 15
Toxin-antitoxin relationship, 15
Discover) of viruses, 18
Beginnings of preventive medicine, 18
Origin of chemotherapy, 18
Story of antimicrobial drugs, 19
Development of poliomyelitis vaccine, 20
Important recent discoveries, 21
Genetic role of DNA, 22
Jumping genes, 22
Interferon, 22
Australia antigen and hepatitis B virus, 23
Production of monoclonal antibodies, 23
3 The Bacterial Cell: Form and Substance, 27
Overview, 27
Definition, 27
Classification, 27
Distribution, 27
Morphology, 28
Size and shape, 28
Structure, 29
Chemical composition, 43
Reproduction: cell division, 43
Transverse division, 43
A clone, 44
4 Biologic Attributes of Bacteria: Sustenance and
Growth, 47
Bacterial needs: environmental factors, 47
Nutrition, 47
Oxygen, 48
Moisture, 49
Temperature, 49
Hydrogen ion concentration (pH), 51
Light, 51
By-products of bacterial growth, 51
Electricity and radiant energy, 51
Chemicals, 52
Osmotic pressure, 52
Bacterial growth: bacterial populations, 53
Exponential growth, 53
Measurement of bacterial growth, 53
The typical growth curve, 54
Applications, 56
Bacterial variation, 56
Causes of variation, 56
Observed variations, 56
Interrelationships of microbes, 57
Symbiosis, 57
Antagonism, 57
5 Biologic Activities of Bacteria: Metabolism, 60
Overview, 60
Major events in metabolism, 60
The basic biochemical reactions, 61
Classes of biologic oxidation, 72
An event unique to bacteria: cell wall synthe
sis, 73
Other effects of bacterial activity, 74
Pigment production, 74
Heat, 75
Light, 75
xiv Detailed contents
6 Biologic Attributes of Bacteria: Genetics, 78
DNA: the molecule of heredity, 78
General considerations, 78
DNA, RNA, and protein synthesis, 83
Genetic processes in microbes, 90
Mutations, 90
Role of bacteriophages, 92
Intermicrobial gene transfer systems, 93
Plasm ids, 97
Genetic recombination, 99
7 Classification of Bacteria, 106
The spirochetes, 108
Aerobic/microaerophilic, motile, helical/vibrioid
gram-negative bacteria, 108
Gram-negative aerobic rods and cocci, 108
Facultatively anaerobic gram-negative rods, 110
Anaerobic gram-negative straight, curved, and
helical rods, 112
Anaerobic gram-negative cocci, 113
The rickettsias and chlamydias, 113
The mycoplasmas, 114
Gram-positive cocci, 115
Endospore-forming gram-positive rods and cocci,
Regular, nonsporing, gram-positive rods, 117
Irregular, nonsporing, gram-positive rods, 117
Mycobacteria, 118
Nocardioforms, 119
Streptomycetes and their allies, 122
Laboratory survey of module one, 124
Evaluation for module one, 128
MODULE TWO
MICROBES: PROCEDURES FOR STUDY
8 Visualization of Microbes, 140
Plan of action for laboratory study of microbes, 140
Importance of laboratory safety, 141
Tools for study, 141
Microscopes, 141
Examination of unstained bacteria, 147
Hanging drop preparations, 147
Wet mount, 148
Dark-field illumination, 148
Examination of stained bacteria, 150
Staining, 150 —
Negative (relief) staining, 153
9 Cultivation, 156
Culture media, 156
General considerations, 156
Applications, 158
Culture methods, 160
Inoculation, 160
Bacteriologic incubator, 161
Inspection of cultures, 162
Pure cultures, 162
Streak plates, 164
Bacterial colony (plate) count, 164
Culture of anaerobic bacteria, 166
Slide cultures, 167
Cultures in embryonated hen s egg, 167
Cultivation of microbes in cell cultures, 167
Antibiotic susceptibility testing, 167
10 Laboratory Identification, 171
Biochemical reactions, 171
Fermentation of sugars, 171
Hydrolysis of starch, 173
Liquefaction of gelatin, 173
Citrate utilization, 173
Indole production, 173
Nitrate reduction (nitrite test), 173
Deoxyribonuclease elaboration, 173
Hydrogen sulfide production, 174
Splitting of urea, 174
Digestion of milk, 174
Oxidase reaction, 174
Niacin test, 174
Optochin growth-inhibition test, 174
Catalase test, 174
Demonstration of specific enzymes, 175
Rapid identification of enteric bacilli, 175
Limulus test for endotoxemia, 175
Automated identification of microbes, 176
Animal inoculation, 176
Review of reactions: identification of bacteria, 178
11 Specimen Collection, 182
Ground rules, 182
Clinical specimens, 183
Pathogens related to specimens, 188
Laboratory survey of module two, 191
Evaluation for module two, 198
Detailed contents xv
MODULE THREE
MICROBES: PRECLUSION OF DISEASE
12 Physical Agents in Sterilization, 208
Mechanical means, 208
Scrubbing, 208
Filtration, 209
Sedimentation, 209
Moist heat, 209
Boiling, 209
Sterilization by steam, 210
Fractional (intermittent) sterilization, 212
Pasteurization, 213
Dry heat, 213
Burning (incineration), 214
Other physical agents, 214
Natural methods, 214
Ultraviolet radiation, 214
X rays and other ionizing radiations, 214
Lasers, 215
Ultrasonics, 215
Action of fluorescent dyes, 215
The microwave oven, 215
13 Chemicals as Antimicrobial Agents, 218
Effects of chemical agents on microbes, 218
Definitions, 218
Qualities of a good disinfectant, 219
Action of antiseptics and disinfectants, 219
Standardization, 221
Common disinfectants and antiseptics, 221
Surface-active compounds, 221
Heavy metal compounds, 223
Alcohols and aldehydes, 224
Phenol and derivatives, 225
Halogen compounds, 227
Acids, 229 ~ —
Oxidizing agents, 229
Dyes, 229
Miscellaneous agents, 229
14 Chemical Agents Therapeutic for Microbial
Diseases, 233
Chemotherapeutic agents, 233
Sulfonamides, 233
Co-trimoxazole, 235
Tuberculostatic drugs, 235
Nitrofurans, 236
Antibiotics, 236
Spectrum of activity, 237
Mode of action of antimicrobial drugs, 237
Selective toxicity, 241
Side effects, 241
The roster of antibiotics, 245
Antivirals, 259
Thiosemicarbazone, 259
Purine and pyrimidine analogs, 259
Amantadine, 261
Interferon, 261
15 Practical Technics, 265
Surgical disinfection and sterilization, 265
Steam sterilization, 265
Cas sterilization, 266
Surgical instruments and supplies, 266
Surgical suite, 271
Body sites, 271
Disinfection of excreta and contaminated materials
from infectious diseases, 273
Hands, 274
Soiled linens and clothing, 274
Shoes, 274
Feces and urine, 274
Discharges from mouth and nose, 275
Sputum, 275
Clinical thermometers, 275
Eating utensils, 275
Terminal disinfection, 275
Disposal of contaminated materials in the diagnostic
laboratory, 276
Disinfection of articles for public use, 276
Fumigation of rooms and disinfection of air, 277
Sterilization of biologic products, 277
Laboratory survey of module three, 280
Evaluation for module three, 283
xvi Detailed contents
MODULE FOUR
MICROBES: PRODUCTION OF INFECTION
16 Role in Disease, 290
Infection, 290
Resident population: microbes normally
present, 290
Intrusion of microbes, 293
Source of microbes causing infections, 293
How microbes reach the body, 293
How microbes enter the body, 294
Event of infection, 294
Koch s postulates, 294
Factors influencing the occurrence of
infection, 295
How microbes cause disease, 295
Local effects of infection, 299
General effects of infection, 300
How disease-producing agents leave the
body, 300
Pattern of infection, 300
Course of infectious disease, 300
Types of infections, 302
Spread of infection, 303
Transmission of communicable diseases, 303
Sources of infection in communicable
diseases, 304
Epidemiologic approach to disease, 306
Spread of disease in the jet age, 308
17 The Body s Defense, 310
Protective mechanisms, 310
Anatomic barriers, 310
Chemical factors, 311
Normal flora in-host defense, 312
Physiologic reserves, 313
Cellular resources, 313
The macrophage system (reticuloendothelial
system), 314
Phagocytosis, 315
Anatomy of the system of macrophages
(RE system), 317
Granulomatous inflammation, 318
Granulocytes, 318
The neutrophil, 318
Lymphoid system (immunologic system), 319
Lymphoid tissue, 319
Lymphatic circulation, 321
Spleen, 322
Thymus, 322
Lymphatic vessels in infection, 322
Responses in lymphoid organs, 323
Inflammation, 323
Definition, 323
Causes, 323
Local changes, 324
Timing in inflammation, 324
Kinds of exudates, 324
Resolution, 325
Suppuration, 325
Chronic inflammation, 325
Inflammatory lesions, 326
Repair, 326
Regeneration, 327
Patterns of infection, 328
18 Immunologic Concepts, 330
Meaning of immunity, 330
Immunity and infection, 330
Kinds of immunity, 330
Level of immunity, 332
Immune system, 332
Humoral immunity, 336
Cell-mediated immunity, 352
Resume of features of the immune system, 356
19 Immunologic Disorders, Including Allergy, 361
Disturbances in immunity, 361
Autoimmunization, 362
Autoimmune diseases, 363
Deficiencies of complement components, 364
Acquired immunodeficiency syndrome
(AIDS), 365
Tissue transplantation, 368
Allograft rejection, 369
Transplantation antigens, 369
Testing for histocompatibility, 372
Immunosuppression, 372
Graft-versus-host reaction, 374
Present status, 374
Immunity and cancer, 374
Fetal antigens, 375
Natural killer (NK) cells, 375
Allergic disorders, 376
What is meant by allergy (hypersensitivity), 376
Immediate-type allergic reactions, 382
Cytotoxic reactions: hemolytic transfusion
reactions, 387
Immune complex diseases, 387
Delayed-type allergic reactions, 389
Laboratory tests to detect allergy, 390
Immunotherapy (desensitization), 391
Detailed contents xvii
20 Immunologic Testing, 395
Reactions for humoral immunity, 395
Detection of antibodies, 395
Kinds of reactions, 396
Special technics, 403
Procedures for cellular immunity, 408
Lymphocytes in peripheral blood, 408
Battery of skin tests, 408
Immunologic competency in vitro, 408
Migration inhibitory factor assay, 409
Lymphocyte surface markers, 409
Application of immunologic methods, 411
Immunology of red blood cell, 411
Agglutinins of the blood, 411
Blood grouping (typing), 414
Blood component therapy, 415
21 Immunizing Biologicals, 419
Immune serums (passive immunization), 419
Antitoxins, 420
Antivenins, 423
Antibacterial serums, 423
Antiviral serums, 425
Convalescent serum, 426
Gamma globulin, 426
Vaccines (active immunization), 427
Bacterial vaccines, 427
Toxoids, 429
Viral vaccines, 429
Precautions for administration of biologic products, 433
Tests for hypersensitivity, 434
Injection site for biologic products, 434
Standards for biologic products, 435
Manufacture, 435
Label, 435
Date of expiration, 435
22 Immunizing Schedules, 438
Recommendations of the Committee on Infectious
Diseases of American Academy of Pediatrics, 438
Combined active immunization, 438
Tetanus, 439
Pertussis, 440
Diphtheria, 440
Smallpox, 441
Mumps, 441
Rubella, 441
Rabies, 442
Tuberculosis, 443
Recommendations of the U S Public Health
Service, 443
Influenza, 443
Hepatitis B, 444
Poliomyelitis, 444
Measles, 446
Typhoid and paratyphoid fevers, 446
Requirements for U S armed forces, 446
International travel, 448
Immunizations, 448
Where to find a doctor, 449
Traveler s diarrhea, 449
Centers for Disease Control (CDC), 449
World Health Organization (WHO), 449
Laboratory survey of module four, 452
Evaluation for module four, 460
MODULE FIVE
MICROBES: PATHOGENS AND PARASITES
23 Pyogenic Cocci, 478
Staphylococcus species (the staphylococci), 478
General considerations, 478
Streptococcus species (the streptococci), 487
General considerations, 487
Scarlet fever, 494
Erysipelas, 495
Streptococcal sore throat (septic sore throat), 496
Rheumatic fever, 496
Puerperal sepsis, 497
Dental caries, 497
Streptococcus (Diplococcus) pneumoniae (the
pneumococci), 498
General considerations, 498
24 Neisseriae, 507
Neisseria gonorrhoeae (the gonococcus), 507
General characteristics, 507
Pathogenicity, 508
Sources and modes of infection, 510
Laboratory diagnosis of gonorrhea, 511
Social importance of gonorrhea, 513
Immunity, 513
Prevention, 515
The STD pandemic, 515
Neisseria meningitidis (the meningococcus), 518
General characteristics, 518
Meningococci and gonococci compared, 519
xviii Detailed contents
Croups of meningococci, 519
Pathogenicity, 519
Sources and modes of infection, 520
Laboratory diagnosis, 521
Immunity, 521
Prevention, 521
Microbial infection of meninges, 523
Other gram-negative cocci (and coccobacilli), 524
Moraxella (Branhamella) catarrhalis, 524
Other neisseriae, 524
Moraxella (Moraxella) lacunata (the
Morax-Axenfeld bacillus), 524
25 Enteric Bacilli and Vibrios, 527
Classification, 528
General characteristics, 529
Laboratory study, 530
Escherichia coli and related organisms (the
coliform bacilli), 531
General characteristics, 531
Pathogenicity, 531
Escherichia coli, 532
Klebsiella-Enterobacter-Serratia species, 536
Arizona-Edwardsiella-Citrobacter species, 537
Providencia (Providence) species, 538
Proteus species (the proteus bacilli), 538
Morganella morganii, 539
Endotoxin shock, 539
Enteric bacilli in hospital-associated infections, 539
Salmonella species, 540
General characteristics, 540
Sources and modes of infection, 541
Pathogenicity, 541
Salmonella typhi (the typhoid bacillus), 542
Paratyphoid bacilli, 545
Other salmonella^ 545—
Shigella species (the dysentery bacilli),~545
General characteristics, 545
Pathogenicity, 546
Pathology, 546
Mode of infection, 546
Laboratory diagnosis, 546
Immunity, 546
Prevention, 547
Vibrio species, 547
Vibrio cholerae (the comma bacillus), 547
Vibrio cholerae biovar eltor, 550
Vibrio parahaemolyticus, 550
26 Small Gram-Negative Rods, 554
Brucella species (agents of brucellosis), 554
Hemophilic bacteria, 557
Bordetella species (agents of pertussis), 558
Haemophilus influenzae (the influenza bacillus),
Haemophilus ducreyi (Ducrey s bacillus), 562
Haemophilus aegyptius, 563
Haemophilus suis, 563
Haemophilus parainfluenzae, 563
Yersinia species, 563
Yersinia pestis (the plague bacillus), 563
Other yersinias, 566
Francisella tularensis (the agent of tularemia), 566
Pasteurella species, 567
Pasteurellas of hemorrhagic septicemia, 567
Calymmatobacterium granulomatis, 568
Gardnerella vaginalis, 568
27 Anaerobes, 571
Overview, 571
Definition, 571
Pertinence, 572
Pathogenicity, 573
Laboratory diagnosis, 573
The approach, 574
Clostridium species, 575
Clostridium tetani (the bacillus of tetanus), 575
Clostridium botulinum (the bacillus of
botulism), 578
Clostridium perfringens, novyi, and septicum
(the Clostridia of gas gangrene), 581
Clostridium difficile, 583
Bacteroides species, 583
Fusobacterium species, 584
Other anaerobes, 584
28 Corynebacteria and Actinomycetes, 587
Corynebacteria, 587
Corynebacterium diphtheriae (the bacillus of
diphtheria), 587
Actinomycetes, 593
Actinomycosis, 593
Nocardiosis, 595
Mycetoma, 595
29 Acid-Fast Mycobacteria, 598
Tuberculosis, 598
Importance, 598
Etiologic agents, 599
Mycobacterium tuberculosis (the human tubercle
bacillus), -599
Mycobacterium bovis (the bovine tubercle
bacillus), 607
Leprosy (Hansen s disease), 608
Mycobacterium leprae (the leprosy bacillus), 608
Mycobacteriosis (atypical tuberculosis), 611
Other mycobacteria (atypical, anonymous,
) unclassified mycobacteria), 611
Detailed contents xix
30 Spirochetes and Spirals, 615
Overview, 615
Treponema pallidum (the spirochete of syphilis), 615
Acquired syphilis, 617
Congenital (prenatal) syphilis, 623
Syphilis and yaws, 624
Borrelia species, 625
Leptospira species, 626
Other spirochetes and associated organisms, 626
Vincent s angina (fusospirochetal disease), 627
Spirillum minus, 628
Rat-bite fever (sodoku), 628
Streptobacillary rat-bite fever, 628
Campylobacter fetus, 629
31 Miscellaneous Microbes, 632
Pseudomonas species, 632
Pseudomonas aeruginosa, 632
Pseudomonas pseudomallei, 635
Pseudomonas mallei, 635
Bacillus anthracis (the anthrax bacillus), 636
Lactobacillus species (the lactobacilli), 637
Listeria monocytogenes, 638
Mycoplasma species, 638
Legionella pneumophilia, 642
32 Rickettsias and Chlamydiae, 647
General discussion, 647
Rickettsial diseases, 650
Typhus fever group, 650
Spotted fever group, 652
Scrub typhus, 654
Trench fever, 654
Q fever, 655
Bartonella bacilliformis, 655
Chlamydiae (bedsoniae), 655
Chlamydial infections, 658
Trachoma, 658
Oculogenital infections, 660
Lymphogranuloma venereum, 661
Psittacosis (parrot fever) and ornithosis, 662
Cat-scratch disease, 663
33 Viruses, 667
General considerations, 667
Definition, 667
Structure, 668
Life cycle, 670
Genetic considerations, 673
Pathogenicity, 674
Classification, 677
Viroids, 682
Categories as to source of virus, 682
Time frames in viral infections, 683
Cultivation, 684
Spread, 688
Immunity, 689
Viral interference, 690
Prevention of viral disease, 690
Bacteriophages (bacterial viruses), 691
General characteristics, 691
Life cycle, 691
Laboratory diagnosis, 692
Importance, 693
Viruses and teratogenesis, 693
Viruses and cancer, 694
Tumor viruses, 695
Oncogenes, 698
Burkitt s lymphoma, 699
34 Viral Diseases, 703
Skin diseases, 703
Measles (rubeola), 703
Rubella (German measles), 705
Smallpox (variola), 708
Molluscum contagiosum, 710
Herpesvirus infections, 710
Chickenpox and shingles (varicella-herpes
zoster), 711
Herpes simplex infections, 712
Cytomegalic inclusion disease, 716
Infectious mononucleosis, 717
Respiratory diseases, 718
Influenza, 718
Acute respiratory syndromes, 723
Common cold (acute coryza), 727
Viral pneumonia, 728
Central nervous system diseases, 728
Rabies (hydrophobia), 728
Viral encephalitis and encephalomyelitis, 731
Poliomyelitis (infantile paralysis), 733
Other enterovirus diseases, 735
Infections with coxsackieviruses, 735
Infections with echoviruses, 736
Other arthropod-borne viral diseases, 736
Yellow fever, 736
Dengue fever, 737
Colorado tick fever, 738
Liver diseases (viral hepatitis), 738
Viral hepatitis type A, 739
Viral hepatitis type B, 742
Non-A, non-B viral hepatitis, 746 *
Miscellaneous viral infections, 746
Mumps (epidemic parotitis), 746
Infantile gastroenteritis (infection with rotavirus),
Condyloma acuminatum, 749
Foot-and-mouth disease, 749
Distemper of dogs, 750 »
Additional diseases caused by viruses, 750
xx Detailed contents
35 Fungi: Medical Mycology, 754
Fungi in profile, 754
Structure, 754
Reproduction, 755
Conditions affecting growth, 756
Classification, 757
Laboratory study, 759
Pathology of fungal disease, 760
Importance, 762
Diseases caused by fungi, 762
Superficial mycoses, 762
Subcutaneous mycoses, 764
Systemic mycoses, 766
Other fungal diseases of humans, 783
Fungal diseases of lower animals, 784
Fungal diseases of plants, 784
36 Protozoa: Medical Parasitology, 788
General characteristics, 788
Structure, 790
Locomotion, 790
Cyst formation, 791
Reproduction, 791
Classification, 791
Laboratory diagnosis, 792
MODULE SIX
MICROBES: PUBLIC WELFARE
38 Microbes Everywhere, 886
Microbes in the processes of nature, 886
Participation in the cycle of an element, 886
Microbes in animal nutrition, 889_
Microbes in industry, 889
Manufacture of dairy products, 889
Manufacture of alcohol and alcoholic
beverages, 890
Baking, 891
Manufacture of vinegar, 891
Production of sauerkraut, 891
Tanning, 892
Curing tobacco, 892
Retting flax and hemp, 892
Manufacture of antibiotics, 892
Oil prospecting, 892
Other industrial processes, 892
39 Microbiology of Water, 896
General considerations, 896
Sanitary classification, 896
Sources of water, 897
Waterborne diseases, 898
Prevention and control, 794
Protozoan diseases, 794
Amebiasis, 794
Infections with hemoflagellates, 798
Trichomoniasis, 804
Infection with intestinal flagellates, 805
Malaria, 806
Toxoplasmosis, 812
Pneumocystosis, 815
Balantidiasis, 817
37 Metazoa: Medical Helminthology, 820
Perspectives, 820
Helminths: general considerations, 820
Arthopods, 822
Registry of pathogens, 823
Trematodes (flukes), 823
Cestodes (tapeworms), 832
Nematodes (roundworms), 836
Laboratory diagnosis, 848
Examination of feces for parasites, 849
Immunodiagnostic tests, 851
Laboratory survey of module five, 854
Evaluation for module five, 861
Water analysis: bacteriologic examination of
water, 899
Purification, 899
Special measures, 903
Fluoride content of water and tooth decay, 903
Ice, 903
Purification of sewage, 903
Swimming pool sanitation, 905
40 Microbiology of Food, 907
Milk, 907
Bacteria in milk, 907
Pasteurized milk, 908
Requirements for a safe milk supply, 909
Food, 912
Food poisoning, 912
Measures to safeguard food, 915
Food preservation, 916
Laboratory survey of module six, 921
Evaluation for module six, 925
Glossary, G1
Color plates, 426
|
any_adam_object | 1 |
author | Smith, Alice L. |
author_facet | Smith, Alice L. |
author_role | aut |
author_sort | Smith, Alice L. |
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building | Verbundindex |
bvnumber | BV001998312 |
classification_tum | BIO 250f |
ctrlnum | (OCoLC)630985706 (DE-599)BVBBV001998312 |
discipline | Biologie |
edition | 10. ed. |
format | Book |
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illustrated | Illustrated |
indexdate | 2024-07-09T15:38:37Z |
institution | BVB |
isbn | 0801646855 |
language | English |
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oclc_num | 630985706 |
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owner | DE-91 DE-BY-TUM |
owner_facet | DE-91 DE-BY-TUM |
physical | Getr. Zählung Ill., graph. Darst. |
publishDate | 1985 |
publishDateSearch | 1985 |
publishDateSort | 1985 |
publisher | Mosby |
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spelling | Smith, Alice L. Verfasser aut Principles of microbiology Alice Lorraine Smith 10. ed. St. Louis u.a. Mosby 1985 Getr. Zählung Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Medizinische Mikrobiologie (DE-588)4038264-3 gnd rswk-swf Medizinische Mikrobiologie (DE-588)4038264-3 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001303491&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
spellingShingle | Smith, Alice L. Principles of microbiology Medizinische Mikrobiologie (DE-588)4038264-3 gnd |
subject_GND | (DE-588)4038264-3 |
title | Principles of microbiology |
title_auth | Principles of microbiology |
title_exact_search | Principles of microbiology |
title_full | Principles of microbiology Alice Lorraine Smith |
title_fullStr | Principles of microbiology Alice Lorraine Smith |
title_full_unstemmed | Principles of microbiology Alice Lorraine Smith |
title_short | Principles of microbiology |
title_sort | principles of microbiology |
topic | Medizinische Mikrobiologie (DE-588)4038264-3 gnd |
topic_facet | Medizinische Mikrobiologie |
url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001303491&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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