Intestinal metabolism of xenobiotics:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Stuttgart [u.a.]
Fischer
1989
|
| Schriftenreihe: | Progress in pharmacology and clinical pharmacology
7,2 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 338 S. Ill., graph. Darst. |
| ISBN: | 3437112236 0895742861 |
Internformat
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Datensatz im Suchindex
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| adam_text | INTESTINAL METABOLISM OF XENOBIOTICS EDITED BY A. SJ. KOSTER * E.
RICHTER F. LAUTERBACH * F. HARTMANN 56 FIGURES AND 37 TABLES GUSTAV
FISCHER VERLAG * STUTTGART * NEW YORK * 1989 CONTENTS PREFACE V SECTION
1 : METHODOLOGY 3 DAWSON, J.R. AND R.D. COMBES 1.1 METHODS FOR PREPARING
MICROSOMAL AND CYTOSOLIC FRACTIONS FROM THE MAMMALIAN INTESTINE 5 1.1.1
INTRODUCTION 5 1.1.2 PRE-TREATMENT OF ANIMALS 7 1.1.3 SEPARATION OF
EPITHELIUM FROM SUBMUCOSA 7 1.1.3.1 SCRAPING METHOD 8 1.1.3.2 VIBRATION
METHODS 10 1.1.4 HOMOGENISATION 11 1.1.5 SEPARATION OF SUB-CELLULAR
FRACTIONS 14 1.1.5.1 PREPARATION OF MICROSOMES 14 1.1.5.2 PREPARATION OF
CYTOSOLIC FRACTION 15 1.1.6 CHARACTERISATION AND USE OF SUBCELLULAR
FRACTIONS 15 1.1.7 CONCLUSIONS 16 1.1.8 REFERENCES 17 DAWSON, J.R. AND
M. SCHWENK 1.2 ISOLATED EPITHELIAL CELLS . 21 1.2.1 INTRODUCTION . 21
1.2.2 CELL ISOLATION PROCEDURES 22 1.2.2.1 MECHANICAL METHODS 22 1.2.2.2
CHELATION METHODS 24 1.2.2.3 ENZYMATIC METHODS 25 1.2.2.4 SUMMARY OF
CELL ISOLATION PROCEDURES 27 1.2.3 VIABILITY TESTS 28 1.2.4 CONTRIBUTION
TO INTESTINAL PHARMACOLOGY AND TOXICOLOGY 30 1.2.5 ISOLATED CELLS AS A
MODEL SYSTEM 34 1.2.6 REFERENCES 36 ROGERS, S.M. AND D.J. BACK 1.3 THE
USE OF USSING CHAMBERS FOR THE STUDY OF INTESTINAL METABOLISM IN VITRO
43 1.3.1 INTRODUCTION 43 1.3.2 ADAPTATION OF USSING CHAMBERS FOR THE
STUDY OF INTESTINAL METABOLISM . 44 1.3.2.1 VIABILITY OF INTESTINAL
PREPARATIONS 45 1.3.3 METABOLISM OF PARACETAMOL BY HUMAN SMALL INTESTINE
AND COLON IN VITRO * AN EXAMPLE OF THE APPLICATION OF USSING CHAMBERS 49
1.3.3.1 METHODS 49 1.3.3.2 RESULTS 50 1.3.4 CONCLUSIONS 51 1.3.5
REFERENCES 52 CARLIER, H., A. BERNARD AND J.S. HUGON 1.4 CELL AND ORGAN
CULTURE 55 1.4.1 INTRODUCTION 55 1.4.2 METHODS OF SMALL INTESTINAL
TISSUE CULTURE 55 1.4.2.1 CELL CULTURE 56 1.4.2.2 INTESTINAL ORGAN
CULTURE 57 1.4.2.3 CULTURE MEDIA 58 1.4.2.4 VIABILITY CRITERIA 60
1.4.2.5 MORPHOLOGY 60 1.4.2.6 CELL PROLIFERATION AND MIGRATION 60
1.4.2.7 SYNTHESIS AND SECRETION OF PROTEINS AND GLYCOPROTEINS 62 1.4.3
STUDIES OF MUCOSAL SMALL INTESTINAL METABOLIC FUNCTIONS 62 1.4.4
DISCUSSION 64 1.4.5 CONCLUSIONS 64 1.4.6 REFERENCES 65 SCHUMANN, K. AND
G.J. STRUGALA 1.5 ISOLATED LUMINALLY PERFUSED INTESTINAL SEGMENTS, THEIR
USE AND LIMITATIONS 6 9 1.5.1 INTRODUCTION 69 1.5.2 CHARACTERISTICS OF
ISOLATED PERFUSED INTESTINAL SEGMENTS 70 1.5.2.1 OXYGEN SUPPLY 70
1.5.2.2 ENERGY SUPPLY 70 1.5.2.3 DRIVING FORCES OF TRANSMURAL FLUID
TRANSFER 70 1.5.2.4 MORPHOLOGICAL ROUTES OF TRANSMURAL FLUID TRANSFER 71
1.5.3 COMPARISON WITH RELATED IN VITRO TECHNIQUES 72 1.5.3.1 ISOLATED
EVERTED INTESTINAL SEGMENTS 72 1.5.3.2 TISSUE ACCUMULATION TECHNIQUE 74
1.5.4 USE AND APPLICATION OF MODIFIED PERFUSION UNITS FOR ISOLATED
INTESTINAL SEGMENTS 75 1.5.4.1 ADAPTATION OF PERFUSION UNITS TO STUDY
THE METABOLISM OF LIPOPHILIC XENOBIOTICS WITH VOLATILE METABOLITES 75
1.5.4.2 ADAPTATION OF PERFUSION UNITS TO STUDY INTESTINAL PROTEIN
SYNTHESIS ... 76 1.5.4.3 ADAPTATION OF PERFUSION UNITS FOR KINETIC
STUDIES 76 1.5.5 CONCLUSIONS 77 1.5.6 REFERENCES 77 HARTMANN, F. AND
PLAUTH, M. 1.6 VASCULARLY PERFUSED SMALL INTESTINE PREPARATIONS 81 1.6.1
INTRODUCTION 81 1.6.2 ROLE OF TISSUE OXYGENATION 82 1.6.3 VASCULAR
INTESTINAL PERFUSIONS USING RED CELLS AS OXYGEN CARRIER 83 1.6.3.1
ISOLATED GUT PREPARATIONS 83 1.6.3.2 IN-SITU PERFUSED INTESTINAL
SEGMENTS 83 1.6.4 VASCULAR INTESTINAL PERFUSIONS USING ARTIFICIAL OXYGEN
CARRIERS 84 1.6.4.1 FLUOROCARBON FC-75 84 1.6.4.2 FLUOROCARBON FC-43 84
1.6.5 SUMMARY AND CONCLUSIONS 90 1.6.6 REFERENCES 93 SECTION 2:
METABOLIC ROUTES 97 PLAUTH, M. AND F. HARTMANN 2.1 THE ROLE OF THE SMALL
INTESTINE IN INTERMEDIARY METABOLISM. METABOLISM OF L-GLUTAMINE 99 2.1.1
INTRODUCTION 99 2.1.2 INTESTINAL GLUTAMINE TRANSPORT 100 2.1.3
BIOCHEMISTRY OF GLUTAMINE 101 2.1.3.1 GLUTAMINE SYNTHESIS 101 2.1.3.2
METABOLISM OF GLUTAMINE AMIDE-NITROGEN . 101 2.1.3.3 METABOLISM OF
GLUTAMINE AMINO-NITROGEN . 103 2.1.3.4 GLUTAMYLTRANSFER 104 2.1.3.5
METABOLISM OF GLUTAMINE CARBON 104 2.1.4 INTESTINAL GLUTAMINE METABOLISM
IN HEALTH AND DISEASE 107 2.1.4.1 INTESTINAL GLUTAMINE METABOLISM IN THE
POSTABSORPTIVE STATE 107 2.1 A.2 INTESTINAL GLUTAMINE METABOLISM IN THE
POSTPRANDIAL STATE 108 2.1.4.3 INTESTINAL GLUTAMINE METABOLISM DURING
STARVATION 108 2.1 A A INTESTINAL GLUTAMINE METABOLISM IN ACIDOSIS 109
2.1.4.5 INTESTINAL GLUTAMINE METABOLISM IN DIABETES 109 2.1.4.6
INTESTINAL GLUTAMINE METABOLISM AFTER TRAUMA 110 2.1.4.7 INTESTINAL
GLUTAMINE METABOLISM INFLUENCED BY CORTICOIDS 110 2.1.4.8 INTESTINAL
GLUTAMINE METABOLISM INFLUENCED BY LACTULOSE AND NEOMYCIN/ PAROMOMYCIN
ILL 2.1.5 SUMMARY 112 2.1.6 REFERENCES 112 COMBES, R.D. 2.2 CYTOCHROME
P-450, MIXED FUNCTION OXIDASES AND FORMATION OF GENO- TOXIC METABOLITES
BY THE INTESTINAL TRACT 11 9 2.2.1 INTRODUCTION 119 2.2.1.1 OBJECTIVES
AND SCOPE 119 2.2.1.2 RELATIONSHIP WITH OTHER CHAPTERS 120 2.2.1.3 OTHER
PUBLISHED LITERATURE 120 2.2.2 CYTOCHROME P-450 AND MFO ENZYMES OF THE
SMALL INTESTINE 120 2.2.2.1 IMPORTANCE OF METABOLISM IN THE GUT 120
2.2.2.2 INTESTINAL CYTOCHROME P-450 MFO ENZYMES 121 2.2.2.3 EFFECTS OF
INDUCERS/INHIBITORS ON INTESTINAL METABOLISM 123 2.2.3 GUT METABOLISM
AND GENOTOXICITY 125 2.2.3.1 METABOLIC ACTIVATION, GENOTOXICITY AND
CARCINOGENESIS 125 2.2.3.2 GENOTOXICITY ASSAYS USED 126 2.2.3.3 PROBLEMS
USING INTESTINAL HOMOGENATES IN GENOTOXICITY ASSAYS 128 2.2.3.4 EXAMPLES
OF EXTRACTION PROTOCOLS FOR INTESTINAL ENZYMES 129 2.2.4 GENERATION OF
GENOTOXIC METABOLITES 132 2.2.4.1 BY THE SMALL INTESTINE 132 2.2.4.2 BY
THE COLON 136 2.2.4.3 BY THE STOMACH AND OESOPHAGUS 138 2.2.5
CONCLUSIONS 140 2.2.6 REFERENCES 141 SCHULZE, J. AND E. RICHTER 2.3 CO-
AND CO-1-HYDROXYLATION OF N-NITROSODIBUTYLAMINE BY INTESTINAL MICROSOMES
OF RAT, RABBIT, HAMSTER AND MOUSE 147 2.3.1 INTRODUCTION 147 2.3.2
MATERIALS AND METHODS . . . . 148 2.3.2.1 ANIMALS * * * 148 2.3.2.2
CHEMICALS , . 148 2.3.2.3 PREPARATION OF MICROSOMES 148 2.3.2.4
NDBA-HYDROXYLATION ASSAY 149 2.3.3 RESULTS 150 2.3.3.1 ANTIBODY
INHIBITION STUDIES . 151 2.3.4 DISCUSSION . 151 2.3.5 CONCLUSIONS 153
2.3.6 REFERENCES 153 SCHWENK, M. 2.4 GLUCURONIDATION AND SULFATION IN
THE GASTROINTESTINAL TRACT 155 2.4.1 ABSTRACT 155 2.4.2 INTRODUCTION 155
2.4.3 THE ENZYMES AND THEIR INTRACELLULAR LOCALIZATION. KNOWLEDGE FROM
STU- DIES IN THE LIVER 156 2.4.4 IDENTIFICATION OF SUBSTRATES 157 2.4.5
INTESTINAL ENZYME ACTIVITIES COMPARED TO LIVER 160 2.4.6 LOCALIZATION
ALONG THE MOUTH-RECTUM AND CRYPT-VILLUS AXIS 160 2.4.7 FACTORS
INFLUENCING INTESTINAL CONJUGATION 161 2.4.8 CONSEQUENCES OF INTESTINAL
CONJUGATION 163 2.4.9 QUESTIONS TO BE ANSWERED BY FUTURE RESEARCH 164
2.4.10 REFERENCES 164 . SIEGERS, C.-P. 2.5 GLUTATHIONE AND GSH-DEPENDENT
ENZYMES 171 2.5.1 INTRODUCTION 171 2.5.2 GLUTATHIONE 172 2.5.3
GLUTATHIONE PEROXIDASE AND GSSG REDUCTASE 174 2.5.4
GLUTATHIONE-S-TRANSFERASES 175 2.5.5 INTESTINAL FORMATION AND METABOLISM
OF GSH-S-CONJUGATES 176 2.5.6 ROLE OF INTESTINAL MICRO FLORA IN THE
METABOLISM OF XENOBIOTICS WITH GLUTATHIONE 177 2.5.7 CONCLUSIONS 177
2.5.8 REFERENCES 178 KOSTER, A.SJ. 2.6 OTHER METABOLIC ROUTES:
ALCOHOL-DEHYDROGENASE, DT-DIAPHORASE, XANTHINE OXIDASE, N-ACETYLASE,
ESTERASE AND EPOXIDE HYDROLASE 181 2.6.1 INTRODUCTION 181 2.6.2
METABOLISM OF ETHANOL 181 2.6.3 OTHER OXIDATION/REDUCTION SYSTEMS 182
2.6.4 PEPTIDE BOND FORMATION AND CLEAVAGE . 183 2.6.5 ACETYLATION,
TRANSACETYLATION AND DEACETYLATION 184 2.6.6 ESTERASE ACTIVITY 186 2.6.7
EPOXIDE HYDROLASE 188 2.6.8 CONCLUSIONS 189 2.6.9 REFERENCES 189 PETER,
H., R. JAGER, N. FEDTKE AND H.M. BOLT 2.7 METABOLISM OF S-METHYL
GLUTATHIONE BY INTESTINAL MICROFLORA DURING ENTEROHEPATIC CIRCULATION IN
RATS AND MICE 195 2.7.1 INTRODUCTION 195 2.7.2 MATERIALS AND METHODS 196
2.7.3 RESULTS AND DISCUSSION 197 2.7.4 REFERENCES 198 THIES, E. AND
C.-P. SIEGERS 2.8 METABOLIC ACTIVATION AND TUMOURIGENESIS 199 2.8.1
INTRODUCTION 199 2.8.2 EXPERIMENTAL CARCINOGENESIS 200 2.8.3 METABOLIC
ACTIVATION OF CARCINOGENS 200 2.8.3.1 MICROSOMAL MONOOXYGENASES 201
2.8.3.2 ETHANOL-OXIDIZING ENZYMES 202 2.8.3.3 PROSTAGLANDINE SYNTHETASES
202 2.8.3.4 EPOXIDE HYDROLASES 203 2.8 3.5 UDP-GLUCURONYLTRANSFERASES,
P-GLUCURONIDASES 203 2.8.3.6 GLUTATHIONE-S-TRANSFERASES 204 2.8.3.7
DT-DIAPHORASE 204 2.8.3.8 INTESTINAL MICROFLORA 204 2.8.3.9
COMPREHENSIVE CONSIDERATIONS 204 2.8.4 COCARCINOGENIC INFLUENCES 205
2.8.4.1 DIETS 205 2.8.4.2 HORMONES, BILE ACIDS 206 2.8.4.3 ETHANOL AS A
COCARCINOGEN 206 2.8.5 CONCLUDING REMARKS 207 2.8.6 REFERENCES 208
SECTION 3 : ABSORPTIO N AND TRANSPORT 215 BERNARD, A. AND H. CARLIER 3.1
ABSORPTION AND METABOLISM OF LIPIDS 217 3.1.1 INTRODUCTION } . . . 217
3.1.2 LUMINAL PHASE 219 3.1.2.1 HYDROLYSIS 219 3.1.2.2 DIFFUSION ACROSS
THE UNSTIRRED WATER LAYER 220 3.1.3 MUCOSAL PHASE 220 3.1.3.1 UPTAKE
THROUGH THE MICROVILLUS MEMBRANE 220 3.1.3.2 CYTOSOLIC TRANSPORT 220
3.1.3.3 ESTERIFICATION PROCESSES 221 3.1.3.4 INTESTINAL LIPOPROTEIN
FORMATION 222 3.1.4 SECRETORY PHASE AND TRANSFER TO THE VASCULAR SYSTEMS
223 3.1.5 CHYLOPORTAL PARTITION 223 3.1.6 METABOLISM OF FATTY ACIDS IN
ENTEROCYTE 226 3.1.7 CONCLUSION 226 3.1.8 REFERENCES . 226 LAUTERBACH,
F., M. SCHORN, G. SPRAKTIES AND R.B. SUND 3.2 COMPARTNIENTALIZATION OF
INTESTINAL CONJUGATION REACTIONS AND CONJUGATE TRANSPORT: STUDIES WITH
PHENOLS AND P-AMINOBENZOIC ACID . . 231 3.2.1 INTESTINAL SECRETION OF
XENOBIOTICS 231 3.2.2 COMPARTMENTALIZATION OF INTESTINAL CONJUGATION
REACTIONS 232 3.2.3 TRANSEPITHELIAL AND TRANSMEMBRANE TRANSPORT OF
ORGANIC ACIDS 236 3.2.4 REFERENCES 239 DE VRIES, M.H., G.A. HOFMAN,
A.SJ. KOSTER AND J. NOORDHOEK 3.3 FLOW DEPENDENCE OF SYSTEMIC AND
PRESYSTEMIC INTESTINAL METABOLISM . . 243 3.3.1 INTRODUCTION 243 3.3.2
INFLUENCE OF BLOOD FLOW RATE ON INTESTINAL ABSORPTION 244 3.3.3
INFLUENCE OF BLOOD FLOW ON SYSTEMIC METABOLISM 245 3.3.4 INFLUENCE OF
BLOOD FLOW ON PRESYSTEMIC METABOLISM 247 3.3.5 REFERENCES 248 MAIER, V,
R. PRIGGE, C. WOJCIKOWSKI, R. FUSGANGER AND V. SCHUSDZIARRA 3.4 THE
SECRETION OF GLUCAGON-LIKE IMMUNOREACTIVITY (GLI, ENTEROGLUCAGON) USING
THE MODEL OF THE ISOLATED RAT JEJUNUM 251 3.4.1 SUMMARY 251 3.4.2
INTRODUCTION 251 3.4.3 MATERIALS AND METHODS 252 3.4.3.1 ISOLATED
PERFUSED RAT JEJUNUM 252 3.4.4 RESULTS 253 3.4.4.1 STANDARDISATION OF
THE PERFUSION SYSTEM 253 3.4.4.2 PERFUSION PRESSURE 255 3.4.4.3 GLUCOSE
UTILIZATION ; . . 256 3.4.4.4 ENZYMATIC ACTIVITIES . 256 3.4.4.5
MOTILITY OF THE GUT 259 3.4.4.6 HORMONE SECRETION: STIMULATION BY
GLUCOSE, ARGININE AND FAT 259 3.4.5 DISCUSSION 260 3.4.5.1 CONSTANT
VOLUME OF PERFUSATES 261 3.4.5.2 GLUCOSE UTILIZATION 261 3.4.5.3 HORMONE
SECRETION RATES 261 3.4.6 REFERENCES 262 SECTION 4: CLINICAL AND
PHARMACEUTICAL ASPECTS 265 HIETANEN, E., M-R. STAHLBERG AND M. MAKI 4.1
DEVELOPMENT OF INTESTINAL DRUG-METABOLIZING ENZYMES IN MAN 267 4.1.1
INTRODUCTION * 267 4.1.2 METHODS 269 4.1.3 RESULTS^ 270 4.1.4 DISCUSSION
271 4.1.5 SUMMARY 272 4.1.6 REFERENCES 272 RAVIS, W.R. AND A.SJ. KOSTER
4.2 INTESTINAL METABOLISM OF NARCOTIC ANALGESICS 275 4.2.1 INTRODUCTION
275 4.2.2 IN VIVO INTESTINAL METABOLISM OF NARCOTIC ANALGESICS 276 4.2.3
IN VITRO INTESTINAL METABOLISM OF NARCOTIC ANALGESICS 280 4.2.4 FACTORS
ALTERING BIOAVAILABILITY OF NARCOTIC ANALGESICS 282 4.2.5 CONCLUSIONS
284 4.2.6 REFERENCES 285 BACK, D.J., M.L E. ORME AND S.M. ROGERS 4.3
INTESTINAL METABOLISM OF CONTRACEPTIVE STEROIDS IN MAN 289 4.3.1
INTRODUCTION 289 4.3.2 IN VITRO STUDIES WITH HUMAN JEJUNAL BIOPSIES 290
4.3.3 IN VITRO STUDIES USING USSING CHAMBERS 290 4.3.4 IN VIVO STUDIES *
PORTAL VEIN CATHETERISATION 292 4.3.5 INTERACTIONS OF CLINICAL
SIGNIFICANCE IN THE GUT WALL 293 4.3.5.1 ASCORBIC ACID 293 4.3.5.2
PARACETAMOL 293 4.3.6 DISCUSSION 295 4.3.7 REFERENCES 296 SUND, R.B. 4.4
PHARMACOKINETICS OF DIPHENOLIC LAXATIVES * A STATUS REPORT . . . . . .
. . 299 4.4.1 INTRODUCTION: LAXATIVES - CHANGING CONCEPTS 299 4.4.2
DIPHENYLMETHANE LAXATIVES 301 4.4.2.1 GENERAL PHARMACOKINETIC ASPECTS
301 4.4.2.2 INTESTINAL METABOLISM 304 4.4.3 ANTHRAQUINONES . 304 4.4.3.1
GENERAL PHARMACOKINETIC ASPECTS 304 4.4.3.2 INTESTINAL METABOLISM 307
4.4.4 REFERENCES 308 SCHWENK, M. 4.5 INTESTINAL METABOLISM BY MONOAMINE
OXIDASE 311 4.5.1 ABSTRACT 311 4.5.2 INTRODUCTION 311 4.5.3 THE ENZYME
AND ITS INTRACELLULAR LOCALIZATION 312 4.5.4 MEASURING MAO-ACTIVITY 312
4.5.5 INTESTINAL ENZYME ACTIVITIES COMPARED TO OTHER ORGANS 313 4.5.6
LOCALIZATION ALONG THE MOUTH-RECTUM AND CRYPT-VILLUS AXIS 313 4.5.7
FACTORS INFLUENCING INTESTINAL MAO-ACTIVITY 313 4.5.8 DIAMINE OXIDASE
AND TRANSFERASES AS ALTERNATIVE METABOLIC PATHWAYS . . 314 4.5.9
PHARMACOLOGICAL CONSEQUENCES OF INTESTINAL MAO-ACTIVITY 314 4.5.10
DEVELOPMENT OF NEW MAO-INHIBITOR DRUGS 315 4.5.11 REFERENCES 316
CONRADY-LORCK, S., G.J. STRUGALA, X.-C. FENG AND B. FICHTL 4.6
INTESTINAL METABOLISM OF T-2 TOXIN, A MAJOR TRICHOTHECENE MYCOTOXIN .
319 4.6.1 INTRODUCTION 319 4.6.2 MATERIAL AND METHODS 320 4.6.2.1
EXPERIMENTS WITH EVERTED INTESTINAL SACS IN VITRO 320 4.6.2.2
EXPERIMENTS WITH AUTOPERFUSED JEJUNAL LOOPS IN SITU 320 4.6.2.3
ANALYTICAL PROCEDURES 321 4.6.2.4 CHEMICALS 321 4.6.3 RESULTS AND
DISCUSSION 322 4.6.3.1 EVERTED INTESTINAL SACS IN VITRO 322 4.6.3.2
AUTOPERFUSED JEJUNAL LOOPS IN SITU 323 4.6.3.3 COMPARISON OF METHODS 324
4.6.4 CONCLUSIONS 325 4.6.5 REFERENCES 325 SUBJECT INDEX 327
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| genre | (DE-588)1071861417 Konferenzschrift 1986 München gnd-content |
| genre_facet | Konferenzschrift 1986 München |
| id | DE-604.BV001637307 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:33:24Z |
| institution | BVB |
| isbn | 3437112236 0895742861 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-001072873 |
| oclc_num | 19127424 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | 338 S. Ill., graph. Darst. |
| publishDate | 1989 |
| publishDateSearch | 1989 |
| publishDateSort | 1989 |
| publisher | Fischer |
| record_format | marc |
| series | Progress in pharmacology and clinical pharmacology |
| series2 | Progress in pharmacology and clinical pharmacology |
| spelling | Intestinal metabolism of xenobiotics ed. by A. Sj. Koster ... Stuttgart [u.a.] Fischer 1989 338 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Progress in pharmacology and clinical pharmacology 7,2 Intestinal Absorption Intestines Metabolism Xenobiotics Metabolism Xenobiotics metabolism Darm (DE-588)4011061-8 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Xenobiotikum (DE-588)4193155-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1986 München gnd-content Xenobiotikum (DE-588)4193155-5 s Stoffwechsel (DE-588)4057699-1 s DE-604 Darm (DE-588)4011061-8 s Koster, Andries Sj. Sonstige oth Progress in pharmacology and clinical pharmacology 7,2 (DE-604)BV000001409 7,2 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001072873&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Intestinal metabolism of xenobiotics Progress in pharmacology and clinical pharmacology Intestinal Absorption Intestines Metabolism Xenobiotics Metabolism Xenobiotics metabolism Darm (DE-588)4011061-8 gnd Stoffwechsel (DE-588)4057699-1 gnd Xenobiotikum (DE-588)4193155-5 gnd |
| subject_GND | (DE-588)4011061-8 (DE-588)4057699-1 (DE-588)4193155-5 (DE-588)1071861417 |
| title | Intestinal metabolism of xenobiotics |
| title_auth | Intestinal metabolism of xenobiotics |
| title_exact_search | Intestinal metabolism of xenobiotics |
| title_full | Intestinal metabolism of xenobiotics ed. by A. Sj. Koster ... |
| title_fullStr | Intestinal metabolism of xenobiotics ed. by A. Sj. Koster ... |
| title_full_unstemmed | Intestinal metabolism of xenobiotics ed. by A. Sj. Koster ... |
| title_short | Intestinal metabolism of xenobiotics |
| title_sort | intestinal metabolism of xenobiotics |
| topic | Intestinal Absorption Intestines Metabolism Xenobiotics Metabolism Xenobiotics metabolism Darm (DE-588)4011061-8 gnd Stoffwechsel (DE-588)4057699-1 gnd Xenobiotikum (DE-588)4193155-5 gnd |
| topic_facet | Intestinal Absorption Intestines Metabolism Xenobiotics Metabolism Xenobiotics metabolism Darm Stoffwechsel Xenobiotikum Konferenzschrift 1986 München |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=001072873&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000001409 |
| work_keys_str_mv | AT kosterandriessj intestinalmetabolismofxenobiotics |