Molecular neurobiology of the olfactory system: molecular, membranous, and cytological studies
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York u.a.
Plenum Pr.
1988
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 379 S. Ill. |
| ISBN: | 030642858X |
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| 245 | 1 | 0 | |a Molecular neurobiology of the olfactory system |b molecular, membranous, and cytological studies |c ed. by Frank L. Margolis ... |
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Record in the Search Index
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| adam_text | Molecular
Neurobiology of the
Olfactory System
Molecular, Membranous, and Cytological Studies
Edited by
Frank L Margolis
Roche Institute of Molecular Biology
Nutley, New Jersey
and
Thomas V Getchell
Wayne State University School of Medicine
Detroit, Michigan
PLENUM PRESS • NEW YORK AND LONDON
Contents
I TRANSDUCTION AND LICAND-RECEPTOR INTERACTIONS
1 Olfactory Receptor Mechanisms: Odorant-Binding Protein and Adenylate
Cyclase
Solomon H Snyder, Pamela B Sklar, and lonathan Pevsner
1 Introduction 3
2 An Odorant-Binding Protein 3
3 Odorant Selectivity in Stimulation of Adenylate Cyclase Activity 11
4 Localization of GTP-Binding Proteins in Nasal Mucosa 15
5 Conclusions 21
References 23
2 Molecular Components of Olfactory Reception and Transduction
Doron Lancet
1 Introduction 25
2 Olfactory Cilia: The Site of Olfactory Reception and Transduction 25
2 1 Olfactory Cilia 25
2 2 Isolated Cilia Preparations 26
3 Candidate Odorant Receptor Proteins in the Sensory Membrane 28
3 1 Expected Properties of Olfactory Receptor Proteins 28
3 2 Olfactory Receptor Candidates 30
4 Cyclic Nucleotide Enzymatic Cascade in Olfactory Transduction 31
4 1 Role of cAMP in Olfaction 31
4 2 Olfactory GTP-Binding Protein 36
4 3 Transduction Components as Odorant Receptor Probes 39
5 Possible Mechanisms of Olfactory Ion-Channel Modulation by Cyclic
Nucleotides 43
5 1 Protein Phosphorylation in Olfactory Epithelium 43
5 2 Direct Ion-Channel Gating 44
6 Conclusions 45
References 45
ix
X CONTENTS
3 The Effect of Cytochrome P-450-Dependent Metabolism and Other Enzyme
Activities on Olfaction
Alan R Dahl
1 Relationships among the Fields of Inhalation Toxicology, Foreign
Compound Metabolism, and Olfactory Physiology 51
2 Xenobiotic Metabolizing Enzymes Identified in the Nose and Their
Function 55
2 1 Nasal Enzymes 55
2 2 Types of Metabolic Transformation 59
2 3 Capacity of Nasal Enzymes 61
2 4 Interactions of Two or More Compounds with Nasal Enzymes 64
2 5 Fate of Inhaled Materials: Are Metabolites of Odorants Present in
Mucus? 65
3 Possible Effects of Nasal Metabolism on Olfaction 66
4 Research Needed to Relate Nasal Metabolism of Odorants to
Olfaction 67
5 Summary and Conclusions 68
References 68
4 Odorant and Autonomic Regulation of Secretion in the Olfactory Mucosa
Marilyn L Cetchell, Barbara Zielinski, and Thomas V Cetchell
1 Introduction 71
2 Organization and Characterization of the Cells in the Olfactory
Mucosa 71
3 Extrinsic Innervation of the Olfactory Mucosa 75
4 Cellular Aspects of Secretion in Sustentacular Cells 81
4 1 Mucous Secretion 81
4 2 Electrolyte and-Water Transport and Secretion 82
4 3 Agents That Induce Secretion from Sustentacular Cells 82
4 4 Effects of Olfactory Nerve Section 85
5 Neuropharmacological Regulation of Glandular Secretion 85
5 1 Agonist-Induced Secretion 85
5 2 Second Messengers and Modulators of Agonist-Induced Secretion 87
5 3 Odorant-lnduced Secretion 89
5 4 Neural Pathways of Agonist-Induced Secretion 90
6 Implications for Sensory Transduction 91
6 1 Prereceptor Events 91
6 2 Postinteractive Events 92
7 Conclusions and Research Needs 92
References 93
CONTENTS xi
5 Autoradiographic Localization of Drug and Neurotransmitter Receptors in the
Olfactory Bulb
Valina L Dawson, Ted M Dawson, and lames K Wamsley
1 Introduction 99
2 Light Microscopic Receptor Autoradiography 101
3 Distribution of Receptor Types in the Olfactory Bulb 104
3 1 Cholinergic Receptors 104
3 2 Biogenic Amines 105
3 3 Amino Acids 106
3 4 Neuropeptides 108
3 5 Drug-Binding Sites 110
3 6 Miscellaneous 111
4 Conclusions 112
References 113^
II MOLECULAR BIOPHYSICS AND MEMBRANE FUNCTION
6 Membrane Probes in the Olfactory System: Biophysical Aspects of Initial
Events
Randall B Murphy
1 Introduction 121
2 The Role of Biophysical Models within a Receptor-Mediated Model of
the Initial Events in Olfaction 121
2 1 Possible Mechanisms 122
22 Evidence for Nonspecific Mechanisms 123
2 3 Further Experimental Evidence 124
3 Surface Potentiarand~Single Ionic Channels 127
4 Physical Methods of Probing Initial Chemoreceptive Mechanisms 128
4 1 General Considerations 129
4 2 Photophysical Methods 129
4 3 Electron Spin Resonance 131
5 Biophysical Studies of Olfactory Epithelium 131
5 1 ESR Studies 131
5 2 Fluorescence Studies 132
5 3 Raman and Infrared Spectroscopy 132
5 4 Difference Absorption Spectrophotometry 133
5 5 Biophysical Studies Using Artificial Membranes 134
6 Summary 137
References 138
xii CONTENTS
7 Membrane Properties of Isolated Olfactory Receptor Neurons
Robert A Maue and Vincent E Dionne
1 Introduction 143
1 1 Basis of Interest in Olfactory Receptor Neurons 143
1 2 Obstacles to Studying Receptor Neuron Membrane Currents 143
1 3 Advantages to Patch-Clamping Isolated Receptor Neurons 144
1 4 Focus of Initial Patch-Clamp Studies 144
2 Experimental System 145
2 1 Preparation of Isolated Olfactory Receptor Neurons 145
2 2 Patch-Clamp Technique and Data Analysis 147
2 3 Perfusion System and Odorant Application 148
3 Results 148
3 1 Ion Channels in Olfactory Receptor Neurons 148
3 2 Response of Receptor Neurons to Odorants 151
4 Discussion 152
4 1 Roles of Ion Channels in Receptor Neuron Activity 152
4 2 Future Directions 156
References 156
8 Voltage-Clamp Studies of the Isolated Olfactory Mucosa
John A DeSimone, Krishna C Persaud, and Gerard L Heck
1 Introduction 159
1 1 Chemoreception: A Property of Every Cell 159
1 2 Chapter Organization 160
2 Ion-Transporting Epithelia 160
2 1 Asymmetrical Structure: Consequences for Function 160
2 2 Special Membrane-Transport Systems 161
2 3 Paracellular Shunts 161
3 Electrophysiological Methods 162
3 1 The Short-Circuit Method (Ussing Method) 162
3 2 Radioisotopes and Active Ion Transport 163
3 3 Other Methods 163
4 Theoretical Methods 164
4 1 Nonequilibrium Thermodynamics 164
4 2 Kinetic Approaches 165
5 Ion Transport and Chemoreception 166
5 1 The Sodium Taste Receptor 166
5 2 Other Ions 166
6 The Olfactory Mucosa 167
6 1 Materials and Methods 168
6 2 Active Ion Transport in the Steady State 169
CONTENTS xiii
6 3 The Current-Voltage Relationship 170
6 4 Odorant-Evoked Current Transients under Voltage Clamp 170
6 5 Dose-Response Relationship 172
7 Cyclic Nucleotide Modulation of Olfactory Transduction 173
7 1 cAMP Evokes an Inward Current Transient 174
7 2 cAMP Enhances Odorant-Evoked Current Transients 175
7 3 Evidence for a Stimulatory G Protein 176
7 4 cGMP Inhibits Odorant-Evoked Current Transients 176
8 Summary and Conclusions 178
References 178
III BIOCHEMICAL-MOLECULAR BIOLOGICAL STUDIES
9 Neurotransmitter Plasticity in the Juxtaglomerular Cells of the Olfactory Bulb
Harriet Baker
1 Introduction 185
1 1 Overview 185
1 2 Anatomy 186
2 Alterations in Olfactory Bulb Structure and Function following Receptor
Afferent Lesions 187
2 1 Changes in the Size of the Olfactory Bulb 187
2 2 Biochemical Alterations in the Olfactory Bulb 187
2 3 Immunocytochemical Observations in the Deafferented Olfactory
Bulb 188
3 Development and Plasticity 200
3 1 Inductive Capacity of the Olfactory Epithelium 200
3 2 Strain Differences in Transmitter Expression in the Olfactory Bulb 200
4 Transneuronal Transport of Exogenous Materials from the Olfactory
Epithelium to Brain T: 203
4 1 Transport of Lectins in the Olfactory System 203
4 2 Transneuronal Transport of Lectin to the Forebrain 204
4 3 Implications of Transneuronal Transport for Disease Processes 205
5 Conclusions 205
References 212
10 Axoplasmic Transport in Olfactory Receptor Neurons
Dieter C Weiss and Klaus Buchner
1 Introduction 217
2 The Olfactory Receptor Neuron as a Specialized Neuronal System 217
3 Transport of Low-Molecular-Weight Material 221
xiv CONTENTS
4 Transport of Bulk Proteins 224
4 1 Rapid Transport 224
4 2 Slow Transport 225
5 Transport of Characterized Proteins 227
6 Retrograde Transport 227
7 Organelle Movement Studied with AVEC-DIC Microscopy 228
8 Transneuronal Transport and the Spread of Virus 232
9 The Study of Axoplasmic Transport Using the Olfactory Receptor
Neuron 233
References 233
11 Molecular Cloning of Olfactory-Specific Gene Products
Frank L Margolis
1 Introduction 237
2 Anatomical Organization 238
3 Biochemical Properties 239
4 Olfactory Marker Protein 240
4 1 Overview 240
4 2 Amino Acid Sequence 241
4 3 Hypothetical Approaches to the Function of Olfactory Marker
Protein 242
4 4 Characterization and Cloning of the mRNA and Gene 243
4 5 Future Directions for Olfactory Marker Protein 246
5 Lesion-Induced Changes in mRNAs 246
5 1 In Vitro Translation 246
5 2 Cloning of Additional mRNAs from Nasal/Olfactory Tissue 250
6 Carnosine Synthetase 256
6 1 Overview 256
6 2 Characterization 257
6 3 Monoclonal Antibodies 257
7 Summary 260
References 261
IV DEVELOPMENT AND DIFFERENTIATION
12 Monoclonal Antibody Mapping of the Rat Olfactory Tract
lames I Morgan
1 Introduction 269
1 1 Scope 269
2 Strategies for Monoclonal Antibody Production 269
CONTENTS xv
2 1 General Considerations 269
2 2 Monoclonal Antibodies to Adult and Embryonic Epithelium 270
2 3 Monoclonal Antibodies Raised against Membranes from Olfactory
Epithelium 271
2 4 Antibodies to Carnosine Synthetase 272
3 Applications of Monoclonal Antibodies 273
3 1 Studies of the Structure of the Olfactory Epithelium 273
3 2 Monoclonal Antibody Studies of Ontogeny in the Olfactory
Epithelium 276
3 3 Monoclonal Antibody Studies of Regeneration in the Olfactory
Epithelium 279
3 4 Monoclonal Antibodies to Specific Proteins 281
3 5 Monoclonal Antibody Studies of Cultures of the Olfactory
Epithelium 282
3 6 The Use of Monoclonal Antibodies in the Identification and
Isolation of Novel Olfactory Tract Antigens 288
4 Discussion 292
References 293
13 Primary Olfactory Neuron Subclasses
Richard A Akeson
1 Introduction 297
2 Olfactory Neuron Subclasses 298
2 1 Morphological Subclasses 298
2 2 Carbohydrate Expression Subclasses 299
2 3 Other Defined Subclasses 306
3 Perspectives on Research Directions 309
3 1 Clonal Olfactory Neurons 309
3 2 Direct Approaches to Molecular Olfactory Receptors 312
3 3 Genetic Approaches 313
4 Summary 314
References 315
14 Cellular Interactions in the Development of the Vertebrate Olfactory System
Albert I Farbman
1 Introduction 319
2 Early Development and Formation of the Olfactory Placode 320
2 1 Experimental Analysis of Induction of the Olfactory Placode 320
3 Effect of Olfactory Receptor Cells on Early Formation of the Olfactory
Bulb 322
4 Effect of the Olfactory Bulb on Differentiation of Receptor Cells in a
Regenerating System 322
XVI CONTENTS
5 Effect of Olfactory Bulb on Receptor Cell Development 325
5 1 Organ Culture Method 325
5 2 Bulbar Effects on OMP Synthesis 325
5 3 Bulbar Effects on Ciliogenesis 327
5 4 Does the Bulb Exert a Tropic Effect? 327
6 Cell-Culture Studies 327
7 Summary 328
References 329
75 Olfactory Tissue Interactions Studied by Intraocular Transplantation
Peter C Barber and Steen Jensen
1 Introduction 333
2 Organization of Olfactory Sensory Epithelial Grafts In Oculo 334
3 Indicators of Neuronal Maturation In Oculo 337
4 Factors Affecting Neuronal Maturation In Oculo 339
4 1 Epithelial Organization 340
4 2 Neurotrophic Influence of the Iris 341
4 3 Innervation of the Graft from the Iris 341
4 4 Presence of Co-transplanted Central Nervous Tissue 342
5 Factors Affecting Overall Growth of Olfactory Epithelium in Oculo 346
6 Effects of Olfactory Epithelium In Oculo on Co-transplanted CNS 346
6 1 Maturation of CNS 346
6 2 Innervation of Co-transplant by Olfactory Axons 347
6 3 Innervation of Olfactory Tissue from the CNS 349
7 Conclusions and Directions 350
References 350
V BIOLOGICAL RELEVANCE OF OLFACTORY FUNCTION
16 Age-Related Alterations in Olfactory Structure and Function
Richard L Doty and James B Snow, Jr
1 Introduction 355
2 Human Olfactory Perception in Later Life 356
2 1 Odor Identification 356
2 2 Odor Detection 356
2 3 Suprathreshold Odor Intensity Perception 357
2 4 Odor Discrimination 358
2 5 Odor Pleasantness 359
3 Human Olfactory Perception in Age-Related Diseases 359
3 1 Alzheimer s Disease 360
CONTENTS xvii
3 2 Parkinson s Disease 363
4 Age-Related Alterations in the Structure and Function of the Nose and
the Olfactory System 365
4 1 Airflow and General Nasal Considerations 365
4 2 Olfactory Neuroepithelium 366
4 3 Olfactory Bulb 367
4 4 Higher Centers 369
5 Summary and Conclusions 369
References 370
Index 375
L
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| spelling | Molecular neurobiology of the olfactory system molecular, membranous, and cytological studies ed. by Frank L. Margolis ... New York u.a. Plenum Pr. 1988 XVII, 379 S. Ill. txt rdacontent n rdamedia nc rdacarrier Chémorécepteurs Neurobiologie moléculaire Odorat Chemoreceptor Cells Chemoreceptors Molecular neurobiology Neurobiology Smell Chemorezeptor (DE-588)4133180-1 gnd rswk-swf Geruchssinn (DE-588)4129703-9 gnd rswk-swf Neurobiologie (DE-588)4041871-6 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Geruchssinn (DE-588)4129703-9 s Neurobiologie (DE-588)4041871-6 s DE-604 Molekularbiologie (DE-588)4039983-7 s Chemorezeptor (DE-588)4133180-1 s Margolis, Frank L. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000785043&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular neurobiology of the olfactory system molecular, membranous, and cytological studies Chémorécepteurs Neurobiologie moléculaire Odorat Chemoreceptor Cells Chemoreceptors Molecular neurobiology Neurobiology Smell Chemorezeptor (DE-588)4133180-1 gnd Geruchssinn (DE-588)4129703-9 gnd Neurobiologie (DE-588)4041871-6 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4133180-1 (DE-588)4129703-9 (DE-588)4041871-6 (DE-588)4039983-7 (DE-588)4143413-4 |
| title | Molecular neurobiology of the olfactory system molecular, membranous, and cytological studies |
| title_auth | Molecular neurobiology of the olfactory system molecular, membranous, and cytological studies |
| title_exact_search | Molecular neurobiology of the olfactory system molecular, membranous, and cytological studies |
| title_full | Molecular neurobiology of the olfactory system molecular, membranous, and cytological studies ed. by Frank L. Margolis ... |
| title_fullStr | Molecular neurobiology of the olfactory system molecular, membranous, and cytological studies ed. by Frank L. Margolis ... |
| title_full_unstemmed | Molecular neurobiology of the olfactory system molecular, membranous, and cytological studies ed. by Frank L. Margolis ... |
| title_short | Molecular neurobiology of the olfactory system |
| title_sort | molecular neurobiology of the olfactory system molecular membranous and cytological studies |
| title_sub | molecular, membranous, and cytological studies |
| topic | Chémorécepteurs Neurobiologie moléculaire Odorat Chemoreceptor Cells Chemoreceptors Molecular neurobiology Neurobiology Smell Chemorezeptor (DE-588)4133180-1 gnd Geruchssinn (DE-588)4129703-9 gnd Neurobiologie (DE-588)4041871-6 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Chémorécepteurs Neurobiologie moléculaire Odorat Chemoreceptor Cells Chemoreceptors Molecular neurobiology Neurobiology Smell Chemorezeptor Geruchssinn Neurobiologie Molekularbiologie Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000785043&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT margolisfrankl molecularneurobiologyoftheolfactorysystemmolecularmembranousandcytologicalstudies |