Immunochemistry and the biosynthesis of antibodies:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Interscience Publ.
1968
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 301 S. Ill., graph. Darst. |
Internformat
MARC
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| 245 | 1 | 0 | |a Immunochemistry and the biosynthesis of antibodies |c Felix Haurowitz |
| 264 | 1 | |a New York [u.a.] |b Interscience Publ. |c 1968 | |
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| 650 | 4 | |a Antigènes | |
| 650 | 4 | |a Immunochimie | |
| 650 | 4 | |a Antibody Formation | |
| 650 | 4 | |a Immunochemistry | |
| 650 | 4 | |a Immunoglobulins | |
| 650 | 4 | |a Proteins |x Synthesis | |
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Datensatz im Suchindex
| _version_ | 1804115468518162432 |
|---|---|
| adam_text | Immunochemistry
and the
Biosynthesis of Antibodies
FELIX HAUROWITZ, MD,D Sc
Distinguished Service Professor
Department of Chemistry
Indiana University
Bloomington, Indiana
INTERSCIENCE PUBLISHERS
a division of John Wiley amp; Sons, New York • London • Sydney
Contents
Foreword v
List of Abbreviations ix
Glossary xi
I Introduction 1
A Basic Concepts of Immunology and 1 mmunochemistry 1
B Techniques of Sensitization with Soluble Antigens 7
C The Precipitin Test 9
References 11
II Specificity and Immunogenicity of Antigens 12
A Protein Antigens 12
B Chemospecificity of Conjugated Proteins 17
C Antigenicity of the Polyamino Acids 24
D Bacterial Polysaccharides 29
E Blood Group Substances 32
F Other Antigens 35
G The Action of Adjuvants 37
H Immunogenicity, Responsiveness and Competition of
Antigens 40
References 42
III Detection of Antibodies 47
A Detection of Antibodies in Solutions 47
B Localization of Antibodies in Tissue Sections 56
References 58
IV Purification and Quantitative Determination of Anti
bodies 60
A Purification of Antibodies 60
B Quantitative Determination of Antibody 67
References 76
XV
xvl Contents
V The Structure of Antibodies and Immunoglobulins 78
A Heterogeneity of the Antibodies 78
B The Peptide Chains of the 7S Antibody Molecules 81
C The Structure of the Light Chains 87
D The Heavy Chains of 7S Antibodies and Immunoglobulins 92
E IgA, IgM, and other Immunoglobulins 95
F Structure and Specificity of the Antibody Molecules 98
References 105
VI Antigen-Antibody Interaction 110
A The Formation of Insoluble Antigen -Antibody Complexes 111
B Soluble Antigen-Antibody Complexes 122
C Combination of Antibody Molecules with Haptens 123
D Kinetics of the Combination of Ant ibody with Hapten or
Antigen 128
E Inhibition of Antigen-Antibody Interaction by Haptens 129
F Intermolecular Forces Involved in Antigen-Antibody
Interaction 135
G Agglutination of Particulate Antigens 139
References 144
VII Complement 147
A Complement Fixation 147
B The Components of Complement 152
C Complement Actions in vitro 156
D Complement Actions in vivo 158
References 160
VIII The Metabolic Fate of Injected Antigen 163
A Methods Used for the Detection of Injected Antigens 163
B The Metabolic Fate of Heavih Substituted Protein
Antigens 169
C The Metabolic Fate of Lighth Substituted Protein
Antigens 170
D Significance of the Persistence of Antigenic Determinants 174
References 178
IX Antibody Production in Biological Systems 180
A Antibody-Forming Organisms 180
B Organs Involved in Antibody Formation 181
Contents xvii
C Cells Involved in Antibody Formation 183
D The Problem of Cellular Uni-, Pluri-, or Omnipotentiality 192
References 196
X Antibody Formation in vivo; Primary and Secondary
Response 199
A The Rate of Antibody Formation 199
B Primary and Secondary Response in tlie Living Organism 208
C Immunological Response in Transferred Cells 214
D Primary and Secondary Response in Tissue Cultures 218
E Comparison of the Secondary with the Primary Response 220
F Autoantibodies and Isoantibodies 223
References 227
XI Other Forms of Immunological Response (Tolerance,
Hypersensitivity) 232
A Acquired Immunological Tolerance (Unresponsiveness) 232
B Hypersensitivity and Cellular Immunity 245
References 252
XII The Mechanism of Antibody Format ion 255
A Basic Phenomena and Problems 255
B Evolution of Theories of Antibody Foi mation 263
C Unsolved Basic Problems 274
References 290
Subject Index 295
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T15:23:06Z |
| institution | BVB |
| language | English |
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| physical | XVII, 301 S. Ill., graph. Darst. |
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| publishDate | 1968 |
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| publisher | Interscience Publ. |
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| spelling | Haurowitz, Felix 1896-1987 Verfasser (DE-588)101558910 aut Immunochemistry and the biosynthesis of antibodies Felix Haurowitz New York [u.a.] Interscience Publ. 1968 XVII, 301 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Antigènes Immunochimie Antibody Formation Immunochemistry Immunoglobulins Proteins Synthesis Antikörper (DE-588)4002290-0 gnd rswk-swf Antikörper (DE-588)4002290-0 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000635034&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Haurowitz, Felix 1896-1987 Immunochemistry and the biosynthesis of antibodies Antigènes Immunochimie Antibody Formation Immunochemistry Immunoglobulins Proteins Synthesis Antikörper (DE-588)4002290-0 gnd |
| subject_GND | (DE-588)4002290-0 |
| title | Immunochemistry and the biosynthesis of antibodies |
| title_auth | Immunochemistry and the biosynthesis of antibodies |
| title_exact_search | Immunochemistry and the biosynthesis of antibodies |
| title_full | Immunochemistry and the biosynthesis of antibodies Felix Haurowitz |
| title_fullStr | Immunochemistry and the biosynthesis of antibodies Felix Haurowitz |
| title_full_unstemmed | Immunochemistry and the biosynthesis of antibodies Felix Haurowitz |
| title_short | Immunochemistry and the biosynthesis of antibodies |
| title_sort | immunochemistry and the biosynthesis of antibodies |
| topic | Antigènes Immunochimie Antibody Formation Immunochemistry Immunoglobulins Proteins Synthesis Antikörper (DE-588)4002290-0 gnd |
| topic_facet | Antigènes Immunochimie Antibody Formation Immunochemistry Immunoglobulins Proteins Synthesis Antikörper |
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