Chemical messengers of the inflammatory process:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
1979
|
| Schriftenreihe: | Handbook of inflammation
1 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVII, 421 S. Ill., graph. Darst. |
| ISBN: | 0444801340 |
Internformat
MARC
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| 245 | 1 | 0 | |a Chemical messengers of the inflammatory process |c ed. John C. Houck |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 1979 | |
| 300 | |a XVII, 421 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Handbook of inflammation |v 1 | |
| 650 | 4 | |a Inflammation (Pathologie) | |
| 650 | 4 | |a Inflammation | |
| 700 | 1 | |a Houck, John C. |d 1931- |e Sonstige |0 (DE-588)172144469 |4 oth | |
| 830 | 0 | |a Handbook of inflammation |v 1 |w (DE-604)BV000900440 |9 1 | |
| 856 | 4 | 2 | |m SWB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000634540&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
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Datensatz im Suchindex
| _version_ | 1804115467858608128 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
SERIES PREFACE INTRODUCTION TO VOLUME ONE LIST OF CONTRIBUTORS
V
VII IX
1. HISTAMINE: MEDIATOR AND MODULATOR IN INFLAMMATION WILLIAM W. BUSSE
1.1.
1.2.
1.3.
1.4.
1.5.
INTRODUCTION 1.1.1. CHEMISTRY AND SITE OF ORIGIN 1.1.2. HISTAMINE
METABOLISM HISTAMINE RELEASE
1.2.1. ANTIGEN INDUCED HISTAMINE RELEASE 1.2.1.1. ANTIGEN BRIDGING OF
THE IGE MOLECULE 1.2.1.2. INFLUENCE OF CALCIUM IONS ON HISTAMINE RELEASE
.2.2. COMPLEMENT MEDIATED RELEASE OF HISTAMINE .2.3. NONIMMUNOLOGICAL
RELEASE OF HISTAMINE .2.4. CONCANAVALIN A (CON A)-INDUCED RELEASE OF
HISTAMINE .2.5. HISTAMINE RELEASE BY HUMAN LEUKOCYTE LYSATES .2.6.
PHYSICAL STIMULI .2.7. HYPOXIA-AND HISTAMINE RELEASE REGULATION AND
RELEASE OF HISTAMINE
.3.1. CYCLIC NUCLEOTIDE MODULATION OF HISTAMINE RELEASE .3.2. CELLULAR
EVENTS IN HISTAMINE RELEASE .3.3. DISODIUM CHROMOGLYCATE HISTAMINE
RECEPTORS .4.1. CLASSICAL ANTIHISTAMINES .4.2. CONCEPTS OF TWO TYPES OF
HISTAMINE RECEPTORS .4.3. COMPARISON OF HI AND H2 RECEPTOR ANTAGONISTS
.4.4. HISTAMINE DERIVED AGONISTS PHARMACOLOGY AND PARTICIPATION OF
HISTAMINE IN ALLERGIC TISSUE INJURY .5.1. GASTRIC SECRETION .5.2. RAT
UTERUS
.5.3. BRONCHIAL SMOOTH MUSCLE HISTAMINE RECEPTORS .5.4. PULMONARY CYCLIC
NUCLEOTIDE RESPONSE TO HISTAMINE
1 3 5 5 5 6
7 7 9
10 10 10 12 12 12 14 14 14 15 15 15 17 18 18 18 19 20
XI
IMAGE 2
XLL
1.5.5. HISTAMINE VASCULAR RECEPTORS 20
1.5.6. PULMONARY VASCULAR HISTAMINE RECEPTORS 22
1.5.7. HISTAMINE EFFECTS ON THE MICROCIRCULATION 22
1.5.8. CARDIAC HISTAMINE RECEPTORS 24
1.5.9. CORONARY PERFUSION RESPONSES TO HISTAMINE 25
1.5.10. HISTAMINE ROLE IN ARRHYTHMIAS 25
1.6. HISTAMINE REGULATION AND MODULATION OF THE INFLAMMATORY AND IMMUNE
RESPONSE 25 1.6.1. HISTAMINE MODULATION OF MEDIATOR RELEASE FROM
SENSITIZED MAST CELLS OR BASOPHILIC LEUKOCYTES 26
1.6.2. HISTAMINE INHIBITION OF LYMPHOCYTE CYTOLYSIS 28
1.6.3. HISTAMINE RECEPTORS ON ANTIBODY PRODUCING CELLS 30
1.6.4. HISTAMINE MODULATION OF THE CELLULAR IMMUNE RESPONSE 31
1.6.5. HISTAMINE INTERACTION WITH EOSINOPHIL CHEMOTAXIS 32
1.6.6. HISTAMINE MODULATION OF GRANULOCYTE FUNCTION 32
1.7. SUMMARY 35
2. KININS AND THE KININ SYSTEM AS INFLAMMATORY MEDIATORS HENRY Z. MOVAT
47
2.1. INTRODUCTION 47
2.2. EARLY VIEWS ON THE CONCEPT OF A KININ SYSTEM AND ITS RELATION TO
BLOOD CLOTTING 49 2.2.1. PERMEABILITY FACTOR (PF/DIL), AND ITS RELATION
TO THE CONTACT PHASE OF KININ FORMATION AND BLOOD COAGULATION 49
2.2.2. THE THESIS OF TWO KININ-FORMING SYSTEMS 51
2.3. FACTOR XII (HAGEMAN FACTOR) 52
2.3.1. ISOLATION 52
2.3.2. PHYSICO-CHEMICAL PROPERTIES 53
2.3.3. ACTIVATION OF FACTOR XII 53
2.4. PREKALLIKREIN-KALLIKREIN 58
2.4.1. ISOLATION 58
2.4.2. PHYSICO-CHEMICAL PROPERTIES 62
2.4.3. ACTIVATION OF PREKALLIKREIN TO KALLIKREIN 62
2.4.4. ASSAYS FOR PREKALLIKREIN AND KALLIKREIN 65
2.4.5. COMPLEXING OF PREKALLIKREIN AND KALLIKREIN IN PLASMA 66
2.4.6. PREKALLIKREIN DEFICIENCY 70
2.4.7. INHIBITION 70
2.5. KININOGENS 71
2.5.1. ISOLATION 71
2.5.1.1. LOW MOLECULAR WEIGHT KININOGEN OF HUMAN PLASMA -J
2.5.1.2. HIGH MOLECULAR WEIGHT KININOGEN OF HUMAN PLASMA 72
2.5.1.3. KININOGENS OF ANIMAL PLASMAS 74
2.5.2. PROPERTIES 76
2.5.3. CLEAVAGE OF KININOGENS 78
2.5.4. HIGH MOLECULAR WEIGHT KININOGEN DEFICIENCY 79
2.6. THE FIBRINOLYTIC SYSTEM 80
2.6.1. ACTIVATION 80
2.6.2. PLASMINOGEN-PLASMIN 83
2.6.2.1. ISOLATION 83
2.6.2.2. PHYSICO-CHEMICAL PROPERTIES 84
2.6.2.3. ACTIVATION OF PLASMINOGEN TO PLASMIN 85
2.6.2.4. EFFECT ON THE KININ SYSTEM 85
2.6.3. INHIBITORS 86
2.6.4. PLASMINOGEN-INDEPENDENT FIBRINOLYSIS 86
2.7. KININ GENERATION BY NEUTROPHIL LEUKOCYTES 86
2.7.1. PROTEASES OF NEUTROPHIL LYSOSOMES 87
2.7.2. INTERACTION BETWEEN NEUTROPHIL PROTEASES AND PLASMA CONSTITUENTS
89 2.8. PLASMA PROTEINASE INHIBITORS 90
2.9. KININS AND THE INFLAMMATORY REACTION 93
IMAGE 3
X L LL
3. PROSTAGLANDINS
S. H. FERREIRA 113
3.1. WHAT IS AN INFLAMMATORY MEDIATOR? 114
3.2. ARE PROSTAGLANDINS INFLAMMATORY MEDIATORS? 114
3.2.1. THE RELEASE OF PROSTAGLANDINS BY AN INFLAMMATORY TRAUMA 115
3.2.1.1. DETECTION OF PROSTAGLANDINS 115
3.2.1.2. OVERVIEW OF THE BIOCHEMISTRY OF PROSTAGLANDIN SYNTHESIS 116
3.2.1.3. THE TRIGGERING OF PROSTAGLANDIN RELEASE 119
3.2.2. SUBSTANCES WHICH INHIBIT SYNTHESIS RELEASE OR ANTAGONISE THE
EFFECT OF PROSTAGLANDINS DIMINISH THE INTENSITY OF ONE OR MORE
COMPONENTS OF THE INFLAMMATORY RESPONSE 121
3.2.2.1. INHIBITION OF CYCLO-OXYGENASE 121
3.2.2.2. PROSTAGLANDIN ANTAGONISTS 124
3.2.2.3. INHIBITION OF PROSTACYCLIN AND THROMBOXANE ISOMERASES 125
3.2.2.4. INHIBITION OF PHOSPHOLIPASE A AND LIPOXYGENASE 126
3.2.3. PROSTAGLANDINS REPRODUCE SEVERAL COMPONENTS OF INFLAMMATORY
REACTION 127 3.2.3.1. VASODILATION, INCREASED VASCULAR PERMEABILITY AND
OEDEMA 127 3.2.3.2. HYPERALGESIA AND PAIN 130
3.2.3.3. CELL MIGRATION AND GRANULOMATOUS REACTION 133
3.2.3.4. FEVER 134
3.2.4. ENHANCEMENT OF THE INTENSITY OF AN INFLAMMATORY COMPONENT BY
INHIBITORS OF PROSTAGLANDIN INACTIVATION 135
3.3. CORTICOIDS AND PROSTAGLANDIN BIOSYNTHESIS 136
3.4. THE ANTI-INFLAMMATORY EFFECT OF PROSTAGLANDINS 138
3.5. CONCLUSIONS 140
4. COMPLEMENT AND CHEMOTAXIS PETER A. WARD, TONY E. HUGH AND DENNIS E.
CHENOWETH 153
4.1. INTRODUCTION 153
4.2. METHODOLOGIES 153
4.2.1. MICROPORE FILTER ASSAY FOR CHEMOTAXIS 154
4.2.1.1. METHOD I 155
4.2.1.2. METHOD II 155
4.2.1.3. METHOD III 158
4.2.2. CHEMOTAXIS UNDER AGAROSE 160
4.3. ROLE OF CATIONS AND CELL-ASSOCIATED ENZYMES 165
4.4. ROLE OF MICROTUBULES AND MICROFILAMENTS 166
4.5. RECEPTORS 167
4.6. CHEMOTACTIC FACTORS 169
4.6.1. C5A AND C5A DES ARG 169
4.6.2. C3 FRAGMENTATION PRODUCTS 172
4.6.3. SYNTHETIC OLIGOPEPTIDES 172
4.6.4. CELL DERIVED CHEMOTACTIC FACTORS 172
4.6.5. LIPID CHEMOTACTIC FACTORS 174
4.7. IN VIVO DEMONSTRATION OF CHEMOTACTIC FACTORS 175
4.8. CONTROL MECHANISMS FOR CHEMOTACTIC FACTORS 175
5. HAGEMAN FACTOR AND THE CONTACT ACTIVATION SYSTEM ROGER C. WIGGINS AND
CHARLES G. COCHRANE 179
5.1. INTRODUCTION 179
5.2. PROTEINS INVOLVED IN THE CONTACT ACTIVATION SYSTEM IN PLASMA 181
5.2.1. HAGEMAN FACTOR (HF) (FACTOR XII) 181
5.2.2. PREKALLIKREIN (PK) HAGEMAN FACTOR-DEPENDENT PLASMINOGEN
PROACTIVATOR 181
5.2.3. FACTOR XI (PLASMA THROMBOPLASTIN ANTECEDENT) 182
5.2.4. HIGH MOLECULAR WEIGHT KININOGEN (HMWK) 182
IMAGE 4
XIV
5.3. THE INTERACTION OF THE PURIFIED PROTEINS OF THE CONTACT ACTIVATION
SYSTEM 182
5.3.1. THE ACTIVATION OF HAGEMAN FACTOR 182
5.3.2. THE RECIPROCAL ACTIVATION OF HAGEMAN FACTOR BY KALLIKREIN AND OF
PREKALLIKREIN BY ACTIVATED HAGEMAN FACTOR 183
5.3.3. THE ROLE OF HIGH MOLECULAR WEIGHT KININOGEN 184
5.3.4. THE IMPORTANCE OF A SURFACE IN CONTACT ACTIVATION 185
5.3.5. IS HAGEMAN FACTOR ACTIVATED IN THE PRESENCE OF SURFACE ALONE? 186
5.3.6. THE TRIGGERING MECHANISM FOR CONTACT-PHASE ACTIVATION AND THE
RECIPROCAL ACTIVATION SYSTEM 186
5.4. THE HAGEMAN FACTOR SYSTEM IN PLASMA 188
5.4.1. THE BINDING AND CLEAVAGE OF HAGEMAN FACTOR IN PLASMA 188
5.4.2. HMWK-MEDIATED BINDING OF PK AND FACTOR XI TO THE NEGATIVELY
CHARGED SURFACE 188
5.4.3. INHIBITION OF ACTIVATED PRODUCTS OF THE CONTACT ACTIVATION SYSTEM
190
5.5. RELATIONSHIP BETWEEN THE CONTACT ACTIVATION SYSTEM AND FACTOR VII
OF THE EXTRINSIC COAGULATION SYSTEM 191
5.6. THE INTERACTION OF THE HAGEMAN FACTOR SYSTEM WITH CELLS 191
5.7. THE ROLE OF THE HAGEMAN FACTOR SYSTEM IN DISEASE PROCESSES 191
6. LYMPHOKINES AND CYTOKINES VEETA EWAN AND TAKESHI YOSHIDA 197
6.1. INTRODUCTION 197
6.2. VARIOUS INFLAMMATORY LYMPHOKINES 198
6.2.1. LYMPHOKINES AFFECTING MACROPHAGES 198
6.2.2. LYMPHOKINES AFFECTING NEUTROPHILS 204
6.2.3. LYMPHOKINES AFFECTING BASOPHILS 204
6.2.4. LYMPHOKINES AFFECTING EOSINOPHILS 205
6.2.5. LYMPHOKINES AFFECTING VASCULAR PERMEABILITY 205
6.2.6. LYMPHOKINES AFFECTING FIBROBLASTS AND OTHER CELLS 206
6.3. PRODUCTION OF SOLUBLE MEDIATORS BY VARIOUS CELLS 207
6.3.1. T LYMPHOCYTES 207
6.3.2. B LYMPHOCYTES 210
6.3.3. LYMPHOID CELL LINES 212
6.3.4. NONLYMPHOID CELL LINES 213
6.3.5. VIRUS-INFECTED OR VIRUS-TRANSFORMED CELLS 215
6.3.6. MISCELLANEOUS SOURCES OF CYTOKINES 216
6.4. CONCLUDING REMARKS 217
7. LYSOSOMAL FACTORS IN INFLAMMATION JOHN M. GLEISNER 229
7.1. INTRODUCTION 229
7.2. RELEASE OF LYSOSOMAL FACTORS 230
7.2.1. CELL DEATH 230
7.2.2. SELECTIVE SECRETORY RELEASE 230
7.2.2.1. REGURGITATION DURING FEEDING 231
7.2.2.2. REVERSE ENDOCYTOSIS 232
7.2.3. MODULATION OF LYSOSOMAL ENZYME (FACTOR) RELEASE 232
7.2.3.1. CULTURED POLYMORPHONUCLEAR LEUKOCYTES AND MACROPHAGES 232
7.2.3.2. ISOLATED LYSOSOMES 233
7.3. ENZYMATIC MEDIATORS 233
7.3.1. ACID PROTEINASES 233
7.3.2. NEUTRAL PROTEINASES 233
7.3.2.1. COLLAGENASE 234
7.3.2.2. ELASTASE 234
7.3.2.3. CHYMOTRYPSIN-LIKE OR CATHEPSIN G . 235
7.3.2.4. SH-DEPENDENT 236
7.3.2.5. NEUTRAL PROTEINASES AND THE INFLAMMATORY RESPONSE 236
IMAGE 5
XV
7.4. NONENZYMATIC MEDIATORS 239
7.4.1. INCREASE IN VASCULAR PERMEABILITY 240
7.4.1.1. CATIONIC PROTEINS 241
7.4.1.2. ANIONIC PROTEIN 243
7.4.1.3. MECHANISM OF PERMEABILITY INCREASE 244
7.4.2. OTHER BIOLOGICAL ACTIVITIES OF NONENZYMATIC LYSOSOMAL PROTEINS
245 7.5. CONCLUSIONS 247
ACID CATHEPSINS J. FREDERICK WOESSNER, JR. 261
8.1. INTRODUCTION 261
8.2. CLASSIFICATION AND PROPERTIES OF THE ACID CATHEPSINS 262
8.2.1. THIOL PROTEINASES 262
8.2.1.1. CATHEPSIN B 262
8.2.1.2. CATHEPSINS H AND L 263
8.2.1.3. COLLAGENOLYTIC CATHEPSIN 264
8.2.1.4. OTHER THIOL PROTEINASES ACTIVE AT ACID PH 264
8.2.2. CARBOXYL PROTEINASES 264
8.2.1.1. CATHEPSIN D 265
8.2.2.2. CATHEPSIN E 267
8.2.2.3. RENIN 267
8.2.3. OTHER ACID PROTEINASES 267
8.3. THE ROLE OF ACID CATHEPSINS IN THE INFLAMMATORY PROCESS 267
8.3.1. THE FUNCTIONING OF ACID CATHEPSINS WITHIN THE LYSOSOMAL SYSTEM OF
THE CELL 267 8.3.2. THE ACTION OF ACID CATHEPSINS RELEASED TO THE CELL
CYTOPLASM 269
8.3.3. THE ROLE OF ACID CATHEPSINS RELEASED TO THE EXTRACELLULAR SPACE
270
8.3.3.1. FACTORS CAUSING THE RELEASE OF ACID CATHEPSINS 270
8.3.3.2. ACTION OF ACID CATHEPSINS ON SERUM COMPONENTS 27)
8.3.3.3. ACTION OF ACID CATHEPSINS ON MATRIX COMPONENTS 273
8.3.4. ACID CATHEPSINS ENTERING THE CIRCULATION 275
8.4. CONTROL OF ACID CATHEPSIN ACTIVITY 275
8.4.1. NATURAL CONTROL MECHANISMS 275
8.4.2. CONTROL BY BLOCKING INTRACELLULAR DIGESTION 276
8.4.3. CONTROL OF CATHEPSINS BY INHIBITION AFTER THEIR RELEASE FROM THE
CELLS 277
9. MACROPHAGE GROWTH FACTOR YVONNE NAURU 285
9.1. INTRODUCTION 285
9.1.1. SCOPE OF REVIEW 285
9.1.2. MACROPHAGES INFLAMMATION, PROLIFERATION IN VIVO 289
9.1.3. COIDENTITY OF MGF, CSF AND MGI 289
9.2. BIOCHEMISTRY OF MGF 290
9.2.1. SOURCES OF MGF 290
9.2.2. ISOLATION, PURIFICATION AND CHEMICAL CHARACTERIZATION OF MGF 290
9.2.3. INTERACTION OF MGF WITH SERUM FACTORS AND COFACTOR REQUIREMENTS
293 9.2.4. MGF AS A CELL MEMBRANE PROTEIN 294
9.3. MGF-CELL INTERACTION 294
9.3.1. ASSAYS FOR MGF 294
9.3.2. THE TARGET CELL 297
9.4. THE MULTIPLE ACTIVITIES OF MGF 303
9.4.1. MGF AS A MITOGENIC FACTOR 303
9.4.2. MGF AS A DIFFERENTIATING FACTOR 306
9.4.3. MGF AS A SURVIVAL FACTOR 308
9.5. IN VIVO SIGNIFICANCE OF MGF 309
IMAGE 6
XVI
10. TUMOR ANGIOGENESIS
DIANNA H. AUSPRUNK 317
10.1. INTRODUCTION 317
10.2. HISTORICAL PERSPECTIVES 318
10.2.1. EARLY STUDIES OF TUMOR VASCULARIZATION 318
10.2.2. HUMORAL MECHANISM 320
10.3. TUMOR ANGIOGENESIS FACTOR (TAF) AND ITS ASSAY 320
10.3.1. ISOLATION AND PURIFICATION 320
10.3.2. CELLS THAT PRODUCE TAF 321
10.3.3. ASSAYS 321
10.3.3.1. DORSAL AIR SAC OF THE RAT 321
10.3.3.2. CHICK CHORIOALLANTOIC MEMBRANE 323
10.3.3.3. RABBIT CORNEA 326
10.3.3.4. ENDOTHILIOL CELL CULTURES 327
10.4. BIOLOGY OF TUMOR ANGIOGENESIS 329
10.4.1. ABILITY OF TUMOR CELLS TO ELICIT ANGIOGENESIS 329
10.4.2. CAPILLARY RESPONSE DURING TUMOR ANGIOGENESIS 329
10.4.2.1. INITIAL VASCULAR REACTIONS 329
10.4.2.2. ENDOTHELIAL PROLIFERATION 331
10.4.2.3. ENDOTHELIAL MIGRATION 331
10.4.3. RELATIONSHIP OF VASCULARIZATION TO TUMOR GROWTH 333
10.4.4. FRAGILITY OF TUMOR VESSELS 336
10.4.5. CAPILLARY REGRESSION 341
10.5. INHIBITION OF TUMOR ANGIOGENESIS 342
10.6. ANGIOGENESIS ACTIVITY IN NORMAL TISSUES 343
10.6.1. REVASCULARIZATION OF NORMAL TISSUE GRAFTS COMPARED TO TUMOR 343
10.6.2. ADULT TISSUES 344
10.6.3. EMBRYONIC AND NEONATAL TISSUES 345
10.6.4. CELLS AND CELL EXTRACTS 345
10.7. SUMMARY 346
11. THE PLACE OFCHALONES AMONG THE REGULATORS OF CELL PRODUCTION IN
INFLAMMATION EDNA B. LAURENCE 353
11.1. INTRODUCTION 353
11.1.1. THE PROBLEM 353
11.1.2. CELLULAR INVOLVEMENT IN THE INFLAMMATORY RESPONSE 354
11.1.3. CELL AND TISSUE LIFE CYCLE 356
11.1.4. CELL PROLIFERATION CYCLE 358
11.2. EVIDENCE FOR CHALONE ACTION 360
11.2.1. THEORECTICAL CONSIDERATIONS 361
11.2.2. INDIRECT EXPERIMENTAL EVIDENCE 362
11.2.3. EARLY ATTEMPTS AT ISOLATION AND THE BIOLOGICAL PROPERTIES 363
11.3. METHODS OF MEASURING CHALONE ACTIVITY 366
11.3.1. MEASUREMENTS OF INHIBITION AT CERTAIN STAGES IN THE CELL CYCLE
366 11.3.1.1. USE OF RADIO-ISOTOPES 366
11.3.1.2. USE OF STATHMOKINETIC AGENTS 367
11.3.1.3. USE OF FLOW MICROFLUORIMETRY AND MICRODENSITOMETRY 367 11.3.2.
MEASUREMENTS ON CHANGES IN CYTOPLASMIC STRUCTURE AND GROWTH 367
11.3.2.1. FLUORESCENT POLARISATION 367
11.3.2.2. OVERALL GROWTH ASSESSMENT FOR SPECIFIC TISSUES 368
11.4. TISSUE SPECIFICITY - THE INVALID EXPERIMENT AND THE NULL RESULT
368
11.5. THE LIFE HISTORY AND CHALONE SYSTEM OF THE CELLS AT THE
INFLAMMATORY SITE 370 11.5.1. MAST CELLS 370
11.5.2. THE MELANOCYCTE SYSTEM 371
11.5.2.1. THE MELANOCYCTE CHALONE 372
IMAGE 7
XV11
11.5.3. THE HAEMOPOIETIC SYSTEM 373
11.5.3.1. THE HAEMOPOIETIC PLURIPOTENTIA STEM CELL (CFUS) 373
11.5.3.2. THE GRANULOCYTE SYSTEM 375
11.5.3.3. THE ERYTHROCYCTE SYSTEM 379
11.5.3.4. THE MACROPHAGE SYSTEM 381
11.5.3.5. THE LYMPHOCYTE SYSTEM 382
11.5.4. THE FIBROBLAST SYSTEM 386
11.5.4.1. THE FIBROBLAST CHALONE 387
11.5.4.2. THE ROLE OF THE FIBROBLAST CHALONE IN THE INFLAMMATORY
RESPONSE 388
11.5.5. THE EPITHELIAL SYSTEM 388
11.5.5.1. NORMAL EPITHELIA 388
11.5.5.2. HYPERPLASTIC EPITHELIA 390
11.6. CHALONES AND PATHOLOGICAL CONDITIONS 393
11.7. CHALONES AND ANTICHALONES 397
11.8. MECHANISM OF CHALONE ACTION 398
11.9. SUMMARY AND CONCLUSIONS 402
SUBJECT INDEX 415
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| id | DE-604.BV001050026 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:23:05Z |
| institution | BVB |
| isbn | 0444801340 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000634540 |
| oclc_num | 5310458 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM DE-20 |
| owner_facet | DE-19 DE-BY-UBM DE-20 |
| physical | XVII, 421 S. Ill., graph. Darst. |
| publishDate | 1979 |
| publishDateSearch | 1979 |
| publishDateSort | 1979 |
| publisher | Elsevier |
| record_format | marc |
| series | Handbook of inflammation |
| series2 | Handbook of inflammation |
| spelling | Chemical messengers of the inflammatory process ed. John C. Houck Amsterdam [u.a.] Elsevier 1979 XVII, 421 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Handbook of inflammation 1 Inflammation (Pathologie) Inflammation Houck, John C. 1931- Sonstige (DE-588)172144469 oth Handbook of inflammation 1 (DE-604)BV000900440 1 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000634540&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chemical messengers of the inflammatory process Handbook of inflammation Inflammation (Pathologie) Inflammation |
| title | Chemical messengers of the inflammatory process |
| title_auth | Chemical messengers of the inflammatory process |
| title_exact_search | Chemical messengers of the inflammatory process |
| title_full | Chemical messengers of the inflammatory process ed. John C. Houck |
| title_fullStr | Chemical messengers of the inflammatory process ed. John C. Houck |
| title_full_unstemmed | Chemical messengers of the inflammatory process ed. John C. Houck |
| title_short | Chemical messengers of the inflammatory process |
| title_sort | chemical messengers of the inflammatory process |
| topic | Inflammation (Pathologie) Inflammation |
| topic_facet | Inflammation (Pathologie) Inflammation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000634540&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000900440 |
| work_keys_str_mv | AT houckjohnc chemicalmessengersoftheinflammatoryprocess |