Drug interaction and lethality analysis:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton, Fla.
CRC Pr.
1988
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 157 S. |
| ISBN: | 0849357438 |
Internformat
MARC
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| 245 | 1 | 0 | |a Drug interaction and lethality analysis |c Marshall N. Brunden ; Thomas J. Vidmar ; Joseph W. McKean |
| 264 | 1 | |a Boca Raton, Fla. |b CRC Pr. |c 1988 | |
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| 650 | 4 | |a Antagonisme médicamenteux - Méthodes statistiques | |
| 650 | 4 | |a Antagonisme médicamenteux - Recherche - Méthodologie | |
| 650 | 2 | |a Calcul mathématique ordinateur | |
| 650 | 2 | |a Interactions médicamenteuses | |
| 650 | 2 | |a Modèle théorique | |
| 650 | 4 | |a Médicaments - Toxicologie - Méthodes statistiques | |
| 650 | 2 | |a Médicaments | |
| 650 | 4 | |a Plans factoriels | |
| 650 | 2 | |a Toxicologie - Méthodes | |
| 650 | 4 | |a Drug Interactions | |
| 650 | 4 | |a Drug antagonism |x Research |x Methodology | |
| 650 | 4 | |a Drug antagonism |x Statistical methods | |
| 650 | 4 | |a Drugs |x Toxicology |x Statistical methods | |
| 650 | 4 | |a Factorial experiment designs | |
| 650 | 4 | |a Mathematical Computing | |
| 650 | 4 | |a Models, Theoretical | |
| 650 | 4 | |a Toxicology |x methods | |
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Datensatz im Suchindex
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| adam_text | DRUG INTERACTION AND LETHALITY ANALYSIS AUTHORS MARSHALL N. BRUNDEN,
PH.D. SENIOR BIOSTATISTICIAN, BIOMATHEMATICS SECTION BIOSTATISTICS
DEPARTMENT, PHARMACEUTICAL RESEARCH AND DEVELOPMENT THE UPJOHN COMPANY
KALAMAZOO, MICHIGAN THOMAS J. VIDMAR, PH.D. BIOSTATISTICIAN,
BIOMATHEMATICS SECTION BIOSTATISTICS DEPARTMENT, PHARMACEUTICAL RESEARCH
AND DEVELOPMENT THE UPJOHN COMPANY KALAMAZOO, MICHIGAN JOSEPH W. MCKEAN,
PH.D. ASSOCIATE PROFESSOR, DEPARTMENT OF MATHEMATICS AND STATISTICS
WESTERN MICHIGAN UNIVERSITY KALAMAZOO, MICHIGAN CRC PRESS, INC. BOCA
RATON, FLORIDA TABLE OF CONTENTS CHAPTER 1 EARLY METHODS APPLIED TO DRUG
COMBINATION STUDIES 1 I. INTRODUCTION 1 II. LITERATURE REVIEW 1
REFERENCES 10 CHAPTER 2 OPTIMAL EXPERIMENTAL DESIGNS * NEW PLANS FOR
DRUG COMBINATION STUDIES 11 I. INTRODUCTION 11 II. STATISTICAL MODELS 11
III. EXPERIMENTAL DESIGNS 17 A. 2 X 2 FACTORIAL DESIGN 17 1. DESIGN
OPTIMIZATION 19 2. RESULTS OF OPTIMIZATION 21 3. ESTIMATION OF DRUG
DOSES 22 4. CASE FOR SUBOPTIMAL DESIGN 24 B. TWO-RAY DESIGN 24 1. DESIGN
OPTIMIZATION 26 2. RESULTS OF OPTIMIZATION 27 C. 3 X 3 FACTORIAL DESIGN
27 1. INTRODUCTION 27 2. DESIGN OPTIMIZATION MODEL 30 A. MODEL 30 B.
DESIGN 31 3. RESULTS OF OPTIMIZATION 33 4. ESTIMATION OF DRUG DOSES 34
5. CASE FOR SUBOPTIMAL DESIGN 34 D. THREE-RAY DESIGN 34 1. DESIGN
OPTIMIZATION ! ; 36 2. RESULTS OF OPTIMIZATION : 39 REFERENCES 4.1
CHAPTER 3 DESIGN EFFICIENCIES IN THE PRESENCE OF DRUG INTERACTION 43 I.
INTRODUCTION : 43 II. INTERACTION QUANTIFICATION 43 A. FOUR-POINT
DESIGNS 43 B. NINE-POINT DESIGNS 44 III. FOUR-POINT DESIGN EFFICIENCIES
UNDER H A 45 IV. NINE-POINT DESIGN EFFICIENCIES UNDER H A 51 V. SUMMARY
53 CHAPTER 4 A GUIDE TO DEVELOPING EXPERIMENTAL PLANS 59 I. INTRODUCTION
59 II. DIGITALIS AND QUINIDINE DATA SET 59 A. 2 X 2 FACTORIAL DESIGN 59
B. TWO-RAY DESIGN 60 C. 3 X 3 FACTORIAL DESIGN 62 D. THREE-RAY DESIGN 63
III. HN2 AND URETHANE DATA SET 68 A. 2 X 2 FACTORIAL DESIGN 68 B.
TWO-RAY DESIGN 69 C. 3 X 3 FACTORIAL DESIGN 69 D. THREE-RAY DESIGN 70
IV. DILANTIN AND PM334 DATA SET 70 A. 2 X 2 FACTORIAL DESIGN 70 B.
TWO-RAY DESIGN 72 C. 3 X 3 FACTORIAL DESIGN 72 D. THREE-RAY DESIGN 72 V.
AMETHOPTERIN AND 6-MERCAPTOPURINE DATA SET 73 A. 2 X 2 FACTORIAL DESIGN
73 B. TWO-RAY DESIGN 73 C. 3 X 3 FACTORIAL DESIGN 74 D. THREE-RAY DESIGN
75 VI. ETHANOL (ETOH) AND PHENCYCLADINE (PCP) DATA SET 75 A. 2 X 2
FACTORIAL DESIGN 75 B. TWO-RAY DESIGN 75 C. 3 X 3 FACTORIAL DESIGN 76 D.
THREE-RAY DESIGN 77 VII. SUMMARY 77 CHAPTER 5 TESTS OF HYPOTHESES OF
LOGISTIC REGRESSION 79 I. INTRODUCTION 79 II. LEAST SQUARES ESTIMATION
79 III. MAXIMUM LIKELIHOOD ESTIMATION 80 IV. EXACT ANALYSIS FOR THE
ESTIMATION OF A SINGLE PARAMETER 82 V. RECOMMENDATIONS 86 REFERENCES 86
CHAPTER 6 DIAGNOSTICS FOR LOGISTIC REGRESSION ,87 I. INTRODUCTION 87 II.
PEARSON RESIDUALS 90 III. COMPONENTS OF DEVIANCE 91 IV. ADJUSTED
COMPONENTS OF DEVIANCE : 93 V. INFLUENCE POINTS 93 VI. COMPUTER PROGRAM
* GLIM 96 VIII. SUMMARY 96 REFERENCES 96 CHAPTER 7 A GUIDE TO THE
APPLICATION OF LOGISTIC REGRESSION IN DRUG COMBINATION STUDIES 97 I.
INTRODUCTION 97 II. DATA SET ONE 97 III. DATA SET TWO 100 IV. DATA SET
THREE 104 REFERENCES ILL CHAPTER 8 ROBUST LOGISTIC REGRESSION 113 I.
INTRODUCTION 113 II. PREGIBON S METHOD 115 III. ALTERNATIVE ROBUST
PROCEDURES 116 IV. ANALYSIS OF DRUG COMBINATION DATA USING ROBUST
METHODS 117 V. COMPUTER SOFTWARE TO PERFORM ROBUST REGRESSION ANALYSIS
118 VI. SUMMARY 118 REFERENCES 118 CHAPTER 9 ESTIMATION OF THE ED 50 IN
DRUG COMBINATION EXPERIMENTS 119 I. INTRODUCTION 119 II. ESTIMATION OF
THE ED 50 AND THE ASYMPTOTIC CONFIDENCE REGIONS ASSUMING A LOGISTIC
MODEL 119 III. BOOTSTRAP METHODS 123 IV. THE BOOTSTRAP TECHNIQUE 124 V.
APPLICATIONS OF THE BOOTSTRAP ESTIMATE 125 REFERENCES 128 APPENDIX 1 2X2
FACTORIAL DESIGN 129 APPENDIX 2 TWO-RAY DESIGN 135 APPENDIX 3 3X3
FACTORIAL DESIGN 137 APPENDIX 4 THREE-RAY DESIGN , 143 APPENDIX 5
COMPUTER PROGRAM TO COMPUTE DIAGNOSTICS 147 APPENDIX 6 COMPUTER PROGRAMS
TO COMPUTE ROBUST ESTIMATES 149 APPENDIX 7 COMPUTER PROGRAM TO COMPUTE
ED 50 USING ROBUST ESTIMATES AND A BOOTSTRAP ESTIMATE OF THE VARIANCE
153 INDEX 155
|
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| author | Brunden, Marshall N. Vidmar, Thomas J. McKean, Joseph W. 1944- |
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| isbn | 0849357438 |
| language | English |
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| spelling | Brunden, Marshall N. Verfasser aut Drug interaction and lethality analysis Marshall N. Brunden ; Thomas J. Vidmar ; Joseph W. McKean Boca Raton, Fla. CRC Pr. 1988 157 S. txt rdacontent n rdamedia nc rdacarrier Antagonisme médicamenteux - Méthodes statistiques Antagonisme médicamenteux - Recherche - Méthodologie Calcul mathématique ordinateur Interactions médicamenteuses Modèle théorique Médicaments - Toxicologie - Méthodes statistiques Médicaments Plans factoriels Toxicologie - Méthodes Drug Interactions Drug antagonism Research Methodology Drug antagonism Statistical methods Drugs Toxicology Statistical methods Factorial experiment designs Mathematical Computing Models, Theoretical Toxicology methods Statistik (DE-588)4056995-0 gnd rswk-swf Versuchsplanung (DE-588)4078859-3 gnd rswk-swf Arzneimittelwechselwirkung (DE-588)4003147-0 gnd rswk-swf Arzneimittelwechselwirkung (DE-588)4003147-0 s Versuchsplanung (DE-588)4078859-3 s Statistik (DE-588)4056995-0 s DE-604 Vidmar, Thomas J. Verfasser aut McKean, Joseph W. 1944- Verfasser (DE-588)124200540 aut GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000541547&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Brunden, Marshall N. Vidmar, Thomas J. McKean, Joseph W. 1944- Drug interaction and lethality analysis Antagonisme médicamenteux - Méthodes statistiques Antagonisme médicamenteux - Recherche - Méthodologie Calcul mathématique ordinateur Interactions médicamenteuses Modèle théorique Médicaments - Toxicologie - Méthodes statistiques Médicaments Plans factoriels Toxicologie - Méthodes Drug Interactions Drug antagonism Research Methodology Drug antagonism Statistical methods Drugs Toxicology Statistical methods Factorial experiment designs Mathematical Computing Models, Theoretical Toxicology methods Statistik (DE-588)4056995-0 gnd Versuchsplanung (DE-588)4078859-3 gnd Arzneimittelwechselwirkung (DE-588)4003147-0 gnd |
| subject_GND | (DE-588)4056995-0 (DE-588)4078859-3 (DE-588)4003147-0 |
| title | Drug interaction and lethality analysis |
| title_auth | Drug interaction and lethality analysis |
| title_exact_search | Drug interaction and lethality analysis |
| title_full | Drug interaction and lethality analysis Marshall N. Brunden ; Thomas J. Vidmar ; Joseph W. McKean |
| title_fullStr | Drug interaction and lethality analysis Marshall N. Brunden ; Thomas J. Vidmar ; Joseph W. McKean |
| title_full_unstemmed | Drug interaction and lethality analysis Marshall N. Brunden ; Thomas J. Vidmar ; Joseph W. McKean |
| title_short | Drug interaction and lethality analysis |
| title_sort | drug interaction and lethality analysis |
| topic | Antagonisme médicamenteux - Méthodes statistiques Antagonisme médicamenteux - Recherche - Méthodologie Calcul mathématique ordinateur Interactions médicamenteuses Modèle théorique Médicaments - Toxicologie - Méthodes statistiques Médicaments Plans factoriels Toxicologie - Méthodes Drug Interactions Drug antagonism Research Methodology Drug antagonism Statistical methods Drugs Toxicology Statistical methods Factorial experiment designs Mathematical Computing Models, Theoretical Toxicology methods Statistik (DE-588)4056995-0 gnd Versuchsplanung (DE-588)4078859-3 gnd Arzneimittelwechselwirkung (DE-588)4003147-0 gnd |
| topic_facet | Antagonisme médicamenteux - Méthodes statistiques Antagonisme médicamenteux - Recherche - Méthodologie Calcul mathématique ordinateur Interactions médicamenteuses Modèle théorique Médicaments - Toxicologie - Méthodes statistiques Médicaments Plans factoriels Toxicologie - Méthodes Drug Interactions Drug antagonism Research Methodology Drug antagonism Statistical methods Drugs Toxicology Statistical methods Factorial experiment designs Mathematical Computing Models, Theoretical Toxicology methods Statistik Versuchsplanung Arzneimittelwechselwirkung |
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