Aspirin and the salicylates:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
London u.a.
Butterworths
1984
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXI, 335 S. Ill. |
| ISBN: | 0407003169 |
Staff View
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Record in the Search Index
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| adam_text | 3 ASPIRIN AND THE SALICYLATES K. D. RAINSFORD, PHD, MRCPATH SENIOR
RESEARCH ASSOCIATE DEPARTMENT OF PHARMACOLOGY, UNIVERSITY OF CAMBRIDGE,
CAMBRIDGE HONORARY LECTURER IN CHEMICAL PATHOLOGY KING S COLLEGE
HOSPITAL MEDICAL SCHOOL, UNIVERSITY OF LONDON, DENMARK HILL, LONDON
VISITING READER IN PHARMACOLOGY DEPARTMENT OF BIOCHEMISTRY, UNIVERSITY
OF SURREY, GUILDFORD UNIVERSITATS- BIBLIOTHEK BUTTERWORTHS LONDON BOSTON
DURBAN SINGAPORE SYDNEY TORONTO WELLINGTON CONTENTS ABBREVIATIONS AND
NOMENCLATURE IX 1 HISTORY AND DEVELOPMENT OF THE SALICYLATES I 1 EARLY
USE OF SALICYLATE-CONTAINING PLANTS L HIPPOCRATIC ERA 1 ROMAN AND GREEK
MEDICINE 1 ASIA AND AMERICA 2 EUROPEAN MIDDLE AGES 2 NINETEENTH CENTURY
3 CHEMICAL DEVELOPMENTS 3 ISOLATION AND PURIFICATION OF SALICYLIC ACID 3
SYNTHESIS AND COMMERCIAL DEVELOPMENT OF ASPIRIN (ACETYLSALICYLIC ACID) 7
OTHER SALICYLATES 11 2 OCCURRENCE, PROPERTIES AND SYNTHETIC DEVELOPMENTS
OF THE SALICYLATES 13 NATURALLY OCCURRING SALICYLATES 13 COMMERCIAL
SYNTHESIS AND PROPERTIES OF THE SALICYLATES 15 SALICYLIC AND
ACETYLSALICYLIC ACIDS, THEIR SALTS AND ESTERS 15 SALICYLAMIDE 16
SALICYLATE DERIVATIVES 17 DIFLUNISAL AND FLUFENISAL 18 BENORYLATE 19
MESECLAZONE 19 EXPERIMENTAL DRUGS 20 3-METHYLSALICYLIC ACID 20 ASPIRIN
ANHYDRIDE 21 DIHYDROXY- AND DIACETOXYBENZOIC ACIDS 21
SALICYLAZOSULPHAPYRIDINE (SULPHASALAZINE) AND 5-AMINOSALICYCLIC ACIDS 22
XVI CONTENTS ESTER PRO-DRUGS 23 OTHER SALICYLATE DERIVATIVES 27
CONCLUSIONS 28 3 ABSORPTION, METABOLISM AND DISPOSITION OF THE
SALICYLATES 32 INTRODUCTION 32 ABSORPTION, METABOLISM AND DISTRIBUTION
32 ASPIRIN, SALICYLATE AND THEIR ESTERS 32 FACTORS INFLUENCING
ABSORPTION 32 NON-ENZYMIC HYDROLYSIS 34 ASPIRIN ESTERASES AND PROTEIN
ACETYLATION 36 HYDROXYLATION AND CONJUGATION OF SALICYLATES 38 PLASMA
PROTEIN BINDING 41 FACTORS INFLUENCING DRUG BINDING TO PLASMA PROTEINS
42 BINDING CHARACTERISTICS 42 BINDING SITES FOR SALICYLATE ON ALBUMIN 44
PROTEIN BINDING IN RELATION TO PHARMACOKINETICS 45 ABSORPTION AND
ELIMINATION KINETICS 45 DRUG FORMULATIONS 47 ASPIRIN-DRUG INTERACTIONS 4
9 DIFLUNISAL 50 BENORYLATE 51 SALICYLAMIDE 53 SALICYLAZOSULPHAPYRIDINE
(SULPHASALAZINE) 53 SALICYLSALICYLIC ACID (DIPLOSAL, SALYSAL, SALSALATE)
55 PERCUTANEOUS ABSORPTION OF SALICYLATE ESTERS AND OTHER DERIVATIVES 55
EXPERIMENTAL PRO-DRUGS 55 ANALYTICAL METHODS 56 COLORIMETRIC AND
SPECTROPHOTOMETRIC PROCEDURES 56 SPECTROFLUORIMETRY 57 THIN-LAYER
CHROMATOGRAPHY 57 GAS-LIQUID CHROMATOGRAPHY 57 HIGH PRESSURE
(PERFORMANCE) LIQUID CHROMATOGRAPHY 58 DETERMINATION OF GLUCURONIDES AND
SULPHATE METABOLITES 58 4 PHARMACOLOGICAL AND BIOCHEMICAL ACTIONS OF THE
SALICYLATES 67 INTRODUCTION 67 ANTI-INFLAMMATORY EFFECTS 69 STUDIES IN
ANIMAL MODELS 69 ACUTE INFLAMMATORY MODELS 71 CONTENTS XVII PAW OEDEMA
ASSAYS 71 PLEURISY, AIR-BLEB AND SPONGE-IMPLANTATION MODELS 73 ACTIONS
OF SALICYLATES IN ACUTE INFLAMMATORY MODELS 73 COMPARATIVE EFFECTS OF
DIFFERENT DRUGS 73 ROLE OF MEDIATORS OF THE INFLAMMATORY RESPONSE 75
STRUCTURE-ACTIVITY RELATIONSHIPS 78 CHRONIC ADJUVANT POLYARTHRITIS
(RATS) 82 COMPARATIVE EFFECTS OF SALICYLATES AND OTHER NSAI DRUGS IN
ADJUVANT ARTHRITIS 87 BIOCHEMICAL AND CELLULAR RESPONSES OF SALICYLATES
IN ADJUVANT DISEASE 88 ACTIONS OF SALICYLATES IN OTHER CHRONIC MODELS OF
INFLAMMATION 90 BIOCHEMICAL EFFECTS OF SALICYLATES IN RELATION TO THEIR
ANTI-INFLAMMATORY ACTIONS 91 SYNTHESIS AND METABOLISM OF PROSTAGLANDINS,
THROMBOXANES AND LEUKOTRIENES 91 EFFECTS OF SALICYLATES ON PROSTAGLANDIN
PRODUCTION 96 ACTIONS OF SALICYLATES ON 12-HETE AND LEUKOTRIENE
PRODUCTION 99 EFFECTS OF SALICYLATES ON FREE RADICAL PRODUCTION 100
EARLY-PHASE AMINES AND KININS 101 HISTAMINE 102 SEROTONIN 102 KININS 103
LYSOSOMAL ENZYMES 103 ENDOTHELIAL DAMAGE, LEUCOCYTE MIGRATION AND
PLATELET ACCUMULATION 106 PLATELET AGGREGATION AND THROMBUS FORMATION
106 MECHANISMS OF INHIBITION OF PLATELET AGGREGATION BY SALICYLATES 107
COMPARISON OF THE ANTI-AGGREGATORY PROPERTIES OF DIFFERENT SALICYLATES:
IMPORTANCE OF CHEMICAL STRUCTURE 109 THROMBOLYTIC/FIBRINOLYTIC ACTIVITY
111 CHEMOTAXIS OF POLYMORPHS AND MONOCYTES 112 DISPLACEMENT OF
ALBUMIN-BOUND PEPTIDES AND TRYPTOPHAN 113 CONNECTIVE TISSUE METABOLISM
113 METABOLISM OF GLUCOSE 115 PRODUCTION OF ATP 115 SYNTHESIS OF
CONNECTIVE TISSUE PROTEOGLYCANS AND GLYCOPROTEINS 118 ANTI-PROLIFERATIVE
ACTIVITIES 122 LYMPHOCYTE TRANSFORMATION AND FUNCTIONS 12 3 ANALGESIC
ACTIVITY 123 INTRODUCTION 123 MECHANISMS OF PAIN RESPONSES 124
COMPARATIVE EFFECTS OF SALICYLATES IN PAIN MODELS IN ANIMALS 124
MECHANISMS OF ANALGESIA 126 RESPONSES IN CENTRAL AND PERIPHERAL NERVES
126 XVIII CONTENTS PROSTAGLANDINS 126 SEROTONIN PRODUCTION IN THE CNS
127 ACTIONS ON NERVE MEMBRANES AND FUNCTIONS 127 OTHER BIOCHEMICAL
CHANGES 129 ANTI-PYRESIS 130 COMPARATIVE EFFICACY OF DIFFERENT
SALICYLATES 130 MODE OF ACTIONS OF SALICYLATES 130 5 SIDE-EFFECTS AND
TOXICOLOGY OF THE SALICYLATES 148 INTRODUCTION 148 GASTROINTESTINAL
SIDE-EFFECTS 151 HISTORICAL 151 ASPIRIN AS A MAJOR CAUSE OF BLEEDING AND
ULCERATION 152 GASTROINTESTINAL SIDE-EFFECTS FROM SALICYLATES IN
ARTHRITIC PATIENTS 154 ASSESSMENT OF GASTROINTESTINAL DAMAGE IN MAN 156
GASTROSCOPY AND GASTROINTESTINAL BLOOD LOSS METHODS 156 INTRAGASTRIC
CELL EXFOLIATION 159 GASTROINTESTINAL PROTEIN LOSS 160 INTRAGASTRIC
BLEEDING 160 FACTORS AFFECTING GASTROINTESTINAL DAMAGE 161 ACIDITY OF
THE GASTRIC CONTENTS 161 THE PRESENCE OF FOOD IN THE STOMACH 161 DOSAGE
AND TIMING OF DRUG INGESTION 161 ORAL VERSUS PARENTERAL EFFECTS OF
SALICYLATES 162 BLOOD GROUP STATUS, RACE, AGE AND SEX 163 EXACERBATION
BY ALCOHOL (ETHANOL) 163 VITAMIN C (ASCORBATE) DEFICIENCY 164 SITE AND
PATHOLOGY OF LESIONS 164 STUDIES IN LABORATORY ANIMALS 165 PROCEDURES
FOR ASSESSMENT OF GASTROINTESTINAL DAMAGE 165 COMPARISON OF THE
GASTM-INTESTINAL DMAGE BY DIFFERENT SALICYLATES 172 FACTORS INFLUENCING
GASTRIC ULCEROGENICITY 176 ALCOHOL CONSUMPTION 176 DISEASE
PSYCHOPHYSIOLOGICAL STRESS 176 NUTRITIONAL STATUS 177 VITAMIN C STATUS
179 DOSAGE, ROUTE AND TIMING OF DRUG ADMINISTRATION 180 SEX AND AGE 184
PARTICLE SIZE OF DRUG 185 PHYSICOCHEMICAL AND STRUCTURAL FEATURES OF
SALICYLATES 185 COMPARISON OF SOME OF THE FACTORS INFLUENCING GASTRIC
MUCOSAL DAMAGE BY ASPIRIN IN MAN WITH THOSE IN LABORATORY ANIMALS 187
INTESTINAL DAMAGE 188 PATHOLOGY OF SALICYLATE-INDUCED GASTROINTESTINAL
DAMAGE 189 CONTENTS XIX THE GASTRIC MUCOSA 189 THE INTESTINAL MUCOSA 200
MECHANISMS OF GASTRIC MUCOSAL DAMAGE BY SALICYLATES 201 PRIMARY CHANGES
201 EFFECTS OF THE MUCOSAL BARRIER 201 DISRUPTION OF MUCUS AND MUCOSAL
CELLS 20 2 CAPILLARY DAMAGE 204 EFFECTS OF SALICYLATES ON MUCOSAL BLOOD
FLOW, ACID SECRETION AND H + ION BACK DIFFUSION 206 PEPSIN AND LYSOSOMAL
MUCOSAL AUTODIGESTION 213 PROSTAGLANDIN INHIBITION AND MUCOSAL
CYTOPROTECTION 214 SECONDARY CHANGES 218 REDUCTION IN MUCUS 218 MUCOSAL
DETOXIFICATION 219 CELL TURNOVER AND MUCOSAL PROTEIN AND NUCLEIC ACID
SYNTHESES 220 TERTIARY CHANGES 221 SUMMARY 221 NEPHROPATHY 221 ANALGESIC
ABUSE SYNDROME 222 STUDIES IN ARTHRITIC PATIENTS 225 PATHOLOGY 226
BIOCHEMICAL EFFECTS OF SALICYLATES 229 FACTORS INFLUENCING DRUG
DISTRIBUTION AND ACTIONS 229 PROSTAGLANDINS, KININS, THE
RENIN-ANGIOTENSIN SYSTEM AND RENAL FUNCTIONS 231 RENAL INTERMEDIARY
METABOLISM AND BIOSYNTHESIS OF MACROMOLECULES 232 HEPATOTOXICITY 233
CLINICAL EVIDENCE 233 PATHOLOGY AND BIOCHEMICAL CHANGES 235
HYPERSENSITIVITY REACTIONS AND ASTHMA 236 ASPIRIN-SENSITIVE ASTHMA 237
URTICARIA AND ANGIOEDEMA 240 TERATOGENESIS AND PREGNANCY 241
MISCELLANEOUS SIDE-EFFECTS 243 ACUTE SALICYLATE POISONING 245 TOXIC
MANIFESTATIONS 245 CENTRAL NERVOUS SYSTEM (CNS) EFFECTS 245
GASTROINTESTINAL EFFECTS 246 METABOLIC EFFECTS AND ACID-BASE BALANCE 246
VOMITING AND ELECTROLYTE IMBALANCE 247 PULMONARY OEDEMA 247 RENAL DAMAGE
247 XX CONTENTS DOSAGE 247 MANAGEMENT 248 CONCLUSIONS 249 6 THERAPEUTIC
USES OF THE SALICYLATES 272 INTRODUCTION 272 ARTHRITIC CONDITIONS 273
RHEUMATOID ARTHRITIS 273 ASPIRIN, SALICYLATE AND THEIR ESTERS COMPARED
WITH ACIDIC NSAI DRUGS 275 SALICYLAZOSULPHAPYRIDINE (SULPHASALAZINE) 278
OTHER SALICYLATES 278 OSTEOARTHRITIS (OSTEOARTHROSIS) 279 MISCELLANEOUS
280 GOUT 280 STIIRS DISEASE (JUVENILE RHEUMATOID ARTHRITIS) 281
SYSTEMATIC LUPUS ERYTHEMATOSUS (SLE) 281 RHEUMATIC FEVER 281 DRUG
MONITORING 281 INTERACTIONS WITH OTHER ANTI-INFLAMMATORY DRUGS 282
ANALGESIA 284 ASSESSMENT OF PAIN 284 MIGRAINE AND HEADACHE 284 ACUTE
SURGERY 286 POSTPARTUM AND EPISIOTOMY 287 DYSMENORRHOEA 288 CANCER 289
ANTI-PYRESIS 289 THROMBOEMBOLIC CONDITIONS 290 PERTURBED METABOLIC
STATES 293 DIABETES MELLITUS 294 THYROIDITIS AND THYROTOXICOSIS 295
BARTTER S SYNDROME 296 OBESITY 296 CYSTIC FIBROSIS 297 OTHER POSSIBLE
USES 297 DERMATOLOGICAL CONDITIONS 297 DIARRHOEA 298 DUCTUS ARTERIOSUS
298 SICKLE-CELL ANAEMIA 298 THROMBOCYTIC THROMBOCYTOPENIC PURPURA 299
CONTENTS XXI ANTI-TUMOUR ACTIVITY 300 PREVENTION OF ALLOGRAFT REJECTION
301 ANTI-VIRAL AND ANTI-PARASITIC ACTIVITIES 301 MULTIPLE SCLEROSIS 302
MISCELLANEOUS 302
|
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| author | Rainsford, Kim D. 1941- |
| author_GND | (DE-588)130488917 |
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| dewey-full | 615/.783 |
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| dewey-search | 615/.783 |
| dewey-sort | 3615 3783 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1. publ. |
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| id | DE-604.BV000743845 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:18:46Z |
| institution | BVB |
| isbn | 0407003169 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000465655 |
| oclc_num | 9852406 |
| open_access_boolean | |
| owner | DE-12 DE-188 |
| owner_facet | DE-12 DE-188 |
| physical | XXI, 335 S. Ill. |
| publishDate | 1984 |
| publishDateSearch | 1984 |
| publishDateSort | 1984 |
| publisher | Butterworths |
| record_format | marc |
| spelling | Rainsford, Kim D. 1941- Verfasser (DE-588)130488917 aut Aspirin and the salicylates K. D. Rainford 1. publ. London u.a. Butterworths 1984 XXI, 335 S. Ill. txt rdacontent n rdamedia nc rdacarrier Anti-inflamatorios (farmacologia) larpcal Aspirine Salicylates Aspirin Acetylsalicylsäure (DE-588)4000351-6 gnd rswk-swf Salicylate (DE-588)4396829-6 gnd rswk-swf Salicylate (DE-588)4396829-6 s DE-604 Acetylsalicylsäure (DE-588)4000351-6 s GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000465655&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Rainsford, Kim D. 1941- Aspirin and the salicylates Anti-inflamatorios (farmacologia) larpcal Aspirine Salicylates Aspirin Acetylsalicylsäure (DE-588)4000351-6 gnd Salicylate (DE-588)4396829-6 gnd |
| subject_GND | (DE-588)4000351-6 (DE-588)4396829-6 |
| title | Aspirin and the salicylates |
| title_auth | Aspirin and the salicylates |
| title_exact_search | Aspirin and the salicylates |
| title_full | Aspirin and the salicylates K. D. Rainford |
| title_fullStr | Aspirin and the salicylates K. D. Rainford |
| title_full_unstemmed | Aspirin and the salicylates K. D. Rainford |
| title_short | Aspirin and the salicylates |
| title_sort | aspirin and the salicylates |
| topic | Anti-inflamatorios (farmacologia) larpcal Aspirine Salicylates Aspirin Acetylsalicylsäure (DE-588)4000351-6 gnd Salicylate (DE-588)4396829-6 gnd |
| topic_facet | Anti-inflamatorios (farmacologia) Aspirine Salicylates Aspirin Acetylsalicylsäure Salicylate |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000465655&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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