Inhibition of polyamine metabolism: biolog. significance and basis for new therapies
Saved in:
| Format: | Book |
|---|---|
| Language: | Undetermined |
| Published: |
Orlando u.a.
Acad. Pr.
1987
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 371 S. |
| ISBN: | 0124818358 |
Staff View
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Record in the Search Index
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| adam_text | INHIBITION OF POLYAMINE METABOLISM BIOLOGICAL SIGNIFICANCE AND BASIS FOR
NEW THERAPIES EDITED BY PETER P. MCCANN MERRELL DOW RESEARCH INSTITUTE
CINCINNATI, OHIO ANTHONY E. PEGG DEPARTMENT OF PHYSIOLOGY AND CANCER
RESEARCH CENTER PENNSYLVANIA STATE UNIVERSITY MEDICAL SCHOOL MILTON S.
HERS HEY MEDICAL CENTER HERSHEY, PENNSYLVANIA ALBERT SJOERDSMA MERRELL
DOW RESEARCH INSTITUTE CINCINNATI, OHIO ACADEMIC PRESS, INC. HARCOURT
BRACE JOVANOVICH, PUBLISHERS SAN DIEGO NEW YORK BERKELEY BOSTON LONDON
SYDNEY TOKYO TORONTO CONTENTS PREFACE XI INTRODUCTION: POLYAMINE
METABOLISM XIII 1 INHIBITION OF BASIC AMINO ACID DECARBOXYLASES INVOLVED
IN POLYAMINE BIOSYNTHESIS PHILIPPE BEY, CHARLES DANZIN, AND MICHEL JUNG
, I. INTRODUCTION 1 II. PROPERTIES OF ODC 2 III. MECHANISM OF ACTION OF
ODC 5 IV. INHIBITION OF ODC 6 V. INHIBITION OF ARGININE DECARBOXYLASE
AND LYSINE DECARBOXYLASE 25 VI. CONCLUSION 25 REFERENCES 27 2
PHARMACOLOGIC INTERFERENCE WITH ENZYMES OF POLYAMINE BIOSYNTHESIS AND OF
5 -METHYLTHIOADENOSINE METABOLISM ANTHONY E. PEGG AND H. GUY
WILLIAMS-ASHMAN I. INTRODUCTION : 33 II. S-ADENOSYLMETHIONINE
DECARBOXYLASE (ADOMETDC) 34 III. SPERMIDINE SYNTHASE 38 IV. SPERMINE
SYNTHASE 40 V. ENZYMATIC DEGRADATION OF 5 -METHYLTHIOADENOSINE (MTA) 42
REFERENCES 46 3 INHIBITION OF ENZYMES OXIDIZING POLYAMINES N. SEILER I.
INTRODUCTION 49 II. COPPER AMINE OXIDASES 52 III. FLAVIN-DEPENDENT
ENZYMES IN POLYAMINE CATABOLISM 63 IV. BIOLOGICAL CONSEQUENCES OF
POLYAMINE OXIDASE INACTIVATION 67 V N CONTENTS V. CONCLUSIONS 73
REFERENCES 74 4 MOLECULAR AND CELLULAR FUNCTIONS OF THE POLYAMINES
LAURENCE J. MARTON AND DAVID R. MORRIS I. INTRODUCTION 79 II. NUCLEIC
ACID STRUCTURE 80 III. MACROMOLECULAR SYNTHESIS 86 HI. TOPOISOMERASE
ACTIVITY 96 IV. MEMBRANE STRUCTURE AND FUNCTION 98 REFERENCES 101 5 THE
USE OF INHIBITORS TO STUDY THE BIOCHEMISTRY AND MOLECULAR BIOLOGY OF
POLYAMINE BIOSYNTHESIS AND UPTAKE ANTHONY E. PEGG I. INTRODUCTION 107
II. STUDIES OF ORNITHINE DECARBOXYLASE 108 III. STUDIES OF
S-ADENOSYLMETHIONINE DECARBOXYLASE (ADOMETDC) 113 IV. STUDIES OF
POLYAMINE TRANSPORT 115 REFERENCES 116 6 INHIBITORS OF POLYAMINE
BIOSYNTHESIS: CELLULAR AND IN VIVO EFFECTS ON TUMOR PROLIFERATION PRASAD
S. SUNKARA, STEPHEN B. BAYLIN, AND GORDON D. LUK I. INTRODUCTION 121 II.
POLYAMINE BIOSYNTHESIS IN NORMAL AND TRANSFORMED CELLS 122 III.
INHIBITORS OF POLYAMINE BIOSYNTHESIS 125 IV. CELLULAR EFFECTS OF
POLYAMINE INHIBITORS 126 V. POLYAMINE INHIBITORS: IN VIVO EFFECTS
AGAINST EXPERIMENTAL TUMORS .. 131 VI. SUMMARY 136 REFERENCES 137 7
POLYAMINE INHIBITION IN VIVO AND IN ORGAN GROWTH AND REPAIR CHARLES
DANZIN AND PIERRE S. MAMONT I. INTRODUCTION 141 II. IN VIVO BIOCHEMISTRY
OF POLYAMINE BIOSYNTHESIS INHIBITORS 142 III. CONSEQUENCES OF POLYAMINE
INHIBITION ON ORGAN GROWTH AND REPAIR . 152 IV. CONCLUSIONS 158
REFERENCES 159 CONTENTS V 8 POLYAMINE SYNTHESIS INHIBITORS ACT AS BOTH
INDUCERS AND SUPPRESSORS OF CELL DIFFERENTIATION OLLE HEBY, GORDON D.
LUK, AND JOEL SCHINDLER I. INTRODUCTION 165 II. GERM CELLS AND EMBRYOS
167 III. ORGAN SYSTEMS 171 IV. PRIMARY CELL CULTURES AND ESTABLISHED
CELL LINES 175 V. SUMMARY AND FUTURE PROSPECTS 182 REFERENCES 183 9 THE
CONTRAGESTATIONAL EFFECTS OF ORNITHINE DECARBOXYLASE INHIBITION /. R.
FOZARD I. INTRODUCTION 187 II. POLYAMINE BIOCHEMICAL CHANGES DURING
GESTATION IN MAMMALS 188 III. EFFECTS OF INHIBITORS OF ODC ON GESTATION
192 IV. CLINICAL SIGNIFICANCE OF THE CONTRAGESTATIONAL EFFECTS OF ODC
INHIBITION 199 V. CONCLUSION 200 REFERENCES 200 10 MODULATION OF
ANTINEOPLASTIC DRUG ACTION BY INHIBITORS OF POLYAMINE BIOSYNTHESIS CARL
W. PORTER AND JUHANI JDNNE I. INTRODUCTION 203 II. GOALS OF COMBINATION
CHEMOTHERAPY 206 III. APPROACHES TO COMBINATION CHEMOTHERAPY 209 IV.
DFMO EFFECTS ON POLYAMINE BIOSYNTHESIS ; 213 V. TARGETED DRUG
INTERACTIONS USING POLYAMINE INHIBITORS 215 VI. SUMMARY 241 REFERENCES
243 11 INHIBITION OF CARCINOGENESIS BY INHIBITORS OF PUTRESCINE
BIOSYNTHESIS AJIT K. VERMA AND R. K. BOUTWELL I. INTRODUCTION 249 II.
EXPERIMENTS AND RESULTS 251 III. PRACTICAL CONSIDERATION 255 IV. SUMMARY
AND CONCLUSIONS 256 REFERENCES 256 VIII CONTENTS 12 INHIBITION OF
POLYAMINE BIOSYNTHESIS IN MICROORGANISMS ALAN J. BITONTI AND PETER P.
MCCANN I. INTRODUCTION 259 II. INHIBITION OF ORNITHINE DECARBOXYLASE 263
III. INHIBITION OF ARGININE DECARBOXYLASE 267 IV. INHIBITION OF
S-ADENOSYLMETHIONINE DECARBOXYLASE 268 V. INHIBITION OF SPERMIDINE
SYNTHASE 269 VI. SPERMINE SYNTHASE 273 VII. MYCOPLASMA 273 VIII. SUMMARY
273 REFERENCES 274 13 INHIBITION OF VIRAL POLYAMINE BIOSYNTHESIS A.
STANLEY TYMS AND JOHN D. WILLIAMSON I. INTRODUCTION 277 II. POLYAMINE
METABOLISM AND THE REPLICATION OF ANIMAL VIRUSES 280 III. QUALITATIVE
AND QUANTITATIVE ASPECTS OF ANTIVIRAL CHEMOTHERAPY 291 IV. POLYAMINES
AND VIRAL DISEASE 293 V. DRUG COMBINATIONS AND ANTIVIRAL CHEMOTHERAPY
296 VI. CONCLUDING REMARKS 300 REFERENCES 304 14 INHIBITION OF POLYAMINE
BIOSYNTHESIS IN PLANTS AND PLANT PATHOGENIC FUNGI ROBERT D. SLOCUM AND
ARTHUR W. GALS TON I. INTRODUCTION 305 II. INHIBITION OF POLYAMINE
BIOSYNTHESIS AND CATABOLISM IN PLANTS 306 III. EFFECTS OF POLYAMINE
BIOSYNTHESIS INHIBITORS ON PLANT GROWTH AND DEVELOPMENT 308 IV. CONTROL
OF PHYTOPATHOGENIC FUNGI WITH DFMO :.. 312 REFERENCES 315 15 PARASITIC
PROTOZOA AND POLYAMINES CYRUS J. BACCHI AND PETER P. MCCANN I.
INTRODUCTION 317 II. FLAGELLATES 318 III. SPOROZOEA 336 IV. AMOEBAE 339
V. CONCLUSIONS 340 REFERENCES 340 CONTENTS IX 16 CLINICAL ASPECTS OF
INHIBITION OF ORNITHINE DECARBOXYLASE WITH EMPHASIS ON THERAPEUTIC
TRIALS OF EFLORNITHINE (DFMO) IN CANCER AND PROTOZOAN DISEASES PAUL J.
SCHECHTER, JOHN L. R. BARLOW, AND ALBERT SJOERDSMA I. INTRODUCTION 345
II. MALIGNANCIES 347 III. AFRICAN TRYPANOSOMIASIS 350 IV. PNEUMOCYSTIS
CARINII PNEUMONIA (PCP) 355 V. OTHER INDICATIONS AND FUTURE CLINICAL
RESEARCH 359 VI. CONCLUSIONS 361 REFERENCES -. 361 INDEX 365
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| isbn | 0124818358 |
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| physical | XVI, 371 S. |
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| spelling | Inhibition of polyamine metabolism biolog. significance and basis for new therapies ed. by Peter P. McCann ... Orlando u.a. Acad. Pr. 1987 XVI, 371 S. txt rdacontent n rdamedia nc rdacarrier Inhibition (DE-588)4273127-6 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Polyaminstoffwechsel (DE-588)4504159-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Polyaminstoffwechsel (DE-588)4504159-3 s Stoffwechsel (DE-588)4057699-1 s Inhibition (DE-588)4273127-6 s DE-604 MacCann, Peter P. Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000442746&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Inhibition of polyamine metabolism biolog. significance and basis for new therapies Inhibition (DE-588)4273127-6 gnd Stoffwechsel (DE-588)4057699-1 gnd Polyaminstoffwechsel (DE-588)4504159-3 gnd |
| subject_GND | (DE-588)4273127-6 (DE-588)4057699-1 (DE-588)4504159-3 (DE-588)4143413-4 |
| title | Inhibition of polyamine metabolism biolog. significance and basis for new therapies |
| title_auth | Inhibition of polyamine metabolism biolog. significance and basis for new therapies |
| title_exact_search | Inhibition of polyamine metabolism biolog. significance and basis for new therapies |
| title_full | Inhibition of polyamine metabolism biolog. significance and basis for new therapies ed. by Peter P. McCann ... |
| title_fullStr | Inhibition of polyamine metabolism biolog. significance and basis for new therapies ed. by Peter P. McCann ... |
| title_full_unstemmed | Inhibition of polyamine metabolism biolog. significance and basis for new therapies ed. by Peter P. McCann ... |
| title_short | Inhibition of polyamine metabolism |
| title_sort | inhibition of polyamine metabolism biolog significance and basis for new therapies |
| title_sub | biolog. significance and basis for new therapies |
| topic | Inhibition (DE-588)4273127-6 gnd Stoffwechsel (DE-588)4057699-1 gnd Polyaminstoffwechsel (DE-588)4504159-3 gnd |
| topic_facet | Inhibition Stoffwechsel Polyaminstoffwechsel Aufsatzsammlung |
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