Molecular cloning of hormone genes:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Clifton, NJ
Humana Pr.
1987
|
| Series: | Molecular biology and biophysics
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 441 S. Ill. |
| ISBN: | 0896030911 |
Staff View
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| 245 | 1 | 0 | |a Molecular cloning of hormone genes |c ed. by Joel F. Habener |
| 264 | 1 | |a Clifton, NJ |b Humana Pr. |c 1987 | |
| 300 | |a XVII, 441 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
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| 650 | 4 | |a Cloning, Molecular | |
| 650 | 4 | |a Hormones |x biosynthesis | |
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Record in the Search Index
| _version_ | 1804115108298752000 |
|---|---|
| adam_text | Molecular Cloning of
Hormone Genes
edited by
Joel F Habener
Humana Press Clifton, New Jersey
Contents
Preface v
List of Contributors xv
Chapter 1
Approaches to Gene Cloning 1
Joel F Habener
1 Introduction 1
2 Construction and Analysis of Recombinant DNA 2
3 Techniques of Identification 5
4 Cloning Techniques 7
5 Hybridization Probes 8
References 9
Chapter 2
Gene Structure and Regulation 11
Joel F Habener
1 Introduction and Background 11
1 1 Discovery of Endocrine and Neurocrine Secretions 11
1 2 Investigations of Early Evolutionary Origins of Peptides as
Hormones and Local Regulatory Peptides 12
1 3 Present Information Based on Molecular and Cellular
Biology 14
2 The Structure and Organization of Genes 15
3 Precursors of the Peptide Hormones 19
3 1 Precursor Sequences Signal Intracellular Segregation 19
3 2 Many Peptide Hormone Precursors Are Polyproteins That
Encode Multiple Peptides
3 3 Coding Sequences of Genes Are Interrupted 24
4 The Generation of Biologic Diversity ? 27
5 Gene Expression 35
5 1 Regulation of Gene Expression 35
5 2 as and trans Mechanisms of Gene Regulation 37
6 Tissue-Specific Gene Expression 40
vii
viii Contents
7 Coupling of Effector Action to Cellular Response 42
References 47
Chapter 3
Insulin Genes: Molecular Cloning and Analyses 53
Shu Jin Chan
1 Introduction 53
2 Molecular Cloning Strategies 54
3 Structure and Expression of the Insulin Gene 56
4 Polymorphism in the Human Insulin Genes 60
5 Abnormal Human Insulins 61
References 63
Chapter 4
The Glucagon Genes 69
Gerhard Heinrich and Joel F Habener
1 Introduction 69
1 1 Background 69
1 2 Recombinant cDNAs Encoding Preprqglucagon 71
2 Cloning and Characterization of Rat Preproglucagon mRNAs and
cDNAs 71
2 1 Preproglucagon cDNAs 71
2 2 Hybridization Analysis of Preproglucagon mRNA 73
3 Glucagon Gene Cloning and Structural Analysis 75
3 1 Hybridization Analysis of the Glucagon Chromosomal
Gene 75
3 2 Structural Analyses of the Rat Glucagon Gene 77
3 3 Experimental Procedures Used for the Isolation of a
Recombinant Bacteriophage Containing the Rat Glucagon
Gene 77
3 4 Partial Nucleotide Sequence Analysis of Gene Subclones 79
3 5 Promoter and Transcriptional Initiation Sites of the Rat
Glucagon Gene 83
4 Implications Derived From the Structure of the Glucagon Gene 85
4 1 Evolution of the Glucagon Gene : 85
4 2 Tissue-Specific Processing of Preproglucagon 87
References 89
Chapter 5
The Somatostatin Genes : 93
Richard H Goodman, Marc R Montminy, Malcolm J Low, and
Joel F Habener
1 Introduction 93
2 Anglerfish Somatostatins 95
3 Mammalian Somatostatin 101
Contents ix
4 Future Directions 112
References 113
Chapter 6
The Human Growth-Hormone Gene Family 121
David D Moore, Richard F Selden, Edouard Prost, Daniel S Ory,
and Howard M Goodman
1 Introduction 121
2 Map of the GH Locus 122
3 Sequences of the GH Family Members : 125
References 133
Chapter 7
Glycoprotein Hormone Genes 137
William W Chin
1 Introduction 137
1 1 General Considerations 137
1 2 Structure of Glycoprotein Hormones 139
1 3 Major Questions 142
2 Molecular Cloning of Genes Encoding the Subunits of
Glycoprotein Hormones 143
2 1 Molecular Cloning of a-Subunit cDNAs 143
2 2 Molecular Cloning of the Genes Encoding the a-Subunit of
Glycoprotein Hormones 149
2 3 Molecular Cloning of cDNA Encoding the p-Subunit of
Human CG 151
2 4 Molecular Cloning of the Genes Encoding the Human
CGp-LHp Subunits 153
2 5 Molecular Cloning of cDNA Encoding the Rat LHp-
Subunit 156
2 6 Molecular Cloning of the Gene Encoding the Rat LHp-
Subunit 158
2 7 Molecular Cloning of cDNA Encoding the TSHp-Subunit 159
2 8 Molecular Cloning of the Genes Encoding the TSHp- and
FSHp-Subunits 160
2 9 Chromosomal Localization of the Subunit Genes of
Glycoprotein Hormones 160
3 Expression of the Subunit Genes 162
4 Summary 165
References •, 165
Chapter 8
Oxytocin and Vasopressin Genes: Expression and Structure 173
Dietmar Richter
1 Introduction 173
2 Elucidation of the Precursor Structures 174
x
Contents
2 1 Cloning Strategy 174
2 2 Structure-Function Relations 176
3 Maturation of the Precursors 179
4 Vasopressin and Oxytocin Genes 183
4 1 Implications of the Gene Structures 187
4 2 Transcriptional Control 189
5 The Vasopressin Gene in Diabetes Insipidus (Brattleboro) Rats 190
5 1 Gene Sequence and the Predicted Vasopressin Precursor 191-
5 2 Transcription and Translation 192
6 Expression of the Oxytocin Gene in Peripheral Organs 196
7 Polyprotein Structures and Their Implications 197
References 201
Chapter 9
The Proopiomelanocortin Genes 207
Michael Uhler and Edward Herbert
1 Introduction 207
2 Cloning of POMC Complementary DNA 209
3 POMC Gene Structure 214
4 Applications of Recombinant-DNA Probes to the Study of POMC
Gene Expression 218
5 Summary 223
References 224
Chapter 10
Enkephalin Genes 229
Ueli Gubler
1 Introduction 229
1 1 Nature of the Peptides 229
1 2 Physiologic Importance 231
1 3 Rationale for Analyzing the Genes 231
1 4 Screening Approaches 232
2 mRNA Characterization and Gene Structure 236
2 1 Characterization of Proenkephalin and Prodynorphin
mRNAs 236
2 2 Molecular Cloning of Bovine and Human Proenkephalin
mRNAs 238
2 3 Isolation of the Human Proenkephalin Gene 246
2 4 Isolation and Characterization of the Rat Proenkephalin
mRNA and Gene
2 5 Isolation of the Toad Proenkephalin Gene 258
2 6 Molecular Cloning of Porcine and Human Prodynorphin
mRNAs 260
2 7 Isolation of the Human Prodynorphin Gene 263
2 8 Isolation of the Rat Prodynorphin Gene 268
2 9 Summary of Structural and Evolutionary Considerations 269
References 273
xii Contents
6 1 Structure of Mouse Submaxillary Preprorenins—A Model
for Renin Processing 327
6 2 Structure of Mouse Kidney Renin Deduced From Genomic
Sequence 329
6 3 Structure of Human Kidney Renin Deduced From cDNA
Sequence 329
7 Structure of the Renin Gene and Comparison With Other
Aspartyl Proteases 332
8 Tissue-Specific Expression of the Renin Gene 336
9 Conclusion 338
References 339
Chapter 14
Nerve Growth Factor: mRNA and Genes That Encode the
P-Subunit 343
Gerhard Heinrich
1 Introduction 343
2 Cloning of DNA Complementary to the mRNA That Encodes the
P-Subunit of Nerve Growth Factor 345
3 Human P-NGF Gene 353
4 Structure of P-NGF mRNA and Gene 358
5 Structure of the P-NGF Precursor Encoded by P-NGF mRNA
and Gene 359
6 Knowledge Gained—and the Future 360
References 361
Chapter 15
Bombesin-Like Peptide Genes 365
Eliot R Spindel
1 Introduction 365
2 Structure of Bombesin-Like Peptides 366
2 1 Amphibian Bomebesin-Like Peptides 366
2 2 Mammalian Bombesin-like Peptides 369
2 3 Conclusions 370
3 Distribution and Physiology 371
3 1 Gastrin-Releasing Peptide 371
3 2 Mammalian Ranatensin 373
4 Molecular Biology 374
4 1 Gastrin-Releasing Peptide • * 374
4 2 Amphibian Bombesin-Like Peptides 381
5 Summary and Perspectives : - 382
6 Acknowledgments
t 382
References 382
Chapter 16
Biosynthesis of Peptides in the Skin of Xenopus laevis:
cDNAs Encoding Precursors of Caerulein, PGL, Xenopsin, and
Thyrotropin-Reieasing Hormone 391
Contents xiii
K Richter, W Hoffmann, R Egger, and G Kreil
1 Introduction 391
2 Precursor Sequences Deduced From Cloned cDNAs 392
2 1 Precursors of Caerulein 392
2 2 Precursor for PGLa, A New Peptide From the Skin of X
laevis 394
2 3 Precursor of Xenopsin 396
2 4 Precursor of Thyrotropin-Releasing Hormone 397
2 5 Comparison of the Precursors for Caerulein, PGLa, and
Xenopsin 398
3 Conclusions 400
References 401
Chapter 17
cDNA Encoding Precursors of the Bee-Venom Peptides
MeHttin and Secapin 405
R Vlasak, I Malec, and G Kreil
1 Introduction 405
2 Cloning and Sequence Analysis of Melittin mRNA 406
3 Sequence Analysis of the Cloned mRNA and
Preprosecapin 407
References 410
Chapter 18
Yeast a-Factor Genes 413
Janet Kurjan
1 Introduction 413
2 Cloning of MFal Using a Genetic Technique 415
3 Structure of MFal 417
4 Cloning of MFal and MFa2 by Hybridization 419
5 Structure of MFa2 and Comparison of MFal and MFa2 422
6 Precursor Processing 424
7 Function of MFal vs MFa2 427
8 Summary 429
References 431
Index 435
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| language | English |
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| physical | XVII, 441 S. Ill. |
| publishDate | 1987 |
| publishDateSearch | 1987 |
| publishDateSort | 1987 |
| publisher | Humana Pr. |
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| series2 | Molecular biology and biophysics |
| spelling | Molecular cloning of hormone genes ed. by Joel F. Habener Clifton, NJ Humana Pr. 1987 XVII, 441 S. Ill. txt rdacontent n rdamedia nc rdacarrier Molecular biology and biophysics Cloning, Molecular Hormones biosynthesis Molecular cloning Peptide Biosynthesis Peptide hormones Peptidhormon (DE-588)4045127-6 gnd rswk-swf Hormon (DE-588)4025864-6 gnd rswk-swf Genklonierung (DE-588)4123275-6 gnd rswk-swf Genklonierung (DE-588)4123275-6 s Peptidhormon (DE-588)4045127-6 s DE-604 Hormon (DE-588)4025864-6 s Habener, Joel F. Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000411787&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular cloning of hormone genes Cloning, Molecular Hormones biosynthesis Molecular cloning Peptide Biosynthesis Peptide hormones Peptidhormon (DE-588)4045127-6 gnd Hormon (DE-588)4025864-6 gnd Genklonierung (DE-588)4123275-6 gnd |
| subject_GND | (DE-588)4045127-6 (DE-588)4025864-6 (DE-588)4123275-6 |
| title | Molecular cloning of hormone genes |
| title_auth | Molecular cloning of hormone genes |
| title_exact_search | Molecular cloning of hormone genes |
| title_full | Molecular cloning of hormone genes ed. by Joel F. Habener |
| title_fullStr | Molecular cloning of hormone genes ed. by Joel F. Habener |
| title_full_unstemmed | Molecular cloning of hormone genes ed. by Joel F. Habener |
| title_short | Molecular cloning of hormone genes |
| title_sort | molecular cloning of hormone genes |
| topic | Cloning, Molecular Hormones biosynthesis Molecular cloning Peptide Biosynthesis Peptide hormones Peptidhormon (DE-588)4045127-6 gnd Hormon (DE-588)4025864-6 gnd Genklonierung (DE-588)4123275-6 gnd |
| topic_facet | Cloning, Molecular Hormones biosynthesis Molecular cloning Peptide Biosynthesis Peptide hormones Peptidhormon Hormon Genklonierung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000411787&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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