Metabolism and action of anti-cancer drugs:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
London [u.a.]
Taylor & Francis
1987
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XV, 336 S. |
| ISBN: | 0850663695 |
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Record in the Search Index
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3^0 METABOLISM AND ACTION OF ANTI-CANCER DRUGS EDITED BY GARTH POWIS
MAYO CLINIC, ROCHESTER, MN AND RUSSELL A. PROUGH UNIVERSITY OF
LOUISVILLE, KY TAYLOR & FRANCIS LONDON, NEW YORK AND PHILADELPHIA 1987
CONTENTS PROLOGUE IX CONTRIBUTORS XI 1. 2-CHLOROETHYLNITROSOUREAS 1
DONALD J. REED HISTORICAL BACKGROUND CLINICAL USES STRUCTURAL FEATURES
ANIMAL METABOLISM HUMAN METABOLISM RELATIONSHIP BETWEEN METABOLISM AND
BIOLOGICAL ACTIVITY ORGAN TOXICITY FUTURE CONCLUSIONS REFERENCES 2.
PROCARBAZINE RUSSELL A. PROUGH AND DONALD J. TWEEDIE INTRODUCTION
CLINICAL USE STRUCTURAL FEATURES ANIMAL METABOLISM HUMAN METABOLISM
RELATIONSHIP BETWEEN METABOLISM AND BIOLOGICAL ACTIVITY FUTURE
DIRECTIONS REFERENCES 3. OXAZAPHOSPHORINES NORMAN E. SLADEK INTRODUCTION
METABOLISM 1 1 6 9 12 12 18 19 20 21 29 29 30 30 33 39 39 42 43 48 48 50
VI METABOLISM AND ACTION OF ANTI-CANCER DRUGS PHARMACOKINETICS IN HUMANS
59 THE CYTOTOXIC METABOLITE*PHOSPHORAMIDE MUSTARD 63 THE SIGNIFICANT
CIRCULATING METABOLITE* 4-HYDROXYCYCLOPHOSPHAMIDE/ALDOPHOSPHAMIDE 66 THE
BLADDER TOXICITY-INDUCING METABOLITE*ACROLEIN 71 FAVOURABLE THERAPEUTIC
INDEX RESIDES WITH 4-HYDROXYCYCLOPHOSPHAMIDE/ALDOPHOSPHAMIDE 72 CELLULAR
BASIS FOR FAVOURABLE INDEX 73 FUTURE DIRECTIONS 78 REFERENCES 80 4.
PURINE AND PYRIMIDINE BIOCHEMISTRY, AND SOME RELEVANT CLINICAL AND
PRECLINICAL CANCER CHEMOTHERAPY RESEARCH 91 DANIEL S. MARTIN
INTRODUCTION 91 NORMAL PURINE BIOSYNTHESIS AND SALVAGE PATHWAYS 94
INTERACTION OF PURINE NUCLEOTIDES WITH BIOSYNTHESIS OF PYRIMIDINES 96
METABOLIC ACTIVATION OF THE MAJOR PURINE ANTI-CANCER AGENTS IS A
REQUIREMENT FOR THEIR CYTOTOXIC EFFECTS 97 ANABOLISM AND MULTIPLE
BIOCHEMICAL LOCI OF ACTION OF 6-MP 98 ANABOLISM AND MULTIPLE BIOCHEMICAL
LOCI OF ACTION OF 6-TG 100 ANABOLISM AND BIOCHEMICAL LOCI OF ACTION OF
MMPR 102 INTERACTION OF MMPR WITH PYRIMIDINE BIOSYNTHESIS 104 RESISTANCE
TO THE MAJOR THIOPURINES 105 CATABOLISM OF THIOPURINES 106 CLINICAL USE
OF THIOPURINES 107 THE INDICATION FOR BIOCHEMICAL MODULATION OF
THIOPURINES 107 THE RATIONALE FOR BIOCHEMICAL MODULATION OF MMPR 108
RESULTS OF PRECLINICAL STUDIES WITH PALA + MMPR + 6-AN 109 PRELIMINARY
BIOCHEMICAL STUDIES WITH PALA + MMPR + 6-AN 111 "RESCUE" TO FACILITATE
MORE EFFECTIVE COMBINATION CHEMOTHERAPY 112 NICOTINAMIDE ANTAGONISTS AS
ANTI-CANCER AGENTS 112 NORMAL PYRIMIDINE BIOSYNTHESIS AND SALVAGE
PATHWAYS 113 CATABOLISM OF NORMAL PYRIMIDINES 116 5-FLUOROURACIL AND ITS
CONVERSION TO NUCLEOTIDES 117 SUMMARY OF MECHANISM(S) OF CYTOTOXICITY OF
FURA 118 BIOCHEMICAL MODULATION OF FURA WITH PALA 118 BIOCHEMICAL
MODULATION WITH METHOTREXATE (MTX) AND FURA 120 BIOCHEMICAL MODULATION
WITH LEUCOVORIN (LV) AND FURA 122 THE SPECIAL CLINICAL NEEDS OF
"MODULATORY" COMBINATION CHEMOTHERAPY 123 CONCLUSIONS 125 REFERENCES 126
CONTENTS VII 5. FOLIC ACID ANTAGONISTS 141 BARTON A. KAMEN INTRODUCTION
141 CLINICAL USE OF MTX 143 BIOCHEMICAL FEATURES 147 PHARMACOLOGY 151
BIOLOGICAL ACTIVITY AND METABOLISM 153 FUTURE PROSPECTS 155 REFERENCES
155 6. THE PLATINUM ANTI-TUMOUR DRUGS 163 RICHARD F. BORCH INTRODUCTION
163 CHEMISTRY 165 GLUTATHIONE AND CISPLATIN METABOLISM 173
METALLOTHIONEIN AND CISPLATIN METABOLISM 175 PHARMACOKINETICS 177 RENAL
HANDLING OF CISPLATIN 179 FUTURE DIRECTIONS 185 REFERENCES 186 7.
METABOLISM OF BLEOMYCIN AND BLEOMYCIN-LIKE COMPOUNDS 194 JOHN S. LAZO,
SAID M. SEBTI AND ANDREW E. FILDERMAN BRIEF HISTORICAL INTRODUCTION 194
CLINICAL USAGE 195 STRUCTURAL FEATURES 196 MECHANISM OF BIOLOGICAL
ACTIVITY 197 METABOLISM IN VIVO 198 METABOLISM IN VITRO 200 RELATIONSHIP
BETWEEN METABOLISM AND ORGAN TOXICITY * 203 RELATIONSHIP BETWEEN
METABOLISM AND ANTI-TUMOUR ACTIVITY 205 FUTURE DIRECTIONS 206 REFERENCES
207 8. ANTHRACYCLINE METABOLISM AND FREE RADICAL FORMATION 211 GARTH
POWIS HISTORICAL PERSPECTIVE 211 STRUCTURAL FEATURES 211 CLINICAL USES
214 METABOLISM 215 FREE RADICAL FORMATION AND BIOLOGICAL ACTIVITY 239
VIII METABOLISM AND ACTION OF ANTI-CANCER DRUGS CONCLUSIONS 245
REFERENCES 246 9. ANTI-STEROIDAL AGENTS 261 SIMON P. ROBINSON AND V.
CRAIG JORDAN HISTORICAL INTRODUCTION 261 CLINICAL APPLICATION OF
ANTISTEROIDAL AGENTS 263 TAMOXIFEN: A NON-STEROIDAL ANTIESTROGEN 267
AMINOGLUTETHIMIDE: AN INHIBITOR OF STEROID SYNTHESIS 274 LUTEINIZING
HORMONE RELEASING HORMONE ANALOGUES 278 STEROIDAL AND NON-STEROIDAL
ANTI-ANDROGENS 281 FUTURE DIRECTIONS 286 REFERENCES 287 10. METABOLISM
OF ANTI-CANCER DRUGS IN DEVELOPMENT 296 MATTHEW M. AMES INTRODUCTION 296
DIAZIQUONE 297 FLUDARABINE PHOSPHATE 301 MENOGARIL 306 TEROXIRONE 310 JV
2 -METHYL-9-HYDROXY ELLIPTICINE 312 SUMMARY 316 REFERENCES 316 INDEX 325 |
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| spelling | Metabolism and action of anti-cancer drugs ed. by Garth Powis London [u.a.] Taylor & Francis 1987 XV, 336 S. txt rdacontent n rdamedia nc rdacarrier Anticancéreux - Effets physiologiques Anticancéreux - Métabolisme Farmacotherapie gtt Kanker gtt Oncolytica gtt Antineoplastic Agents metabolism Antineoplastic Agents pharmacology Antineoplastic agents Metabolism Antineoplastic agents Physiological effect Cytostatikum (DE-588)4068347-3 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Wirkungsmechanismus (DE-588)4292866-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Cytostatikum (DE-588)4068347-3 s DE-604 Wirkungsmechanismus (DE-588)4292866-7 s Stoffwechsel (DE-588)4057699-1 s Powis, Garth Sonstige oth GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000402249&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Metabolism and action of anti-cancer drugs Anticancéreux - Effets physiologiques Anticancéreux - Métabolisme Farmacotherapie gtt Kanker gtt Oncolytica gtt Antineoplastic Agents metabolism Antineoplastic Agents pharmacology Antineoplastic agents Metabolism Antineoplastic agents Physiological effect Cytostatikum (DE-588)4068347-3 gnd Stoffwechsel (DE-588)4057699-1 gnd Wirkungsmechanismus (DE-588)4292866-7 gnd |
| subject_GND | (DE-588)4068347-3 (DE-588)4057699-1 (DE-588)4292866-7 (DE-588)4143413-4 |
| title | Metabolism and action of anti-cancer drugs |
| title_auth | Metabolism and action of anti-cancer drugs |
| title_exact_search | Metabolism and action of anti-cancer drugs |
| title_full | Metabolism and action of anti-cancer drugs ed. by Garth Powis |
| title_fullStr | Metabolism and action of anti-cancer drugs ed. by Garth Powis |
| title_full_unstemmed | Metabolism and action of anti-cancer drugs ed. by Garth Powis |
| title_short | Metabolism and action of anti-cancer drugs |
| title_sort | metabolism and action of anti cancer drugs |
| topic | Anticancéreux - Effets physiologiques Anticancéreux - Métabolisme Farmacotherapie gtt Kanker gtt Oncolytica gtt Antineoplastic Agents metabolism Antineoplastic Agents pharmacology Antineoplastic agents Metabolism Antineoplastic agents Physiological effect Cytostatikum (DE-588)4068347-3 gnd Stoffwechsel (DE-588)4057699-1 gnd Wirkungsmechanismus (DE-588)4292866-7 gnd |
| topic_facet | Anticancéreux - Effets physiologiques Anticancéreux - Métabolisme Farmacotherapie Kanker Oncolytica Antineoplastic Agents metabolism Antineoplastic Agents pharmacology Antineoplastic agents Metabolism Antineoplastic agents Physiological effect Cytostatikum Stoffwechsel Wirkungsmechanismus Aufsatzsammlung |
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