Peptides of poisonous Amanita mushrooms:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York [u.a.]
Springer
1986
|
| Series: | Springer series in molecular biology
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 256 S. Ill. |
| ISBN: | 0387166416 3540166416 |
Staff View
MARC
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| 242 | 0 | 0 | |a Peptide d. giftigen Knollenblätterpilzes |y ger |
| 245 | 1 | 0 | |a Peptides of poisonous Amanita mushrooms |
| 264 | 1 | |a New York [u.a.] |b Springer |c 1986 | |
| 300 | |a XIV, 256 S. |b Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Springer series in molecular biology | |
| 650 | 4 | |a Amanites - Composition | |
| 650 | 4 | |a Champignons - Composition | |
| 650 | 4 | |a Champignons vénéneux - Composition | |
| 650 | 4 | |a Mycotoxines | |
| 650 | 4 | |a Peptides | |
| 650 | 4 | |a Agaricales |x analysis | |
| 650 | 4 | |a Amanita | |
| 650 | 4 | |a Amanita |x Composition | |
| 650 | 4 | |a Fungal Proteins |x analysis | |
| 650 | 4 | |a Fungi |x Composition | |
| 650 | 4 | |a Mushroom Poisoning | |
| 650 | 4 | |a Mushrooms, Poisonous |x Composition | |
| 650 | 4 | |a Mycotoxins | |
| 650 | 4 | |a Mycotoxins |x analysis | |
| 650 | 4 | |a Peptides | |
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| 650 | 0 | 7 | |a Mykotoxin |0 (DE-588)4040984-3 |2 gnd |9 rswk-swf |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-000380554 | ||
Record in the Search Index
| _version_ | 1804115057516216320 |
|---|---|
| adam_text | TheodorWieland
Peptides of
Poisonous Amanita
Mushrooms
With 78 Figures
Springer-Verlag
New York Berlin Heidelberg
London Paris Tokyo
Contents
Introduction 1
Mushrooms Causing Death in Rare Cases 3
Deadly Poisonous Amanita Mushrooms and Their Constituents
Toadstools Accumulating Amatoxins 10
Poisoning by Amatoxins 13
Two Centuries of A manita Research 15
Recognition, Isolation, and Characterization of the Peptide
Toxins 22
Recognition of Toxic Components 22
Chromatographic Procedures 22
Paper Chromatography 22; Thin-Layer Chromatography
22; Visualization 25; Color Reaction on Newsprint 26;
Liquid Chromatography 27
Quantification of Amatoxins and Phallotoxins 28
Quantitative Chromatography 28; High-Performance
Liquid Chromatography 29; Radioimmunoassay 29;
Inhibition of RNA Polymerase 29; Phallotoxins and
Act in 30
Quantities of Toxic Cyclopeptides in Various Mushrooms 31
Isolation and Characterization of the Cyclopeptides 36
Isolation 36
Chemical Properties 37
Physical Properties 39
Mass Spectroscopy 39; Ultraviolet Spectroscopy 39;
Fluorescence and Phosphorescence 42; Circular Dichroism
(CD) and Optical-Rotatory Dispersion (ORD) 42;
Nuclear Magnetic-Resonance (NMR) Spectroscopy 44
Toxicological Properties 45
XII Contents
The Chemistry of the Amatoxins, Phallotoxins and Viro-
toxins 47
Common Features 47
The Hydroxyamino Acids 48
Elucidation of the Structure and Synthesis of the Non-
Lactonizing Members 49; Elucidation of the Structure and
Synthesis of the Lactonizing Amino Acids 49
Amatoxins 52
Structure and Conformation 52
Structure-Activity Relationships 55
The 6 -Hydroxyl Group 56; Molecular Shape 56; The
Sulfoxide Moiety 56; The Side Chains 58; Chemical
Modifications at the 6 -Hydroxy-Indole Moiety 63
Protein Conjugates of Amatoxins 67
Methods of Conjugation 67
Radioactively-Labelled Amatoxins 69
Phallotoxins 69
Structure and Conformation 69
Spatial Structure of Phallotoxins 72
Structure-Activity Relationships 74
Molecular Shape 74; The Role of the Side Chains 75;
Chemical Modifications 75; Synthetic Analogues 83;
Conclusions 85
Virotoxins 88
Structure 88
Structure-Activity Relationships 89
Presumptive Derivation from Phallotoxins 91
Synthetic Approaches at the Toxic Peptides 92
Synthesis of Thioethers of L-Tryptophan 92
Peptide Synthesis 93
Cyclization 94
Synthesis of Phallotoxins 94
Total Synthesis of Phalloin 98; The Savige-Fontana
Approach 98
Analogues of Amanin 100
Molecular Pathology of the Amanita Peptides 101
Uptake of the Toxins by the Liver 101
Amatoxins 104
Mechanism of Amatoxin Intoxication 104
Contents
Pathological Symptoms of Intoxication 104; Inhibition of
RNA Synthesis 104; The Amatoxin-RNA-Polymerase II
Complex 106; The Amatoxin-Binding Subunit 108;
Other Amatoxin-Binding Proteins 109; The Mechanism of
Polymerase Inhibition 110; Susceptibility of RNA Poly-
merasesfrom Different Origin 111
Amatoxins in Cell Biology 113
Morphological and Biochemical Effects in Vivo 113;
Effect of Amatoxins on Isolated Cells 116; Amatoxin-
Resistant Cell Lines and Organisms 121; Amanitin-
Resistant Drosophila 123
Amatoxins in Virus Research 124
Deoxyriboviruses 124; Riboviruses 125
Amatoxins in Physiology 126
Hormonal Induction of Protein Synthesis 127
Phallotoxins and Virotoxins 129
Molecular Mechanism of Toxicity 129
Phenomenology of Intoxication 130; Interaction of
Phalloidin with Actin 135
The Pathological Events, a Consequence of the Phallo-
toxin-Actin Interaction 147
Swelling of the Liver, Vacuolization 148; Secretory
Processes 150 Inhibition of Protein Synthesis 152;
Effects on Stimulatory Transmission 154
Phalloidin and Motility of Cells 155
Influence on Muscle Contraction 156; Influence on Cyto-
plasmic Streaming and Motility of Non-Muscle Cells 158
Fluorescent Phallotoxins as Tools in Biological Research
Visualization of F-Actin 162; Eicosanoids and Actin
Fibers 164; Actin Structure and Cell Transformation 165;
Miscellaneous Studies 168
Tolerance and Protective Agents 173
Tolerance 173; Antagonists, Protectors 176
Non-Toxic Peptides from Amanita phalloides 181
Antamanide and Other Cycloamanides 181
Antamanide 181
Isolation and Properties 181; Structure of Antamanide
182; Synthesis of Antamanide and Analogues 185; Metal-
Ion-Complexing Properties 186; Complexing Aptitude
XIV Contents
and Biological Activity 186; Conformations of Antamanide
and Analogues 190; Structure-Activity Relationships 194;
Solubility 200; The Mode of Action of Antamanide 203
Additional Cycloamanides 205
Phallolysin 207
Hemolytical ly-Active Proteins from Mush r ooms and Bacteria 207
Purif icat ion a nd Charac te r i za t ion of Phal lolysin 208
Mechan i sm of Hemoly tic Activi ty 208
Toxicity 208; Mechanism of Action 209; Similarity of
the Hemolytic Effects of Phallotoxin and Staphylococcal
a-Toxin 210
Retrospectives and Outlook 211
References 213
Subject Index 249
|
| any_adam_object | 1 |
| author | Wieland, Theodor 1913-1995 |
| author_GND | (DE-588)117750050 |
| author_facet | Wieland, Theodor 1913-1995 |
| author_role | aut |
| author_sort | Wieland, Theodor 1913-1995 |
| author_variant | t w tw |
| building | Verbundindex |
| bvnumber | BV000611474 |
| callnumber-first | Q - Science |
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| callnumber-raw | QK629.A53 |
| callnumber-search | QK629.A53 |
| callnumber-sort | QK 3629 A53 |
| callnumber-subject | QK - Botany |
| classification_rvk | WD 5250 |
| ctrlnum | (OCoLC)13580819 (DE-599)BVBBV000611474 |
| dewey-full | 589.2/223 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 589 - [Unassigned] |
| dewey-raw | 589.2/223 |
| dewey-search | 589.2/223 |
| dewey-sort | 3589.2 3223 |
| dewey-tens | 580 - Plants |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV000611474 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:16:34Z |
| institution | BVB |
| isbn | 0387166416 3540166416 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000380554 |
| oclc_num | 13580819 |
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| physical | XIV, 256 S. Ill. |
| publishDate | 1986 |
| publishDateSearch | 1986 |
| publishDateSort | 1986 |
| publisher | Springer |
| record_format | marc |
| series2 | Springer series in molecular biology |
| spelling | Wieland, Theodor 1913-1995 Verfasser (DE-588)117750050 aut Peptide d. giftigen Knollenblätterpilzes ger Peptides of poisonous Amanita mushrooms New York [u.a.] Springer 1986 XIV, 256 S. Ill. txt rdacontent n rdamedia nc rdacarrier Springer series in molecular biology Amanites - Composition Champignons - Composition Champignons vénéneux - Composition Mycotoxines Peptides Agaricales analysis Amanita Amanita Composition Fungal Proteins analysis Fungi Composition Mushroom Poisoning Mushrooms, Poisonous Composition Mycotoxins Mycotoxins analysis Wulstling (DE-588)4079404-0 gnd rswk-swf Mykotoxin (DE-588)4040984-3 gnd rswk-swf Peptide (DE-588)4045125-2 gnd rswk-swf Wulstling (DE-588)4079404-0 s Peptide (DE-588)4045125-2 s DE-604 Mykotoxin (DE-588)4040984-3 s HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000380554&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wieland, Theodor 1913-1995 Peptides of poisonous Amanita mushrooms Amanites - Composition Champignons - Composition Champignons vénéneux - Composition Mycotoxines Peptides Agaricales analysis Amanita Amanita Composition Fungal Proteins analysis Fungi Composition Mushroom Poisoning Mushrooms, Poisonous Composition Mycotoxins Mycotoxins analysis Wulstling (DE-588)4079404-0 gnd Mykotoxin (DE-588)4040984-3 gnd Peptide (DE-588)4045125-2 gnd |
| subject_GND | (DE-588)4079404-0 (DE-588)4040984-3 (DE-588)4045125-2 |
| title | Peptides of poisonous Amanita mushrooms |
| title_auth | Peptides of poisonous Amanita mushrooms |
| title_exact_search | Peptides of poisonous Amanita mushrooms |
| title_full | Peptides of poisonous Amanita mushrooms |
| title_fullStr | Peptides of poisonous Amanita mushrooms |
| title_full_unstemmed | Peptides of poisonous Amanita mushrooms |
| title_short | Peptides of poisonous Amanita mushrooms |
| title_sort | peptides of poisonous amanita mushrooms |
| topic | Amanites - Composition Champignons - Composition Champignons vénéneux - Composition Mycotoxines Peptides Agaricales analysis Amanita Amanita Composition Fungal Proteins analysis Fungi Composition Mushroom Poisoning Mushrooms, Poisonous Composition Mycotoxins Mycotoxins analysis Wulstling (DE-588)4079404-0 gnd Mykotoxin (DE-588)4040984-3 gnd Peptide (DE-588)4045125-2 gnd |
| topic_facet | Amanites - Composition Champignons - Composition Champignons vénéneux - Composition Mycotoxines Peptides Agaricales analysis Amanita Amanita Composition Fungal Proteins analysis Fungi Composition Mushroom Poisoning Mushrooms, Poisonous Composition Mycotoxins Mycotoxins analysis Wulstling Mykotoxin Peptide |
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