The Togaviridae and Flaviviridae:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York u.a.
Plenum Pr.
1986
|
| Series: | The viruses
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XV, 453 S. Ill. |
| ISBN: | 0306421763 |
Staff View
MARC
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| 245 | 1 | 0 | |a The Togaviridae and Flaviviridae |c ed. by Sondra Schlesinger ... |
| 264 | 1 | |a New York u.a. |b Plenum Pr. |c 1986 | |
| 300 | |a XV, 453 S. |b Ill. | ||
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Record in the Search Index
| _version_ | 1804115022187593728 |
|---|---|
| adam_text | The
Togaviridae and
Flaviviridae
Edited by
SONDRA SCHLESINGER
and
MILTON J SCHLESINGER
Washington University School of Medicine
St Louis, Missouri
PLENUM PRESS • NEW YORK AND LONDON
Contents
Chapter 1
Comparative and Historical Aspects of the Togaviridae
and Flaviviridae
fames S Poiteifield
I Introduction 1
II Yellow Fever 2
A Early History 2
B Carlos J Finlay and the Walter Reed Commission 2
C Yellow Fever Commissions of the Rockefeller
Foundation 3
D Asibi Virus and the 17D Yellow Fever Vaccine 3
III Early Studies on Viral Encephalitides 5
IV Arthropod-Borne Viruses 5
A Antigenic Relationships among Arboviruses 6
B Serological Groups A and B 7
V Viral Classification and Nomenclature 8
VI Arbovirus Study Group: Togaviruses and Togaviridae 9
VII Non-Arthropad-Borne Togaviruses 11
VIII Contribution of the World Health Organization 14
IX Contribution of the American Committee on Arthropod-
Borne Viruses 14
X Impact of Molecular Biology on Viral Classification 15
XI Flaviviridae as a Separate Family 15
References 16
Chapter 2
Alphavirus Structure
Stephen C Harrison
I Introduction 21
II General Properties 21
ix
xii CONTENTS
Chapter 6
Defective RNAs of Alphaviruses
Sondra Schlesinger and Barbara G Weiss
I Introduction 149
II Identification of Sequences Retained in the Defective
Interfering Genomes of Sindbis and Semliki
Forest Viruses 150
A Characterization of the Defective Interfering RNAs 150
B Sequence Organization of Defective Interfering RNAs of
Sindbis and Semliki Forest Viruses 150
C Expression of Cloned Defective
Interfering Genomes 155
III Defective Interfering Particles of Alphaviruses and
Persistent Infections 161
A Characteristics of Persistent Infections in
Mammalian Systems 162
B Evolution of Sindbis Virus and Its Defective Interfering
RNAs during Persistent Infection of Baby Hamster
Kidney Cells 162
IV Defective Interfering Particles as a Probe for Analysis of
Viral Replication and Identification of Host Factors 163
A Generation and Accumulation of Defective Interfering
Particles in Different Host Cells 164
B Biological Heterogeneity among Alphavirus Defective
Interfering Particles 165
V Conclusion 166
References 166
Chapter 7 -
Replication of Alphaviruses in~Mosquito Cells
Dennis T Brown and Lynn D Condreay
I Introduction 171
II Growth of Alphaviruses in Whole Insects
and Insect Larvae 172
III Development of Cell Cultures for Use in Studies of
Alphavirus-Insect Cell Interactions 178
IV Early Events in the Infection of Cultured Insect Cells
with Alphaviruses 179
V Development of Alphaviruses during Acute Infection
of Insect Cells 181
A Kinetics of Virus Production 181
B Synthesis of Viral RNA and Protein 182
CONTENTS xiii
C Assembly and Maturation of Alphavirus 184
D Cell Response to Alphavirus Infection 188
VI Role of Insect Host-Cell Functions in the Reproduction
of Alphaviruses 191
VII Establishment and Maintenance of Persistent Alphavirus
Infections of Insect Cells 195
A Transition from Acute to Persistent Infection 195
B Role of Temperature-Sensitive Mutants and Defective
Interfering Particles in the Establishment of Persistent
Infection 197
C Appearance and Function of Antiviral Compounds 201
VIII Conclusions and Perspectives 202
References 203
Chapter 8
Alphavirus Pathogenesis and Immunity
Diane E Griffin
I Introduction 209
II Disease Pathogenesis 210
A Eastern Equine Encephalitis 210
B Western Equine Encephalitis 211
C Sindbis Virus 212
D Venezuelan Equine Encephalitis 215
E Semliki Forest Virus 218
F Chikungunya and O nyong-nyong Viruses 220
G Ross River Virus 221
III Development of the Immune Response 222
A Natural Immunity • 222
B Virus-Specific Immunity 224
IV Summary 236
References 7 7T 236
Chapter 9
The Use of Monoclonal Antibodies in Studies of the Structural
Proteins of Togaviruses and Flaviviruses
fohn T Roehrig
I Introduction 251
II Alphaviruses 252
A Serology and Classification of Alphaviruses 252
B Antigenic Mapping of Alphavirus Structural Proteins
Using Monoclonal Antibodies 253
C Alphavirus Immunity 261
xiv CONTENTS
D Monoclonal Antibodies in Alphavirus Serology
and Epidemiology 2,64
E Vaccine Strategy 265
III Flaviviruses 265
A Serology and Classification of Flaviviruses 265
B Antigenic Mapping of Flavivirus Structural Proteins
Using Monoclonal Antibodies 266
C Flavivirus Immunity 269
D Monoclonal Antibodies in Flavivirus Serology
and Epidemiology 272
E Vaccine Strategy 272
IV Other Viruses 273
V Assessment of Future Research Goals 274
References 275
Chapter 10
Structure of the Flavivirus Genome
Charles M Rice, Ellen G Strauss, and James H Strauss
I Introduction 279
II Physical Structure of the Genome 279
III Genome Organization 282
A Gene Order 282
B Translation Strategy 291
C Proteolytic Cleavages in Processing of
Flavivirus Proteins 294
IV Characteristics of Flavivirus Proteins from
Sequence Data 303
V Structures in the Flavivirus Genome 310
VI Evolution of Flaviviruses 314
VII Concluding Remarks 319
References 7 tt 320
Chapter 11
Replication of Flaviviruses
Margo A Brinton m
I Introduction 327
II Virion Morphology and Composition 329
A Morphology 329
B Physicochemical Properties and Chemical
Composition 329
C Structural Proteins 330
D Genome RNA 333
CONTENTS xv
III Infection of Cultured Cells 335
A Effect on Host-Cell Macromolecular Synthesis 336
B Immune Enhancement 337
IV Viral Morphogenesis 339
A Intracellular Sites of Viral Macromolecular
Synthesis 342
V Viral RNA Synthesis 344
VI Viral Protein Synthesis 347
VII Genetically Controlled Resistance to Flaviviruses 350
VIII Defective Interfering Particles 352
DC Persistent Infections 357
X Flavivirus Mutants 359
XI Summary 364
References 365
Chapter 12
Pathology of the Flaviviruses
Thomas P Monath
I Introduction 375
II Medical Importance of the Flaviviruses 376
III Pathobiological Significance of Natural Virus Variation
and Heterogeneity 379
IV Pathogenesis of Flaviviral Encephalitis 385
A Host Factors That Influence Pathogenesis 386
B Major Aspects of Pathogenesis 390
C Immune Responses 400
V Pathogenesis of Flaviviral Hemorrhagic Fevers 409
A Comparative Pathology 410
B Sites of Viral Replication 413
C Pathogenesis of Dengue Hemorrhagic Fever/Dengue
ShockrSyndrome 415
D Yellow Fever: Pathophysiological Correlations 419
E Immune Modulation, Suppression,
and Lymphocytolysis 421
F Persistent and Congenital Infections 423
G Genetic Host Resistance 423
References 424
Index 441
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| indexdate | 2024-07-09T15:16:00Z |
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| isbn | 0306421763 |
| language | English |
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| physical | XV, 453 S. Ill. |
| publishDate | 1986 |
| publishDateSearch | 1986 |
| publishDateSort | 1986 |
| publisher | Plenum Pr. |
| record_format | marc |
| series2 | The viruses |
| spelling | The Togaviridae and Flaviviridae ed. by Sondra Schlesinger ... New York u.a. Plenum Pr. 1986 XV, 453 S. Ill. txt rdacontent n rdamedia nc rdacarrier The viruses Flavivirus Flaviviruses Togaviridae Togaviruses Togaviren (DE-588)4276383-6 gnd rswk-swf Flaviviren (DE-588)4538441-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Togaviren (DE-588)4276383-6 s DE-604 Flaviviren (DE-588)4538441-1 s Schlesinger, Sondra Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000357732&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The Togaviridae and Flaviviridae Flavivirus Flaviviruses Togaviridae Togaviruses Togaviren (DE-588)4276383-6 gnd Flaviviren (DE-588)4538441-1 gnd |
| subject_GND | (DE-588)4276383-6 (DE-588)4538441-1 (DE-588)4143413-4 |
| title | The Togaviridae and Flaviviridae |
| title_auth | The Togaviridae and Flaviviridae |
| title_exact_search | The Togaviridae and Flaviviridae |
| title_full | The Togaviridae and Flaviviridae ed. by Sondra Schlesinger ... |
| title_fullStr | The Togaviridae and Flaviviridae ed. by Sondra Schlesinger ... |
| title_full_unstemmed | The Togaviridae and Flaviviridae ed. by Sondra Schlesinger ... |
| title_short | The Togaviridae and Flaviviridae |
| title_sort | the togaviridae and flaviviridae |
| topic | Flavivirus Flaviviruses Togaviridae Togaviruses Togaviren (DE-588)4276383-6 gnd Flaviviren (DE-588)4538441-1 gnd |
| topic_facet | Flavivirus Flaviviruses Togaviridae Togaviruses Togaviren Flaviviren Aufsatzsammlung |
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