Fatty acid metabolism and its regulation:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier
1984
|
| Series: | New comprehensive biochemistry
7 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XI, 209 S. Ill., graph. Darst. |
| ISBN: | 0444805281 |
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| 245 | 1 | 0 | |a Fatty acid metabolism and its regulation |c ed. Shosaku Numa |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 1984 | |
| 300 | |a XI, 209 S. |b Ill., graph. Darst. | ||
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Record in the Search Index
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| adam_text | IMAGE 1
CONTENTS
PREFACE V
CHAPTER I ACETYL-COENZYME A CARBOXYLASE AND ITS REGULATION SHOSAKU NUMA
AND TADASHI TANABE (KYOTO AND SUITA) 1
1. INTRODUCTION 1
2. PURIFICATION 2
3. STRUCTURE , 3
A. SUBUNIT STRUCTURE 3
B. MOLECULAR FORMS 5
4. REACTION MECHANISM 6
5. REGULATION OF ACETYL-COA CARBOXYLASE 10
A. ACTIVATION AND INHIBITION 11
B. PHOSPHORYLATION AND DEPHOSPHORYLATION 16
C. SYNTHESIS AND DEGRADATION 17
6. CONCLUDING REMARKS 22
REFERENCES 23
CHAPTER 2 ANIMAL AND BACTERIAL FATTY ACID SYNTHETASE: STRUCTURE,
FUNCTION AND REGULATION ALFRED W. ALBERTS AND MICHAEL D. GREENSPAN
(RAHWAY) 29
1. INTRODUCTION 29
2. REACTION SEQUENCE 30
3. SUBSTRATE SPECIFICITY AND COFACTOR REQUIREMENTS 32
4. CHAIN TERMINATION 35
5. PURIFICATION, PHYSICAL PROPERTIES AND REACTION MECHANISM 39
6. BACTERIAL FATTY ACID SYNTHASE 44
7. REGULATION 48
ACKNOWLEDGEMENTS 54
REFERENCES 54
CHAPTER 3 GENETICS OF FATTY ACID BIOSYNTHESIS IN YEAST ECKHART SCHWEIZER
(ERLANGEN) 59
1. INTRODUCTION 59
2. ACETYL-COA CARBOXYLATION 60
A. BIOTIN APOCARBOXYLASE LIGASE MUTATIONS 61
B. ACETYL-COA CARBOXYLASE MUTATIONS 61
IMAGE 2
VLLL
C. ACETYL-COA CARBOXYLASE STRUCTURE 62
3. SATURATED FATTY ACID BIOSYNTHESIS 65
A. REACTION MECHANISM AND FAS ENZYME STRUCTURE 65
B. BIOCHEMICAL PROPERTIES OF FATTY ACID SYNTHETASE MUTANTS (FAS) 67
C. INTERALLELIC COMPLEMENTATION BETWEEN FAS MUTANTS 69
D. IN VITRO COMPLEMENTATION BETWEEN FAS MUTANT SYNTHETASES 75
E. INCORPORATION OF 4 -PHOSPHOPANTETHEINE INTO APO-FAS 76
4. UNSATURATED FATTY ACID BIOSYNTHESIS 76
5. REGULATION OF FATTY ACID BIOSYNTHESIS IN YEAST 77
A. FEEDBACK INHIBITION OF ACC AND FAS 77
B. REGULATION OF ENZYME SYNTHESIS 78
C. CONTROL OF FAS COMPONENT ENZYME ACTIVITIES 78
D. CONTROL OF YEAST FATTY ACID COMPOSITION 79
6. CONCLUDING REMARKS 79
REFERENCES 81
CHAPTER 4 THE REGULATION OF DESATURATION AND ELONGATION OF FATTY ACIDS
IN MAMMALS BY R. JEFFCOAT AND A.T. JAMES (BEDFORD) 85
1. INTRODUCTION 85
2. THE BIOCHEMISTRY OF DESATURATION 88
A. CHARACTERISATION OF THE ENZYME 88
B. CHARACTERISATION OF THE SUBSTRATE 88
3. THE ENZYMOLOGY OF DESATURATION 89
A. MECHANISM OF ENZYME ACTIVITY 89
B. FRACTIONATION OF THE 4 9-DESATURASE COMPLEX 90
4. THE PHYSIOLOGICAL ROLE OF A B- AND 45-DESATURASES 93
A. THE ENZYMOLOGY OF A 6- AND 45-DESATURASES 93
B. THE BIOCHEMISTRY OF A 6- AND 45-DESATURASES 94
5. EVIDENCE FOR OTHER DESATURASES 96
A. 4 8-DESATURASE 96
B. 4 4-DESATURASE 96
6. GENERAL PROPERTIES OF DESATURASES 97
A. SPECIFICITY 97
B. ROLE OF CYTOPLASMIC PROTEINS 98
C. METAL IONS 99
7. ELONGATION OF FATTY ACIDS 99
8. THE CONTROL OF LIPOGENESIS BY DESATURATION AND ELONGATION 102
A. DIETARY CONTROL 102
B. HORMONAL CONTROL 107
(I) DESATURATION, 108 - (II) ELONGATION, 109 - 9. CONCLUSIONS 109
REFERENCES 110
CHAPTER 5 FATTY ACID OXIDATION AND ITS REGULATION JON BREMER AND HARALD
OSMUNDSEN (OSLO) 113
1. INTRODUCTION 113
2. COMPARTMENTATION OF FATTY ACID METABOLISM 113
A. LONG-CHAIN FATTY ACIDS 114
IMAGE 3
IX
B. SHORT-CHAIN FATTY ACIDS 115
3. FATTY ACID ACTIVATION 115
A. SHORT- AND MEDIUM-CHAIN ACYL-COA SYNTHASES 115
(I) ACETYL-COA SYNTHASE, 115 - (II) PROPIONYL-COA SYNTHASE, 116 - (III)
BUTYRYL-COA SYNTHASE, 116 - (IV) MEDIUM-CHAIN ACYL-COA SYNTHASE, 116 -
B. LONG-CHAIN ACYL-COA SYNTHASE(S) 117
(I) CELLULAR LOCALIZATION, 117 - (II) PROPERTIES, 117 - C. REACTION
MECHANISM OF ACYL-COA SYNTHASES 117
D. ACYL-COA SYNTHASE (GDP-FORMING) 118
4. MITOCHONDRIAL OXIDATION OF FATTY ACIDS 118
A. THE FUNCTION OF CARNITINE 118
(I) CARNITINE ACETYLTRANSFERASE, 120 - (II) CARNITINE
PALMITOYLTRANSFERASE, 120 - (III) CARNI- TINE TRANSLOCASE, 121 - B.
(8-OXIDATION ENZYMES OF THE MITOCHONDRIA 121
(I) ACYL-COA DEHYDROGENASES, 121 - (II) ENOYL-COA HYDRATASES
(CROTONASES), 122 - (III) L-( + )-/J-HYDROXYACYL-COA DEHYDROGENASES, 123
- (IV) ACETYL-COA ACYLTRANSFERASES (THIO- LASES), 124 - C. OXIDATION OF
UNSATURATED FATTY ACIDS 124
(I) A 3-EIS-A2-TRANS-ENOY -COA ISOMERASE, 124 - (II) 2,4-DIENOYL-COA
4-REDUCTASE, 125 - (III) 3-HYDROXYACYL-COA EPIMERASE, 125 - D.
FUNCTIONAL CHARACTERISTICS OF MITOCHONDRIAL/J-OXIDATION 125
E. KETOGENESIS AND KETONE BODY UTILIZATION 126
(I) 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE, (HMG-COA SYNTHASE), 127 -
(II) 3-HYDROXY- 3-METHYLGLUTARYL-COA LYASE, 128 - (III) HYDROXYBUTYRATE
DEHYDROGENASE, 128 - (IV) ACETYL- COA HYDROLASE, 128 - (V) SUCCINYL-COA:
ACETOACETATE-COA TRANSFERASE, 129 - 5. PEROXISOMAL FATTY ACID OXIDATION
129
A. /8-OXIDATION ENZYMES OF PEROXISOMES 129
(I) ACYL-COA OXIDASE, 129 - (II) 2-ENOYL-COA HYDRATASE AND
/?-HYDROXYACYL-COA DEHYDRO- GENASE, 130 - (III) ACETYL-COA ACYLTRANSF
ERASE (THIOLASE), 130 - B. FUNCTIONAL CHARACTERISTICS OF
PEROXISOMAL/?-OXIDATION 130
C. HEPATIC CAPACITIES FOR PEROXISOMAL /J-OXIDATION 132
6. A-OXIDATION OF FATTY ACIDS 132
7. W-OXIDATION OF FATTY ACIDS 133
8. REGULATION OF FATTY ACID OXIDATION 134
A. EFFECT OF COMPETING SUBSTRATES 135
B. EFFECT OF METABOLITES AND COFACTORS 135
(I) MALONYL-COA, 135 - (II) GLYCEROPHOSPHATE, 136 - (III) CARNITINE, 137
- (IV) COENZYME A, 137 - C. INDUCIBLE CHANGES IN PEROXISOMAL AND
MITOCHONDRIAL /J-OXIDATION 138
D. EFFECT OF HORMONES 138
(I) INSULIN AND GLUCAGON, 138 - (II) VASOPRESSIN, 139 - (III) THYROID
HORMONES, 139 - (IV) ADRENAL CORTEX HORMONES, 140 - (V) SEX HORMONES,
140 - 9. FATTY ACID /I-OXIDATION IN VARIOUS TISSUES 140
A. HEART AND SKELETAL MUSCLE 141
B. KIDNEY 142
C. GASTROINTESTINAL TISSUES 142
D. WHITE ADIPOSE TISSUE 142
E. BROWN ADIPOSE TISSUE 142
F. BRAIN 143
10. INHIBITORS OF FATTY ACID ^-OXIDATION 143
A. INHIBITORS OF TRANSPORT OF ACYL GROUPS ACROSS THE INNER MITOCHONDRIAL
MEMBRANE 143 B. INHIBITORS OF ACYL-COA DEHYDROGENASE 145
IMAGE 4
C. INHIBITORS OF THIOLASE 145
REFERENCES 147
CHAPTER 6 FATTY ACID BIOSYNTHESIS IN HIGHER PLANTS P.K. STUMPF (DAVIS)
155
1. INTRODUCTION 155
2. INITIAL STEPS 155
A. ORIGIN OF ACETYL-COA 155
(I) LEAF CELL, 155 - (II) SEED CELL, 157 - B. FORMATION OF MALONYL-COA
157
C. PLANT ACYL CARRIER PROTEINS 159
3. THE PLANT FATTY ACID SYNTHETASE (FAS) SYSTEM 161
A. SITES OF SYNTHESIS 161
B. MOLECULAR STRUCTURE OF THE FAS SYSTEM 165
(I) ACETYL-COA : ACP TRANSACYLASE AND MALONYL-COA : ACP TRANSACYLASE,
166 - (II) /?-KETO- ACYL-ACP SYNTHETASE I, 166 - (III) ,8-KETOACYL-ACP
SYNTHETASE II, 167 - (IV) /3-KETOACYL-ACP REDUCTASE, 167 - (V)
D-/?-HYDROXYACYL-ACP DEHYDRASE, 167 - (VI) ENOYL-ACP REDUCTASE, 168 -
(VII) GENERAL ASPECTS, 168 - C. TERMINATION MECHANISMS 169
4. BIOSYNTHESIS OF UNSATURATED FATTY ACIDS 172
A. INTRODUCTION 172
B. BIOSYNTHESIS OF OLEIC ACID 172
C. BIOSYNTHESIS OF LINOLEIC AND A-LINOLENIC ACIDS 175
REFERENCES 178
CHAPTER 7 LIPID DEGRADATION IN HIGHER PLANTS H. KINDL (MARBURG) 181
1. INTRODUCTION 181
2. METABOLIC SITUATIONS OF LIPID DEGRADATION 181
A. COUPLING OF TRIGLYCERIDE HYDROLYSIS, FATTY ACID Y8-OXIDATION,
GLYOXYLATE CYCLE AND GLUCONEOGEN- ESIS 181
B. LIPID TURNOVER IN GREEN LEAVES 183
C. LIPID CATABOLISM IN RESPIRATORY ACTIVE TISSUE 184
3. MECHANISM OF LIPID DEGRADATION 184
A. HYDROLYTIC ENZYMES 184
(I) LIPASE, 184 - (II) LIPASES OF LIPID BODIES, 185 - (III) LIPASES OF
GLYOXYSOMES, 185 - (IV) OTHER LIPASES, 185 - (V) LIPOLYTIC ACYL
HYDROLASES, 186 - (VI) GALACTOLIPASE IN CHLOROPLASTS. 186 - (VII) OTHER
LIPOLYTIC ACTIVITIES, 186 - (VIII) PHOSPHOLIPASE D, 187 - B. FATTY ACID
/S-OXIDATION 187
(I) ENTRY INTO /3-OXIDATION, 188 - (II) CONVERSION OF FATTY ACYL-COA
INTO ACETYL-COA, 188 - (III) UTILIZATION OF ACETYL-COA AND NADH, 189 -
(IV) DEGRADATION OF UNSATURATED FATTY ACIDS, 191 - C. A-OXIDATION OF
FATTY ACIDS 192
(I) MECHANISM OF A-OXIDATION, 192 - (II) INTRACELLULAR LOCATION OF
A-OXIDATION, 193 - D. U-OXIDATION OF FATTY ACIDS 194
E. LIPOXIDATION 194
IMAGE 5
XI
4. INTERRELATIONSHIPS TO OTHER PATHWAYS 197
A. GLYOXYLATE CYCLE 197
B. FURTHER CONVERSIONS 200
C. PRODUCTS OF /8-OXIDATION BEING USED BY CITRATE CYCLE 200
5. CONTROL OF FATTY ACID DEGRADATION AND BIOSYNTHESIS OF GLYOXYSOMES 200
REFERENCES 202
SUBJECT INDEX 205
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| id | DE-604.BV000478324 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:14:33Z |
| institution | BVB |
| isbn | 0444805281 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000295090 |
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| physical | XI, 209 S. Ill., graph. Darst. |
| publishDate | 1984 |
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| series | New comprehensive biochemistry |
| series2 | New comprehensive biochemistry |
| spelling | Fatty acid metabolism and its regulation ed. Shosaku Numa Amsterdam [u.a.] Elsevier 1984 XI, 209 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier New comprehensive biochemistry 7 Fatty Acids cabt Enzymology cabt Metabolism cabt Acides gras - Métabolisme - Régulation Lipidios (metabolismo) larpcal Lipidios larpcal Regelmechanismen gtt Stofwisseling gtt Vetzuren gtt Enzymes Fatty Acids metabolism Fatty acids Metabolism Regulation Regulation (DE-588)4049075-0 gnd rswk-swf Fettsäurestoffwechsel (DE-588)4154234-4 gnd rswk-swf Fettsäurestoffwechsel (DE-588)4154234-4 s DE-604 Regulation (DE-588)4049075-0 s Numa, Shōsaku 1929-1992 Sonstige (DE-588)135632552 oth New comprehensive biochemistry 7 (DE-604)BV000003914 7 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000295090&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fatty acid metabolism and its regulation New comprehensive biochemistry Fatty Acids cabt Enzymology cabt Metabolism cabt Acides gras - Métabolisme - Régulation Lipidios (metabolismo) larpcal Lipidios larpcal Regelmechanismen gtt Stofwisseling gtt Vetzuren gtt Enzymes Fatty Acids metabolism Fatty acids Metabolism Regulation Regulation (DE-588)4049075-0 gnd Fettsäurestoffwechsel (DE-588)4154234-4 gnd |
| subject_GND | (DE-588)4049075-0 (DE-588)4154234-4 |
| title | Fatty acid metabolism and its regulation |
| title_auth | Fatty acid metabolism and its regulation |
| title_exact_search | Fatty acid metabolism and its regulation |
| title_full | Fatty acid metabolism and its regulation ed. Shosaku Numa |
| title_fullStr | Fatty acid metabolism and its regulation ed. Shosaku Numa |
| title_full_unstemmed | Fatty acid metabolism and its regulation ed. Shosaku Numa |
| title_short | Fatty acid metabolism and its regulation |
| title_sort | fatty acid metabolism and its regulation |
| topic | Fatty Acids cabt Enzymology cabt Metabolism cabt Acides gras - Métabolisme - Régulation Lipidios (metabolismo) larpcal Lipidios larpcal Regelmechanismen gtt Stofwisseling gtt Vetzuren gtt Enzymes Fatty Acids metabolism Fatty acids Metabolism Regulation Regulation (DE-588)4049075-0 gnd Fettsäurestoffwechsel (DE-588)4154234-4 gnd |
| topic_facet | Fatty Acids Enzymology Metabolism Acides gras - Métabolisme - Régulation Lipidios (metabolismo) Lipidios Regelmechanismen Stofwisseling Vetzuren Enzymes Fatty Acids metabolism Fatty acids Metabolism Regulation Regulation Fettsäurestoffwechsel |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000295090&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003914 |
| work_keys_str_mv | AT numashosaku fattyacidmetabolismanditsregulation |