Molecular and cellular basis of digestion:
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier
1986
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVIII, 539 S. Ill., graph. Darst. |
| ISBN: | 0444806970 |
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MARC
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| 245 | 1 | 0 | |a Molecular and cellular basis of digestion |c ed.: P. Desnuelle |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 1986 | |
| 300 | |a XVIII, 539 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Digestion |2 cabt | |
| 650 | 7 | |a Physiology |2 cabt | |
| 650 | 2 | |a Cellules - Enzymologie | |
| 650 | 2 | |a Digestion | |
| 650 | 4 | |a Cells |x enzymology | |
| 650 | 4 | |a Digestion | |
| 650 | 4 | |a Digestive enzymes | |
| 650 | 4 | |a Intestinal absorption | |
| 650 | 4 | |a Molecular Biology | |
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| 689 | 0 | 0 | |a Verdauung |0 (DE-588)4062676-3 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Desnuelle, Pierre |e Sonstige |4 oth | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000249673&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-000249673 | ||
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| _version_ | 1804114865467424768 |
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| adam_text | _Molecular and Cellular Basis of
Digestion
Editor:
P Desnuelle
Centre National de la Recherche Scientijique, Centre de Biochimie et de Biologie Moliculaire, 31, Chemin
Joseph-Aiguier, P O Box 71,13402 Marseille Cedex 9 (France)
Co-Editors:
H Sjostrom and O Noren
Department of Biochemistry C, Panum Institute, University of Copenhagen, Blegdamsvej 3c,
DK-2200 Copenhagen JV (Denmark)
Elsevier
Amsterdam • New York • Oxford
Contents
Foreword v
PART I General 1
Chapter 1 Glycoproteins: structure and biosynthesis
by Jean Montreuil ( Villeneuve d Ascq) 3
1 Introduction 3
2 Types of glycan-protein linkages, classification of glycoproteins 4
3 Primary structure of glycoprotein glycans 4
3 1 Concepts and rules, 5 — 3 2 Description of glycan primary structures, 6 —
4 Spatial conformation of glycans 9
4 1 Glycosaminoglycans and proteoglycans, 11 — 4 2 Mucin-like glycans and glycoprote-
ins, 11 — 4 3 Glycans of JV-glycosylproteins, 12 — 4 4 Conformational changes of glycans
Mobility of the antennae, 13 —
5 Glycoprotein biosynthesis 14
5 1 The reaction and its partners, 14 — 5 2 Biosynthesis of O-glycosylproteins, 15 — 5 3
Biosynthesis of JV-glycosylproteins, 16 — 5 4 Control of the biosynthesis of glycoproteins,
6 Conclusions - 21
Acknowledgements 21
References 22
Chapter 2 Cell surface asymmetry is a prerequisite for the function of transporting and
secreting epithelia
by Daniel Louvard, Hubert Reggio and Evelyne Coudrier (Paris and Marseille) 25
1 Introduction 25
2 Structural and functional polarity of epithelia 26
2 1 The extracellular matrix as a source of asymmetry in epithelia, 26 — 2 2 The asymmet-
ric distribution of plasma-membrane proteins is superimposed onto an asymmetrical distri-
bution of the cytoskeletal networks, 27 — 2 3 The junctional complexes play an essential
role in transporting epithelia but their structure is still poorly understood at a molecular le-
vel, 29—
3 The organisation of the brush border of enterocytes 32
3 1 Brush-border enzymes, 33 — 3 2 Organization of the microvillar microlilaments, 33 —
3 3 Microfilaments-membrane interactions in microvilli, 36 — 3 4 The terminal web of the
brush border, 37 —
4 Biogenesis of cell polarity: a goal for future studies 38
References 40
Chapter 3 Early biochemical events in the biogenesis and topogenesis of secretory and
membrane proteins
by George Scheele (jVew York) 43
1 Protein translocation across the RER membrane 43
2 Translocation receptors 49
3 Start-transport and stop-transport signal sequences 51
4 Insertion and orientation of secretory and membrane proteins 52
5 Cotranslational and posttranslational processing of secretory and membrane proteins 54
References 59
Chapter 4 Intracellular transport of newly synthesized secretory and membrane prote-
ins
by H Sjostrom, 0 j Wn, E M Danielsen and S -U Gorr (Copenhagen) 61
1 Introduction 61
2 Types and number of pathways towards the plasma membrane 63
2 1 Transport from rough endoplasmic reticulum to the Golgi apparatus, 63 — 2 2 Posl-
Golgi exocytic pathways, 63 — 2 3 Membrane recycling, 65 — 2 4 Crinophagic pathway,
65 — 2 5 Overlap between different pathways, 66 —
3 Isolation and characterization of transport vesicles 66
3 1 Secretory granules, 66 — 3 2 Purification of vesicles of the constitutive pathway, 67 —
3 3 Purification of endocytic vesicles, 67 — 3 4 Coated vesicles, 68 —
4 Sorting 71
4 1 Sorting in the membrane, 71 — 4 2 Sorting of vesicles, 74 — 4 3 Sorting after fusion,
74 — 4 4 Sorting sequences, 75 —
Acknowledgement 76
References 76
Chapter 5 Hormonal regulation of digestive secretions
by Jens Juul Hoist ( Copenhagen) 79
1 Introduction 79
2 Chemistry of the gastrointestinal regulatory peptides 80
2 1 Identification of regulatory transmitters (peptides), 80 — 2 2 Biosynthesis of regulatory
peptides, 87 — 2 3 Tissue-specific differential processing, 88 — 2 4 Peptide families, 89 —
3 Secretion of regulatory peptides 90
3 1 Endocrine secretion, 90 — 3 2 Paracrine secretion, 92 — 3 3 Criteria for paracrine
control, 92 — 3 4 Peptidergic nerves, 95 — 3 5 Stimulus for release of regulatory peptides,
99 — 3 6 Stimulus-secretion coupling, 100 —
4 Mode of action 100
5 Peptidergic control of gastric and pancreatic secretions 103
5 1 Gastric secretion, 103 — 5 2 Pancreatic secretion, 105 —
References 107
XI
Chapter 6 Adaptation of pancreatic and intestinal hydrolases to dietary changes
by Antoine Puigserver, Catherine Wicker and Christine Gaucher (Marseille) 113
1 Introduction 113
2 Influence of diet composition on the level and biosynthesis rate of some digestive enzymes 114
2 1 Secretory pancreatic hydrolases, 114 — 2 2 Membrane-bound intestinal hydrolases, 116
3 Possible role of hormones in the dietary regulation of digestive enzymes 119
3 1 Control of pancreatic amylase biosynthesis by insulin, 119 — 3 2 Control of intestinal
lactase by thyroxine, 120 —
4 Molecular mechanisms mediating enzyme adaptation to diet 121
5 Concluding comments 123
References 123
Chapter 7 Structure and function of gastrointestinal mucus
by G G Forstner and J F Forstner ( Toronto) 125
1 Introduction 125
2 Composition of intestinal mucin 125
2 1 Native mucin, 125 — 2 2 Peptide domains, 127 — 2 3 Oligosaccharides: general fea-
tures, 129 — 2 4 Acidic and neutral species, 129 —
3 Physical properties of intestinal mucins 129
3 1 Gel formation, 129 — 3 2 Molecular size and shape, 130 — 3 3 Models, 130 —
4 Secretion of mucin, 131
4 1 Mechanisms of secretion, 131 —4 2 Intracellular distribution of secretory granules, 132
— 4 3 Measurement of secreted mucin, 132 — 4 4 Stimulants of secretion, 133 — 4 5 Muc-
in and fluid/clecrtolyte secretion, 135 — 4 6 Fate of secreted mucin, 135 —
5 Functional aspects 136
5 1 Lubrication, 136 — 5 2 Trapping of bacteria and parasites, 137 — 5 3 Permeability
barrier, 137 — 5 4 Digestive zone, 138 —
6 Mucus and disease 138
6 1 Neoplastic disease, 138 — 6 2 Transitional epithelium, 139 — 6 3 Inflammatory bowel
disease, 140 — 6 4 Peptic ulcer disease, 140 — 6 5 Cystic fibrosis, 141 —
References 141
PART II The Bile 145
Chapter 8 A quantitative dynamic concept on the role of bile in fat digestion
by Jacques C Hauton (Marseille) 147
1 General intoduction 147
2 A dynamic concept on the behaviour of lipids 148
2 1 Introduction and proposal of a new unit, 148 — 22A quantitative classification of
lipids based on interphase partition coefficients, 149 — 2 3 Mathematical relations resulting
from the quantitative classification of lipids, 150 — 2 4 Application to class 5 bile salts and
class 4 phosphatidylcholines, 151 — 2 5 Genesis and physico-chemical parameters of mixed
micelles, 152 — 2 6 Presence of two different lipid-water interfaces in mixed micelles A
new triangular co-ordinate model, 153 — 2 7 Possible co-existence of a stable imerfacial
phase and a micellar phase, 156 — 2 8 Mixed premicelles comprising classes 3:5 or 4:5 lipids,
157 — 2 9 Effect of partial blocking of the SA and/or the SD lipid-water interfaces, 157 —
3 Interphase molecular exchanges in the absence of non-lipidic carrier 159
4 Structure of the bile-lipoprotein complex 159
4 1 Gel filtration without bile salt equilibration, 160 — 4 2 Gel filtration with bile salt equi-
libration, 160 — 4 3 Dynamic structure of the human bile-lipoprotein complex, 161 —
5 Origin of the bile-lipoprotein complex 162
6 Role of bile in fat digestion 163
6 1 Site of action of the main pancreatic lipolytic enzymes, 163 — 6 2 Role of bile in the
intestinal absorption of lipids, 164 — 6 3 Entero-hepatic circulation of bile salts, 166 —
7 Conclusion 167
Acknowledgements 167
References 167
Addendum 170
PART III The Pancreas 171
Chapter 9 The exocrine pancreas
by George Scheele and Horst Kem (Hew York and Marburg) 173
1 Morphological structure of the acinar and ductal pancreas 173
2 Secretory proteins in the exocrine pancreas 176
3 Secretory pathway 180
4 Hormonal regulation of the exocrine pancreas 183
5 Coordinate and anticoordinate regulation of protein synthesis by hormonal stimulation 185
6 Alterations in the secretory pathway during secretagogue stimulation 188
7 Discharge of secretory proteins in the exocrine pancreas — parallel vs nonparallel 190
References 192
Chapter 10 Chemistry and enzymology of pancreatic endopeptidases
by P Desnuellef Marseille) 195
1 Introduction : 195
2 Specificity 196
3 Molecular properties and activation of zymogens 197
4 The catalytic site 200
5 Reaction pathway 201
6 Mechanism of action 202
7 Multiplicity of forms 203
8 Naturally occurring inhibitors 204
9 Organization of messenger RNAs and genes 206
9 1 mRNAs, 206 — 9 2 Gene structure, 207 — 9 3 Chromosomal gene localization, 209
References 209
Addendum 211
Chapter 11 Crystal structures of pancreatic serine endopeptidases
by Wolfram Bode and Robert Huber (Martinsried) 213
1 Introduction 213
2 The general structure of serine proteinases 215
Xlll
3 The zymogens and their mode of activation 222
4 Enzyme-ligand complexes and the catalytic mechanism 225
4 1 Pretransition state Michaelis complexes, 226 — 4 2 Tetrahedral intermediate analogs,
229 — 4 3 Acyl enzyme intermediates, 230 — 4 4 Enzyme-product complexes, 231 — 4 5
The reaction pathway, 231 —
References 233
Chapter 12 Pancreatic ezopeptidases
by Anioine Puigserver, Catherine Chapus and Brigitte Kerfelec (Marseille) 235
1 Introduction 235
2 Molecular characteristics of procarboxypeptidases A and B 236
3 Dissociation and reconstitution of the complex forms of procarboxy peptidase A 238
4 Intrinsic activity of procarboxypeptidases A and B 239
5 Activation of procarboxypeptidases 240
6 Catalysis by carboxypeptidase A 242
6 1 Chemical modification of active site residues, 242 — 6 2 X-Ray diffraction crystal anal-
ysis, 243—
7 Multiple binding sites of carboxypeptidase B 245
8 Concluding remarks 245
References 246
Chapter 13 Pancreatic amylase: molecular genetics and evolution
by Miriam H Meisler and Deborah L Gumucio (Ann Arbor) 249
1 Introduction 249
2 Cloning the amylase mRNA 249
3 Gene structure 250
4 A clustered multigene family 251
5 Regulation of pancreatic amylase mRNA 253
6 Post-translational processing of amylase proteins 254
7 Amylase structure 256
8 Evolution of amylase sequences 256
9 Concluding remarks 261
Acknowledgements 261
References 261
Addendum 263
Chapter 14 Pancreatic ribonuclease and deoxyribonuclease
by Pierre Desnuelle (Marseille) 265
1 Pancreatic ribonuclease (ribonucleate 3 -pyridino-oligonucleotidohydrolase, EC314 22) 265
1 1 Introduction, 265 — 1 2 Purification, action on RNA and assay, 266 — 1 3 Structure,
267 — 1 4 Reduction and oxidation, 269 — 1 5 Chemical labeling, 270 — 1 6 Mechanism
of action, 270— 1 7 Macromolecular inhibitors, 271 —
2 Pancreatic deoxyribonuclease (deoxyribonucleate 5 -oligonucleotide hydrolase, E C
3145) 272
2 1 Introduction, 272 — 2,2 Purification and structure, 272 — 2 3 Chemical labeling, 273
— 2 4 Role of divalent cations, 273 —
References 273
Addendum 274
Chapter 15 Pancreatic lipase and phospholipase
by Pierre Desnuelle (Marseille) 275
1 Introduction 275
2 General properties of lipase and phospholipase 276
2 1 Michaelis curves for the hydrolysis of insoluble substrates by lipase, 276 — 2 2 Lipolysis
is affected by the quality of the interface, 277 — 2 3 Dynamics of enzyme binding to lipid
interfaces, 278 — 2 4 Activation of lipolytic enzymes at interfaces, 279 — 2 5 Interfacial
denaturation, 280 — 2 6 Postional specificity of lipolytic enzymes, 281 —
3 Pancreatic phospholipase A2 (phosphatido-2-acyl-hydrolase, EC 311 4) 281
3 1 Purification and assay, 281 — 3 2 Covalent and three-dimensional structure, 283 —
3 3 The catalytic site, 283 — 3 4 The substrate-binding sites, 284 — 3 5 The calcium-bind-
ing site, 286 — 3 6 Activation of prophospholipase, 286 —
4 Pancreatic lipase (triacylglycerol lipase, EC 311 3) 286
4 1 Purification and assay, 286 — 4 2 Chemical structure, 287 — 4 3 Chemical specificity,
288 — 4 4 Mechanism of action, 288 —
5 Pancreatic colipase 289
5 1 Inhibition of lipase activity by bile salts, 289 — 5 2 Existence of a pancreatic colipase,
290 — 5 3 Purification and chemical structure, 291 — 5 4 The colipase effect, 291 — 5 5
Mechanism of action, 293 —
References 294
Addendum 296
Chapter 16 Pancreatic carboxylic-ester hydrolase and non-enzymatic constituents of
pancreatic juice
by Charlotte Erlanson-Albertsson (Lund) 297
1 Introduction 297
2 Carboxylic-ester hydrolase (E C3111) 298
2 1 Assay systems, 298 — 2 2 Purification, 298 — 2 3 Molecular properties, 299 — 2 4
Substrate specificity, 299 — 2 5 Activation by bile salt, 300 — 2 6 Mode of action, 302
— 2 7 Physiological function, 303 —
3 Other constituents of pancreatic juice 304
3 1 Serum proteins, 304 — 3 2 Lysosomal enzymes, 304 — 3 3 Lactoferrin, 304 — 3 4
Carcinoembryonic antigen, 305 — 3 5 Pancreatic stone protein, 305 —
4 Concluding remarks 305
Acknowledgements 306
References 306
PART IV The Intestine 309
Chapter 17 Cytodifferentiation of the intestinal villus epithelium
by K Hajfen, M Kedinger and B Lacroix (Strasbourg) 311
1 Current views on the morphology of the intestinal mucosa 311
1 1 The intestinal epithelium, 311 — 1 2 Epithelial cell renewal, 315 —
XV
2 Functional relationship between stromal and epithelial cells in the small intestine 316
3 Enterocytic features in colonic cancer cells: foetal resurgence 319
References 321
Chapter 18 Control mechanisms in the ontogenesis of villus cells
by M Kedinger, K HaJJen and P Simon-Assmann (Strasbourg) 323
1 Developmental pattern of brush-border enzymes in correlation with some morphogenetic
events 323
2 Regulation of enzyme maturation 325
2 1 Epithelial-mesenchymal interactions, 325 — 2 2 Hormonal control of brush-border
enzymes, 329 —
3 Conclusions 332
References 332
Chapter 19 The enzymes of the enterocyte plasma membrane
by 0 florin, H Sjostrgm, E M Danielsen, G M Cornell and H Skovbjerg (Copenhagen) 335
1 Introduction 335
2 The intestinal microvillus 336
3 The intestinal basolateral membrane 339
3 1 Introduction, 339 — 3 2 The Na+,K+-ATPase, 340 —
4 Properties of the microvillar enzymes 342
4 1 Introduction, 342 — 4 2 Distribution of the microvillar enzymes, 343 — 4 3 Structure
of the microvillar enzymes, 345 — 4 4 Enzymatic properties, 351 — 4 5 Role in digestion,
353 —
5 Biosynthesis of microvillar enzymes 355
5 1 Introduction, 355 — 5 2 Site of synthesis, 356 — 5 3 Passage through the Golgi com-
plex, 357 — 5 4 Pathway from the Golgi to microvillus, 359 — 5 5 Proteolytic processing,
359 —
6 Catabolism of microvillar enzymes 360
Acknowledgements 361
References 361
Chapter 20 Cytosolic peptidases of the small intestine
by H Sjostrbm and 0 j or(n (Copenhagen) 367
1 Introduction 367
2 Distinct enzymes and their characteristics 368
2 1 Leucine aminopeptidase, 368 — 2 2 Tripeptide arhinopeptidase, 369 — 2 3 Arginine
aminopeptidase, 370 — 2 4 Pyroglutamyl aminopeptidase, 370 — 2 5 Aminoacyl-histidine
dipeptidase, 370 — 2 6 Prolyl dipeptidase, 371 — 2 7 Proline dipeptidase, 371 — 2 8 Glyc-
yl-leucine dipeptidase, 372 — 2 9 Other cytosol peptidases, 373 —
3 Distribution 374
3 1 Various tissues, 374 — 3 2 In the intestine, 374 —
4 Development 375
4 1 Phylogenesis, 375 — 4 2 Ontogenesis, 375 —
5 Genetics 375
5 1 Chromosomal localisation, 375 — 5 2 Enzyme deficiencies, 376 —
6 Function 376
Acknowledgement 378
References 378
Chapter 21 The absorption of sugars and amino acids across the small intestine
by Giorgio Semenza and Angela Corcdli (Zurich and Bari) 381
1 General 381
1 1 The biochemistry and molecular biology of the small intestinal transport system, 382
— 1 2 Interference among substrates, 384 — 13A few words about vesicles, 384 — 1 4
On the so-called diffusion , 386 —
2 Intestinal absorption of sugars and derivatives 387
2 1 The absorption of D-fructose, 387 — 2 2 The absorption of sugars and of sugar deriva-
tives of the D-glucose/D-galactose type, 388 — 2 3 The hydrolase-related transport of sugars,
400 — 2 4 L-Ascorbate, 400 — 2 5 Myo-inositol, 401 —
3 Intestinal absorption of amino acids and derivatives, 401
3 1 Transport of amino acids across the BBM, 404 — 3 2 Transport of amino acids across
the BLM, 407 —
Acknowledgements 408
References 408
Chapter 22 The intestinal glycocalyz
by A M Ugolev and V A Tsvetkova (Leningrad) 413
1 Introduction 413
2 Distribution and structure 413
3 Turnover rate 414
4 Functions 415
References 419
Chapter 23 The brush-border membrane of the rat colonic columnar epithelial cell
by Hans-Peter Hauri, Bruno Stieger and Adrian Marxer (Basel) 421
1 Structure and functions of the colonic mucosa 421
2 Problems encountered with the isolation of the brush-border membranes from colonocytes 422
3 Development of a method for the isolation of brush-border membranes from rat colonocytes 424
4 Protein composition of the brush-border membranes from rat distal colon 428
5 Conclusion and perspectives : 430
Acknowledgements 431
References 431
PART V The Salivary Glands 433
Chapter 24 Morphology and secretory mechanisms of salivary glands
byE W Van Lennep, D I Cook and J A Young (Sydney) 435
1 Introduction 435
2 Morphology of the secretory endpieces 436
2 1 Ultrastructure of secretory endpiece cells, 436 — 2 2 Ultrastructure of secretory gra-
nules, 437 — 2 3 Contents of secretion granules in endpiece cells, 438 — 2 4 Myoepithe-
lium, 438 —
XV11
3 Stimulus-secretion coupling in salivary glands 439
3 1 Receptor types, 439 — 3 2 Stimulus-protein secretion coupling, 440 — 3 3 Membrane
retrieval after exocytosis, 443 — 3 4 Stimulation of secretory protein synthesis, 443 —
4 Secretion of salt and water 444
4 1 The sodium pump, 445 — 4 2 The basolateral membrane and the anion symport, 445
— 4 3 The apical membrane and the hypothetical chloride channel, 446 — 4 4 The cytosol
and the intracellular activity of inorganic ions, 447 — 4 5 The paracellular pathway, 448
— 4 6 Stimulation of secretion, an overview, 448 —
5 The ducts 449
5 1 Morphology of the duct system, 449 — 5 2 Protein secretion by duct epithelial cells,
450 —
References 453
Chapter 25 Salivary amylase: evolution and tissue-specific expression
by Miriam H Meisler and Deborah L Gumucio (Ann Arbor) 457
1 Introduction 457
2 Cloning of salivary amylase mRNA 457
3 Gene structure and relationship to pancreatic amylase 458
4 Distance between salivary amylase (Amy-1) and pancreatic amylase (Amy-2) loci 458
5 Gene copy number 460
6 Expression in liver 460
7 Ectopic expression 462
8 Amylase evolution in the vertebrates 462
Acknowledgements 465
References 465
Addendum 466
Chapter 26 Lingual lipase
by Pierre Desnuelle (Marseille) 467
1 Introduction 467
2 Location and purification 467
3 Molecular properties and action on triacylglycerol substrates 469
4 Biological role 470
References 470
Addendum 471
PART VI The Stomach 473
Chapter 27 The stomach Cellular Aspects
by Herbert F Helander (Umei) 475
1 Introduction 475
2 Oxyntic gland area 476
2 1 The surface mucous cells, 476 — 2 2 The mucous neck cells, 478 — 2 3 The zymogen
cells, 481 — 2 4 The parietal cells, 483 —
3 Cardiac glands 488
4 Pyloric glands? 488
5 Morphological aspects of stimulation 488
xvm
References 489
Chapter 28 Pepsin, chymosin and their zymogens
by Bent Foltmann (Copenhagen) 491
1 Introduction 491
2 Structure 492
2 1 Primary structure, 492 — 2 2 Three-dimensional structure, 494 —
3 Activity 496
4 Activation 497
5 Development 501
6 Genetics 503
7 Evolutionary overview 503
References 504
Chapter 29 Molecular mechanisms of gastric HC1 secretion
by Miguel J M Lewin (Paris) 507
1 Ion transport by gastric vesicles 507
1 1 H+ transport, 508—1 2 K+ and Cl~ transport, 511 — 1 3 HC1 transport, 513 —
2 (H+,K+)-ATPase 515
2 1 Subcellular localization, 515 — 2 2 Biochemical features, 516 — 2 3 Catalytic cycle,
516 — 2 4 H+/ATP stoichiometry, 520 — 2 5 Molecular structure, 521 —
Acknowledgements 523
References 524
Addendum 526
PART VII Subject Index 527
Subject Index 529
|
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| discipline | Biologie |
| format | Book |
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| id | DE-604.BV000405363 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:13:31Z |
| institution | BVB |
| isbn | 0444806970 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000249673 |
| oclc_num | 13122785 |
| open_access_boolean | |
| owner | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-12 DE-19 DE-BY-UBM DE-355 DE-BY-UBR DE-188 |
| physical | XVIII, 539 S. Ill., graph. Darst. |
| publishDate | 1986 |
| publishDateSearch | 1986 |
| publishDateSort | 1986 |
| publisher | Elsevier |
| record_format | marc |
| spelling | Molecular and cellular basis of digestion ed.: P. Desnuelle Amsterdam [u.a.] Elsevier 1986 XVIII, 539 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Digestion cabt Physiology cabt Cellules - Enzymologie Digestion Cells enzymology Digestive enzymes Intestinal absorption Molecular Biology Verdauung (DE-588)4062676-3 gnd rswk-swf Verdauung (DE-588)4062676-3 s DE-604 Desnuelle, Pierre Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000249673&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular and cellular basis of digestion Digestion cabt Physiology cabt Cellules - Enzymologie Digestion Cells enzymology Digestive enzymes Intestinal absorption Molecular Biology Verdauung (DE-588)4062676-3 gnd |
| subject_GND | (DE-588)4062676-3 |
| title | Molecular and cellular basis of digestion |
| title_auth | Molecular and cellular basis of digestion |
| title_exact_search | Molecular and cellular basis of digestion |
| title_full | Molecular and cellular basis of digestion ed.: P. Desnuelle |
| title_fullStr | Molecular and cellular basis of digestion ed.: P. Desnuelle |
| title_full_unstemmed | Molecular and cellular basis of digestion ed.: P. Desnuelle |
| title_short | Molecular and cellular basis of digestion |
| title_sort | molecular and cellular basis of digestion |
| topic | Digestion cabt Physiology cabt Cellules - Enzymologie Digestion Cells enzymology Digestive enzymes Intestinal absorption Molecular Biology Verdauung (DE-588)4062676-3 gnd |
| topic_facet | Digestion Physiology Cellules - Enzymologie Cells enzymology Digestive enzymes Intestinal absorption Molecular Biology Verdauung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000249673&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT desnuellepierre molecularandcellularbasisofdigestion |