Mutagenicity testing in environmental pollution control:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Chichester
Ellis Horwood u.a.
1985
|
| Edition: | 1. publ. |
| Series: | Ellis Horwood series in analytical chemistry
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 195 S. Ill., Kt. |
| ISBN: | 085312681X |
Staff View
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Record in the Search Index
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|---|---|
| adam_text | JVIUTAGENICITY TESTING
IN ENVIRONMENTAL
POLLUTION CONTROL
F K ZIMMERMANN
Institute fiir Mikrobiologie, Technische Hochschule
Darmstadt, West Germany
and
R E TAYLOR-MAYER
Slippery Rock University, Pennsylvania, USA
ELLIS HORWOOD LIMITED
Publishers • Chichester
Halsted Press: a division of
JOHN WILEY amp; SONS
New York • Chichestei • Brisbane • Toronto
Table of Contents
Foreword 9
F J de Serres, National Institute of Environmental Health Sciences
USA
1 Introduction 11
F K Zimmermann, Technische Hochschule, Darmstadt, FRG
2 The genetic apparatus of man
B K Vig, University of Nevada, Reno, Nevada, USA
2 1 Introduction 14
2 2 Mitotic cell division 14
2 3 The human genome 15
2 4 Meiotic cell division 17
2 5 Errors of chromosome number in man 18
2 6 Aberrations of chromosome structure 19
2 7 Point mutation in man 20
2 8 Complex patterns of inheritance 21
References 21
3 Mutagenicity testing — some background information
F K Zimmermann, Technische Hochschule, Darmstadt, FRG, and
R E Taylor-Mayer, Slippery Rock University, Pennsylvania, USA
3 1 Introduction 23
3 2 Definitions 26
3 3 Types of mutation and genetic change 28
3 4 Mutagenic change and repair systems 31
Table of Contents
3 5 Changes in the pattern of gene expression 33
3 6 Mutation vs epigenetic effects 34
3 7 Problems in selecting a mutagenicity test battery 37
3 8 Metabolic activation 40
3 9 The problem of detoxification 41
3 10 Complications in testing complex mixtures 41
3 11 Dosage selection 41
3 12 Evaluation of data 42
3 13 How well validated are mutagenicity tests? 43
3 14 Controls, reproducibility and dose response curves 43
3 15 Conclusion 45
General references 45
References 45
4 Chemical separation and in situ mutagenicity testing
M Miller and A Bjflrseth, Central Institute for Industrial Research,
Oslo, Norway, and V S Houk, Environmental Protection Agency,
Research Triangle Park, NC 27711, U S A
4 1 Introduction 47
4 2 Experimental methods 48
4 3 Applications 51
4 4 The TLC/Salmonella assay as a screening technique 66
4 5 Conclusions 67
References 67
5 Mutagens in food and drinks, and their carcinogenicity
M Nagao, K Wakabayashi and T Sugimura, National Cancer
Center Research Institute, Tokyo, Japan
5 1 Cooked food 69
5 2 Vegetables 74
5 3 Precursors of mutagens that become mutagenic after nitrite
treatment 78
5 4 Mutagens in beverages 80
5 5 Discussion 81
References 82
6 Mutagenic-activity in Dutch river waters and its biological significance
for fish
C F van Kreijl and W Slooff, National Institute for Public Health
and Environmental Hygiene, Leidschendam, The Netherlands
6 1 Introduction 86
6 2 Carcinogens and mutagens identified in Rhine Water 87
6 3 Mutagenicity of Dutch river waters 90
6 4 Mutagenic activity in bile fluid of Rhine fish 97
6 5 Biological effects on fish 99
6 6 Discussion and conclusions 101
References 103
Table of Contents
7 The detection of mutagens in the tissue of marine organisms exposed
to environmental pollutants
J M Parry, University College of Swansea, Wales
7 1 Introduction 105
7 2 Preparation of tissue samples 106
7 3 Detection of nutrilites 107
7 4 Detection of mutagenic activity 109
7 5 Examples of the use of tissue bioassay 112
References 117
8 Detection of genetic activity in effluents from pulp and paper mills:
Mutagenicity in Saccharomyces cerevisiae
E R Nestmann, Department of National Health and Welfare,
Ottawa, Ontario, Canada
8 1 Detection of genetic activity 118
8 2 Pulp and paper-mill effluent — a complex mixture 120
8 3 Yeast testing of an extract of effluent 120
8 4 Yeast testing of components of effluents 122
8 5 Further development of yeast for mutagenic testing 124
References 124
9 In vitro mutagenicity testing of airborne particulates
G M Alink and J J van Houdt, Agricultural University, Wageningen,
The Netherlands
9 1 Materials and methods 128
9 2 Results 130
9 3 Discussion 142
References 145
10 Genetic assays of maize for environment pollution control
M J Plewa, University of Illinois, Urbana, Illinois, USA
10 1 Introduction 147
10 2 In situ analysis of pesticides ; 149
10 3 In situ analysis of municipal sewage sludge applied to soil 154
10 4 Recommendations for in situ analyses 156
10 5 Development of a rapid environmental monitor 156
10 6 Conclusions 163
References 164
11 Induction of mitotic aneuploidy in yeast with aprotic polar solvents
F K Zimmermann, V W Mayer, R E Taylor-Mayer, U Groschel-
Stewart and I Scheel, Institut fiir Mikrobiologie, Technische
Hochschule, Darmstadt, FRG
11 1 Introduction 166
11 2 Materials and Methods 167
Table of Contents
11 3 Results 173
11 4 Discussion 175
References 179
12 Ionizing radiation - a case study in the evolution of risk
evaluation 180
P Unrau, Chalk River Nuclear Laboratories, Ontario, Canada
References 188
Index 189
|
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| series2 | Ellis Horwood series in analytical chemistry |
| spelling | Mutagenicity testing in environmental pollution control [ed.:] F. K. Zimmermann ... 1. publ. Chichester Ellis Horwood u.a. 1985 195 S. Ill., Kt. txt rdacontent n rdamedia nc rdacarrier Ellis Horwood series in analytical chemistry Environmental Pollution analysis Environmental Pollution prevention & control Mutagenicity Tests Mutagenicity testing Umweltmutagen (DE-588)4186808-0 gnd rswk-swf Mutagenitätstest (DE-588)4261911-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Mutagenitätstest (DE-588)4261911-7 s Umweltmutagen (DE-588)4186808-0 s DE-604 Zimmermann, Friedrich Karl Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000245003&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mutagenicity testing in environmental pollution control Environmental Pollution analysis Environmental Pollution prevention & control Mutagenicity Tests Mutagenicity testing Umweltmutagen (DE-588)4186808-0 gnd Mutagenitätstest (DE-588)4261911-7 gnd |
| subject_GND | (DE-588)4186808-0 (DE-588)4261911-7 (DE-588)4143413-4 |
| title | Mutagenicity testing in environmental pollution control |
| title_auth | Mutagenicity testing in environmental pollution control |
| title_exact_search | Mutagenicity testing in environmental pollution control |
| title_full | Mutagenicity testing in environmental pollution control [ed.:] F. K. Zimmermann ... |
| title_fullStr | Mutagenicity testing in environmental pollution control [ed.:] F. K. Zimmermann ... |
| title_full_unstemmed | Mutagenicity testing in environmental pollution control [ed.:] F. K. Zimmermann ... |
| title_short | Mutagenicity testing in environmental pollution control |
| title_sort | mutagenicity testing in environmental pollution control |
| topic | Environmental Pollution analysis Environmental Pollution prevention & control Mutagenicity Tests Mutagenicity testing Umweltmutagen (DE-588)4186808-0 gnd Mutagenitätstest (DE-588)4261911-7 gnd |
| topic_facet | Environmental Pollution analysis Environmental Pollution prevention & control Mutagenicity Tests Mutagenicity testing Umweltmutagen Mutagenitätstest Aufsatzsammlung |
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