Handbook of monoclonal antibodies: applications in biology and medicine
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Park Ridge, NJ
Noyes Publ.
1985
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXI, 477 S. |
| ISBN: | 0815510349 |
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Datensatz im Suchindex
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| adam_text | HANDBOOK OF
MONOCLONAL ANTIBODIES
Applications in
Biology and Medicine
Edited by
Soldano Ferrone
Department of Microbiology and Immunology
New York Medical College
Valhalla, New York
Manfred P Dierich
Institute of Hygiene
University of Innsbruck
Innsbruck, Austria
np
Sole distribution by:
Gothard House Publications
Gothard House, Henley-on-Thames,
Oxon RG91AJ
Tel: 0491 573602
NOYES PUBLICATIONS
Park Ridge, New Jersey, U S A
Contents and Subject Index
Preface v
Contributors vii
1 MONOCLONAL ANTIBODY PRODUCTION: PRINCIPLES AND
PRACTICE 1
Stephen Fazekas de St Groth
Historical 1
The Case Against Antisera 1
Production of Monoclonal Antibodies 2
Principles 2
Practice, 1975 3
Practice, 1983 5
Use and Misuse of Monoclonal Antibodies 7
The Consequences of Heterogeneity 7
Cross Reactivity 7
Affinity 7
Isotypy 7
Criteria for the Effective Use of Monoclonals 8
Purification of Antigens 8
Antigenic Analysis 8
Diagnostics 9
Therapeutics 9
References 10
2 LYMPHOCYTE SUBPOPULATIONS IN RODENTS: FUNCTIONAL
SUBPOPULATIONS IN RODENTS 11
Mark R Greenwood and R Michael Parkhouse
Introduction 11
Heterogeneity of T Cells 12
xi
xii Contents and Subject Index
Functional Heterogeneity of T Cells 12
T Cell Markers 13
Thy-1 13
Markers on Mouse T Cells 14
Markers on Rat T Cells 16
Heterogeneity of B Cells 16
Functional Heterogeneity in B Cells 17
Bi and B2 Cells 17
The CBA/N Defect 17
*** C3H/HeJ Mice 19
Pre-Progenitor B Cells 19
Virgin and Memory B Cells 20
Immunoglobin on B Cells 20
The Fc Receptor (FcR) 22
la Antigens 22
The Complement Receptor 23
Antisera and Monoclonal Antibodies which Recognize B
Cells 23
Lyb-2 23
Lyb-3 24
Lyb-5 24
Lyb-7 24
Pel 24
MBLA 24
Qa-1 and Qa-2 24
19B5 24
DNL 19A 25
RA 3-2C2 25
Concluding Remarks 25
References 27
3 LYMPHOCYTE SUBPOPULATION SEPARATION BY MONOCLONAL
ANTIBODIES 36
Rudiger W Braun
Introduction 36
Direct and Indirect Cytotoxicity 37
Rosetting Procedures 39
Panning and Procedures 40
Fluorescence Activated Cell Sorting 41
Separation by Microspheres 42
Affinity Chromatography 43
Conclusions 43
References 44
4 IMMUNOFLUORESCENCE ANALYSIS OF LEUCOCYTE/LYMPHO-
CYTE MEMBRANE ANTIGENS WITH MONOCLONAL ANTIBODIES 48
Wolfgang Ax and Sabine Schottler
Introduction 48
Contents and Subject Index xiii
Materials 48
Monoclonal Antibodies 49
Conjugate 49
Agar Slide 49
Dilution Medium/Washing Solution 49
Procedure 49
Lymphocyte/Leucocyte Isolation from Blood—Room
Temperature 49
Monocyte Isolation from Lymphocyte-Containing Layer of
Density Gradient—37°C 49
Lymphocyte Fluorescence Labeling (0 - 4°C) 50
Microscopic Evaluation 50
Principles 50
Filter Sets for Epi-Fluorescence 51
Preparation of Samples - Reading 51
Microphotography 51
Television 53
Discussion 53
References 54
5 PHENOTYPING OF HUMAN NK CELLS WITH MONOCLONAL
ANTIBODIES 56
Dietrich Kraft, Helmut Rumpold and OlegEremin
Introduction 56
Characterization of NK Cells by MoAB Raised Against Cells of
the T, B and Myelomonocytic Cell Series 57
Characterization of NK Cells by Anti-LGL MoAB 58
HNK-1 (Anti-Leu7) 58
NK-8 59
3G8 59
VEP13 59
B73 1 62
NKP-15 (Anti-Leulla) 64
GO22 (Anti-Leullb) 64
Comparison of the Anti-NK/PMNL FcryR MoAB B73 1, 3G8,
Anti-Leulla, Anti-Leullb and VEP13 64
MoAB with Various Specificities 65
H25 and H366 65
Anti-N901 65
HNC-1A3 66
Evidence for a Third Lymphocytic Lineage, as Ascertained by
Studies with MoAB 66
Summary 66
References 67
6 MONOCLONAL ANTIBODIES AND HUMAN MYELOMONOCYTIC
CELLS - 71
Walter Knapp
Introduction 71
xiv Contents and Subject Index
Cells of the Myelomonocytic Series 71
Monoclonal Antibodies Reactive with Myelomonocy tic Cells 72
Granulocytic Antibodies 72
Monocytic Antibodies 74
Myelomonocytic Antibodies 76
Receptors for Complement Components 76
Monoclonal Antibodies to Fc-Receptors 77
Nomenclature of Monoclonal Antibodies to Myelomonocytic
Cells 78
Differentiation of Myelomonocytic Cells 79
Progenitor Cells 79
Granulocytic Differentiation 79
Monocytic Differentiation 80
Macrophage Differentiation 81
Dendritic Cells 82
Malignant Proliferations of Myelomonocytic Cells 82
Acute Myeloid Leukemias (AML) 82
Chronic Myelogenous Leukemia (CML) 84
References 84
7 MONOCLONAL ANTIBODIES AS PROBES TO DEFINE HUMAN
T CELL SURFACE STRUCTURES AND FUNCTIONS 91
Stefan C Meuer, Stuart F Schlossman and Ellis L Reinherz
Introduction 91
Monoclonal Antibodies to Human T Lymphocyte Surface
Antigens 92
Differentiation and Function of Human T Lymphocytes 92
The Biology of the Helper and Suppressor T Cell Subsets 95
The Role of Surface Molecules for Human T Cell Recognition 97
Clinical Applications 100
References 103
8 MONOCLONAL ANTIBODIES AS TOOLS TO STUDY RECEPTOR-
TRANSDUCER-EFFECTOR SYSTEMS 109
Manfred Schmitt, Richard G Painter and Charles G Cochrane
Introduction 109
Monoclonal Antibodies as Receptor Specific Analytic Probes I l l
Effects of Monoclonal Antibodies on N-Formyl Chemotactic
Peptide Mediated Stimulation of Human Neutrophils 116
References 125
9 MONOCLONAL ANTIBODIES IN ENZYMOLOGY 131
Franco Celada and Boris Rotman
Introduction 131
Identification and Purification of Enzymes 132
Anti-Enzyme MoAB to Detect Tumor-Related Specificities 133
Functional MoAB to Study Association of Molecules on Cell
Organelles and Membranes 134
Contents and Subject Index xv
Multifunctional Enzyme Molecules 134
Isozymes and Enzyme Complexes 135
MoABs to Study Antibody-Mediated Effects on Protein
Conformation 137
Definition of the Epitope 140
Dissection of an Epitope 142
New Methodology, Future Developments 143
References 145
10 MONOCLONAL ANTIBODIES IN THE ANALYSIS OF STRUCTURE
AND FUNCTION OF COMPLEMENT COMPONENTS 150
Reinhard Burger
Introduction 150
Production of Monoclonal Antibodies to Complement
Components: Methodological Aspects 151
Immunization Protocol 151
Antibody Assays 152
Monoclonal Antibodies to Complement Components of the
Classical Pathway 152
Antibodies to Cl 152
Ab 48 3 to Purified Clq 152
Antibodies to Clq Bound to Immune Complexes and to
Neoantigenic Determinants of Clq 153
Ab 146 Recognizing Membrane-Associated Clq with Fc
Receptor Function 154
Antibodies to C4 and C2 154
Antibodies to C3 155
Antibody WM1 to C3c 155
Antibodies 3,4 and 9 to C3c, or C3g 155
Antibodies to C3d 156
Antibodies Against Functionally Relevant Sites of C3 156
Antibodies to the Terminal Components C5, C6, C7, C8
and C9 158
Monoclonal Antibodies to Components of the Alternative
Pathway 159
Antibodies to Factor B 159
Antibodies to Factor D 160
Monoclonal Antibodies to the Serum Regulatory Proteins 160
An Antibody to I (C3b INA) 160
Antibodies to H 161
Naturally Occurring Monoclonal Antibodies to Complement
Components: Nephritic Factor 161
Commercially Available Monoclonal Antibodies to Complement
Components 162
Conclusion: Further Applications of Monoclonal Antibodies
to Complement 162
References 163
xvi Contents and Subject Index
11 MONOCLONAL ANTIBODIES AND COAGULATION 166
Kenneth G Mann, Jerry A Katzmann, W Barry Foster and
David N Pass
Introduction 166
Methods of Monoclonal Antibody Preparation and Assay 172
Quantitation of Monoclonal Antibody Binding 180
Isolation of Coagulation Proteins and Preparation of Immuno-
depleted Plasma Using Monoclonal Antibodies 182
#, Structural Analysis with Monoclonal Antibodies 185
von Willebrand Factor and Platelet Adhesion 189
Anti-Platelet Monoclonal Antibodies 190
Summary 191
References 191
12 MONOCLONAL ANTIBODIES AND HUMAN CHLORIONIC
GONADOTROPIN: MAPPING OF EPITOPES AND RECEPTOR-
INTERACTION SITES 195
Siegfried Schwarz, Peter Berger, Reinhard Kofler and Georg Wick
Introduction 195
Production and Characterization of Monoclonal Antibodies to
hCG and bLH 198
Development of a Holo-hCG Specific Immuno Radio Metric
Assay (IRMA) 199
Choice of MoAB 199
IRMA-Protocol 199
Validation of the 22-13*-IRMA 200
Mapping of hCG Epitopes 203
Analysis of Results 205
Relationship of Receptor-Interaction Sites and Immunological
Epitopes of hCG 208
Measurement of Different Forms of hCG by Epitope-Selective
IRMAs 210
Concluding Remarks and Perspectives 214
References 216
Books 216
Journals 216
13 MONOCLONAL ANTIBODIES AND VIRUSES: APPLICATION TO
THE EPSTEIN-BARR SYSTEM 221
Nikolaus Mueller-Lantzsch
Introduction 221
Characterization of Late EBV Proteins by Monoclonal
Antibodies 222
Procedure for Antibody Production 222
Monoclonal Antibodies Against EBV Envelope Proteins 223
Immunological Differences of EBV Strains Analyzed by
Monoclonal Antibodies 225
Contents and Subject Index xvii
EBV Specific Membrane Antigen (MA) Immunofluorescence
by Monoclonal Antibodies 226
Neutralization Potential of EBV Specific Monoclonal Anti-
bodies 227
Monoclonal Antibody Specific for Capsid Antigen of EBV 228
Identification of Polypeptide Components of the EBV Early
Antigen Complex with Monoclonal Antibodies 229
Monoclonal Antibodies to EBV-Induced Transformation-
Associated Cell Surface-Antigen • 229
Conclusions 230
References 231
14 MONOCLONAL ANTIBODIES AND HERPES SIMPLEX VIRUS
INFECTIONS 235
Joseph C Glorioso and Myron Levine
Introduction 235
Production of Anti-HSV Monoclonal Antibodies and Studies
of HSV Infection 237
The Antigenic Structure of HSV Glycoproteins 238
Epitopes Defined by Synthetic Oligopeptides 238
Analysis of Antigenic Sites Using Monoclonal Antibodies
and Antibody Selected Variants 239
Monoclonal Antibody Selection of Glycoprotein Deficient
Mutants and the Definition of Antigenic Domains 242
Monoclonal Antibodies and Diagnosis of HSV Infections 244
Serotyping of HSV Isolates 245
Detection of HSV Antigens in Herpetic Lesions 245
Detection of HSV Antibodies in Body Fluids 246
Monoclonal Antibodies in Immune Protection 248
Monoclonal Antibodies and the Molecular Biology of HSV
Infection 250
Future Prospects and Directions 251
References 251
15 MONOCLONAL ANTIBODIES AND BACTERIA 261
Thomas F Schulz and Manfred P Dierich
Introduction 261
Use of Monoclonal Antibodies in Investigating Aspects of Host-
Parasite Relationship 262
Introduction 262
Infections Caused by Gram-Negative Organisms 262
Infections Caused by Gram-Positive Organisms 265
Use of Monoclonal Antibodies to Investigate the Surface
Structure of Bacteria 268
Attempts to Define Molecules Responsible for the Adhesion
of Bacteria to Animal Cells 268
Attempts to Define Surface Structures Determining the
Antigenic Phenotype of Bacteria 269
xviii Contents and Subject Index
Attempts to Investigate the Structure-Function Relationship
of Isolated Membrane Molecules 276
Monoclonal Antibodies to Bacterial Toxin 276
Use of Monoclonal Antibodies in the Diagnosis of Infectious
Diseases 278
Some Methods Employed in the Production of Monoclonal
Antibody to Bacteria ; 282
Immunization Schedules 282
Screening for Antibody Production of Hybridomas 283
f References 283
16 MONOCLONAL ANTIBODIES IN DIAGNOSTIC PATHOLOGY 293
Salim E Kabawat, Frederic I Preffer and Atul K Bhan
Introduction 293
Staining Methods 294
Characterization of Lymphocyte Subclasses 297
Analysis of Cell Mediated Reactions 301
Characterization of Malignant Lymphomas 302
Monoclonal Antibodies in Tumor Diagnosis 304
Differentiation Antigens 304
Hormones as Endocrine Markers 304
Blood Group Antigens 305
Major Histocompatibility Complex Antigens 305
Antibodies to Intermediate Filaments 306
Antibodies to Other Cellular Structural Proteins 310
Oncofetal and Oncoplacental Antigens 310
Carcinoembryonic Antigen 310
Alpha-Fetoprotein 313
Human Chorionic Gonadotropin 313
Other Oncoplacental Antigens 313
Tumor Associated Antigens 313
Summary • 317
References 317
17 MONOCLONAL ANTIBODIES AND DETECTION OF
MALIGNANCIES 329
Duane R Schultz
Introduction 329
Oncofetal Antigens 330
Alpha-Fetoprotein 330
Carcinoembryonic Antigen 332
Pancreatic Tumor-Associated Antigens 334
Colorectal Carcinoma-Specific Antigens 338
Tumor Imaging with Monoclonal Antibodies 339
Potential Problems Associated with Monoclonal Antibodies 340
References 341
Contents and Subject Index xix
18 MONOCLONAL ANTIBODIES AND MELANOMAS 347
Judith P Johnson and Gert Riethmiiller
Introduction 347
Melanoma Surface Antigens Defined by Monoclonal Anti-
bodies: The Evolution from Melanoma Specific to
Melanoma Associated 348
la Like Antigens 348
p97 350
Melanoma Associated Proteoglycan-Glycoprotein 351
GD3 Ganglioside 351
•• Melanoma vs Nevus and Melanocyte: Asking the Real
Question 351
Looking for Tumor-Specific Markers with Monoclonal
Antibodies: Asking the Right Question 353
References 354
19 MONOCLONAL ANTIBODIES AND CHARACTERIZATION OF
HUMAN LYMPHOPROLIFERATIVE MALIGNANCIES 360
Daniel M Knowles II
Introduction 360
T Lymphocyte Markers 362
OKT Monoclonal Antibodies 363
Monoclonal Antibodies in the Phenotypic Characterization of
T Cell Malignancies 365
Monoclonal Antibody Leu 1/OKT1 367
B Lymphocyte Markers 368
Monoclonal Antibodies BA-1 and BA-2 369
Monoclonal Antibodies Bl , B2, and B4 369
OKB Monoclonal Antibodies 370
Monoclonal Antibodies BL1, BL2, BL3 371
Monoclonal Antibodies Pro-Iml and Pro-Im2 373
Monoclonal Antibodies in the Phenotypic Characterization of
B Cell Malignancies 373
Conclusion 376
References 376
20 MONOCLONAL ANTIBODIES AND HUMAN HISTO-
COMPATIBILITY ANTIGENS 382
Piergiorgio Natali, Aldo Bigotti, Carlo Russo, Kohsaku Sakaguchi,
Muneo Igarashi and Soldano Ferrone
Monoclonal Antibodies to HLA Allospecificities Defined by
Conventional Alloantisera 385
Use of Monoclonal Antibodies in the Lymphocytotoxic Assay
for HLA Typing 388
New Information Derived from the Application of Anti HLA
Monoclonal Antibodies 389
Conclusion 398
References 398
xx Contents and Subject Index
21 MONOCLONAL ANTIBODIES IN THE THERAPY OF RENAL
TRANSPLANT REJECTION 404
Charles B Carpenter
T Cell Differentiation Antigens 405
Selection of a Monoclonal Antibody for In Vivo Use 407
Testing of Anti-Human Monoclonal Antibodies in Primates 409
Reversal of Acute Renal AHograft Rejection in Man 410
OKT3 410
Anti-T12 411
f CBL1 413
Immunogenicity of Mouse Monoclonal Antibodies 414
Treatment of Acute Graft-Versus-Host Disease (GVHD) 414
Conclusions 415
References 416
22 MONOCLONAL ANTIBODIES AS THERAPEUTIC TOOLS IN
MEDICINE 419
Jean-Francois Bach and Lucienne Chatenoud
Introduction 419
Specific Problems of Monoclonal Antibody Production for
Clinical Use 420
Experimental and Human Therapeutic Use of Monoclonal
Antibodies 421
Nonspecific Immunosuppression (Antilymphocyte
Antibodies) 421
Specific Immunosuppression in Autoimmune Diseases 423
Immunotherapy of Leukemia and Cancer 424
Serotherapy of Infectious and Parasitic Diseases 426
Cure of Intoxication (Antidrug Antibodies) 427
Mechanisms of In Vivo Action of Monoclonal Antibodies 427
Escape Mechanisms from the Therapeutic Effect of Monoclonal
Antibodies and Their Prevention 428
Antigenic Modulation 428
Xenosensitization 429
Immunotoxins 431
Conclusions and Prospectives 432
References 432
23 MONOCLONAL ANTIBODIES IN THE THERAPY OF MALIGNANT
DISEASES 436
Robert O Dill man and Ivor Royston
Introduction 436
Introductory Comments 436
Advantages of Monoclonal Antibodies over Antisera 436
Monoclonal Antibodies as Passive Therapy 437
Passive Cytotoxic Therapy 437
Heterologous Antisera Trials 438
Monoclonal Antibody Therapy in Animal Models 440
Contents and Subject Index xxi
Monoclonal Antibodies as Passive Cytotoxic Therapy 441
Review of Trials 441
Binding to Target Cells 443
Biological and Clinical Effects 443
Toxicity and Side Effects 444
Bioavailability and Pharmacokinetics 446
Free Antigen 446
Antigenic Modulation/Immunoselection 447
Endogenous Anti-Mouse Antibody 447
Monoclonal Antibodies as Regulatory Therapy 447
General Considerations 447
Anti-Idiotype Monoclonal Antibodies 448
Anti-Transferrin Receptor Therapy 450
Conclusions Regarding Passive MoAB Therapy 450
Monoclonal Antibody Conjugates as Active Therapy 451
Radioisotope Conjugates 451
General Considerations 451
Isotope-Antisera Conjugate Experience 452
Radioimmunodetection and Radioimmunotherapy with
Monoclonal Antibodies in Animal Models 453
Radioimmunoscintigraphy in Humans with Monoclonal
Antibody Conjugates 453
Other Considerations 455
Conclusions 456
Chemotherapy Conjugates 456
General Considerations 456
Therapy in Animal Models 456
Therapy in Man 457
Conclusions 457
Immunotoxin Conjugates 457
General Considerations 457
Immunotoxins In Vitro 458
Immunotoxins in Animal Models 458
Conclusions Regarding Immunotoxins 459
Monoclonal Antibodies in Bone Marrow Transplantation 459
General Considerations 459
Allogeneic Marrow Transplantation 459
In Vivo Anti-GVHD 459
In Vitro Anti-GVHD 460
Autologous Marrow Transplantation 460
Concluding Remarks 461
References 462
APPENDIX: LIST OF COMMERCIALLY AVAILABLE MONOCLONAL
ANTIBODIES 473
|
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| spelling | Handbook of monoclonal antibodies applications in biology and medicine ed. by Soldano Ferrone ... Park Ridge, NJ Noyes Publ. 1985 XXI, 477 S. txt rdacontent n rdamedia nc rdacarrier Monoclonal Antibodies cabt Antibodies, Monoclonal Monoclonal antibodies Handbooks, manuals, etc Monoklonaler Antikörper (DE-588)4040094-3 gnd rswk-swf Monoklonaler Antikörper (DE-588)4040094-3 s DE-604 Ferrone, Soldano Sonstige oth HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000242784&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Handbook of monoclonal antibodies applications in biology and medicine Monoclonal Antibodies cabt Antibodies, Monoclonal Monoclonal antibodies Handbooks, manuals, etc Monoklonaler Antikörper (DE-588)4040094-3 gnd |
| subject_GND | (DE-588)4040094-3 |
| title | Handbook of monoclonal antibodies applications in biology and medicine |
| title_auth | Handbook of monoclonal antibodies applications in biology and medicine |
| title_exact_search | Handbook of monoclonal antibodies applications in biology and medicine |
| title_full | Handbook of monoclonal antibodies applications in biology and medicine ed. by Soldano Ferrone ... |
| title_fullStr | Handbook of monoclonal antibodies applications in biology and medicine ed. by Soldano Ferrone ... |
| title_full_unstemmed | Handbook of monoclonal antibodies applications in biology and medicine ed. by Soldano Ferrone ... |
| title_short | Handbook of monoclonal antibodies |
| title_sort | handbook of monoclonal antibodies applications in biology and medicine |
| title_sub | applications in biology and medicine |
| topic | Monoclonal Antibodies cabt Antibodies, Monoclonal Monoclonal antibodies Handbooks, manuals, etc Monoklonaler Antikörper (DE-588)4040094-3 gnd |
| topic_facet | Monoclonal Antibodies Antibodies, Monoclonal Monoclonal antibodies Handbooks, manuals, etc Monoklonaler Antikörper |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000242784&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ferronesoldano handbookofmonoclonalantibodiesapplicationsinbiologyandmedicine |