Drug dynamics for analytical, clinical, and biological chemists:
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York u.a.
Dekker
1984
|
| Edition: | 1. print. |
| Series: | Drugs and the pharmaceutical sciences
26 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VII, 176 S. |
| ISBN: | 0824772393 |
Staff View
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| 650 | 4 | |a Pharmaceutical Preparations |x metabolism | |
| 650 | 4 | |a Pharmacokinetics | |
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Record in the Search Index
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| adam_text | DRUG DYNAMICS FOR ANALYTICAL, CLINICAL, AND BIOLOGICAL CHEMISTS BENJAMIN
J. GUDZINOWICZ BURROWS T. YOUNKIN, JR. DEVELOPMENT GROUP CLINICAL
CHEMISTRY SECTION DEPARTMENT OF PATHOLOGY RHODE ISLAND HOSPITAL
PROVIDENCE, RHODE ISLAND MICHAEL J. GUDZINOWICZ UNIVERSITY OF TEXAS
SYSTEM CANCER CENTER SCIENCE PARK-RESEARCH DIVISION SMITHVILLE, TEXAS
U MIVERSITATS- BIBLIOTHEK MARCEL DEKKER, INC. NEW YORK AND BASEL R
CONTENTS PREFACE III INTRODUCTION 1 1. DRUG ADMINISTRATION: ROUTES OF
ENTRY 3 I. PARENTERAL ROUTES OF ADMINISTRATION 3 INTRAVASCULAR
ADMINISTRATION / INTRA-ARTERIAL ADMINISTRATION / INTRAMUSCULAR
ADMINISTRATION / SUBCUTANEOUS ADMINISTRATION / INTRADERMAL
ADMINISTRATION / TOPICAL (PERCUTANEOUS) ADMIN- ISTRATION / DRUG
ADMINISTRATION BY INHALATION II. ENTERAL ROUTES OF ADMINISTRATION 6
SUBLINGUAL ADMINISTRATION / ORAL ADMINISTRATION / RECTAL ADMINISTRATION
2. PRINCIPLES GOVERNING DRUG ABSORPTION AND DISTRIBUTION 9 I.
PHYSICOCHEMICAL PROPERTIES 11 IONIZATION / LIPID SOLUBILITY / MOLECULAR
SHAPE AND SIZE VI CONTENTS II. DRUG TRANSFER SYSTEMS 16 III. KINETICS OF
DRUG ABSORPTION 19 ZERO-ORDER ABSORPTION KINETICS FOR CONSTANT INFUSIONS
/ FIRST-ORDER ABSORPTION KINETICS AFTER SINGLE-DOSE ADMINISTRATION IV.
DISTRIBUTION OF DRUGS IN THE BODY 24 APPARENT VOLUME OF DISTRIBUTION /
UNEQUAL DISTRIBUTION OF DRUGS 3. MAJOR PATHWAYS OF AND FACTORS
INFLUENCING BIOTRANS- FORMATION OF DRUGS 41 I. ENZYMATIC SYSTEMS FOR
DRUG BIOTRANSFORMATION 45 ENZYMATIC INHIBITION / ENZYMATIC STIMULATION
II. FACTORS AFFECTING DRUG BIOTRANSFORMATION 54 GENETIC FACTORS
(PHARMACOGENETICS) / AGE DIFFERENCES / SEX DIFFERENCES / SPECIES
DIFFERENCES / STRAIN DIFFERENCES / OTHER FACTORS III. PATHWAYS OF DRUG
BIOTRANSFORMATION 58 NONSYNTHETIC-METABOLIZING REACTIONS / SYNTHETIC
REACTIONS T. ELIMINATION OR EXCRETION OF DRUGS 77 I. PULMONARY
DISPOSITION OF DRUGS 77 II. RENAL DISPOSITION OF DRUGS 79 I III. HEPATIC
DISPOSITION OF DRUGS 81 IV. KINETICS OF DRUG ELIMINATION 82 FIRST-ORDER
KINETICS / ZERO-ORDER KINETICS / BIOLOGIC OR ELIMINATION HALF-LIFE 5.
MECHANISMS OF DRUG ACTION 103 I. DRUG RECEPTORS 103 II. BINDING FORCES
OF DRUG-RECEPTOR INTERACTIONS 103 CONTENTS VII III. DRUG
STRUCTURE-BIOLOGICAL ACTIVITY RELATIONSHIP 108 STRUCTURALLY SPECIFIC
DRUGS / STRUCTURALLY NONSPECIFIC DRUGS IV. THEORIES OF DRUG ACTION 116
OCCUPANCY THEORY / RATE THEORY / INDUCED-FIT THEORY / MACROMOLECULAR
PERTURBATION THEORY V. CHARACTERIZATION OF DRUG EFFECTS 124
DOSE-RESPONSE RELATIONSHIPS / RESPONSE-TIME OR DOSE-TIME RELATIONSHIPS
REFERENCES 139 AUTHOR INDEX 149 SUBJECT INDEX 155
|
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| indexdate | 2024-07-09T15:12:47Z |
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| isbn | 0824772393 |
| language | English |
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| physical | VII, 176 S. |
| publishDate | 1984 |
| publishDateSearch | 1984 |
| publishDateSort | 1984 |
| publisher | Dekker |
| record_format | marc |
| series | Drugs and the pharmaceutical sciences |
| series2 | Drugs and the pharmaceutical sciences |
| spelling | Gudzinowicz, Benjamin J. Verfasser aut Drug dynamics for analytical, clinical, and biological chemists 1. print. New York u.a. Dekker 1984 VII, 176 S. txt rdacontent n rdamedia nc rdacarrier Drugs and the pharmaceutical sciences 26 Médicaments - Métabolisme Pharmacocinétique Drugs Metabolism Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacology Pharmakodynamik (DE-588)4174134-1 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Pharmakodynamik (DE-588)4174134-1 s DE-604 Younkin, Burrows T. Verfasser aut Gudzinowicz, Michael J. Verfasser aut Drugs and the pharmaceutical sciences 26 (DE-604)BV000002008 26 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000219465&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gudzinowicz, Benjamin J. Younkin, Burrows T. Gudzinowicz, Michael J. Drug dynamics for analytical, clinical, and biological chemists Drugs and the pharmaceutical sciences Médicaments - Métabolisme Pharmacocinétique Drugs Metabolism Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacology Pharmakodynamik (DE-588)4174134-1 gnd |
| subject_GND | (DE-588)4174134-1 (DE-588)4151278-9 |
| title | Drug dynamics for analytical, clinical, and biological chemists |
| title_auth | Drug dynamics for analytical, clinical, and biological chemists |
| title_exact_search | Drug dynamics for analytical, clinical, and biological chemists |
| title_full | Drug dynamics for analytical, clinical, and biological chemists |
| title_fullStr | Drug dynamics for analytical, clinical, and biological chemists |
| title_full_unstemmed | Drug dynamics for analytical, clinical, and biological chemists |
| title_short | Drug dynamics for analytical, clinical, and biological chemists |
| title_sort | drug dynamics for analytical clinical and biological chemists |
| topic | Médicaments - Métabolisme Pharmacocinétique Drugs Metabolism Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacology Pharmakodynamik (DE-588)4174134-1 gnd |
| topic_facet | Médicaments - Métabolisme Pharmacocinétique Drugs Metabolism Pharmaceutical Preparations metabolism Pharmacokinetics Pharmacology Pharmakodynamik Einführung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000219465&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000002008 |
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