Genes:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York [u.a.]
Wiley
1985
|
| Edition: | 2. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XV, 716 S. Ill., zahlr. graph. Darst. |
| ISBN: | 0471807893 |
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MARC
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Record in the Search Index
| _version_ | 1804114761516843008 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
PART1 DNA AS A STORE OF INFORMATION
CHAPTER 1 DNA IS THE GENETIC MATERIAL HEREDITY WORKS THROUGH
MACROMOLECULES PROTEINS FUNCTION THROUGH THEIR
CONFORMATION HOW DO PROTEINS ACQUIRE THE CORRECT CONFORMATION? THE
DISCOVERY OF DNA
DNA IS THE (ALMOST) UNIVERSAL GENETIC MATERIAL THE COMPONENTS OF DNA DNA
IS A DOUBLE HELIX
DNA REPLICATION IS SEMICONSERVATIVE
CHAPTER 2
GENES ARE CARRIED ON CHROMOSOMES DISCOVERY OF THE GENE THE ROLE OF
CHROMOSOMES IN HEREDITY
EACH GENE LIES ON A SPECIFIC CHROMOSOME GENES LIE IN A LINEAR ARRAY THE
GENETIC MAP IS CONTINUOUS ONE GENE-ONE PROTEIN A DETAILED DEFINITION:
THE CISTRON
A NOTE ABOUT TERMINOLOGY
3 4
9
12
13 15 17 20
25 26 28 33
33 38 38 40 42
CHAPTER 3 MUTATIONS CHANGE THE SEQUENCE OF DNA 43
THE GENETIC CODE IS READ IN TRIPLETS 44
POINT MUTATIONS CHANGE SINGLE BASE PAIRS 45 MUTATIONS ARE CONCENTRATED
AT HOTSPOTS 48 THE RATE OF MUTATION 50
CHAPTER 4
THE TOPOLOGY OF NUCLEIC ACIDS 52 SINGLE STRANDED NUCLEIC ACIDS MAY HAVE
SECONDARY STRUCTURE 52
INVERTED REPEATS AND SECONDARY STRUCTURE 54 DUPLEX DNA HAS ALTERNATIVE
DOUBLE-HELICAL STRUCTURES 57
A LEFT-HANDED FORM OF DNA 59
CLOSED DNA CAN BE SUPERCOILED 60
SUPERCOILING INFLUENCES THE STRUCTURE OF THE DOUBLE HELIX 62
DNA CAN BE DENATURED AND RENATURED 63 NUCLEIC ACIDS HYBRIDIZE BY BASE
PAIRING 65
CHAPTER 5
ISOLATING THE GENE 67
RESTRICTION ENZYMES CLEAVE DNA INTO SPECIFIC FRAGMENTS 68
CONSTRUCTING A RESTRICTION MAP FROM THE FRAGMENTS 70
RESTRICTION SITES CAN BE USED AS GENETIC MARKERS 73
IX
IMAGE 2
CONTENTS
OBTAINING THE SEQUENCE OF DNA 76
PROKARYOTIC GENES AND PROTEINS ARE COLIN EAR 79
EUKARYOTIC GENES CAN BE INTERRUPTED 81 SOME DNA SEQUENCES CODE FOR MORE
THAN ONE PROTEIN 82
THE SCOPE OF THE PARADIGM 83
PART 2
T U R N I NG G E N ES I N TO P R O T E I NS ES
CHAPTER 6 BREAKING THE GENETIC CODE 87
PROTEINS ARE SYNTHESIZED IN ONE DIRECTION 88 THE SEARCH FOR MESSENGER
RNA 88
TRANSFER RNA IS THE ADAPTOR 89
RIBOSOMES TRAVEL IN CONVOY 91
MOST CODONS REPRESENT AMINO ACIDS 94
IS THE CODE UNIVERSAL? 97
CHAPTER 7
THE ASSEMBLY LINE FOR PROTEIN SYNTHESIS 99
THE RIBOSOMAL SITES OF ACTION 99
STARTING THE POLYPEPTIDE CHAIN 100
INITIATION NEEDS 30S SUBUNITS AND ACCESSORY FACTORS 102
THE BRIEF FREEDOM OF 30S SUBUNITS IS CONTROLLED BY IF3 104
IF2 PICKS OUT THE INITIATOR TRNA 105
EUKARYOTIC INITIATION INVOLVES MANY FACTORS 106 ELONGATION: T FACTOR
BRINGS AMINOACYL-TRNA INTO THE A SITE 108
TRANSLOCATION MOVES THE RIBOSOME 110 FINISHING OFF: THREE CODONS
TERMINATE PROTEIN SYNTHESIS 113
CHAPTER 8
TRANSFER RNA: THE TRANSLATIONAL ADAPTOR 115 THE UNIVERSAL CLOVERLEAF 116
THE TERTIARY STRUCTURE IS. L-SHAPED 116
HOW DO SYNTHETASES RECOGNIZE TRNAS? 120 DISCRIMINATION IN THE CHARGING
STEP 121
CODON-ANTICODON RECOGNITION INVOLVES WOBBLING 123
TRNA CONTAINS MANY MODIFIED BASES 125
BASE MODIFICATION MAY CONTROL CODON RECOGNITION 127
MITOCHONDRIA HAVE MINIMAL TRNA SETS 127 MUTANT TRNAS READ DIFFERENT
CODONS 129 SUPPRESSOR TRNAS COMPETE FOR THEIR CODONS 132 TRNA MAY
INFLUENCE THE READING FRAME 133
CHAPTER 9
THE RIBOSOME TRANSLATION FACTORY 136
RIBOSOMES ARE COMPACT RIBONUCLEOPROTEIN PARTICLES 137
RIBOSOMAL PROTEINS INTERACT WITH RRNA 139 RECONSTITUTION IN VITRO MIMICS
ASSEMBLY IN VIVO 143
SUBUNIT ASSEMBLY IS LINKED TO TOPOLOGY 144 ALL RIBOSOMAL COMPONENTS CAN
BE MUTATED 145 RIBOSOMES HAVE SEVERAL ACTIVE CENTERS 147 THE ACCURACY OF
TRANSLATION 149
CHAPTER 10
THE MESSENGER RNA TEMPLATE 151 THE TRANSIENCE OF BACTERIAL MESSENGERS
151 MOST BACTERIAL MRNAS ARE POLYCISTRONIC 153 TRANSLATION OF
POLYCISTRONIC MESSENGERS 155
A FUNCTIONAL DEFINITION FOR EUKARYOTIC MRNA 156 THE POWER OF IN VITRO
TRANSLATION SYSTEMS 158 MOST EUKARYOTIC MRNAS ARE POLYADENYLATED AT THE
3 END 159
ALL EUKARYOTIC MRNAS HAVE A METHYLATED CAP AT THE 5 END 161
INITIATION MAY INVOLVE BASE PAIRING BETWEEN MRNA AND RRNA 163
SMALL SUBUNITS MAY MIGRATE TO INITIATION SITES ON EUKARYOTIC MRNA 165
PROTEIN SYNTHESIS IS LINKED TO CELLULAR LOCATION 166
PART 3
PRODUCING THE TEMPLATE 171 CHAPTER 11 RNA POLYMERASES: THE BASIC
TRANSCRIPTION APPARATUS TRANSCRIPTION IS CATALYZED BY RNA
POLYMERASE SIGMA FACTOR CONTROLS BINDING TO DNA CORE ENZYME SYNTHESIZES
RNA COMPLEX EUKARYOTIC RNA POLYMERASES
CHAPTER 12
PROMOTERS: THE SITES FOR CONTROLLING INITIATION BINDING SITES FOR E.
COLI RNA POLYMERASE CONSENSUS SEQUENCES IN E. COLI PROMOTERS
FUNCTIONS OF THE CONSENSUS SEQUENCES SUBSTITUTION OF SIGMA FACTORS MAY
CONTROL INITIATION PROMOTERS FOR RNA POLYMERASE II ARE
UPSTREAM OF THE STARTPOINT
173
173 176 178 180
182 183 185 188
191
196
IMAGE 3
CONTENTS
XI
RNA POLYMERASE II PROMOTERS ARE MULTIPARTITE 199 ENHANCERS ARE
BIDIRECTIONAL ELEMENTS THAT ASSIST INITIATION 201
A DOWNSTREAM PROMOTER FOR RNA POLYMERASE III 203
CHAPTER 13 TERMINATION AND ANTITERMINATION 206
TWO TERMINATION MODES IN E. COLI INVOLVE PALINDROMES 207
HOW DOES RHO FACTOR WORK? 208
ANTITERMINATION DEPENDS ON SPECIFIC SITES 211 MORE SUBUNITS FOR RNA
POLYMERASE? 215 DIFFICULTIES IN EUKARYOTES 217
PART 4
C O N T R O L L I NG P R O K A R Y O T IC GENE E X P R E S S I ON 219
CHAPTER 14 THE OPERON: THE LACTOSE PARADIGM INDUCTION AND REPRESSION ARE
CONTROLLED BY
SMALL MOLECULES STRUCTURAL GENES ARE CONTROLLED BY REGULATOR GENES THE
CONTROL CIRCUIT OF THE OPERON CONSTITUTIVE MUTATIONS DEFINE REPRESSOR
ACTION THE OPERATOR IS C/S-DOMINANT UNINDUCIBLE MUTATIONS CAN OCCUR IN
THE PROMOTER OR REPRESSOR
HOW DOES REPRESSOR BLOCK TRANSCRIPTION? CONTACTS IN THE OPERATOR THE
INTERACTION OF REPRESSOR SUBUNITS REPRESSOR AS A DNA-BINDING PROTEIN
GETTING OFF DNA STORING SURPLUS REPRESSOR A PARADOX OF INDUCTION
CHAPTER 15 CONTROL CIRCUITS: A PANOPLY OF OPERONS DISTINGUISHING
POSITIVE AND NEGATIVE CONTROL THE TRYPTOPHAN OPERON IS REPRESSIBLE THE
TRYPTOPHAN OPERON IS CONTROLLED BY
ATTENUATION ALTERNATIVE SECONDARY STRUCTURES CONTROL ATTENUATION THE
GENERALITY OF ATTENUATION
REPRESSION CAN OCCUR AT MULTIPLE LOCI CATABOLITE REPRESSION INVOLVES
POSITIVE REGULATION AT THE PROMOTER
221
221
222 224
224 227
228 228 230 231 232 233 234 236
237 237 239
241
241 246 248
249
AUTOGENOUS CONTROL OF RIBOSOMAL PROTEIN TRANSLATION 251
AUTOGENOUS CONTROL AND MACROMOLECULAR ASSEMBLIES 253
HARD TIMES PROVOKE THE STRINGENT RESPONSE 254
CHAPTER 16
LYTIC CASCADES AND LYSOGENIC REPRESSION 256
LYTIC DEVELOPMENT IS CONTROLLED BY A CASCADE 257
FUNCTIONAL CLUSTERING IN PHAGES T7 AND T4 259 THE LAMBDA LYTIC CASCADE
RELIES ON ANTITERMINATION 259
LYSOGENY IS MAINTAINED BY AN AUTOGENOUS CIRCUIT 263
REPRESSOR IS A DIMER THAT BINDS COOPERATIVELY AT EACH OPERATOR 266 HOW
IS REPRESSOR SYNTHESIS ESTABLISHED? 271 ANTIREPRESSOR IS NEEDED FOR
LYTIC INFECTION 273 A DELICATE BALANCE: LYSOGENY VERSUS LYSIS 276
PART 5 CONSTITUTION OF THE EUKARYOTIC GENOME 279
CHAPTER 17 THE EXTRAORDINARY POWER OF DNA TECHNOLOGY 281
ANY DNA SEQUENCE CAN BE CLONED IN BACTERIA 281 CONSTRUCTING THE CHIMERIC
DNA 283
COPYING MRNA INTO DNA 286
ISOLATING SPECIFIC GENES FROM THE GENOME 287 WALKING ALONG THE
CHROMOSOME 289
EUKARYOTIC GENES CAN BE TRANSLATED IN BACTERIA 291
CHAPTER 18
EUKARYOTIC GENOMES: A CONTINUUM OF SEQUENCES 293
THE C-VALUE PARADOX DESCRIBES VARIATIONS IN GENOME SIZE 293
REASSOCIATION KINETICS DEPEND ON SEQUENCE COMPLEXITY 295
EUKARYOTIC GENOMES CONTAIN SEVERAL SEQUENCE COMPONENTS 297
NONREPETITIVE DNA COMPLEXITY CAN ESTIMATE GENOME SIZE 298
EUKARYOTIC GENOMES CONTAIN REPETITIVE SEQUENCES 299
MODERATELY REPETITIVE DNA CONSISTS OF MANY DIFFERENT SEQUENCES 299
MEMBERS OF REPETITIVE SEQUENCE FAMILIES ARE RELATED BUT NOT IDENTICAL
301
IMAGE 4
XII
CONTENTS
CHAPTER 19
STRUCTURAL GENES: AS REPRESENTED IN MRNA 304
MOST STRUCTURAL GENES LIE IN NONREPETITIVE DNA 305
HOW MANY NONREPETITIVE GENES ARE EXPRESSED? 306
ESTIMATING GENE NUMBERS BY THE KINETICS OF RNA-DRIVEN REACTIONS 307
GENES ARE EXPRESSED AT WIDELY VARYING LEVELS 309 OVERLAPS BETWEEN MRNA
POPULATIONS 310
CHAPTER 20
THE ORGANIZATION OF INTERRUPTED GENES 312
VISUALIZING INTERRUPTED GENES BY ELECTRON MICROSCOPY 313
RESTRICTION MAPPING OF INTERRUPTED GENES 315 CHARACTERIZING GENOMIC DNA
FRAGMENTS 319 GENES COME IN ALL SHAPES AND SIZES 320
INTRONS IN GENES CODING FOR RRNA AND TRNA 322 EXON-INTRON JUNCTIONS HAVE
A CONSENSUS SEQUENCE 323
ONE GENE S INTRON CAN BE ANOTHER GENE S EXON 324
MUTATIONS MAP MOSTLY IN EXONS 327
COMPLEX LOCI ARE EXTREMELY LARGE AND INVOLVED IN REGULATION 329
HOW DID INTERRUPTED GENES EVOLVE? 333
PART 6
CLUSTERS OF RELATED SEQUENCES 33?
CHAPTER 21 STRUCTURAL GENES BELONG TO FAMILIES 341
GLOBIN GENES ARE ORGANIZED IN TWO CLUSTERS 342 UNEQUAL CROSSING-OVER
REARRANGES GENE CLUSTERS 344
MANY A-THALASSEMIAS RESULT FROM UNEQUAL CROSSING-OVER 346
NEW GENES ARE GENERATED IN *-THALASSEMIAS 346 GENE CLUSTERS SUFFER
CONTINUAL REORGANIZATION 347
SEQUENCE DIVERGENCE DISTINGUISHES TWO TYPES OF SITES IN DNA 349
THE EVOLUTIONARY CLOCK TRACES THE DEVELOPMENT OF GLOBIN GENES 350
MECHANISMS FOR MAINTAINING ACTIVE SEQUENCES 352
PSEUDOGENES ARE DEAD ENDS OF EVOLUTION 353 GENE FAMILIES ARE COMMON FOR
ABUNDANT PROTEINS 355
CHAPTER 22
GENOMES SEQUESTERED IN ORGANELLES 357
ORGANELLE GENES SHOW NONMENDELIAN INHERITANCE 357
ORGANELLE GENOMES ARE CIRCULAR DNA MOLECULES 358
ORGANELLES EXPRESS THEIR OWN GENES 359 THE LARGE MITOCHONDRIAL GENOME OF
YEAST 362 THE COMPACT MITOCHONDRIAL GENOME OF MAMMALS 363
RECOMBINATION OCCURS IN (SOME) ORGANELLE DNAS 365
REARRANGEMENTS OF YEAST MITOCHONDRIAL DNA 366
CHAPTER 23
IDENTITY AND VARIATION IN TANDEM GENE CLUSTERS 368 A VARIETY OF TANDEM
GENE CLUSTERS CODE FOR HISTONES 369
GENES FOR RRNA AND TRNA ARE REPEATED 371 A TANDEM REPEATING UNIT
CONTAINS BOTH RRNA GENES 372
SOME RRNA GENES ARE EXTRACHROMOSOMAL 374 ABOUT NONTRANSCRIBED SPACERS
AND PROMOTERS 375
5S GENES AND PSEUDOGENES ARE INTERSPERSED 376 AN EVOLUTIONARY DILEMMA
377
BACTERIAL RRNA GENES FORM MIXED OPERONS WITH TRNA GENES 378
TRNA GENES MAY LIE IN CLUSTERS 379
CHAPTER 24
ORGANIZATION OF SIMPLE SEQUENCE DNA 381
HIGHLY REPETITIVE DNA FORMS SATELLITES 382 SATELLITE DNA OFTEN LIES IN
HETEROCHROMATIN 383 ARTHROPOD SATELLITES HAVE VERY SHORT IDENTICAL
REPEATS 384
MAMMALIAN SATELLITES CONSIST OF HIERARCHICAL REPEATS 385
RECONSTRUCTING THE STAGES OF MOUSE SATELLITE DNA EVOLUTION 386
VARIATIONS IN THE PRESENT REPEATING UNIT 388 THE CONSEQUENCES OF UNEQUAL
CROSSING OVER 389 CROSSOVER FIXATION COULD MAINTAIN IDENTICAL REPEATS
391
IMAGE 5
CONTENTS
XIII
PART 7 REACHING MATURITY: RNA PROCESSING 393
CHAPTER 25 CUTTING AND TRIMMING STABLE RNA PROSPHODIESTER BONOS CAN BE
CLEAVED ON
EITHER SIDE RNAASE III RELEASES THE PHAGE T7 EARLY MRNAS RNAASE III
SEPARATES RRNAS FROM THEIR PRECURSOR CLEAVAGE SITES IN THE PATHWAY FOR
EUKARYOTIC
RRNA RELEASE TRNAS ARE CUT AND TRIMMED BY SEVERAL ENZYMES
CHAPTER 26 RNA AS CATALYST: MECHANISMS OF RNA SPLICING
YEAST TRNA SPLICING INVOLVES CUTTING AND REJOINING THE EXTRAORDINARY
SPLICING OF TETRAHYMENA RRNA
RNA AS CATALYST: AN EXTENSION OF BIOCHEMICAL CATALYSIS AN INTRON THAT
MAY CODE FOR A REGULATOR PROTEIN
NUCLEAR RNA SPLICING FOLLOWS PREFERRED PATHWAYS MUTATIONS IN CONSENSUS
SEQUENCES AFFECT SPLICING
NUCLEAR SPLICING JUNCTIONS MAY BE INTERCHANGEABLE IS SNRNA INVOLVED IN
SPLICING?
CHAPTER 27
CONTROL OF RNA PROCESSING HNRNA IS LARGE AND UNSTABLE MRNA IS DERIVED
FROM HNRNA POLYADENYLATION AND THE GENERATION OF 3
ENDS HNRNA IS MORE COMPLEX THAN MRNA IS THERE CONTROL AFTER
TRANSCRIPTION? MODELS FOR CONTROLLING GENE EXPRESSION THE POTENTIAL OF
CELLULAR POLYPROTEINS
PART 8
THE PACKAGING OF PNA
395
396 396
399
400
402
405
406
410
412
413
418
420
421 424
429 429 431
433 435 436
437 440
445
CHAPTER 28 ABOUT GENOMES AND CHROMOSOMES 447
CONDENSING VIRAL GENOMES INTO THEIR COATS 448 THE BACTERIALGENOME IS A
NUCLEOID WITH MANY SUPERCOILED LOOPS 451
THE CONTRAST BETWEEN INTERPHASE CHROMATIN AND MITOTIC CHROMOSOMES 454
THE EUKARYOTIC CHROMOSOME AS A SEGREGATION DEVICE 458
THE EXTENDED STATE OF LAMPBRUSH CHROMOSOMES 462
POLYTENY FORMS GIANT CHROMOSOMES 463 TRANSCRIPTION DISRUPTS CHROMOSOME
STRUCTURE 465
CHAPTER 29
CHROMATIN STRUCTURE: THE NUCLEOSOME 468
THE PROTEIN COMPONENTS OF CHROMATIN 469 CHROMATIN CONTAINS DISCRETE
PARTICLES 470 THE NUCLEOSOME IS THE BASIC SUBUNIT OF ALL CHROMATIN 471
THE CORE PARTICLE IS HIGHLY CONSERVED 473 DNA IS COILED AROUND THE
HISTONE OCTAMER 474 DNA IS SYMMETRICALLY EXPOSED TO NUCLEASES 477 THE
UNRESOLVED QUESTION OF THE PERIODICITY
OF DNA 479
THE ARRANGEMENT OF HISTONES AND DNA 480 ARE NUCLEOSOMES ARRANGED IN
PHASE? 481 THE PATH OF NUCLEOSOMES IN THE CHROMATIN FIBER 485
LOOPS, DOMAINS, AND SCAFFOLDS 488
CHAPTER 30 THE NATURE OF ACTIVE CHROMATIN 489
NUCLEOSOME ASSEMBLY VERSUS CHROMATIN REPRODUCTION 490
NUCLEOSOME ASSEMBLY REQUIRES NONHISTONE PROTEINS 491
ARE TRANSCRIBED GENES ORGANIZED IN NUCLEOSOMES? 494
THE DNAASE-SENSITIVE DOMAINS OF TRANSCRIBABLE CHROMATIN 497
NONHISTONE PROTEINS CONFER DNAASE SENSITIVITY 499
HISTONES SUFFER TRANSIENT MODIFICATIONS 500 H2A IS CONJUGATED WITH
UBIQUITIN ON A SUBSET OF NUCLEOSOMES 502
GENE EXPRESSION IS ASSOCIATED WITH DEMETHYLATION 503
SOME MODELS FOR THE CONTROL OF METHYLATION 504 DNAASE HYPERSENSITIVE
SITES LIE UPSTREAM FROM ACTIVE PROMOTERS 506
HYPERSENSITIVE SITES EXCLUDE NUCLEOSOMES 508 SPECULATIONS ABOUT THE
NATURE OF GENE ACTIVATION 511
IMAGE 6
XIV
CONTENTS
PART 9 PERPETUATION OF DNA 513
CHAPTER 31 THE REPLICON: UNIT OF REPLICATION
SEQUENTIAL REPLICATION FORMS EYES THE BACTERIAL GENOME IS A SINGLE
REPLICON CONNECTING REPLICATION TO THE CELL CYCLE EACH EUKARYOTIC
CHROMOSOME CONTAINS MANY
REPLICONS ISOLATING THE ORIGINS OF YEAST REPLICONS REPLICATION CAN
PROCEED THROUGH EYES,
ROLLING CIRCLES, OR D LOOPS PLASMID INCOMPATIBILITY IS CONNECTED WITH
COPY NUMBER
CHAPTER 32
THE APPARATUS FOR DNA REPLICATION EUKARYOTIC DNA POLYMERASES PROKARYOTIC
DNA POLYMERASES HAVE SEVERAL
ENZYMATIC ACTIVITIES DNA SYNTHESIS IS SEMIDISCONTINUOUS OKAZAKI
FRAGMENTS ARE PRIMED BY RNA THE COMPLEXITY OF THE BACTERIAL REPLICATION
APPARATUS INITIATING SYNTHESIS OF A SINGLE DNA STRAND MOVEMENT OF THE
PRIMOSOME INITIATING REPLICATION AT DUPLEX ORIGINS THE REPLICATION
APPARATUS OF PHAGE T4
THE REPLICATION APPARATUS OF PHAGE T7 THE PROBLEM OF LINEAR REPLICONS
CHAPTER 33 SYSTEMS THAT SAFEGUARD DNA THE OPERATION OF RESTRICTION AND
MODIFICATION
THE ALTERNATE ACTIVITIES OF TYPE I ENZYMES THE DUAL ACTIVITIES OF TYPE
III ENZYMES DEALING WITH INJURIES IN DNA EXCISION-REPAIR SYSTEMS IN E.
COLI
RECOMBINATION-REPAIR SYSTEMS IN E. COLI AN SOS SYSTEM OF MANY GENES
MAMMALIAN REPAIR SYSTEMS
CHAPTER 34 RECOMBINATION AND OTHER TOPOLOGICAL MANIPULATIONS OF DNA
TOPOLOGICAL MANIPULATION OF DNA GYRASE INTRODUCES NEGATIVE SUPERCOILS IN
DNA
515 516 517 519
521 523
525
527
532 533
533 537 539
541 542 544 547 551 552 553
557
558 560 563
564 566 569 570
572
573 574
577
RECOMBINATION REQUIRES SYNAPSIS OF HOMOLOGOUS DUPLEX DNAS 578
BREAKAGE AND REUNION INVOLVES HETERODUPLEX DNA 580
DO DOUBLE-STRAND BREAKS INITIATE RECOMBINATION? 582
ISOLATION OF RECOMBINATION INTERMEDIATES 584 THE STRAND-EXCHANGE
FACILITY OF RECA 586 RECA AND THE CONDITIONS OF RECOMBINATION 588 GENE
CONVERSION ACCOUNTS FOR INTERALLELIC
RECOMBINATION 590
SPECIALIZED RECOMBINATION RECOGNIZES SPECIFIC SITES 592
STAGGERED BREAKAGE AND REUNION IN THE CORE 594
PART 10 THE DYNAMIC GENOME: DNA IN F L UX 599
CHAPTER 35 TRANSPOSABLE ELEMENTS IN BACTERIA 601
THE DISCOVERY OF TRANSPOSITION IN BACTERIA 602 INSERTION SEQUENCES ARE
BASIC TRANSPOSONS 603 COMPOSITE TRANSPOSONS HAVE IS MODULES 605 ONLY ONE
MODULE OF TN10 IS FUNCTIONAL 607 THE MODULES OF TN5 ARE ALMOST IDENTICAL
BUT
VERY DIFFERENT 608
TRANSPOSITION INVOLVES REPLICATIVE RECOMBINATION 609
TRANSPOSITION OF TN3 PROCEEDS BY COINTEGRATE RESOLUTION 612
SOME UNUSUAL FEATURES OF TRANSPOSING PHAGE MU 616
SALMONELLA PHASE VARIATION OCCURS BY INVERSION 617
CHAPTER 36 MOBILE ELEMENTS IN EUKARYOTES 621
YEAST TY ELEMENTS RESEMBLE BACTERIAL TRANSPOSONS 622
SEVERAL TYPES OF TRANSPOSABLE ELEMENTS RESIDE IN D. MELANOGASTER 623
THE ROLE OF TRANSPOSABLE ELEMENTS IN HYBRID DYSGENESIS 626
THE RETROVIRUS LIFE CYCLE INVOLVES TRANSPOSITION-LIKE EVENTS 627
RETROVIRUSES MAY TRANSDUCE CELLULAR SEQUENCES 630
RNA-DEPENDENT TRANSPOSITIONS MAY HAVE OCCURRED IN THE CELL 631
THE ALU FAMILY 633
IMAGE 7
CONTENTS
XV
CONTROLLING ELEMENTS IN MAIZE ARE TRANSPOSABLE 634
DS MAY TRANSPOSE OR CAUSE CHROMOSOME BREAKAGE 636
DS TRANSPOSITION IS CONNECTED WITH REPLICATION 638
YEAST HAS SILENT AND ACTIVE LOCI FOR MATING TYPE 640
SILENT AND ACTIVE CASSETTES HAVE THE SAME SEQUENCES 642
UNIDIRECTIONAL TRANSPOSITION IS INITIATED BY THE RECIPIENT MAT LOCUS 644
CHAPTER 37 REARRANGEMENTS AND THE GENERATION OF IMMUNE DIVERSITY 646
ORGANIZATION OF IMMUNOGLOBULINS 647
IMMUNOGLOBULIN GENES ARE ASSEMBLED FROM THEIR PARTS 649
THE DIVERSITY OF GERM-LINE INFORMATION 652 JOINING REACTIONS GENERATE
ADDITIONAL DIVERSITY 654
RECOMBINATION OF V AND C GENES GENERATES DELETIONS AND REARRANGEMENTS
655
SOME POSSIBLE CAUSES OF ALLELIC EXCLUSION 658
FURTHER DNA RECOMBINATION CAUSES CLASS SWITCHING 659
REARRANGEMENT IS RESPONSIBLE FOR ACTIVATING IG GENES 660
EARLY HEAVY-CHAIN EXPRESSION CAN BE CHANGED BY RNA PROCESSING 661
SOMATIC MUTATION GENERATES ADDITIONAL DIVERSITY 663
T-CELL RECEPTOR IS RELATED TO IMMUNOGLOBULINS 665
COMPLEXITY OF MAJOR HISTOCOMPATIBILITY LOCI 665
CHAPTER 38 ENGINEERING CHANGES IN THE GENOME 668
TISSUE-SPECIFIC VARIATIONS OCCUR IN THE DROSOPHILA GENOME 668
SELECTION OF AMPLIFIED GENOMIC SEQUENCES 671 EXOGENOUS SEQUENCES CAN BE
INTRODUCED BY TRANSFECTION 675
TRANSFECTED DNA CAN ENTER THE GERM LINE 677
GLOSSARY 681
INDEX 695
|
| any_adam_object | 1 |
| author | Lewin, Benjamin |
| author_facet | Lewin, Benjamin |
| author_role | aut |
| author_sort | Lewin, Benjamin |
| author_variant | b l bl |
| building | Verbundindex |
| bvnumber | BV000296831 |
| callnumber-first | Q - Science |
| callnumber-label | QH430 |
| callnumber-raw | QH430 |
| callnumber-search | QH430 |
| callnumber-sort | QH 3430 |
| callnumber-subject | QH - Natural History and Biology |
| classification_rvk | WG 1700 |
| classification_tum | BIO 180f |
| ctrlnum | (OCoLC)11030563 (DE-599)BVBBV000296831 |
| dewey-full | 575.1 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 575 - Specific parts of & systems in plants |
| dewey-raw | 575.1 |
| dewey-search | 575.1 |
| dewey-sort | 3575.1 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 2. ed. |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV000296831 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T15:11:51Z |
| institution | BVB |
| isbn | 0471807893 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-000180868 |
| oclc_num | 11030563 |
| open_access_boolean | |
| owner | DE-12 DE-703 DE-20 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-M49 DE-BY-TUM DE-29 DE-188 |
| owner_facet | DE-12 DE-703 DE-20 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-M49 DE-BY-TUM DE-29 DE-188 |
| physical | XV, 716 S. Ill., zahlr. graph. Darst. |
| publishDate | 1985 |
| publishDateSearch | 1985 |
| publishDateSort | 1985 |
| publisher | Wiley |
| record_format | marc |
| spelling | Lewin, Benjamin Verfasser aut Genes Benjamin Lewin 2. ed. New York [u.a.] Wiley 1985 XV, 716 S. Ill., zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genetica gtt Génétique Genetics Molekulargenetik (DE-588)4039987-4 gnd rswk-swf Gen (DE-588)4128987-0 gnd rswk-swf Genetik (DE-588)4071711-2 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Genetik (DE-588)4071711-2 s DE-604 Molekulargenetik (DE-588)4039987-4 s DE-188 Gen (DE-588)4128987-0 s 1\p DE-604 SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000180868&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Lewin, Benjamin Genes Genetica gtt Génétique Genetics Molekulargenetik (DE-588)4039987-4 gnd Gen (DE-588)4128987-0 gnd Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)4039987-4 (DE-588)4128987-0 (DE-588)4071711-2 (DE-588)4123623-3 |
| title | Genes |
| title_auth | Genes |
| title_exact_search | Genes |
| title_full | Genes Benjamin Lewin |
| title_fullStr | Genes Benjamin Lewin |
| title_full_unstemmed | Genes Benjamin Lewin |
| title_short | Genes |
| title_sort | genes |
| topic | Genetica gtt Génétique Genetics Molekulargenetik (DE-588)4039987-4 gnd Gen (DE-588)4128987-0 gnd Genetik (DE-588)4071711-2 gnd |
| topic_facet | Genetica Génétique Genetics Molekulargenetik Gen Genetik Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000180868&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT lewinbenjamin genes |