Enzyme catalysis and regulation:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York u.a.
Acad. Pr.
1982
|
| Series: | Molecular biology
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | X, 263 S. graph. Darst. |
| ISBN: | 0123219620 0123219604 |
Staff View
MARC
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| 650 | 4 | |a Catalysis | |
| 650 | 4 | |a Enzyme Activation | |
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Record in the Search Index
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|---|---|
| adam_text | IMAGE 1
CONTENTS
PREFACE IX
1. PROTEIN STRUCTURE AND DYNAMICS
REFERENCES 13
GENERAL REFERENCES ON PROTEINS AND ENZYMES 13
2. PROBES OF ENZYME STRUCTURE
INTRODUCTION 14
AMINO ACID SEQUENCING 14
X-RAY CRYSTALLOGRAPHY 15
CHEMICAL MODIFICATION 16
OPTICAL SPECTROSCOPY 20
NUCLEAR MAGNETIC RESONANCE 26
SPIN LABELS 35
REFERENCES 37
3. STEADY-STATE ENZYME KINETICS
INTRODUCTION 38
SINGLE SUBSTRATE-SINGLE PRODUCT 38
V
1
IMAGE 2
VI CONTENTS
KING-ALTMAN METHOD 42
INHIBITION OF ENZYME CATALYSIS 44
MULTIPLE SUBSTRATES 48
ISOTOPE EXCHANGE AT EQUILIBRIUM 52
PH DEPENDENCE OF ENZYME CATALYSIS 54
TEMPERATURE DEPENDENCE OF ENZYME CATALYSIS 59
CONCLUSION 59
REFERENCES 60
4. TRANSIENT KINETIC METHODS FOR STUDYING ENZYMES
INTRODUCTION 61
RAPID MIXING METHODS 61
CHEMICAL RELAXATION METHODS 64
GENERAL SOLUTIONS OF KINETIC EQUATIONS 67
RATE EQUATIONS NEAR EQUILIBRIUM 69
REFERENCES 75
5. SOME CHEMICAL ASPECTS OF ENZYME CATALYSIS
CATALYSIS 76
ACID-BASE CATALYSIS 77
NUCLEOPHILIC CATALYSIS 87
ELECTROPHILIC CATALYSIS 89
STEREOCHEMISTRY 90
KINETIC ISOTOPE EFFECTS 94
REFERENCES 98
6. ELEMENTARY STEPS IN ENZYME CATALYSIS
INTRODUCTION 99
BINDING OF SUBSTRATES 99
CONFORMATIONAL CHANGES 102
ACID-BASE CATALYSIS 105
COVALENT INTERMEDIATES 106
ADVANTAGES OF ENZYMES 107
REFERENCES 108
IMAGE 3
CONTENTS VUE
7. CASE STUDIES OF SELECTED ENZYME MECHANISMS
INTRODUCTION 110
PANCREATIC RIBONUCLEASE 110
CHYMOTRYPSIN 121
LYSOZYME 132
CREATINE KINASE 143
REFERENCES 149
8. REGULATION OF ENZYME ACTIVITY
INTRODUCTION 152
EXPERIMENTAL MANIFESTATIONS OF REGULATORY ENZYMES 156 EQUILIBRIUM
BINDING ISOTHERMS 161
MOLECULAR MODELS FOR ALLOSTERISM 166
STEADY-STATE KINETICS 173
PROTEIN POLYMERIZATION-DEPOLYMERIZATION 175
HYSTERETIC ENZYMES 176
TRANSIENT KINETICS 179
CONCLUSION 185
REFERENCES 186
9. CASE STUDIES OF SELECTED REGULATORY ENZYMES
INTRODUCTION 187
ASPARTATE TRANSCARBAMOYLASE 187
PHOSPHOFRUCTOKINASE 200
REFERENCES 207
1 0. MULTIENZYME COMPLEXES
INTRODUCTION 209
GENERAL MECHANISTIC PRINCIPLES 210
TRYPTOPHAN SYNTHASE 212
PYRUVATE AND A-KETOGLUTARATE DEHYDROGENASE 214
FATTY ACID SYNTHASE 220
CONCLUSION 224
REFERENCES 224
IMAGE 4
VUEI CONTENTS
1 1. MEMBRANE-BOUND ENZYMES
INTRODUCTION 226
MEMBRANE STRUCTURE AND FUNCTION 227
SS -HYDROXYBUTYRATE DEHYDROGENASE 229
(NA + + K + )-ACTIVATED ATPASE 231
ATP SYNTHESIS 236
ADENYLATE CYCLASE 241
CONCLUSION 244
REFERENCES 245
APPENDIX: PRACTICE PROBLEMS 247
INDEX 257
|
| any_adam_object | 1 |
| author | Hammes, Gordon G. |
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| dewey-ones | 574 - [Unassigned] |
| dewey-raw | 574.19/25 |
| dewey-search | 574.19/25 |
| dewey-sort | 3574.19 225 |
| dewey-tens | 570 - Biology |
| discipline | Chemie / Pharmazie Biologie |
| format | Book |
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| indexdate | 2024-07-09T15:07:32Z |
| institution | BVB |
| isbn | 0123219620 0123219604 |
| language | English |
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| physical | X, 263 S. graph. Darst. |
| publishDate | 1982 |
| publishDateSearch | 1982 |
| publishDateSort | 1982 |
| publisher | Acad. Pr. |
| record_format | marc |
| series2 | Molecular biology |
| spelling | Hammes, Gordon G. Verfasser aut Enzyme catalysis and regulation New York u.a. Acad. Pr. 1982 X, 263 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology Enzymes Régulation (Biologie) Biological control systems Catalysis Enzyme Activation Enzymes Regulation Enzym (DE-588)4014988-2 gnd rswk-swf Enzymkatalyse (DE-588)4152480-9 gnd rswk-swf Enzymatische Regulation (DE-588)4136839-3 gnd rswk-swf Enzymatische Regulation (DE-588)4136839-3 s DE-604 Enzymkatalyse (DE-588)4152480-9 s Enzym (DE-588)4014988-2 s SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=000007306&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hammes, Gordon G. Enzyme catalysis and regulation Enzymes Régulation (Biologie) Biological control systems Catalysis Enzyme Activation Enzymes Regulation Enzym (DE-588)4014988-2 gnd Enzymkatalyse (DE-588)4152480-9 gnd Enzymatische Regulation (DE-588)4136839-3 gnd |
| subject_GND | (DE-588)4014988-2 (DE-588)4152480-9 (DE-588)4136839-3 |
| title | Enzyme catalysis and regulation |
| title_auth | Enzyme catalysis and regulation |
| title_exact_search | Enzyme catalysis and regulation |
| title_full | Enzyme catalysis and regulation |
| title_fullStr | Enzyme catalysis and regulation |
| title_full_unstemmed | Enzyme catalysis and regulation |
| title_short | Enzyme catalysis and regulation |
| title_sort | enzyme catalysis and regulation |
| topic | Enzymes Régulation (Biologie) Biological control systems Catalysis Enzyme Activation Enzymes Regulation Enzym (DE-588)4014988-2 gnd Enzymkatalyse (DE-588)4152480-9 gnd Enzymatische Regulation (DE-588)4136839-3 gnd |
| topic_facet | Enzymes Régulation (Biologie) Biological control systems Catalysis Enzyme Activation Enzymes Regulation Enzym Enzymkatalyse Enzymatische Regulation |
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