Verfügbarkeit: Lasso Peptides

Lasso Peptides: Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds

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Bibliographische Detailangaben
Hauptverfasser:	Li, Yanyan (VerfasserIn), Zirah, Séverine (VerfasserIn), Rebuffat, Sylvie (VerfasserIn)
Format:	Elektronisch E-Book
Sprache:	English
Veröffentlicht:	New York, NY [u.a.] Springer 2015
Schriftenreihe:	SpringerBriefs in Microbiology
Schlagworte:	Medizin Medicine Immunology Microbiology Vaccines Biomedicine
Online-Zugang:	TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract
Beschreibung:	1 Online-Ressource
ISBN:	9781493910106
DOI:	10.1007/978-1-4939-1010-6

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Datensatz im Suchindex

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adam_text	LASSO PEPTIDES / LI, YANYAN : 2015 TABLE OF CONTENTS / INHALTSVERZEICHNIS OVERVIEW ON LASSO PEPTIDE RESEARCH FROM THE PRODUCER MICROORGANISMS TO THE LASSO SCAFFOLD BIOLOGICAL ACTIVITIES OF LASSO PEPTIDES AND STRUCTURE-ACTIVITY RELATIONSHIPS BIOSYNTHESIS, REGULATION AND EXPORT OF LASSO PEPTIDES LASSO PEPTIDE BIOENGINEERING AND BIOPROSPECTING DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. LASSO PEPTIDES / LI, YANYAN : 2015 ABSTRACT / INHALTSTEXT LASSO PEPTIDES FORM A GROWING FAMILY OF FASCINATING RIBOSOMALLY-SYNTHESIZED AND POST-TRANSLATIONALLY MODIFIED PEPTIDES PRODUCED BY BACTERIA. THEY CONTAIN 15 TO 24 RESIDUES AND SHARE A UNIQUE INTERLOCKED TOPOLOGY THAT INVOLVES AN N-TERMINAL 7 TO 9-RESIDUE MACROLACTAM RING WHERE THE C-TERMINAL TAIL IS THREADED AND IRREVERSIBLY TRAPPED. THE RING RESULTS FROM THE CONDENSATION OF THE N-TERMINAL AMINO GROUP WITH A SIDE-CHAIN CARBOXYLATE OF A GLUTAMATE AT POSITION 8 OR 9, OR AN ASPARTATE AT POSITION 7, 8 OR 9. THE TRAPPING OF THE TAIL INVOLVES BULKY AMINO ACIDS LOCATED IN THE TAIL BELOW AND ABOVE THE RING AND/OR DISULFIDE BRIDGES CONNECTING THE RING AND THE TAIL. LASSO PEPTIDES ARE SUBDIVIDED INTO THREE SUBTYPES DEPENDING ON THE ABSENCE (CLASS II) OR PRESENCE OF ONE (CLASS III) OR TWO (CLASS I) DISULFIDE BRIDGES. THE LASSO TOPOLOGY RESULTS IN HIGHLY COMPACT STRUCTURES THAT GIVE TO LASSO PEPTIDES AN EXTRAORDINARY STABILITY TOWARDS BOTH PROTEASE DEGRADATION AND DENATURING CONDITIONS.LASSO PEPTIDES ARE GENERALLY RECEPTOR ANTAGONISTS, ENZYME INHIBITORS AND/OR ANTIBACTERIAL OR ANTIVIRAL (ANTI-HIV) AGENTS. THE LASSO SCAFFOLD AND THE ASSOCIATED BIOLOGICAL ACTIVITIES SHOWN BY LASSO PEPTIDES ON DIFFERENT KEY TARGETS MAKE THEM PROMISING MOLECULES WITH HIGH THERAPEUTIC POTENTIAL. THEIR APPLICATION IN DRUG DESIGN HAS BEEN EXEMPLIFIED BY THE DEVELOPMENT OF AN INTEGRIN ANTAGONIST BASED ON A LASSO PEPTIDE SCAFFOLD. THE BIOSYNTHESIS MACHINERY OF LASSO PEPTIDES IS THEREFORE OF HIGH BIOTECHNOLOGICAL INTEREST, ESPECIALLY SINCE SUCH HIGHLY COMPACT AND STABLE STRUCTURES HAVE TO DATE REVEALED INACCESSIBLE BY PEPTIDE SYNTHESIS. LASSO PEPTIDES ARE PRODUCED FROM A LINEAR PRECURSOR LASA, WHICH UNDERGOES A MATURATION PROCESS INVOLVING SEVERAL STEPS, IN PARTICULAR CLEAVAGE OF THE LEADER PEPTIDE AND CYCLIZATION.THE POST-TRANSLATIONAL MODIFICATIONS ARE ENSURED BY A DEDICATED ENZYMATIC MACHINERY, WHICH IS COMPOSED OF AN ATP-DEPENDENT CYSTEINE PROTEASE (LASB) AND A LACTAM SYNTHETASE (LASC) THAT FORM AN ENZYMATIC COMPLEX CALLED LASSO SYNTHETASE. MICROCIN J25, PRODUCED BY ESCHERICHIA COLI AY25, IS THE ARCHETYPE OF LASSO PEPTIDES AND THE MOST EXTENSIVELY STUDIED. TO DATE ONLY AROUND FORTY LASSO PEPTIDES HAVE BEEN ISOLATED, BUT GENOME MINING APPROACHES HAVE REVEALED THAT THEY ARE WIDELY DISTRIBUTED AMONG PROTEOBACTERIA AND ACTINOBACTERIA, PARTICULARLY IN STREPTOMYCES, MAKING AVAILABLE A RICH RESOURCE OF NOVEL LASSO PEPTIDES AND ENZYME MACHINERIES TOWARDS LASSO TOPOLOGIES DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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author	Li, Yanyan Zirah, Séverine Rebuffat, Sylvie
author_GND	(DE-588)138577188
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dewey-full	616.9041
dewey-hundreds	600 - Technology (Applied sciences)
dewey-ones	616 - Diseases
dewey-raw	616.9041
dewey-search	616.9041
dewey-sort	3616.9041
dewey-tens	610 - Medicine and health
discipline	Biologie Medizin
doi_str_mv	10.1007/978-1-4939-1010-6
format	Electronic eBook
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spelling	Li, Yanyan Verfasser (DE-588)138577188 aut Lasso Peptides Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds Yanyan Li ; Séverine Zirah ; Sylvie Rebuffat New York, NY [u.a.] Springer 2015 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier SpringerBriefs in Microbiology Medizin Medicine Immunology Microbiology Vaccines Biomedicine Zirah, Séverine Verfasser aut Rebuffat, Sylvie Verfasser aut Erscheint auch als Druckausgabe 978-1-4939-1009-0 https://doi.org/10.1007/978-1-4939-1010-6 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027669014&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027669014&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	Li, Yanyan Zirah, Séverine Rebuffat, Sylvie Lasso Peptides Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds Medizin Medicine Immunology Microbiology Vaccines Biomedicine
title	Lasso Peptides Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds
title_auth	Lasso Peptides Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds
title_exact_search	Lasso Peptides Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds
title_full	Lasso Peptides Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds Yanyan Li ; Séverine Zirah ; Sylvie Rebuffat
title_fullStr	Lasso Peptides Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds Yanyan Li ; Séverine Zirah ; Sylvie Rebuffat
title_full_unstemmed	Lasso Peptides Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds Yanyan Li ; Séverine Zirah ; Sylvie Rebuffat
title_short	Lasso Peptides
title_sort	lasso peptides bacterial strategies to make and maintain bioactive entangled scaffolds
title_sub	Bacterial Strategies to Make and Maintain Bioactive Entangled Scaffolds
topic	Medizin Medicine Immunology Microbiology Vaccines Biomedicine
topic_facet	Medizin Medicine Immunology Microbiology Vaccines Biomedicine
url	https://doi.org/10.1007/978-1-4939-1010-6 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027669014&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027669014&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA
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