Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones:
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | Volltext Inhaltsverzeichnis |
| Beschreibung: | 251 S. |
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MARC
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| 100 | 1 | |a Zhang, Guoliang |d 1982- |e Verfasser |0 (DE-588)1026230640 |4 aut | |
| 245 | 1 | 0 | |a Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones |c von Guoliang Zhang |
| 246 | 1 | 3 | |a Phytochemische Untersuchungen an zwei Ancistrocladus-Arten, Semi-Synthese dimerer Naphthylisochinolin-Alkaloide und Strukturoptimierung von antitumoralen Naphthochinonen |
| 264 | 1 | |c 2012 | |
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| 502 | |a Würzburg, Univ., Diss., 2012 | ||
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| 650 | 0 | 7 | |a Naphthylisochinolinalkaloide |0 (DE-588)4286335-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Ancistrocladaceae |0 (DE-588)4205738-3 |2 gnd |9 rswk-swf |
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| 689 | 0 | 1 | |a Naphthylisochinolinalkaloide |0 (DE-588)4286335-1 |D s |
| 689 | 0 | 2 | |a Naphthochinone |0 (DE-588)4348353-7 |D s |
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Datensatz im Suchindex
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|---|---|
| adam_text | IMAGE 1
CONTENTS
GENERAL INTRODUCTION 1
1 INTRODUCTION 1
1.1 NATURAL PRODUCT CHEMISTRY 1
1.2 ANCISTROCLADACEAE AND DIONCOPHYLLACEAE 3
2 MULTIPLE MYELOMA AND NAPHTHOQUINONES 7
RESULTS AND DISCUSSION 16
3 ISOLATION AND CHARACTERIZATION O F NAPHTHYLISOQUINOLINE ALKALOIDS FROM
THE CHINESE ANCISTROCLADUS TECTORIUS SPECIES 16
3.1 NAPHTHYLISOQUINOLINE ALKALOIDS FROM A. TECTORIUS 16
3.2 RESULTS AND DISCUSSION 18
3.3 CONCLUSION 29
4 ISOLATION AND CHARACTERIZATION O F NAPHTHYLISOQUINOLINE ALKALOIDS FROM
A
CONGOLESE ANCISTROCLADUS SPECIES 30
4.1 NAPHTHYLISOQUINOLINE ALKALOIDS FROM AN AFRICAN ANCISTROCLADUS
SPECIES 30 4.2 RESULTS AND DISCUSSION 31
4.3 CONCLUSION 36
4.4 BIOACTIVITIES O F THE NEW NATURALLY OCCURRING ALKALOIDS 37
5 SEMI-SYNTHESIS O F UNPRECEDENTED DIMERIC NAPHTHYLISOQUINOLINE
ALKALOIDS 40
5.1 SYNTHESIS O F JOZIMINE A2 (85) AND ITS 3 -EP/-ATROPO-DIASTEREOMER
(3 -EP/-85) 41 5.2 SYNTHESIS O F JOZIMINE A3 (93) 43
5.3 ONE-STEP SYNTHESIS O F DIONCOTETRALONES A (94A) AND B (94B) 45
5.4 FURTHER SEMI-SYNTHESES FROM DIONCOPHYLLINE A (6) 47
5.5 BIOACTIVITIES O F THE SYNTHETIC ALKALOIDS 48
6 ISOLATION AND CHARACTERIZATION O F NAPHTHOQUINONES FROM CELL CULTURES
O F TRIPHYOPHYLLUM PELTATUM 50
6.1 COMPOUNDS ISOLATED FROM CELL CULTURES O F T. PELTATUM 50
6.2 T. PELTATUM 50
6.3 RESULTS AND DISCUSSION 51
6.4 CONCLUSION ; 54
7 PHYTOCHEMICAL INVESTIGATIONS ON NEPENTHACEAE 55
7.1 INTRODUCTION AND RESULTS 55
7.2 CONCLUSION 56
8 SYNTHESIS O F DIONCOQUINONES B (10) AND C (102), AND THEIR ANALOGS 57
8.1 SYNTHESIS O F DIONCOQUINONES B (10) AND C (102) 57
HTTP://D-NB.INFO/1027152279
IMAGE 2
8.2 SYNTHESIS O F ANALOGS O F DIONCOQUINONE B (10) 61
8.3 SAR STUDIES OF PREPARED NAPHTHOQUINONES 64
8.4 CONCLUSION 67
9 SYNTHESIS O F EPOXIDES AND SAR STUDIES 68
10 TOTAL SYNTHESIS O F TRIPHOQUINONE (187A) 71
10.1 INTRODUCTION 71
10.2 RETROSYNTHETIC ANALYSIS 71
10.3 SYNTHESIS O F BIARYLS 72
10.4 CONCLUSION 77
11 CYCLODYSIDINS A - D , CYCLIC LIPOPEPTIDES FROM THE STREPTOMYCES
STRAIN
RV15 DERIVED FROM A MARINE SPONGE 78
11.1 CYCLIC PEPTIDES FROM STREPTOMYCES STRAIN 78
11.2 RESULTS AND DISCUSSION 78
11.3 CONCLUSION 82
12 SUMMARY 83
13 ZUSAMMENFASSUNG 92
EXPERIMENTAL SECTION 101
1 GENERAL ASPECTS 101
1.1 ANALYTICAL APPARATUSES 101
1.2 OTHER APPARATUSES 102
1.3 CHROMATOGRAPHICAL METHODS 103
1.4 CHEMICALS 103
1.5 CELL CULTURES O F T. PELTATUM 104
2 PHYTOCHEMICAL INVESTIGATION ON A. TECTORIUS 106
2.1 EXTRACTION AND ISOLATION 106
2.2 ANCISTECTORINE AI (60) 108
2.3 IV -METHYLANCISTECTORINE AI (61) 109
2.4 ANCISTECTORINE A2 (62A) 110
2.5 5-E/ Z-ANCISTECTORINE A2 (62B) 111
2.6 4 - 9-DEMETHYLANCISTECTORINE A2 (63) 112
2.7 ANCISTECTORINE A3 (64) 113
2.8 ANCISTECTORINE BI (65) 114
2.9 ANCISTECTORINE CI (66) 115
2.10 5-EP/-ANCISTROLIKOKINE D (67) 116
2.11 KNOWN ALKALOIDS 117
3 PHYTOCHEMICAL INVESTIGATION ON A CONGOLESE ANCISTROCLADUS SPECIES....
137
3.1 EXTRACTION AND ISOLATION 137
3.2 6-O-DEMETHYLANCISTROBREVINE C (84) 137
3.3 JOZIMINE A2 (85) 138
3.4 KNOWN ALKALOIDS 140
IMAGE 3
4 SEMI-SYNTHESIS OF DIMERIC NAPHTHYLISOQUINOLINE ALKALOIDS 142
4.1 SYNTHESIS O F JOZIMINE A2 (85) AND ITS 3 -EPIMER 3 -EP/-85 142
4.2 SYNTHESIS O F JOZIMINE A3 (93) 147
4.3 SYNTHESIS O F DIONCOTETRALONES A (94A) AND B (94B) 149
4.4 SYNTHESIS O F 4 ,5 -0,0-DIDEMETHYIDIONCOPHYLLINE A(99A/99B) 151
5 PHYTOCHEMICAL INVESTIGATION ON T. PELTATUM 153
5.1 EXTRACTION AND ISOLATION 153
5.2 DIONCOQUINONE C (102)... 154
5.3 DIONCOQUINONE D (103) 154
5.4 DIONCOQUINONE E (104) 155
5.5 TRIPHOQUINOL A (107) 156
5.6 KNOWN COMPOUNDS 156
6 PHYTOCHEMICAL INVESTIGATION ON N. ALATA 160
6.1 EXTRACTION AND ISO LATION 160
6.2 KNOWN COMPOUNDS 160
7 SYNTHESIS O F NAPHTHOQUINONES 163
7.1 SYNTHESIS O F THE DIONCOQUINONE B PRECURSOR 42 163
7.2 SYNTHESIS O F DIONCOQUINONE C (102) 166
7.3 SYNTHESIS O F THE DIONCOQUINONE B ANALOG 151 176
7.4 SYNTHESIS O F THE DIONCOQUINONE B ANALOGS 155 AND 161 186
7.5 SYNTHESIS O F THE DIONCOQUINONE B ANALOGS 171 AND 173 198
8 SYNTHESIS O F TRIPHOQUINONE (187A) 207
9 CYCLODYSIDINS A - D 223
9.1 CYCLODYSIDIN A (216) 223
9.2 CYCLODYSIDIN B (217) 224
8.3 CYCLODYSIDIN C (218) 224
9.4 CYCLODYSIDIN D (219) 224
LITERATURE 228
ACKNOWLEDGEMENTS 245
PUBLICATIONS 247
POSTERS AND ORAL PRESENTATIONS AT CONGRESSES AND SYMPOSIA 248
WORKSHOPS 249
CURRICULUM VITAE 250
AFFIDAVIT 251
|
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| spelling | Zhang, Guoliang 1982- Verfasser (DE-588)1026230640 aut Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones von Guoliang Zhang Phytochemische Untersuchungen an zwei Ancistrocladus-Arten, Semi-Synthese dimerer Naphthylisochinolin-Alkaloide und Strukturoptimierung von antitumoralen Naphthochinonen 2012 251 S. txt rdacontent n rdamedia nc rdacarrier Würzburg, Univ., Diss., 2012 Naphthochinone (DE-588)4348353-7 gnd rswk-swf Naphthylisochinolinalkaloide (DE-588)4286335-1 gnd rswk-swf Ancistrocladaceae (DE-588)4205738-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Ancistrocladaceae (DE-588)4205738-3 s Naphthylisochinolinalkaloide (DE-588)4286335-1 s Naphthochinone (DE-588)4348353-7 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-72734 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-72734 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025286843&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Zhang, Guoliang 1982- Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones Naphthochinone (DE-588)4348353-7 gnd Naphthylisochinolinalkaloide (DE-588)4286335-1 gnd Ancistrocladaceae (DE-588)4205738-3 gnd |
| subject_GND | (DE-588)4348353-7 (DE-588)4286335-1 (DE-588)4205738-3 (DE-588)4113937-9 |
| title | Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones |
| title_alt | Phytochemische Untersuchungen an zwei Ancistrocladus-Arten, Semi-Synthese dimerer Naphthylisochinolin-Alkaloide und Strukturoptimierung von antitumoralen Naphthochinonen |
| title_auth | Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones |
| title_exact_search | Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones |
| title_full | Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones von Guoliang Zhang |
| title_fullStr | Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones von Guoliang Zhang |
| title_full_unstemmed | Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones von Guoliang Zhang |
| title_short | Phytochemical Research on Two Ancistrocladus Species, Semi-Synthesis of Dimeric Naphthylisoquinoline Alkaloids, and Structure Optimization of Antitumoral Naphthoquinones |
| title_sort | phytochemical research on two ancistrocladus species semi synthesis of dimeric naphthylisoquinoline alkaloids and structure optimization of antitumoral naphthoquinones |
| topic | Naphthochinone (DE-588)4348353-7 gnd Naphthylisochinolinalkaloide (DE-588)4286335-1 gnd Ancistrocladaceae (DE-588)4205738-3 gnd |
| topic_facet | Naphthochinone Naphthylisochinolinalkaloide Ancistrocladaceae Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-72734 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025286843&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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