Multiscale modeling of vascular dynamics of micro- and nano-particles: application to drug delivery system
Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
San Rafael, CA
Morgan & Claypool Publishers
[2019]
|
| Ausgabe: | Version: 20191201 |
| Schriftenreihe: | IOP Concise Physics
|
| Schlagworte: | |
| Online-Zugang: | UBT01 Volltext |
| Zusammenfassung: | Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles, adhesion on the endothelium wall, and subsequent internalization into diseased cells. To study the transport and adhesion of particles in vasculature, the authors of this book have made great effort to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This text discusses the recent achievements from the establishment of fundamental physical problems to the development of a multiscale model and, finally, large-scale simulations for understanding the transport of particle-based drug carriers in blood flow |
| Beschreibung: | 1 Online-Ressource Illustrationen, Diagramme |
| ISBN: | 9781643277929 9781643277905 |
| DOI: | 10.1088/2053-2571/ab4124 |
Internformat
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| 250 | |a Version: 20191201 | ||
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| 520 | 3 | |a Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles, adhesion on the endothelium wall, and subsequent internalization into diseased cells. To study the transport and adhesion of particles in vasculature, the authors of this book have made great effort to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This text discusses the recent achievements from the establishment of fundamental physical problems to the development of a multiscale model and, finally, large-scale simulations for understanding the transport of particle-based drug carriers in blood flow | |
| 653 | 0 | |a Drug targeting | |
| 653 | 0 | |a Drug carriers (Pharmacy) | |
| 653 | 0 | |a Nanoparticles ; Therapeutic use | |
| 653 | 0 | |a Blood-vessels | |
| 653 | 0 | |a Biomechanics | |
| 653 | 0 | |a Biomedical materials ; Mechanical properties | |
| 653 | 0 | |a Multiscale modeling | |
| 653 | 0 | |a Drug Delivery Systems | |
| 653 | 0 | |a Drug Carriers | |
| 653 | 0 | |a Nanoparticles ; therapeutic use | |
| 653 | 0 | |a Blood Vessels ; physiology | |
| 653 | 0 | |a Biocompatible Materials | |
| 653 | 0 | |a Biomechanical Phenomena | |
| 653 | 0 | |a Models, Anatomic | |
| 653 | 0 | |a Models, Biological | |
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| illustrated | Not Illustrated |
| index_date | 2024-07-03T15:28:56Z |
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| isbn | 9781643277929 9781643277905 |
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| spelling | Ye, Huilin Verfasser aut Multiscale modeling of vascular dynamics of micro- and nano-particles application to drug delivery system Huilin Ye, Zhiqiang Shen and Ying Li (University of Connecticut, Storrs, CT, USA) Version: 20191201 San Rafael, CA Morgan & Claypool Publishers [2019] 1 Online-Ressource Illustrationen, Diagramme txt rdacontent c rdamedia cr rdacarrier IOP Concise Physics Recent advances in this exciting field see the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance efficacy and specificity, the control and guidance of drug carriers in vasculature become crucial. The current bottlenecks in the optimal design of drug-carrying particles are lack of knowledge about the transport of particles, adhesion on the endothelium wall, and subsequent internalization into diseased cells. To study the transport and adhesion of particles in vasculature, the authors of this book have made great effort to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This text discusses the recent achievements from the establishment of fundamental physical problems to the development of a multiscale model and, finally, large-scale simulations for understanding the transport of particle-based drug carriers in blood flow Drug targeting Drug carriers (Pharmacy) Nanoparticles ; Therapeutic use Blood-vessels Biomechanics Biomedical materials ; Mechanical properties Multiscale modeling Drug Delivery Systems Drug Carriers Nanoparticles ; therapeutic use Blood Vessels ; physiology Biocompatible Materials Biomechanical Phenomena Models, Anatomic Models, Biological Biophysics ; bicssc SCIENCE / Life Sciences / Biophysics ; bisacsh Shen, Zhiqiang Verfasser aut Li, Ying Verfasser aut Erscheint auch als Druck-Ausgabe 978-1-64327-789-9 Erscheint auch als Druck-Ausgabe, PoD 978-0-7503-3019-0 Erscheint auch als Druck-Ausgabe, myPrint 978-0-7503-2696-4 https://doi.org/10.1088/2053-2571/ab4124 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Ye, Huilin Shen, Zhiqiang Li, Ying Multiscale modeling of vascular dynamics of micro- and nano-particles application to drug delivery system |
| title | Multiscale modeling of vascular dynamics of micro- and nano-particles application to drug delivery system |
| title_auth | Multiscale modeling of vascular dynamics of micro- and nano-particles application to drug delivery system |
| title_exact_search | Multiscale modeling of vascular dynamics of micro- and nano-particles application to drug delivery system |
| title_exact_search_txtP | Multiscale modeling of vascular dynamics of micro- and nano-particles application to drug delivery system |
| title_full | Multiscale modeling of vascular dynamics of micro- and nano-particles application to drug delivery system Huilin Ye, Zhiqiang Shen and Ying Li (University of Connecticut, Storrs, CT, USA) |
| title_fullStr | Multiscale modeling of vascular dynamics of micro- and nano-particles application to drug delivery system Huilin Ye, Zhiqiang Shen and Ying Li (University of Connecticut, Storrs, CT, USA) |
| title_full_unstemmed | Multiscale modeling of vascular dynamics of micro- and nano-particles application to drug delivery system Huilin Ye, Zhiqiang Shen and Ying Li (University of Connecticut, Storrs, CT, USA) |
| title_short | Multiscale modeling of vascular dynamics of micro- and nano-particles |
| title_sort | multiscale modeling of vascular dynamics of micro and nano particles application to drug delivery system |
| title_sub | application to drug delivery system |
| url | https://doi.org/10.1088/2053-2571/ab4124 |
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