Dynamic insight into naïve lymphocyte extravasation in vivo:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Münster
2016
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | 125 Seiten Illustrationen 30 cm |
Internformat
MARC
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| 100 | 1 | |a Yan, Li-Sue Serena |d 1982- |e Verfasser |0 (DE-588)1102925349 |4 aut | |
| 245 | 1 | 0 | |a Dynamic insight into naïve lymphocyte extravasation in vivo |c Li-Sue Serena Yan |
| 264 | 1 | |a Münster |c 2016 | |
| 300 | |a 125 Seiten |b Illustrationen |c 30 cm | ||
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Datensatz im Suchindex
| _version_ | 1804176476990341120 |
|---|---|
| adam_text | CONTENTS
INTRODUCTION.................................................................................................................................-
9 -
1.1
BACKGROUND........................................................................................................................-
9 -
1.2 SPECIALIZED LYMPHOID TISSUE STRUCTURES
.......................................................................
-11 -
1.2.1 THE HIGH ENDOTHELIAL VENULES (HEVS)
......................................................................
-13 -
1.2.2 THE STROMAL
NETWORKS...............................................................................................-1
6 -
1.2.3 THE
LYMPHATICS..........................................................................................................-
1 6 *
1.3 ENTRY OF IMMUNE CELLS THROUGH HEVS
...........................................................................
-17 -
1.3.1 HEV
CHARACTERISTICS...................................................................................................-1
8 -
1.3.2 HEVS * PATHOPHYSIOLOGICAL CONDITIONS
...................................................................
-19 -
1.3.3
ENTRYOFTANDBCELLS.................................................................................................-2
1 -
1.3.4 ENTRY OF OTHER MMUNE CELL TYPES
...........................................................................
- 23 -
1.4 DCS REGULATE IMMUNE CELL ENTRY THROUGH HEVS
...........................................................
- 24-
1.4.1 DENDRITIC CELL
TRAFFICKING............................................................................................-2
4 -
1.4.2 MAINTENANCE OF HEV
PHENOTYPE............................................................................
- 26 -
1.4.3 CONTROLLING LYMPHOCYTE HOMING TO
LNS.................................................................. -
27 -
1.5 INTRANODAL MIGRATION OF
LYMPHOCYTES............................................................................-28
-
1.5.1 T CELLS
TRAFFICKING.......................................................................................................-2
9 -
1.5.2 B CELL
TRAFFICKING........................................................................................................-
31-
1.5.3 DENDRITIC CELL
TRAFFICKING............................................................................................-32
-
1.6 EGRESS THROUGH EFFERENT
LYMPHATICS.......................................................
***********-33-
1.7 LYMPHOCYTE TRANSENDOTHELIAL MIGRATION
.......................................................................
- 35 -
1.8 DYNAMIC
IMMUNO-LMAGING..............................................................................................-
* *
-
1.9 AIM
OFTHESIS...................................................................................................................-40
-
MATERIALS AND
METHODS.............................................................................................................-
41 -
2.1
INTRODUCTION.....................................................................................................................-4
2 -
2.2 DEVELOPMENT AND OVERVIEW OF THE MAGE SYSTEM
........................................................
- 43 -
2.3 CONFOCAL INTRAVITAL MICROSCOPY (IVM) OF MURINE INGUINAL LYMPH
NODE... - 44-
2.4 APPLICATIONS OF THE
METHOD.............................................................................................-4
5 -
2.5 COMPARISON WITH OTHER
METHODS......................................................................................-
45 -
2.6 LIMITATIONS OF THE
APPROACH..............................................................................................-
46 -
2.7 EXPERIMENTAL
DESIGN........................................................................................................-4
7 -
2.7.1 LABELING WITH FLUORESCENT INTRAVITAL MARKERS
..........................................................
- 48 -
2.7.2 CHOICE OF
FLUOROPHORES.............................................................................................-4
9 -
2.7.3 PREPARATION AND INJECTION OF LEUKOCYTES
...................................................................
- 49 -
2.7.4 CHEMOKINE INDUCTION OF IN VIVO TRANSMIGRATION
........................................................
- 50 -
2.7.5 VISUALIZING LYMPH NODE VASCULATURE (HEVS & BASEMENT MEMBRANE)
.....- 50 -
2.7.6 CONFOCAL INTRAVITAL MICROSCOPY OF MURINE INGUINAL LYMPH NODE
.....- 51 -
2.7.7 DURATION OF CONTINUOUS
IMAGING.................................................................................-
52 -
2.7.8 STATISTICAL
ANALYSIS.....................................................................................................-5
2 -
2.8
MATERIALS.........................................................................................................................-
53 -
2.8.1
REAGENTS...................................................................................................................-
53 -
2.8.2
EQUIPMENT................................................................................................................-5
4 -
2.8.3
MICROSCOPE...............................................................................................................-5
4 -
2.8.4 REAGENT
SET-UP.........................................................................................................-5
5 -
2.9
PROCEDURE...........................................................................................................
****-5 6 -
2.10 ANTICIPATED
RESULTS........................................................................................................-6
2 -
RESULTS..........................................................................................................................................-
69 -
3.1 REAL-TIME IMAGING AND ANALYSIS OF HEV ULTRASTRUCTURE IN
VIVO.......................................- 69 -
3.2 FOUR-DIMENSIONAL IMAGING FOR ANALYSIS OF HEVS N VIVO
.................................................
- 74 -
3.3 CCL19*INDUCED MIGRATION OF ADOPTIVE TRANSFERRED LYMPHOCYTES TOWARDS
SUPERFICIAL HEVS.-
* * -
3.4 HEVS ARE SITES OF HIGH CELLULAR FLU X
...................................................................................
- 81 -
3.5 HEV POCKETS ARE FORMED BY ACCUMULATED LYMPHOCYTES
..................................................
- 83
-
3.6 FOUR-DIMENSIONAL IMAGING FOR ANALYSIS OF LEUKOCYTE *** N VIVO
.................................
- 85 -
3.7 NAIVE LYMPHOCYTE MAINLY USE PARACEHULAR *** IN VIVO
................................................
- 88 -
3.8 LYMPHOCYTES UNDERGO SHAPE CHANGE DURING ***
...........................................................
- 93 -
3.9 REALTIME FORMATION OF HEV
POCKETS.................................................................................-
95 -
3.10 HEV POCKET
LOCATION........................................................................................................-
99 -
DISCUSSION................................................................................................................................*
102 *
TRAFFICKING OF MMUNE CELLS N NFLAMED LYMPH NODES
........................................................
-104 -
REFERENCES...............................................................................................................................-109-
LIST OF TABLES AND
FIGURES........................................................................................................-120
-
ABBREVIATION............................................................................................................................-122-
|
| any_adam_object | 1 |
| author | Yan, Li-Sue Serena 1982- |
| author_GND | (DE-588)1102925349 |
| author_facet | Yan, Li-Sue Serena 1982- |
| author_role | aut |
| author_sort | Yan, Li-Sue Serena 1982- |
| author_variant | l s s y lss lssy |
| building | Verbundindex |
| bvnumber | BV043697579 |
| ctrlnum | (OCoLC)956312305 (DE-599)DNB1104174227 |
| dewey-full | 571.966 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.966 |
| dewey-search | 571.966 |
| dewey-sort | 3571.966 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Thesis Book |
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| indexdate | 2024-07-10T07:32:48Z |
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| language | English |
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| physical | 125 Seiten Illustrationen 30 cm |
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| spelling | Yan, Li-Sue Serena 1982- Verfasser (DE-588)1102925349 aut Dynamic insight into naïve lymphocyte extravasation in vivo Li-Sue Serena Yan Münster 2016 125 Seiten Illustrationen 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Westfälische Wilhelms-Universität Münster 2016 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1104174227/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029110090&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Yan, Li-Sue Serena 1982- Dynamic insight into naïve lymphocyte extravasation in vivo |
| subject_GND | (DE-588)4113937-9 |
| title | Dynamic insight into naïve lymphocyte extravasation in vivo |
| title_auth | Dynamic insight into naïve lymphocyte extravasation in vivo |
| title_exact_search | Dynamic insight into naïve lymphocyte extravasation in vivo |
| title_full | Dynamic insight into naïve lymphocyte extravasation in vivo Li-Sue Serena Yan |
| title_fullStr | Dynamic insight into naïve lymphocyte extravasation in vivo Li-Sue Serena Yan |
| title_full_unstemmed | Dynamic insight into naïve lymphocyte extravasation in vivo Li-Sue Serena Yan |
| title_short | Dynamic insight into naïve lymphocyte extravasation in vivo |
| title_sort | dynamic insight into naive lymphocyte extravasation in vivo |
| topic_facet | Hochschulschrift |
| url | http://d-nb.info/1104174227/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029110090&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT yanlisueserena dynamicinsightintonaivelymphocyteextravasationinvivo |
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