Mathematical modeling and simulation in enteric neurobiology:
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hackensack, NJ [u.a.]
World Scientific
2009
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIX, 319 S. graph. Darst. |
| ISBN: | 9789812834805 981283480X |
Internformat
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Datensatz im Suchindex
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ROUSTEM MIFTAHOF POHANG UNIVERSITY OF SCIENCE SC TECHNOLOGY, KOREA HONG
GIL NAM POHANG UNIVERSITY OF SCIENCE 8. TECHNOLOGY, KOREA DAVID LIONEL
WINGATE QUEEN MARY, UNIVERSITY OF LONDON, UK MATHEMATICAL MODELING AND
SIMULATION IN ENTERIC NEUROBIOLOGY WORLD SCIENTIFIC NEW JERSEY * LONDON
* SINGAPORE * BEIJING * SHANGHAI * HONG KONG * TAIPEI * CHENNAI CONTENTS
PREFACE XV LIST OF SYMBOLS XIX ACRONYMS XXV INTRODUCTION XXVII 1
OVERVIEW OF ENTERIC NEUROBIOLOGY 1 1.1 THE ROLE OF THE GUT 1 1.2
REGIONAL FUNCTION IN THE HUMAN GUT 3 1.3 THE INTRINSIC INNERVATION OF
THE GUT 6 1.4 GASTROINTESTINAL SMOOTH MUSCLE 9 1.5 EXTRINSIC INNERVATION
11 1.6 THE EFFECT OF FOOD ON THE GUT 13 1.7 CLINICAL PHARMACOLOGY 17 2
MYOELECTRICAL ACTIVITY OF THE SMOOTH MUSCLE 20 2.1 MYOELECTRICAL AND
MECHANICAL ACTIVITY 20 2.1.1 BIOLOGICAL BACKGROUND 21 2.1.2 MATHEMATICAL
MODEL 25 2.1.3 NUMERICAL ALGORITHM 30 2.1.4 PHYSIOLOGICAL RESPONSE 34
2.1.5 EFFECT OF INCREASE IN G A 35 2.1.6 EFFECT OF INCREASE IN GCA-K
AND G(? A 36 2.1.7 EFFECT OF CYCLIC CHANGES IN G(I A 38 VII VIII
MATHEMATICAL MODELING AND SIMULATION IN ENTERIC NEUROBIOLOGY 2.1.8
EFFECT OF INCREASE IN |^ A AND F^ 40 2.1.9 EFFECT OF INCREASE IN GCA-K
AN D DECREASE IN GQ A . 41 2.1.10 REMARKS 41 2.2 EFFECTS OF ION
CHANNEL MODULATORS 44 2.2.1 BIOLOGICAL BACKGROUND 44 2.2.2 EFFECT OF
FORSKOLIN '. 45 2.2.3 EFFECT OF LEMAKALIM " 46 2.2.4 EFFECT OF HIGH
CONCENTRATION OF EXTERNAL K^J 46 2.2.5 EFFECT OF PHENCYCLIDINE 48 2.2.6
EFFECTS OF SELECTIVE K + -CHANNEL AGONISTS/ ANTAGONISTS 49 2.2.7 REMARKS
52 3 PHARMACOLOGY OF MYOELECTRICAL ACTIVITY 56 3.1 EFFECTS OF SPECIFIC
INHIBITORS OF THE CA 2+ -ATPASE AND THE RYANODINE-SENSITIVE CA 2+
CHANNELS OF THE SARCOPLASMIC RETICULUM 56 3.1.1 EFFECTS OF CYCLOPIAZONIC
ACID 57 3.1.2 EFFECTS OF CYCLOPIAZONIC ACID AND RYANODINE 60 3.1.3
EFFECTS OF CYCLOPIAZONIC ACID AND NON-SELECTIVE CA 2+ CHANNEL
ANTAGONISTS 60 3.1.4 EFFECTS OF CYCLOPIAZONIC ACID AND SELECTIVE CA 2+
CHANNEL ANTAGONISTS 61 3.1.5 EFFECTS OF THAPSIGARGIN, NON-SELECTIVE AND
SELECTIVE CA 2+ CHANNEL ANTAGONISTS, AND RYANODINE 63 3.1.6 EFFECTS OF
THAPSIGARGIN AND HIGH [CA 2+ ] 0 66 3.1.7 EFFECTS OF THAPSIGARGIN, HIGH
[CA 2+ ] 0 , [K+] O AND SELECTIVE CA 2+ CHANNEL ANTAGONISTS 69 3.2
EFFECTS OF 1,4-DIHYDROPYRIDINE ENANTIOMERS (-)-(S)-BAY K 8644 AND
(+)-(R)-BAYK 8644 71 3.2.1 EFFECTS OF (-)-(S)-BAYK 8644 71 3.2.2 EFFECTS
OF (-)-(S)-BAYK 8644 AND HIGH [K+] O 73 3.2.3 EFFECTS OF (+)-(R)-BAY K
8644 74 3.3 EFFECTS OF MOTILIDES 75 CONTENTS IX 3.3.1 EFFECTS OF MOTILIN
AND ERYTHROMYCIN 76 3.3.2 EFFECTS OF MOTILIDES AND RYANODINE 80 3.3.3
EFFECTS OF MOTILIDES, A NON-SELECTIVE CA 2+ CHANNEL BLOCKER AND
THAPSIGARGIN 80 3.4 EFFECTS OF BENZODIAZEPINES 82 3.4.1 EFFECTS OF
BENZODIAZEPINES ALONE 84 3.4.2 REVERSE OF THE EFFECTS OF BENZODIAZEPINES
89 3.5 REMARKS 92 4 PHYSICOCHEMICAL BASIS OF SYNAPTIC TRANSMISSION 100
4.1 INTRODUCTION 100 4.2 CHDLINERGIC NEUROTRANSMISSION 101 4.2.1
BIOLOGICAL BACKGROUND 101 4.2.2 MATHEMATICAL MODEL 103 4.2.3 NUMERICAL
ALGORITHM 108 4.2.4 PHYSIOLOGICAL NEUROTRANSMISSION 110 4.2.5 REMARKS
112 4.3 INHIBITION OF CHOLINERGIC NEUROTRANSMISSION 113 4.3.1
INTRODUCTION 113 4.3.2 BIOLOGICAL BACKGROUND 113 4.3.3 MATHEMATICAL
MODEL 114 4.3.4 EFFECT OF CHLORIDE SALTS OF DIVALENT CATIONS 117 4.3.5
EFFECT OF ^-BUNGAROTOXIN 117 4.3.6 EFFECT OF BOTULINUM TOXIN 118 4.3.7
CHANGE IN THE CONCENTRATION OF EXTRACELLULAR CA 2+ . . 118 4.3.8 EFFECT
OF CHOLINERGIC ANTAGONISTS 119 4.4 FACILITATION OF CHOLINERGIC
NEUROTRANSMISSION 120 4.4.1 BIOLOGICAL BACKGROUND 120 4.4.2 MATHEMATICAL
MODEL 121 4.4.3 EFFECT OF CHOLINERGIC AGONISTS 123 4.4.4 EFFECT OF TTX
124 4.4.5 EFFECT OF REPETITIVE STIMULATION 124 4.4.6 REMARKS 125 4.5
ADRENERGIC NEUROTRANSMISSION 128 4.5.1 BIOLOGICAL BACKGROUND 128 4.5.2
MATHEMATICAL MODEL 129 X MATHEMATICAL MODELING AND SIMULATION IN ENTERIC
NEUROBIOLOGY 4.5.3 PHYSIOLOGICAL ADRENERGIC TRANSMISSION 135 4.5.4
REMARKS 137 4.6 ALTERED ADRENERGIC NEUROTRANSMISSION 138 4.6.1 EFFECTS
OF EXTRACELLULAR CA 2+ REMOVAL AND APPLICATION OF TTX 138 4.6.2
INHIBITION OF NEURONAL UPTAKE-1 MECHANISM 138 4.6.3 INHIBITION OF
CATECHOL-O-METHYLTRANSFEFASE 140 4.6.4 MATHEMATICAL MODEL 140 4.6.5
EFFECT OF A I-ADRENOCEPTOR ANTAGONISTS 145 4.6.6 MATHEMATICAL MODEL 145
4.6.7 EFFECT OF THE REPETITIVE STIMULATION 149 4.6.8 REMARKS 150 5
NEURONAL ASSEMBLIES 151 5.1 PLANAR NEURONAL NETWORK 151 5.1.1
INTRODUCTION 151 5.1.2 BIOLOGICAL BACKGROUND 152 5.2 INHIBITORY NEURAL
CIRCUIT 153 5.2.1 AXO-AXONAL INTERACTION 153 5.2.2 EFFECT OF COMT
INHIBITORS 155 5.2.3 EFFECT OF C^-ADRENOCEPTOR BLOCKERS 156 5.3 A MODEL
OF THE SENSORY PATHWAY 156 5.3.1 INTRODUCTION 156 5.3.2 BIOLOGICAL
BACKGROUND 157 5.3.3 MATHEMATICAL MODEL 159 5.3.4 RESPONSES TO
DEFORMATION 163 5.3.5 EFFECT OF IBERIOTOXIN AND CHTX 166 5.3.6 EFFECT OF
& -CGTX 168 5.3.7 EFFECT OF TTX : 169 5.3.8 EFFECT OF PURINOCEPTOR
AGONISTS 169 5.3.9 EFFECT OF PROTEIN KINASE C ACTIVATOR 170 5.3.10
EFFECT OF DPDPE 172 5.3.11 REMARKS 172 5.4 ENTERAL SYMPATHETIC
COMMUNICATION 175 5.4.1 INTRODUCTION 175 5.4.2 MATHEMATICAL MODEL 176
CONTENTS XI 5.4.3 EFFECT OF A SINGLE DEFORMATION 178 5.4.4 EFFECT OF A
PERIODIC DEFORMATION 183 5.4.5 EFFECT OF INTERMITTENT DEFORMATION 186
5.4.6 REMARKS 188 5.5 A PLANAR NEURONAL NETWORK 192 5.5.1 EFFECT OF
CHOLINERGIC AND ADRENERGIC AGONISTS AND ANTAGONISTS . R 195 5.5.2 EFFECT
OF CHOLINESTERASE INHIBITORS 195 5.5.3 EFFECT OF CHOLINERGIC ANTAGONISTS
195 5.5.4 REMARKS 196 6 MULTIPLE'NEUROTRANSMISSION 199 6.1
CO-TRANSMISSION BY ACETYLCHOLINE AND SEROTONIN 199 6.1.1 INTRODUCTION
199 6.1.2 BIOLOGICAL BACKGROUND 200 6.1.3 MATHEMATICAL MODEL 201 6.1.4
ELECTRICAL ACTIVITY OF MECHANORECEPTORS 207 6.1.4.1 PHYSIOLOGICAL
RESPONSE 207 6.1.4.2 EFFECT OF 5-HT 3 RECEPTORS 208 6.1.4.3 EFFECT OF
5-HT 3 -RECEPTOR ANTAGONISTS . . . . 208 6.1.5 ELECTRICAL ACTIVITY OF
THE PRIMARY NEURON 209 6.1.5.1 STIMULATION OF MECHANORECEPTORS 209
6.1.5.2 EFFECT OF 5-HT3 RECEPTORS 209 6.1.5.3 EFFECT OF 5-HT 3 -RECEPTOR
ANTAGONISTS . . . . 212 6.1.5.4 EFFECT OF 5-HT4 RECEPTORS 212 6.1.5.5
EFFECT OF CO-ACTIVATION OF 5-HT 3 AND 5-HT 4 RECEPTORS 212 6.1.5.6
EFFECT OF CISAPRIDE 213 6.1.6 ELECTRICAL ACTIVITY OF THE MOTOR NEURON
214 6.1.6.1 EFFECT OF NACH RECEPTORS 214 6.1.6.2 EFFECT OF 5-HT3 AND
5-HT4 RECEPTORS . . . . 215 6.1.6.3 EFFECT OF CO-ACTIVATION OF 5-HT 3
AND NACH RECEPTORS 215 6.1.6.4 EFFECT OF CO-ACTIVATION OF 5-HT 4 AND
NACH RECEPTORS 215 XII MATHEMATICAL MODELING AND SIMULATION IN ENTERIC
NEUROBIOLOGY 6.1.6.5 EFFECT OF 5-HT 3 /5-HT 4 -RECEPTOR AGONISTS AND
CO-ACTIVATION OF NACH RECEPTORS . . . . 218 6.1.6.6 EFFECTS OF 5-HT 3
-RECEPTOR ANTAGONIST AND CO-ACTIVATION OF NACH RECEPTORS 219 6.1.7
ELECTRICAL ACTIVITY OF SMOOTH MUSCLE 219 6.1.7.1 EFFECT OF/XACH
RECEPTORS 219 6.1.7.2 EFFECT OF 5-HT 4 RECEPTORS . . . '." 220 6.1.7.3
EFFECT OF CO-ACTIVATION OF 5-HT 4 AND /ZACH RECEPTORS 220 6.1.7.4 EFFECT
OF 5-HT 4 RECEPTOR ANTAGONISTS AND CO-ACTIVATION OF 5-HT 3 AND FIACH
RECEPTORS 220 6.1.8 REMARKS 221 6.2 CO-TRANSMISSION BY ACH AND
EXCITATORY AMINO ACIDS . . . . 223 6.2.1 BIOLOGICAL BACKGROUND 223 6.2.2
ELECTRICAL ACTIVITY OF THE PRIMARY NEURON 225 6.2.2.1 EFFECT OF
MECHANICAL STIMULATION 225 6.2.2.2 EFFECT OF AMPA RECEPTORS 227 6.2.2.3
EFFECT OF NMDA RECEPTORS 227 6.2.2.4 EFFECT OF CO-ACTIVATION OF NMDA AND
AMPA RECEPTORS 228 6.2.3 ELECTRICAL ACTIVITY OF THE MOTOR NEURON 230
6.2.3.1 EFFECT OF NACH RECEPTORS 230 6.2.3.2 EFFECT OF NMDA RECEPTORS
231 6.2.3.3 EFFECT OF CO-ACTIVATION OF NACH AND NMDA RECEPTORS 231 6.2.3
A EFFECT OF CO-ACTIVATION OF NACH AND AMPA RECEPTORS 231 6.2.3.5 EFFECT
OF CO-ACTIVATION OF AMPA, NMDA AND NACH RECEPTORS 232 6.2.4 SMOOTH
MUSCLE * NEURONAL CHAIN PREPARATION . . . 232 6.2.4.1 EFFECT OF NACH
RECEPTORS 232 6.2.4.2 EFFECT OF CO-ACTIVATION OF AMPA AND NACH RECEPTORS
233 CONTENTS XIII 6.2.4.3 EFFECT OF CO-ACTIVATION OF NACH, AMPA AND NMDA
RECEPTORS 233 6.2.5 REMARKS 233 6.3 CO-TRANSMISSION BY ACH AND SUBSTANCE
P 235 6.3.1 INTRODUCTION 235 6.3.2 BIOLOGICAL BACKGROUND 236 6.3.3
MATHEMATICAL MODEL R 237 6.3.4 EFFECT OF RANDOMLY APPLIED HIGH FREQUENCY
STIMULI 239 6.3.5 EFFECT OF LOW FREQUENCY STIMULATION 242 6.3.6 REMARKS
242 FUNCTIONAL UNIT 244 7.1 INTRODUCTION : 244 7.2 BIOLOGICAL BACKGROUND
245 7.3 MATHEMATICAL MODEL 247 7.4 NUMERICAL ALGORITHM 259 7.5
ELECTROMECHANICAL WAVE PHENOMENON 261 7.6 EFFECT OF LIDOCAINE N-ETHYL
BROMIDE QUARTERYSALTQX-314 268 7.7 EFFECT OF CHANGES IN EXTRACELLULAR CA
2+ 268 7.8 EFFECT OF CHOLINERGIC ANTAGONISTS 269 7.9 REMARKS 269
DYNAMICS OF INTESTINAL PROPULSION 273 8.1 MODEL FORMULATION 274 8.2
NUMERICAL ALGORITHM 276 8.3 PENDULAR MOVEMENTS 277 8.4 SEGMENTAL
CONTRACTIONS 280 8.5 PERISTALTIC REFLEX 282 8.6 EFFECT OF MULTIPLE
NEUROTRANSMISSION AND DRUGS ON PELLET PROPULSION 287 8.6.1 INTRODUCTION
. : 287 8.6.2 EFFECT OF CO-ACTIVATION OF 5-HT 3 , NACH AND YUACH
RECEPTORS 287 XIV MATHEMATICAL MODELING AND SIMULATION IN ENTERIC
NEUROBIOLOGY 8.6.3 EFFECTS OF ALOSETRON 291 8.6.4 EFFECTS OF SELECTIVE
5-HT 4 RECEPTOR AGONISTS 292 8.6.5 EFFECTS OF SELECTIVE 5-HT 4 RECEPTOR
ANTAGONISTS . . 292 8.6.6 EFFECT OF CISAPRIDE 294 8.7 REMARKS 294
REFERENCES _. 296 INDEX 313 |
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| id | DE-604.BV025556368 |
| illustrated | Illustrated |
| indexdate | 2024-08-01T00:10:33Z |
| institution | BVB |
| isbn | 9789812834805 981283480X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020156203 |
| oclc_num | 636346990 |
| open_access_boolean | |
| owner | DE-11 DE-355 DE-BY-UBR DE-83 |
| owner_facet | DE-11 DE-355 DE-BY-UBR DE-83 |
| physical | XXIX, 319 S. graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | World Scientific |
| record_format | marc |
| spelling | Miftahof, Roustem N. 1957- Verfasser (DE-588)1207473669 aut Mathematical modeling and simulation in enteric neurobiology Roustem Miftahof ; Hong Gil Nam ; David Lionel Wingate Hackensack, NJ [u.a.] World Scientific 2009 XXIX, 319 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Darmwandnervensystem (DE-588)4617308-0 gnd rswk-swf Biologisches Modell (DE-588)4726968-6 gnd rswk-swf Darmwandnervensystem (DE-588)4617308-0 s Biologisches Modell (DE-588)4726968-6 s DE-604 Nam, Hon Gil Verfasser aut Wingate, David Lionel Verfasser aut HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020156203&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Miftahof, Roustem N. 1957- Nam, Hon Gil Wingate, David Lionel Mathematical modeling and simulation in enteric neurobiology Darmwandnervensystem (DE-588)4617308-0 gnd Biologisches Modell (DE-588)4726968-6 gnd |
| subject_GND | (DE-588)4617308-0 (DE-588)4726968-6 |
| title | Mathematical modeling and simulation in enteric neurobiology |
| title_auth | Mathematical modeling and simulation in enteric neurobiology |
| title_exact_search | Mathematical modeling and simulation in enteric neurobiology |
| title_full | Mathematical modeling and simulation in enteric neurobiology Roustem Miftahof ; Hong Gil Nam ; David Lionel Wingate |
| title_fullStr | Mathematical modeling and simulation in enteric neurobiology Roustem Miftahof ; Hong Gil Nam ; David Lionel Wingate |
| title_full_unstemmed | Mathematical modeling and simulation in enteric neurobiology Roustem Miftahof ; Hong Gil Nam ; David Lionel Wingate |
| title_short | Mathematical modeling and simulation in enteric neurobiology |
| title_sort | mathematical modeling and simulation in enteric neurobiology |
| topic | Darmwandnervensystem (DE-588)4617308-0 gnd Biologisches Modell (DE-588)4726968-6 gnd |
| topic_facet | Darmwandnervensystem Biologisches Modell |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020156203&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT miftahofroustemn mathematicalmodelingandsimulationinentericneurobiology AT namhongil mathematicalmodelingandsimulationinentericneurobiology AT wingatedavidlionel mathematicalmodelingandsimulationinentericneurobiology |