Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Gießen
DVG Service GmbH
2022
|
| Ausgabe: | 1. Auflage |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | VI, 95 Seiten Illustrationen, Diagramme 21 cm |
| ISBN: | 9783863456542 |
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| 245 | 1 | 0 | |a Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam |c by Björn Welzel (né Gailus) |
| 250 | |a 1. Auflage | ||
| 264 | 1 | |a Gießen |b DVG Service GmbH |c 2022 | |
| 300 | |a VI, 95 Seiten |b Illustrationen, Diagramme |c 21 cm | ||
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| 502 | |b Dissertation |c University of Veterinary Medicine Hannover |d 2022 | ||
| 650 | 7 | |a rats |2 cabt | |
| 650 | 7 | |a birth |2 cabt | |
| 650 | 7 | |a asphyxia |2 cabt | |
| 650 | 7 | |a respiration |2 cabt | |
| 650 | 7 | |a midazolam |2 cabt | |
| 650 | 7 | |a neonatal mortality |2 cabt | |
| 650 | 7 | |a perinatal mortality |2 cabt | |
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Datensatz im Suchindex
| _version_ | 1804184947253051392 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
1
ABSTRACT
..................................................................................................................
1
2
ZUSAMMENFASSUNG
.................................................................................................
3
3
GENERAL
INTRODUCTION
...........................................................................................
5
3.1
BIRTH
ASPHYXIA
AND
HYPOXIC-ISCHEMIC
ENCEPHALOPATHY
.................................
5
3.1.1
DEFINITION,
DIAGNOSIS,
AND
SIGNIFICANCE
......................................................................
5
3.1.2
PATHOGENESIS
OF
HIE
...................................................................................................
6
3.1.3
LONG-TERM
CONSEQUENCES
OF
HIE
................................................................................
9
3.2
NEONATAL
SEIZURES
............................................................................................
10
3.2.1
DEFINITION
AND
ETIOLOGY
.............................................................................................
10
3.2.2
CLASSIFICATION
OF
NEONATAL
SEIZURES
...........................................................................
11
3.2.3
CONTRIBUTION
OF
NEONATAL
SEIZURES
TO
LONG-TERM
CONSEQUENCES
OF
HIE
.....................
13
3.3
THERAPEUTIC
INTERVENTION
................................................................................
14
3.3.1
TREATMENT
OF
HIE
......................................................................................................
14
3.3.2
TREATMENT
OF
NEONATAL
SEIZURES
.................................................................................
15
3.3.3
MIDAZOLAM
AS
A
TREATMENT
OPTION
FOR
NEONATAL
SEIZURES
AND
HIE
.............................
18
3.4
PRECLINICAL
MODELS
OF
HIE
AND
NEONATAL
SEIZURES
........................................
22
3.4.1
LARGE
ANIMAL
AND
PRIMATE
MODELS
............................................................................
22
3.4.2
RODENT
MODELS
..........................................................................................................
23
3.4.3
A
NOVEL
NONINVASIVE
RAT
MODEL
OF
BIRTH
ASPHYXIA
WITH
NEONATAL
SEIZURES
..............
25
4
WORKING
HYPOTHESES
AND
AIMS
OF
STUDIES
.......................................................
30
5
LONG-TERM
OUTCOME
IN
A
NONINVASIVE
RAT
MODEL
OF
BIRTH
ASPHYXIA
WITH
NEONATAL
SEIZURES:
COGNITIVE
IMPAIRMENT,
ANXIETY,
EPILEPSY,
AND
STRUCTURAL
BRAIN
ALTERATIONS
..............................................................................................
31
5.1
ABSTRACT
..........................................................................................................
32
6
MIDAZOLAM
PREVENTS
THE
ADVERSE
OUTCOME
OF
NEONATAL
ASPHYXIA
.............
33
6.1
ABSTRACT
..........................................................................................................
34
7
GENERAL
DISCUSSION
.............................................................................................
35
7.1
LONG-TERM
CONSEQUENCES
OF
ASPHYXIA
.........................................................
35
7.1.1
BEHAVIORAL
CONSEQUENCES
OF
ASPHYXIA
......................................................................
35
7.1.2
SPONTANEOUS
RECURRENT
SEIZURES
AFTER
ASPHYXIA
........................................................
39
7.1.3
STRUCTURAL
BRAIN
ALTERATIONS
.......................................................................................
41
7.2
FACE
VALIDITY
AND
TRANSLATION
OF
THE
NEW
ASPHYXIA
MODEL
.........................
44
7.3
MIDAZOLAM
TREATMENT
AND
SUBSEQUENT
SUPPRESSION
OF
NEONATAL
SEIZURES
..
47
7.4
THE
DEVELOPMENT
OF
NEW
THERAPEUTIC
OPTIONS
FOR
HIE
AND
NEONATAL
SEIZURES
IN
THE
NONINVASIVE
RAT
MODEL
OF
BIRTH
ASPHYXIA
............................
50
7.5
CONCLUDING
REMARKS
.......................................................................................
52
8
REFERENCES
.............................................................................................................
54
9
SUPPLEMENTAL
MATERIAL
.......................................................................................
85
9.1
CONSUMABLES
AND
DEVICES
.............................................................................
85
9.2
PRIMARY
ANTIBODIES
FOR
IMMUNOHISTOCHEMISTRY
...........................................
89
9.3
SECONDARY
ANTIBODIES
FOR
IMMUNOHISTOCHEMISTRY
.......................................
89
9.4
BUFFERS
AND
SOLUTIONS
.....................................................................................
89
9.5
PROTOCOL
FOR
IMMUNOHISTOCHEMISTRY
(FREE-FLOATING
BRAIN
SLICES)
................
90
9.6
PROTOCOL
FOR
THIONIN
STAINING
(MOUNTED
BRAIN
SLICES)
...................................
90
10
PUBLICATIONS,
POSTERS,
AND
ORAL
PRESENTATIONS
.............................................
91
10.1
PUBLICATIONS
..................................................................................................
91
10.2
POSTER
PRESENTATIONS
.....................................................................................
92
10.3
ORAL
PRESENTATIONS
........................................................................................
92
11
ACKNOWLEDGEMENTS
..........................................................................................
94
|
| adam_txt |
TABLE
OF
CONTENTS
1
ABSTRACT
.
1
2
ZUSAMMENFASSUNG
.
3
3
GENERAL
INTRODUCTION
.
5
3.1
BIRTH
ASPHYXIA
AND
HYPOXIC-ISCHEMIC
ENCEPHALOPATHY
.
5
3.1.1
DEFINITION,
DIAGNOSIS,
AND
SIGNIFICANCE
.
5
3.1.2
PATHOGENESIS
OF
HIE
.
6
3.1.3
LONG-TERM
CONSEQUENCES
OF
HIE
.
9
3.2
NEONATAL
SEIZURES
.
10
3.2.1
DEFINITION
AND
ETIOLOGY
.
10
3.2.2
CLASSIFICATION
OF
NEONATAL
SEIZURES
.
11
3.2.3
CONTRIBUTION
OF
NEONATAL
SEIZURES
TO
LONG-TERM
CONSEQUENCES
OF
HIE
.
13
3.3
THERAPEUTIC
INTERVENTION
.
14
3.3.1
TREATMENT
OF
HIE
.
14
3.3.2
TREATMENT
OF
NEONATAL
SEIZURES
.
15
3.3.3
MIDAZOLAM
AS
A
TREATMENT
OPTION
FOR
NEONATAL
SEIZURES
AND
HIE
.
18
3.4
PRECLINICAL
MODELS
OF
HIE
AND
NEONATAL
SEIZURES
.
22
3.4.1
LARGE
ANIMAL
AND
PRIMATE
MODELS
.
22
3.4.2
RODENT
MODELS
.
23
3.4.3
A
NOVEL
NONINVASIVE
RAT
MODEL
OF
BIRTH
ASPHYXIA
WITH
NEONATAL
SEIZURES
.
25
4
WORKING
HYPOTHESES
AND
AIMS
OF
STUDIES
.
30
5
LONG-TERM
OUTCOME
IN
A
NONINVASIVE
RAT
MODEL
OF
BIRTH
ASPHYXIA
WITH
NEONATAL
SEIZURES:
COGNITIVE
IMPAIRMENT,
ANXIETY,
EPILEPSY,
AND
STRUCTURAL
BRAIN
ALTERATIONS
.
31
5.1
ABSTRACT
.
32
6
MIDAZOLAM
PREVENTS
THE
ADVERSE
OUTCOME
OF
NEONATAL
ASPHYXIA
.
33
6.1
ABSTRACT
.
34
7
GENERAL
DISCUSSION
.
35
7.1
LONG-TERM
CONSEQUENCES
OF
ASPHYXIA
.
35
7.1.1
BEHAVIORAL
CONSEQUENCES
OF
ASPHYXIA
.
35
7.1.2
SPONTANEOUS
RECURRENT
SEIZURES
AFTER
ASPHYXIA
.
39
7.1.3
STRUCTURAL
BRAIN
ALTERATIONS
.
41
7.2
FACE
VALIDITY
AND
TRANSLATION
OF
THE
NEW
ASPHYXIA
MODEL
.
44
7.3
MIDAZOLAM
TREATMENT
AND
SUBSEQUENT
SUPPRESSION
OF
NEONATAL
SEIZURES
.
47
7.4
THE
DEVELOPMENT
OF
NEW
THERAPEUTIC
OPTIONS
FOR
HIE
AND
NEONATAL
SEIZURES
IN
THE
NONINVASIVE
RAT
MODEL
OF
BIRTH
ASPHYXIA
.
50
7.5
CONCLUDING
REMARKS
.
52
8
REFERENCES
.
54
9
SUPPLEMENTAL
MATERIAL
.
85
9.1
CONSUMABLES
AND
DEVICES
.
85
9.2
PRIMARY
ANTIBODIES
FOR
IMMUNOHISTOCHEMISTRY
.
89
9.3
SECONDARY
ANTIBODIES
FOR
IMMUNOHISTOCHEMISTRY
.
89
9.4
BUFFERS
AND
SOLUTIONS
.
89
9.5
PROTOCOL
FOR
IMMUNOHISTOCHEMISTRY
(FREE-FLOATING
BRAIN
SLICES)
.
90
9.6
PROTOCOL
FOR
THIONIN
STAINING
(MOUNTED
BRAIN
SLICES)
.
90
10
PUBLICATIONS,
POSTERS,
AND
ORAL
PRESENTATIONS
.
91
10.1
PUBLICATIONS
.
91
10.2
POSTER
PRESENTATIONS
.
92
10.3
ORAL
PRESENTATIONS
.
92
11
ACKNOWLEDGEMENTS
.
94 |
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| author | Welzel, Björn |
| author_GND | (DE-588)1259532216 |
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| bvnumber | BV048838520 |
| ctrlnum | (OCoLC)1355678855 (DE-599)DNB1274395844 |
| edition | 1. Auflage |
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| illustrated | Illustrated |
| index_date | 2024-07-03T21:36:57Z |
| indexdate | 2024-07-10T09:47:26Z |
| institution | BVB |
| isbn | 9783863456542 |
| language | English |
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| physical | VI, 95 Seiten Illustrationen, Diagramme 21 cm |
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| spelling | Welzel, Björn Verfasser (DE-588)1259532216 aut Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam by Björn Welzel (né Gailus) 1. Auflage Gießen DVG Service GmbH 2022 VI, 95 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation University of Veterinary Medicine Hannover 2022 rats cabt birth cabt asphyxia cabt respiration cabt midazolam cabt neonatal mortality cabt perinatal mortality cabt (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf https://d-nb.info/1274395844/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034103984&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p emakn 0,18276 20221212 DE-101 https://d-nb.info/provenance/plan#emakn 2\p dnb 20221215 DE-101 https://d-nb.info/provenance/plan#dnb |
| spellingShingle | Welzel, Björn Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam rats cabt birth cabt asphyxia cabt respiration cabt midazolam cabt neonatal mortality cabt perinatal mortality cabt |
| subject_GND | (DE-588)4113937-9 |
| title | Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam |
| title_auth | Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam |
| title_exact_search | Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam |
| title_exact_search_txtP | Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam |
| title_full | Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam by Björn Welzel (né Gailus) |
| title_fullStr | Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam by Björn Welzel (né Gailus) |
| title_full_unstemmed | Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam by Björn Welzel (né Gailus) |
| title_short | Long-term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam |
| title_sort | long term outcome in a rat model of birth asphyxia with neonatal seizures and the impact of pharmacological intervention with midazolam |
| topic | rats cabt birth cabt asphyxia cabt respiration cabt midazolam cabt neonatal mortality cabt perinatal mortality cabt |
| topic_facet | rats birth asphyxia respiration midazolam neonatal mortality perinatal mortality Hochschulschrift |
| url | https://d-nb.info/1274395844/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=034103984&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT welzelbjorn longtermoutcomeinaratmodelofbirthasphyxiawithneonatalseizuresandtheimpactofpharmacologicalinterventionwithmidazolam |
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