Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics:
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| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | German |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | kostenfrei Inhaltsverzeichnis |
| Beschreibung: | 192 S. Ill., graph. Darst. |
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Datensatz im Suchindex
| _version_ | 1804152571516944384 |
|---|---|
| adam_text | DISSERTATION ZUR
ERLANGUNG
DES
DOKTORGRADES
DER FAKULTAT
FUR CHEMIE UND PHARMAZIE
DER
LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN
ANALYSIS OF AGING BY QUANTITATIVE PROTEOMICS
AND
MITOCHONDRIAL ORGANELLAR PROTEOMICS
DIRK MARTIN WALTHER
AUS
HEIDELBERG
2012
HTTP://D-NB.INFO/1059601605
CONTENTS
SUMMARY V
CONTENTS VII
1 INTRODUCTION 1
1.1 BIOLOGY OF AGING 1
1.1.1 PARADIGMS OF AGING RESEARCH 1
1.1.2 INVERTEBRATE MODEL SYSTEMS 6
1.1.3 INSULIN/INSULIN-LIKE GROWTH FACTOR
1 SIGNALING 11
1.1.4 PROTEOSTASIS AND PROTEIN AGGREGATION DURING AGING 18
1.2 MASS SPECTROMETRY-BASED QUANTITATIVE PROTEOMICS 22
1.2.1 MASS ANALYZERS FOR MS-BASED PROTEOMICS 22
1.2.2 FRAGMENTATION METHODS IN TANDEM MASS SPECTROMETRY 26
1.2.3 INSTRUMENTS FOR HIGH RESOLUTION MS-BASED SHOTGUN PROTEOMICS . 27
1.2.4 QUANTIFICATION STRATEGIES 29
1.2.5 COMPUTATIONAL PROTEOMICS AND BIOINFORMATICS 33
1.2.6 MITOCHONDRIAL ORGANELLAR PROTEOMICS 35
2 RESULTS 39
2.1 ACCURATE QUANTIFICATION OF MORE THAN 4000 MOUSE TISSUE PROTEINS RE
VEALS MINIMAL PROTEOME CHANGES DURING AGING 39
2.1.1 AIM AND SUMMARY 39
2.1.2 CONTRIBUTION 40
2.1.3 PUBLICATION 40
2.2 EXTENSIVE PROTEOME REMODELING DURING AGING IN C.
ELEGANS
REVEALED BY
QUANTITATIVE PROTEOMICS 48
2.2.1 AIM AND SUMMARY 48
2.2.2 CONTRIBUTION 49
2.2.3 MANUSCRIPT 49
VII
CONTENTS
2.3 THE MITOCHONDRIAL CONTACT SITE COMPLEX, A DETERMINANT OF MITOCHON
DRIAL ARCHITECTURE 120
2.3.1 AIM AND SUMMARY 120
2.3.2 CONTRIBUTION 120
2.3.3 PUBLICATION 121
2.4 A CRUCIAL ROLE OF MIM2 IN THE BIOGENESIS OF MITOCHONDRIAL OUTER MEM
BRANE PROTEINS 137
2.4.1 AIM AND SUMMARY 137
2.4.2 CONTRIBUTION 137
2.4.3 PUBLICATION 138
3 DISCUSSION AND OUTLOOK 149
3.1 THE PROTEOME OF AGING 149
3.1.1 STUDYING AGING BY QUANTITATIVE PROTEOMICS 149
3.1.2 THE PROTEOME OF MICE, BUT NOT OF WORMS IS CONSERVED DURING
AGING 150
3.1.3 OUTLOOK AND FUTURE DIRECTIONS 152
3.2 MITOCHONDRIAL ORGANELLAR PROTEOMICS 154
ABBREVIATIONS 157
REFERENCES 159
CURRICULUM VITAE 191
VIII
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| spelling | Walther, Dirk Martin Verfasser aut Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics von Dirk Martin Walther 2012 192 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2012 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-174637 https://nbn-resolving.org/urn:nbn:de:bvb:19-174637 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027545745&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Walther, Dirk Martin Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics |
| subject_GND | (DE-588)4113937-9 |
| title | Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics |
| title_auth | Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics |
| title_exact_search | Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics |
| title_full | Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics von Dirk Martin Walther |
| title_fullStr | Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics von Dirk Martin Walther |
| title_full_unstemmed | Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics von Dirk Martin Walther |
| title_short | Analysis of aging by quantitative proteomics and mitochondrial organellar proteomics |
| title_sort | analysis of aging by quantitative proteomics and mitochondrial organellar proteomics |
| topic_facet | Hochschulschrift |
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