Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice: 11. November 2008
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Wien
2008
|
| Schriftenreihe: | Forschungsberichte der Sektion IV / Bundesministerium für Gesundheit, Familie und Jugend, Sektion IV
2008,3 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 105 S. zahlr. graph. Darst., Tab. |
| ISBN: | 9783902611246 |
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Datensatz im Suchindex
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| adam_text | Contents
ABSTRACT 4
1.INTRODUCTION 6
2. MATERIAL AND METHODS 8
2.1. Crop production and choice of comparators 8
2.2. Diet 10
2.2.1. Diet composition 10
2.2.2. Analyses of corn and diets 11
2.3. Animals and housing 13
2.4. multigeneration study (mgs) 14
2.4.1. Performance and reproduction data 14
2.4.2. Organ weights 15
2.4.3. Histology 16
2.4.4. Immunohistochemistry 17
2.4.5. Ultrastructural investigations 19
2.4.6. Microarray analyses 19
2.4.7. q-RT-PCR 22
2.4.8. miRNA analyses 23
2.5. Life term study (LTS) 24
2.5.1. Feed intake and body mass survey 24
2.5.2. Survival 24
2.6. Reproductive Assessment by Continuous Breeding (RACB) 25
2.6.1. Performance and reproduction 25
2.6.2. q-RT-PCR 27
3. RESULTS 28
3.1. Diet 28
3.1.1. Harvest in 2005 (diets for MGS and LTS) 28
3.1.2. Harvest in 2007 (diets for RACB) 32
3.2. Multi Generation Study (MGS) 36
3.2.1. Performance and reproduction 36
3.2.2. Organ weights 53
3.2.3. Histology 57
3.2.4. Immunohistochemistry 58
3.2.5. Ultrastructural investigation 59
3.2.6. Microarray analyses 64
3.2.7. q-RT-PCR 69
3.2.8. miRNA profiling 71
3.3. Life term study (LTS) 72
3.4. Reproductive Assessment by Continuous Breeding (RACB) 73
3.4.1. Performance and reproduction 73
3.4.2. q-RT-PCR 82
4. DISCUSSION 83
5. CONCLUSION 90
6. DISKUSSION 91
7. SCHLUSSFOLGERUNG 98
8. OVERVIEW OF TABLES 99
9. OVERVIEW OF FIGURES 101
10. REFERENCE LIST 103
_______
8. Overview of tables
Table 1: 1st cp4 EPSPS gene cassette 9
Table 2: 2nd cp4 EPSPS gene cassette 9
Table 3: Gene cassette of MON 810 9
Table 4: Overview about diets used 10
Table 5: Diet composition according to Sniff 11
Table 6: Overview of succession of generations 14
Table 7: Data collection of parental mice per generation 14
Table 8: Data collection of the offspring per generation 15
Table 9: Histological evaluation of the different anatomical sides 17
Table 10: Genes on the TLDA fulfilling with a 2-fold deregulation (p 0.05) between ISO
vs GM groups 22
Table 11: Succession of generation in the RACB 25
Table 12: Data of parental mice collected in the RACB 26
Table 13: Data of offspring collected in the RACB 26
Table 14: Test on genetic modification with PCR 28
Table 15: Crude nutrients and gross energy in the corn 28
Table 16: Crude nutrients and gross energy in the diets 29
Table 17: Minerals and trace elements in the corn 29
Table 18: Minerals and trace elements in the diets 29
Table 19: Carotene and vitamin analyses in the corn 30
Table 20: Carotene and vitamin analyses in the diets 30
Table 21: Fatty acid profile of corn (g lOOg1 total fatty acids) 30
Table 22: Amino acids of the diet 31
Table 23: Investigation of feed hygiene 31
Table 24: Investigation of feed hygiene 32
Table 25: Evaluation of herbicide levels in the diet 32
Table 26: Test on genetic modification with PCR 33
Table 27: Crude nutrients and gross energy in the corn and diets 33
Table 28: Minerals and trace elements in the corn and diets 33
Table 29: Carotene and Vitamins in the corn and diets 33
Table 30: Fatty acid profile of corn (g lOOg 1 total fatty acids) 34
Table 31: Amino acids of the diet 34
Table 32: Investigation of feed hygiene 35
Table 33: Evaluation of herbicide residues in the diet 35
Table 34: Overview of succession of generation and season when performed 36
Table 35: Performance of mice fed 33% isogenic (ISO) or genetically modified (GM) corn
in their diet over several generations 38
Table 36: Reproduction data of mice fed 33% isogenic (ISO) or genetically modified
(GM) corn in their diet over several generations 39
Table 37: Individual pup mass [g] per group at birth, 7, 14, 21 and 28 days after birth
from parents with 33% of near isogenic (ISO) or transgenic(GM) corn in their diet. 43
Table 38: Individual pup mass [g] per group 5 and 6 weeks after birth from parents with
33% of near isogenic (ISO) or transgenic (GM) corn in their diet 44
Table 39: Performance of mice fed 33% isogenic (ISO) or Austrian reference (A REF)
corn in their diet over several generations 47
Table 40: Reproduction data of mice fed 33% isogenic (ISO) or genetically modified
(GM) corn in their diet over several generations 48
Table 41: Individual pup mass [g] per group at birth, 7, 14, 21 and 28 days after birth
from parents with 33% of near isogenic (ISO) or Austrian reference (A REF) corn in
their diet 51
Table 42: Individual pup mass [g] per group 5 and 6 weeks after birth from parents with
33% of near isogenic (ISO) or Austrian reference (A REF) corn in their diet 52
Table 43: CD3+ Intraepithelial lymphocytes in the gut tissue ( per 0.1 mm ) 58
Table 44: CD20+ cells in the lamina propria of the small intestine ( per 0.1 mm 59
Page 99 of 105
Table 45: Macrophages in the lamina propria of the small intestine of female mice ( per
0.1 mm2) 59
Table 46: Pore density (pores/Mm nuclear membrane length) from different tissue of
mice fed 33% genetically modified (GM) or isogenic (ISO) corn 61
Table 47: Nuclear shape irregularity of different anatomical sites from mice fed 33%
isogenic (ISO) or Austrian reference (A REF) corn 61
Table 48: Pore density (pores/urn nuclear membrane length) of different anatomical
sites of mice fed 33% isogenic (ISO) or Austrian reference (A REF) corn 63
Table 49: GSEA of deregulated genes (p 0.05 and 2fold change) between GM and ISO
groups describing biological processes* 64
Table 50: GSEA of deregulated genes (p 0.05 and 2fold change) between GM and ISO
groups describing pathways* 65
Table 51: GSEA of deregulated genes (p 0.05 and 2fold change) between ISO and A
REF groups describing biological processes* 66
Table 52: GSEA of deregulated genes (p 0.05 and 2fold change) between ISO and A
REF groups describing pathways* 66
Table 53: GSEA of deregulated genes (p 0.05 and 2fold change) between GM and
ISO+A REF groups describing biological processes* 68
Table 54: GSEA of deregulated genes (p 0.05 and 2fold change) between GM and
ISO+A REF groups describing pathways* 68
Table 55: Fold changes of deregulated genes confirmed by q-RT-PCR in the MGS and the
RACB 69
Table 56: Fold changes of deregulated genes confirmed by q-RT-PCR of the individual
and pooled studies 69
Table 57: Overview of litters in the RACB 73
Table 58: Performance of mice fed 33% isogenic (ISO) or genetically modified (GM) corn
in their diet over several deliveries 75
Table 59: Reproduction data of mice fed 33% isogenic (ISO) or genetically modified
(GM) corn in their diet over several generations 77
Table 60: Individual pup mass [g] per group at birth, 7, 14 and 21 days after birth from
parents with 33% of near isogenic (ISO) or transgenic(GM) corn in their diet 81
Page 100 of 105
9. Overview of figures
Figure 1: Feed intake of adult mice fed 33% isogenic (ISO) or genetically modified (GM)
corn in their diet in several generations 36
Figure 2: Distribution of litter size at delivery from females fed 33% isogenic (ISO) or
genetically modified (GM) corn in their diet in several generations ..40
Figure 3 a-b and 3 a -b : Mass of whole litter [g] and individual pup weight [g] at sev¬
eral time points of the Fl and F2 generation after birth of offspring from parental mice
fed 33% isogenic (ISO) or genetically modified (GM) corn in their
diet 41
Figure 3 c-d and 3 c -d : Mass of whole litter [g] and individual pup weight [g] at sev¬
eral time points of the Fl and F2 generation after birth of offspring from parental mice
fed 33% isogenic (ISO) or genetically modified (GM) corn in their
diet 42
Figure 4: Feed intake of adult mice fed 33% isogenic (ISO) or Austrian reference (A
REF) corn in their diet in several generations 45
Figure 5: Distribution of litter size at delivery from females fed 33% isogenic (ISO) or
Austrian reference corn in their diet in several generations 46
Figure 6 a-b and 6 a -b : Mass of whole litter [g] and individual pup weight [g] at sev¬
eral time points of the Fl and F2 generation after birth of offspring from parental mice
fed 33% isogenic (ISO) or Austrian reference(A REF) com in their
diet 49
Figures 6 c-d and 6 c -d : Mass of whole litter [g] and individual pup weight [g] at sev¬
eral time points of the F3 and F4 generation after birth of offspring from parental mice
fed 33% isogenic (ISO) or Austrian reference (A REF) corn in their
diet 50
Figure 7: Relative mass of testes of 5 week old mice fed 33% isogenic (ISO) or geneti¬
cally modified (GM) corn in their diet 53
Figure 8: Relative mass of liver (a), spleen (b) and kidneys(c) of 5 week old mice fed
33% isogenic (ISO) or genetically modified (GM) corn in their diet 54
Figure 9: Relative mass of testes of 5 week old mice fed 33% isogenic (ISO) or Austrian
reference (A REF) corn in their diet 55
Figure 10: Relative mass of liver (a), spleen (b) and kidneys (c) of 5 week old mice fed
33% isogenic (ISO) or Austrian reference (A REF) corn in their diet...56
Figure 11: Fibrillar centres (FC) and dense fibrillar components (DFC) of liver (a) (hepa-
tocytes), spleen (b) (lymphocytes) and pancreatic acinar cells (c) from the F3 generation
of mice fed 33% genetically modified (GM) or isogenic (ISO)
corn 60
Figure 12a-c: Fibrillar centres (FC) and dense fibrillar components (DFC) of liver (a),
spleen (b) and pancreatic acinar cells (c) from the F3 generation of mice fed 33% isog¬
enic (ISO) or Austrian Reference (A REF) corn 62
Figure 13: Venn diagram depicting the number of deregulated genes in the F3 genera¬
tion of mice fed 33% genetically modified (GM) corn. Isogenic (ISO) and Austrian refer¬
ence (A REF) corn were used as controls 67
Figure 14: Bar graphs of normalized data of jejunal miRNAs (each bar represents one
miRNA) of the 3rd generation (F3) from mice fed 33% isogenic(ISO) or transgenic(GM)
corn 71
Figure 15: Bar graphs of normalized data of jejunal miRNAs (each bar represents one
miRNA) of the 3rd generation (F3) from mice fed 33% isogenic(ISO) or Austrian reference
corn (A REF) 71
Figure 16: Test on survival by Kaplan-Meyer from female mice fed 33 % isogenic (ISO),
Austrian reference (A REF) or genetically modified (GM) corn 72
Figure 17: Feed intake within the first 2 weeks of the RACB of the mating pairs fed 33%
isogenic (ISO) or genetically modified (GM) corn in their diet 73
Page 101 of 105
Figure 18: Distribution of litter size at delivery from females fed 33% isogenic (ISO) or
genetically modified (GM) corn in their diet over 4 litters 76
Figure 19 a-b and 19 a -b : Mass of whole litter [g] and individual pup weight [g] at
several time points of the 1st and 2nd Fl generation after birth of offspring from parental
mice fed 33% isogenic (ISO) or genetically modified (GM) corn in their
diet 79
Figure 19 c-d and 19 c -d : Mass of whole litter [g] and individual pup weight [g] at
several time points of the 1st and 2nd Fl generation after birth of offspring from parental
mice fed 33% isogenic (ISO) or genetically modified (GM) corn in their
diet 80
Page 102 of 105
|
| any_adam_object | 1 |
| author | Velimirov, Alberta Binter, Claudia Zentek, Jürgen |
| author_facet | Velimirov, Alberta Binter, Claudia Zentek, Jürgen |
| author_role | aut aut aut |
| author_sort | Velimirov, Alberta |
| author_variant | a v av c b cb j z jz |
| building | Verbundindex |
| bvnumber | BV035252292 |
| classification_tum | BIO 734f BIO 753f VET 440f LAN 220f CIT 972f LAN 640f |
| ctrlnum | (OCoLC)438904939 (DE-599)BVBBV035252292 |
| discipline | Biologie Agrarwissenschaft Chemie-Ingenieurwesen Biotechnologie Veterinärmedizin Pflanzenbau |
| format | Book |
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| id | DE-604.BV035252292 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:29:40Z |
| institution | BVB |
| isbn | 9783902611246 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017057917 |
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| physical | 105 S. zahlr. graph. Darst., Tab. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| record_format | marc |
| series2 | Forschungsberichte der Sektion IV / Bundesministerium für Gesundheit, Familie und Jugend, Sektion IV |
| spelling | Velimirov, Alberta Verfasser aut Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice 11. November 2008 A. Velimirov ; C. Binter ; J. Zentek Wien 2008 105 S. zahlr. graph. Darst., Tab. txt rdacontent n rdamedia nc rdacarrier Forschungsberichte der Sektion IV / Bundesministerium für Gesundheit, Familie und Jugend, Sektion IV 2008,3 Gentechnisch erzeugtes Produkt (DE-588)4535464-9 gnd rswk-swf Futterpflanzen (DE-588)4136640-2 gnd rswk-swf Fütterung (DE-588)4018837-1 gnd rswk-swf Maus (DE-588)4169148-9 gnd rswk-swf Fruchtbarkeitsmerkmal (DE-588)4155508-9 gnd rswk-swf Transgene Pflanzen (DE-588)4311513-5 gnd rswk-swf Maissorte (DE-588)4280736-0 gnd rswk-swf Maissorte (DE-588)4280736-0 s Transgene Pflanzen (DE-588)4311513-5 s Futterpflanzen (DE-588)4136640-2 s Maus (DE-588)4169148-9 s DE-604 Fruchtbarkeitsmerkmal (DE-588)4155508-9 s Fütterung (DE-588)4018837-1 s Gentechnisch erzeugtes Produkt (DE-588)4535464-9 s b DE-604 Binter, Claudia Verfasser aut Zentek, Jürgen Verfasser aut Bundesministerium für Gesundheit, Familie und Jugend, Sektion IV Forschungsberichte der Sektion IV 2008,3 (DE-604)BV022482249 2008,3 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017057917&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Velimirov, Alberta Binter, Claudia Zentek, Jürgen Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice 11. November 2008 Gentechnisch erzeugtes Produkt (DE-588)4535464-9 gnd Futterpflanzen (DE-588)4136640-2 gnd Fütterung (DE-588)4018837-1 gnd Maus (DE-588)4169148-9 gnd Fruchtbarkeitsmerkmal (DE-588)4155508-9 gnd Transgene Pflanzen (DE-588)4311513-5 gnd Maissorte (DE-588)4280736-0 gnd |
| subject_GND | (DE-588)4535464-9 (DE-588)4136640-2 (DE-588)4018837-1 (DE-588)4169148-9 (DE-588)4155508-9 (DE-588)4311513-5 (DE-588)4280736-0 |
| title | Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice 11. November 2008 |
| title_auth | Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice 11. November 2008 |
| title_exact_search | Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice 11. November 2008 |
| title_full | Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice 11. November 2008 A. Velimirov ; C. Binter ; J. Zentek |
| title_fullStr | Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice 11. November 2008 A. Velimirov ; C. Binter ; J. Zentek |
| title_full_unstemmed | Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice 11. November 2008 A. Velimirov ; C. Binter ; J. Zentek |
| title_short | Biological effects of transgenic maize NK603xMON810 fed in long term reproduction studies in mice |
| title_sort | biological effects of transgenic maize nk603xmon810 fed in long term reproduction studies in mice 11 november 2008 |
| title_sub | 11. November 2008 |
| topic | Gentechnisch erzeugtes Produkt (DE-588)4535464-9 gnd Futterpflanzen (DE-588)4136640-2 gnd Fütterung (DE-588)4018837-1 gnd Maus (DE-588)4169148-9 gnd Fruchtbarkeitsmerkmal (DE-588)4155508-9 gnd Transgene Pflanzen (DE-588)4311513-5 gnd Maissorte (DE-588)4280736-0 gnd |
| topic_facet | Gentechnisch erzeugtes Produkt Futterpflanzen Fütterung Maus Fruchtbarkeitsmerkmal Transgene Pflanzen Maissorte |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017057917&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV022482249 |
| work_keys_str_mv | AT velimirovalberta biologicaleffectsoftransgenicmaizenk603xmon810fedinlongtermreproductionstudiesinmice11november2008 AT binterclaudia biologicaleffectsoftransgenicmaizenk603xmon810fedinlongtermreproductionstudiesinmice11november2008 AT zentekjurgen biologicaleffectsoftransgenicmaizenk603xmon810fedinlongtermreproductionstudiesinmice11november2008 |