The Cerebral Perivascular Cells:
Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Emp...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Berlin, Heidelberg
Springer Berlin Heidelberg
1998
|
| Schriftenreihe: | Advances in Anatomy, Embryology and Cell Biology
147 |
| Schlagworte: | |
| Online-Zugang: | UBR01 URL des Erstveröffentlichers |
| Zusammenfassung: | Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Employing the combination of (a) a lesion model in which neuronal degeneration and neuronophagia are caused without disruption of the blood--brain barrier, (b) stable labeling of the neuronophages via phagocytosis of the permanent nontoxic fluorescent marker Fluoro-Gold from preloaded neurons, and (c) immunocytochemical identification of all FG-labeled brain neuronophages, the authors provide evidence that the only cells in the rat CNS which can be regarded as the resident antigen presenting cells of the brain are perivascular cells |
| Beschreibung: | 1 Online-Ressource (XI, 90 p. 23 illus) |
| ISBN: | 9783642722516 |
| DOI: | 10.1007/978-3-642-72251-6 |
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Datensatz im Suchindex
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| any_adam_object | |
| author | Angelov, D. N. Walther, M. Neiss, W. F. Streppel, M. |
| author_facet | Angelov, D. N. Walther, M. Neiss, W. F. Streppel, M. |
| author_role | aut aut aut aut |
| author_sort | Angelov, D. N. |
| author_variant | d n a dn dna m w mw w f n wf wfn m s ms |
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| bvnumber | BV046145919 |
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| ctrlnum | (ZDB-2-SME)978-3-642-72251-6 (OCoLC)1119148036 (DE-599)BVBBV046145919 |
| dewey-full | 612.8 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.8 |
| dewey-search | 612.8 |
| dewey-sort | 3612.8 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| doi_str_mv | 10.1007/978-3-642-72251-6 |
| format | Electronic eBook |
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| id | DE-604.BV046145919 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:36:28Z |
| institution | BVB |
| isbn | 9783642722516 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-031526104 |
| oclc_num | 1119148036 |
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| physical | 1 Online-Ressource (XI, 90 p. 23 illus) |
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| publishDate | 1998 |
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| publisher | Springer Berlin Heidelberg |
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| series2 | Advances in Anatomy, Embryology and Cell Biology |
| spelling | Angelov, D. N. Verfasser aut The Cerebral Perivascular Cells by D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius Berlin, Heidelberg Springer Berlin Heidelberg 1998 1 Online-Ressource (XI, 90 p. 23 illus) txt rdacontent c rdamedia cr rdacarrier Advances in Anatomy, Embryology and Cell Biology 147 Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Employing the combination of (a) a lesion model in which neuronal degeneration and neuronophagia are caused without disruption of the blood--brain barrier, (b) stable labeling of the neuronophages via phagocytosis of the permanent nontoxic fluorescent marker Fluoro-Gold from preloaded neurons, and (c) immunocytochemical identification of all FG-labeled brain neuronophages, the authors provide evidence that the only cells in the rat CNS which can be regarded as the resident antigen presenting cells of the brain are perivascular cells Neurosciences Cell Biology Cytology Tiermodell (DE-588)4140660-6 gnd rswk-swf Gehirn (DE-588)4019752-9 gnd rswk-swf Zelluläre Immunität (DE-588)4197656-3 gnd rswk-swf Antigenpräsentation (DE-588)4211468-8 gnd rswk-swf Hirnzelle (DE-588)4159947-0 gnd rswk-swf Hirnzelle (DE-588)4159947-0 s Antigenpräsentation (DE-588)4211468-8 s Tiermodell (DE-588)4140660-6 s DE-604 Gehirn (DE-588)4019752-9 s Zelluläre Immunität (DE-588)4197656-3 s Walther, M. aut Neiss, W. F. aut Streppel, M. aut Erscheint auch als Druck-Ausgabe 9783540646389 Erscheint auch als Druck-Ausgabe 9783642722523 https://doi.org/10.1007/978-3-642-72251-6 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Angelov, D. N. Walther, M. Neiss, W. F. Streppel, M. The Cerebral Perivascular Cells Neurosciences Cell Biology Cytology Tiermodell (DE-588)4140660-6 gnd Gehirn (DE-588)4019752-9 gnd Zelluläre Immunität (DE-588)4197656-3 gnd Antigenpräsentation (DE-588)4211468-8 gnd Hirnzelle (DE-588)4159947-0 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4019752-9 (DE-588)4197656-3 (DE-588)4211468-8 (DE-588)4159947-0 |
| title | The Cerebral Perivascular Cells |
| title_auth | The Cerebral Perivascular Cells |
| title_exact_search | The Cerebral Perivascular Cells |
| title_full | The Cerebral Perivascular Cells by D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius |
| title_fullStr | The Cerebral Perivascular Cells by D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius |
| title_full_unstemmed | The Cerebral Perivascular Cells by D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius |
| title_short | The Cerebral Perivascular Cells |
| title_sort | the cerebral perivascular cells |
| topic | Neurosciences Cell Biology Cytology Tiermodell (DE-588)4140660-6 gnd Gehirn (DE-588)4019752-9 gnd Zelluläre Immunität (DE-588)4197656-3 gnd Antigenpräsentation (DE-588)4211468-8 gnd Hirnzelle (DE-588)4159947-0 gnd |
| topic_facet | Neurosciences Cell Biology Cytology Tiermodell Gehirn Zelluläre Immunität Antigenpräsentation Hirnzelle |
| url | https://doi.org/10.1007/978-3-642-72251-6 |
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