Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | V, 70 S. Ill., graph. Darst. 30 cm |
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
ZUSAMMENFASSUNG II
SUMMARY III
1 INTRODUCTION 1
1.1 CLINICAL FEATURES AND EPIDEMIOLOGY 1
1.2 ANTIMYCOTIC THERAPY AND RESISTANCE 1
1.3 PREDISPOSING CONDITIONS AND RISK FACTORS 2
1.4 THE VAGINAL ECOSYSTEM 4
1.5 THE PATHOGEN C. ALBICANS AND ITS VIRULENCE FACTORS 4
1.6 INNATE IMMUNITY OF EPITHELIA AGAINST CANDIDA INFECTION 6
1.7 NEUTROPHILS IN RWC 8
1.8 ANTIMICROBIAL PEPTIDES 8
1.9 AIM OF THE STUDY 12
2 MATERIALS AND METHODS 13
2.1 CLINICAL SAMPLES 13
2.2 CANDIDA ALBICANS ISOLATES 15
2.3 CELL CULTURE 16
2.4 GENE EXPRESSION ANALYSIS 19
2.5 HISTOLOGICAL AND CYTOLOGICAL ANALYSES 21
2.6 STATISTICAL ANALYSIS AND DATA PRESENTATION 22
3 RESULTS 24
3.1 CHARACTERISTICS OF THE STUDY PARTICIPANTS 24
3.2 AMP EXPRESSION IN RWC PATIENTS AND THE CONTROL GROUP 26
3.3 HIGHER SUSCEPTIBILITY OF PATHOGENIC ISOLATES TO PROTAMINE 34
3.4 FURTHER CHARACTERISTICS OF THE PATIENT GROUP 35
3.5 INFECTION ASSAYS ON VAGINAL EPITHELIAL CELL LINE MONOLAYERS 37
IV
HTTP://D-NB.INFO/1049564863
4 DISCUSSION
39
4.1
REGULATION OF AMPS IN RWC
39
4.2
DOWNREGULATION OF HBD
-3
IN ACUTE RWC
40
4.3
NEUTROPHILS, INFLAMMATION AND SYMPTOMATICITY
42
4.4
C. GLABRATA AND THE DEVELOPMENT OF FUNGAL RESISTANCE
43
4.5
MORPHOLOGICAL APPEARANCE OF RWC
45
4.6
CAUSES OF TREATMENT FAILURE
46
4.7
LIMITATIONS OF THE STUDY
47
4.8
CONCLUSION: FACTORS LEADING TO RECURRENCE OF WC
47
ACKNOWLEDGEMENTS
49
A
A GLOSSARY OF ABBREVIATIONS AND SYMBOLS
50
B MATERIALS AND DEVICES
51
C DATA FROM CELL CULTURE EXPERIMENTS
53
D ETHICS COMMITTEE STATEMENT
58
E BIBLIOGRAPHY
60
CURRICULUM VITAE
70
V
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| author | Stopsack, Konrad Hermann 1986- |
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| ctrlnum | (OCoLC)879650051 (DE-599)DNB1049564863 |
| discipline | Medizin |
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| spelling | Stopsack, Konrad Hermann 1986- Verfasser (DE-588)1047850532 aut Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides vorgelegt von Konrad Hermann Stopsack 2013 V, 70 S. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Freiburg (Breisgau), Univ., Diss., 2014 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027263048&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Stopsack, Konrad Hermann 1986- Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides |
| subject_GND | (DE-588)4113937-9 |
| title | Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides |
| title_auth | Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides |
| title_exact_search | Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides |
| title_full | Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides vorgelegt von Konrad Hermann Stopsack |
| title_fullStr | Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides vorgelegt von Konrad Hermann Stopsack |
| title_full_unstemmed | Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides vorgelegt von Konrad Hermann Stopsack |
| title_short | Immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides |
| title_sort | immune response to vulvovaginal candidiasis with special regard to antimicrobial peptides |
| topic_facet | Hochschulschrift |
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