Handbook of immune response genes:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Plenum Pr.
1998
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 393 S. graph. Darst. |
| ISBN: | 0306456478 |
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| 100 | 1 | |a Mak, Tak W. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Handbook of immune response genes |c Tak W. Mak and John J. L. Simard |
| 264 | 1 | |a New York [u.a.] |b Plenum Pr. |c 1998 | |
| 300 | |a XIV, 393 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Genen |2 gtt | |
| 650 | 7 | |a Immuunreacties |2 gtt | |
| 650 | 4 | |a Genes |x immunology |v Handbooks | |
| 650 | 4 | |a Immune System Diseases |x genetics |v Handbooks | |
| 650 | 4 | |a Immunogenetics |v Handbooks | |
| 650 | 4 | |a Immunogenetics |x Handbooks, manuals, etc | |
| 650 | 4 | |a Ir genes |x Handbooks, manuals, etc | |
| 650 | 4 | |a Major histocompatibility complex |x Genetic aspects |x Handbooks, manuals, etc | |
| 700 | 1 | |a Simard, John J. |e Verfasser |4 aut | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-008225492 | ||
Datensatz im Suchindex
| _version_ | 1804126753579335680 |
|---|---|
| adam_text | Contents
1. GENES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX 1
1.1. MHC of the Laboratory Mouse 1
1.1.1. Class I (Class la or Classical Class I Molecules) 2
1.1.2. Class Ib 5
1.1.3. Class II 6
1.1.4. Class III Genes 8
1.2. The Human Leukocyte Antigens (HLA) 9
1.2.1. HLA Class I 10
1.2.2. HLA Class Ib 15
1.2.3. Class I Transcriptional Regulation 16
1.2.4. HLA Class II 16
1.3. Peptide Binding Pockets 24
1.3.1. Class I Peptide Binding 24
1.3.2. Class II Peptide Binding 32
References 34
2. GENES OF THE ANTIGEN PROCESSING PATHWA YS 45
2.1. The Class I Pathway for Antigen Processing and Presentation 46
2.1.1. Proteasome 46
2.1.2. LMP2 and LMP7 49
2.1.3. PA28a/PA28(3 51
2.1.4. TAP1 and TAP2 51
2.1.5. Calnexin (p88, IP90) 53
2.2. Class II Antigen Presentation Pathway 53
2.2.1. Invariant Chain 53
2.2.2. CLIP 55
2.2.3. HLA DM/H 2M 57
References 58
3. T LYMPHOCYTE GENES 67
3.1. T Cell Receptor Genes 69
3.1.1. a|3 69
3.1.2. 78 71
xi
xii CONTENTS
3.2. Recombination and Expression of TCR Genes 73
3.3. Machinery 75
3.3.1. Recombination Activating Genes 1 and 2 (RAG1 and RAG2)... 75
3.3.2. Terminal Deoxynucleotidyl Transferase (TdT) 75
3.3.3. DNA Dependent Protein Kinase (DNA PK) 76
3.4. Signaling and Coreceptors 77
3.4.1. CD3 Complex 77
3.4.2. CD4 (T4, Leu3, L3T4) 80
3.4.3. CD8 80
3.4.4. CD28 81
3.4.5. IL 2/IL 2R System 81
3.4.6. CD45 82
3.4.7. CTLA 4 83
3.5. T Cell Accessory Molecules 84
3.5.1. CD2 (LFA 2, Leu 5, Tp50) 84
3.5.2. CD5 84
3.5.3. FAS (CD95)/FASL 84
3.5.4. LFA 1 (CD18/CD1 la) 85
3.5.5. Very Late Activation (VLA) Integrins (CD49a_f/CD29) 86
3.6. Thymic Development of T Cells 86
References 86
4. B LYMPHOCYTE GENES 109
4.1. Immunoglobulin Genes 112
4.1.1. Heavy Chain Genes 112
4.1.2. k Light Chain 115
4.1.3. A. Light Chain 120
4.1.4. Surrogate Light Chain (VpreB/ 5) 121
4.2. Genetic Elements Regulating Recombination and Receptor Diversity ... 122
4.2.1. Recombination Signal Sequences (RSS) 122
4.2.2. Somatic Hypermutation: Enhancer/Matrix
Attachment Regions (Ei/MARs) 124
4.3. Machinery 125
4.3.1. Recombination Activating Genes (RAG1 and RAG2) 125
4.3.2. Terminal Deoxynucleotidyl Transferase (TdT) 126
4.3.3. DNA Dependent Protein Kinase (DNA PK) 127
4.4. B Cell Signaling 127
4.4.1. B Cell Receptor Complex (Iga/IgP; CD79a/CD79b) 127
4.4.2. CD19 127
4.4.3. CD20 129
4.4.4. CD22 130
4.4.5. CD45 130
4.4.6. Signaling Kinases and Phosphatases 130
4.5. The Immunoglobulins 131
4.5.1. IgA 131
4.5.2. IgD 134
4.5.3. IgE 135
I CONTENTS xiii
4.5.4. IgG 136
4.5.5. IgM 139
4.6. Fc Receptors 140
4.6.1. IgA Receptors 140
4.6.2. IgE Receptors 142
4.6.3. IgG Receptors 142
4.6.4. IgM Receptors 144
4.7. B Cell Development 146
References 148
5. AUTOIMMUNE DISORDERS: HLA, GENETIC PREDISPOSITION,
AND THE IMMUNE SYSTEM 171
5.1. HLA Class 1 173
5.2. HLA Class II 174
5.2.1. HLA DP 174
5.2.2. HLA DQ 174
5.2.3. HLA DR 175
5.3. Calculating Relative Risk Values for HLA Disease Associations 175
5.4. Addison s Disease 175
5.5. Ankylosing Spondylitis 176
5.6. Autoimmune Liver Disease 176
5.6.1. Autoimmune Hepatitis 177
5.6.2. Primary Biliary Cirrhosis 178
5.6.3. Primary Sclerosing Cholangitis 178
5.7. Behcet s Disease 178
5.8. Celiac Disease 179
5.9. Cicatricial Pemphigoid 179
5.10. Dermatitis Herpetiformis 180
5.11. Insulin Dependent Diabetes Mellitus 180
5.12. Multiple Sclerosis 181
5.13. Myasthenia Gravis 182
5.14. Pemphigus Vulgaris 183
5.15. Reiter s Syndrome 183
5.16. Rheumatoid Arthritis 183
5.17. Systemic Lupus Erythematosus 184
References 185
6. NEOPLASIAS INVOLVING TRANSLOCATION OF ANTIGEN
RECEPTOR GENES 203
6.1. Neoplasias Involving the T Cell Receptor 203
6.1.1. HOX11 (TLX1) 203
6.1.2. pl6INK4 (MTS1) 205
6.1.3. p56LCK 205
6.1.4. c MYC 206
6.1.5. MTCP1 (C6.1B) 206
6.1.6. TALI (SCL/TCL5)/TAL2/LYL1 206
6.1.7. TCL1 207
xiv CONTENTS
6.1.8. TCL3 (TAN1/NOTCH1) 207
6.1.9. TTG1 (RBTN1)/TTG2 (RBTN2) 207
6.2. Neoplasias Involving the B Cell Receptor 208
6.2.1. BCL1 (Cyclin D1/PRAD1) 208
6.2.2. BCL2 208
6.2.3. BCL3 209
6.2.4. BCL6 (LAZ3, BCL5) 209
6.2.5. BCL7a 210
6.2.6. Interleukin 3 (IL 3) 210
6.2.7. c MYC 210
6.2.8. NF kB2 (Lyt 10, p50B) 211
References 211
7. CYTOKINES OF THE IMMUNE RESPONSE 219
7.1. Short Chain Helical Bundle 221
7.1.1. Interleukin 2 221
7.1.2. Interleukin 3 224
7.1.3. Interleukin 4 231
7.1.4. Interleukin 5 232
7.1.5. Interleukin 9 232
7.1.6. Interleukin 13 233
7.1.7. Interleukin 15 234
7.1.8. Interferon 7 235
7.2. Long Chain Helical Bundle 236
7.2.1. Interleukin 6 236
7.2.2. Interleukin 7 237
7.2.3. Interleukin 10 238
7.2.4. Interleukin 11 239
7.2.5. Interleukin 12 240
7.2.6. Interferons a and 3 (Type I Interferons) 242
7.3. p Trefoil [Interleukin 1 (IL la, IL ip, IL lra)] 243
7.4. (3 Jelly Roll (Trimers) 244
7.4.1. Tumor Necrosis Factor (TNFa) 244
7.4.2. Lymphotoxins a (TNFfi) and (3 246
7.5. Cysteine Knot [Transforming Growth Factor 3 (TGF3I, 32, 33)].... 248
7.6. a Chemokines (C X C; Interleukin 8) 249
7.7. Others 250
7.7.1. Interleukin 14 [High MW B Cell Growth Factor (BCGF1)] 250
7.7.2. Interleukin 16 (Lymphocyte Chemoattractant Factor) 250
7.7.3. Interleukin 17 [Cytotoxic T Lymphocyte Associated
Antigen 8 (CTLA8)] 251
7.7.4. Interleukin 18 [Interferon 7 Inducing Factor (IGIF)] 251
References 251
8. LEUKOCYTE CLUSTER OF DIFFERENTIATION ANTIGENS 299
A Reference Table for Cluster of Differentiation (CD) Antigens 300
References 345
INDEX 383
|
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| id | DE-604.BV012145668 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T18:22:28Z |
| institution | BVB |
| isbn | 0306456478 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-008225492 |
| oclc_num | 37993204 |
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| owner_facet | DE-29 DE-11 |
| physical | XIV, 393 S. graph. Darst. |
| publishDate | 1998 |
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| publisher | Plenum Pr. |
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| spelling | Mak, Tak W. Verfasser aut Handbook of immune response genes Tak W. Mak and John J. L. Simard New York [u.a.] Plenum Pr. 1998 XIV, 393 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genen gtt Immuunreacties gtt Genes immunology Handbooks Immune System Diseases genetics Handbooks Immunogenetics Handbooks Immunogenetics Handbooks, manuals, etc Ir genes Handbooks, manuals, etc Major histocompatibility complex Genetic aspects Handbooks, manuals, etc Simard, John J. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008225492&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mak, Tak W. Simard, John J. Handbook of immune response genes Genen gtt Immuunreacties gtt Genes immunology Handbooks Immune System Diseases genetics Handbooks Immunogenetics Handbooks Immunogenetics Handbooks, manuals, etc Ir genes Handbooks, manuals, etc Major histocompatibility complex Genetic aspects Handbooks, manuals, etc |
| title | Handbook of immune response genes |
| title_auth | Handbook of immune response genes |
| title_exact_search | Handbook of immune response genes |
| title_full | Handbook of immune response genes Tak W. Mak and John J. L. Simard |
| title_fullStr | Handbook of immune response genes Tak W. Mak and John J. L. Simard |
| title_full_unstemmed | Handbook of immune response genes Tak W. Mak and John J. L. Simard |
| title_short | Handbook of immune response genes |
| title_sort | handbook of immune response genes |
| topic | Genen gtt Immuunreacties gtt Genes immunology Handbooks Immune System Diseases genetics Handbooks Immunogenetics Handbooks Immunogenetics Handbooks, manuals, etc Ir genes Handbooks, manuals, etc Major histocompatibility complex Genetic aspects Handbooks, manuals, etc |
| topic_facet | Genen Immuunreacties Genes immunology Handbooks Immune System Diseases genetics Handbooks Immunogenetics Handbooks Immunogenetics Handbooks, manuals, etc Ir genes Handbooks, manuals, etc Major histocompatibility complex Genetic aspects Handbooks, manuals, etc |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=008225492&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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