Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis:

Lung fibrosis is a dysregulated or exaggerated tissue repair process resulting in the thickening or scarring of lung tissue. It involves the presence of sustained or repeated exposure to a stressor and intricate dynamics between several inflammatory and immune response cells, and the microenvironmen...

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Bibliographische Detailangaben
1. Verfasser: Halappanavar, Sabina (VerfasserIn)
Weitere Verfasser: Sharma, Monita (MitwirkendeR), Solorio-Rodriguez, Silvia (MitwirkendeR), Wallin, Hakan (MitwirkendeR), Vogel, Ulla (MitwirkendeR), Sullivan, Kristie (MitwirkendeR), Clippinger, Amy J.. (MitwirkendeR)
Format: Elektronisch E-Book
Sprache:English
Veröffentlicht: Paris OECD Publishing 2023
Schriftenreihe:OECD Series on Adverse Outcome Pathways no.33
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Zusammenfassung:Lung fibrosis is a dysregulated or exaggerated tissue repair process resulting in the thickening or scarring of lung tissue. It involves the presence of sustained or repeated exposure to a stressor and intricate dynamics between several inflammatory and immune response cells, and the microenvironment of the alveolar-capillary region consisting of both immune and non-immune cells, and the lung interstitium. This AOP is applicable to a broad group of stressors of diverse properties e.g. metal dusts, pharmacological products, fibres, microorganisms, chemicals, including novel technology-enabled stressors such as nanomaterials. This AOP is referred to as AOP 173 in the Collaborative Adverse Outcome Pathway Wiki (AOP-Wiki).
Beschreibung:1 Online-Ressource (155 p.) 21 x 28cm.
DOI:10.1787/10372cb8-en

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