Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
2006
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Regensburg, Univ., Diss., 2007 |
| Beschreibung: | II, 59 Bl. Ill., graph. Darst. |
Internformat
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Datensatz im Suchindex
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TABLE OF CONTENTS
1. Summary 1
2. Introduction 3
2.1 Myocardial infarction and coronary artery disease 3
2.1.1 Definition of myocardial infarction and coronary artery disease 3
2.1.2 Epidemiology 3
2.1.3 Pathophysiology of coronary artery disease and myocardial infarction 5
2.2 Genetics of complex diseases 8
2.2.1 Interindividual genetic variability 8
2.2.2 Phenotype 10
2.2.3 Monogenic traits 10
2.2.4 Complex genetic traits 11
2.2.5 Genetic mapping 12
2.3 Myocardial infarction as a complex genetic trait 17
2.4 Aim of the thesis 19
3. Material and Methods 20
3.1 Study populations 20
3.2 DNA processing 21
3.2.1 DNA extraction and storage 21
3.2.2 DNA quantitation, dilution and normalization 21
3.2.3 DNA quality control 22
3.3 MALDI TOF MS genotyping 23
3.3.1 Assay design 23
3.3.2 PCR amplification of the DNA 24
3.3.3 Homogeneous MassEXTEND reaction 25
3.3.4 Spotting the hME reaction the products 27
I
3.3.5 Mass spectrometry 28
3.3.6 Genotype calling and genotype data management 28
3.4 Bioinformatics tools and SNP identification 29
3.5 Statistical analyses 30
4. Results 31
4.1 Characteristics of study populations 31
4.2 Annotation of the LTA genomic region 32
4.3 SNP identification and assay design 34
4.4 Genetic analyses 36
4.4.1 Descriptive statistics 36
4.4.2 Single marker analysis 37
4.4.3 Haplotype analysis 39
5. Discussion 40
6. Literature 45
7. Curriculum Vitae 51
8. Bibliography 53
9. Appendix 54
9.1 Devices, chemicals and consumables 54
9.2 List of abbreviations 56
9.3 URLs 57
10. Declaration 58
11. Acknowledgements 59
n |
| adam_txt |
TABLE OF CONTENTS
1. Summary 1
2. Introduction 3
2.1 Myocardial infarction and coronary artery disease 3
2.1.1 Definition of myocardial infarction and coronary artery disease 3
2.1.2 Epidemiology 3
2.1.3 Pathophysiology of coronary artery disease and myocardial infarction 5
2.2 Genetics of complex diseases 8
2.2.1 Interindividual genetic variability 8
2.2.2 Phenotype 10
2.2.3 Monogenic traits 10
2.2.4 Complex genetic traits 11
2.2.5 Genetic mapping 12
2.3 Myocardial infarction as a complex genetic trait 17
2.4 Aim of the thesis 19
3. Material and Methods 20
3.1 Study populations 20
3.2 DNA processing 21
3.2.1 DNA extraction and storage 21
3.2.2 DNA quantitation, dilution and normalization 21
3.2.3 DNA quality control 22
3.3 MALDI TOF MS genotyping 23
3.3.1 Assay design 23
3.3.2 PCR amplification of the DNA 24
3.3.3 Homogeneous MassEXTEND reaction 25
3.3.4 Spotting the hME reaction the products 27
I
3.3.5 Mass spectrometry 28
3.3.6 Genotype calling and genotype data management 28
3.4 Bioinformatics tools and SNP identification 29
3.5 Statistical analyses 30
4. Results 31
4.1 Characteristics of study populations 31
4.2 Annotation of the LTA genomic region 32
4.3 SNP identification and assay design 34
4.4 Genetic analyses 36
4.4.1 Descriptive statistics 36
4.4.2 Single marker analysis 37
4.4.3 Haplotype analysis 39
5. Discussion 40
6. Literature 45
7. Curriculum Vitae 51
8. Bibliography 53
9. Appendix 54
9.1 Devices, chemicals and consumables 54
9.2 List of abbreviations 56
9.3 URLs 57
10. Declaration 58
11. Acknowledgements 59
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| spelling | Sedlacek, Kamil 1974- Verfasser (DE-588)133548694 aut Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations von Kamil Sedlacek 2006 II, 59 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Regensburg, Univ., Diss., 2007 Genetische Variabilität (DE-588)4264352-1 gnd rswk-swf Lymphotoxin (DE-588)4168376-6 gnd rswk-swf Herzinfarkt (DE-588)4024654-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Herzinfarkt (DE-588)4024654-1 s Lymphotoxin (DE-588)4168376-6 s Genetische Variabilität (DE-588)4264352-1 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015740826&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sedlacek, Kamil 1974- Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations Genetische Variabilität (DE-588)4264352-1 gnd Lymphotoxin (DE-588)4168376-6 gnd Herzinfarkt (DE-588)4024654-1 gnd |
| subject_GND | (DE-588)4264352-1 (DE-588)4168376-6 (DE-588)4024654-1 (DE-588)4113937-9 |
| title | Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations |
| title_auth | Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations |
| title_exact_search | Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations |
| title_exact_search_txtP | Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations |
| title_full | Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations von Kamil Sedlacek |
| title_fullStr | Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations von Kamil Sedlacek |
| title_full_unstemmed | Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations von Kamil Sedlacek |
| title_short | Common genetic variation in Lymphotoxin-alpha genomic region and susceptibility to myocardial infarction in german populations |
| title_sort | common genetic variation in lymphotoxin alpha genomic region and susceptibility to myocardial infarction in german populations |
| topic | Genetische Variabilität (DE-588)4264352-1 gnd Lymphotoxin (DE-588)4168376-6 gnd Herzinfarkt (DE-588)4024654-1 gnd |
| topic_facet | Genetische Variabilität Lymphotoxin Herzinfarkt Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015740826&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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