Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene: association with inflammatory bowel disease and response to infliximab treatment
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Mikrofilm Buch |
| Sprache: | English |
| Veröffentlicht: |
2004
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Kiel, Univ., Diss., 2004 |
| Beschreibung: | 59 Bl. graph. Darst. |
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Datensatz im Suchindex
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| adam_text | 1 INTRODUCTION 1
1.1 PathophysiologyoflBD 2
1.2 Pharmacogenetics in Crohn s disease: Response to infliximab treatment 4
1.3 Genetic background of IBD 6
1.4 Positional and functional candidate genes 7
1.4.1 LITAF g
1.4.2 CARD15 8
2 MATERIAL AND METHODS 9
2.1 Participants 9
2.1.1 Families and trios 9
2.1.2 Response to infliximab treatment 10
2.2 Sequencing for de novo variant detection 12
2.2.1 LITAF 13
2.2.2 CARD15 13
2.3 SNP genotyping 17
2.3.1 LITAF 18
2.3.2 CARD15 19
2.4 Statistical analysis 25
3 RESULTS 26
3.1 Variant detection 26
3.1.1 LITAF 26
3.1.2 CARDI5 27
3.2 SNP Typing 28
3.2.1 LITAF 28
3.2.2 CARD15 31
4 DISCUSSION . . 38
4.1 LITAF 38
4.1.1 Association with IBD and response to infliximab treatment 38
4.2 CARD15 39
4.2.1 Association with IBD 39
4.2.2 Approach on gene finding 39
4.2.3 Role of CARD15 in other samples 42
4.2.4 Role of CARD15 variations in development of Crohn s disease 42
4.2.5 Association with response to infliximab treatment 44
5 SUMMARY 46
6 REFERENCES 48
|
| adam_txt |
1 INTRODUCTION 1
1.1 PathophysiologyoflBD 2
1.2 Pharmacogenetics in Crohn's disease: Response to infliximab treatment 4
1.3 Genetic background of IBD 6
1.4 Positional and functional candidate genes 7
1.4.1 LITAF g
1.4.2 CARD15 8
2 MATERIAL AND METHODS 9
2.1 Participants 9
2.1.1 Families and trios 9
2.1.2 Response to infliximab treatment 10
2.2 Sequencing for de novo variant detection 12
2.2.1 LITAF 13
2.2.2 CARD15 13
2.3 SNP genotyping 17
2.3.1 LITAF 18
2.3.2 CARD15 19
2.4 Statistical analysis 25
3 RESULTS 26
3.1 Variant detection 26
3.1.1 LITAF 26
3.1.2 CARDI5 27
3.2 SNP Typing 28
3.2.1 LITAF 28
3.2.2 CARD15 31
4 DISCUSSION .'. 38
4.1 LITAF 38
4.1.1 Association with IBD and response to infliximab treatment 38
4.2 CARD15 39
4.2.1 Association with IBD 39
4.2.2 Approach on gene finding 39
4.2.3 Role of CARD15 in other samples 42
4.2.4 Role of CARD15 variations in development of Crohn's disease 42
4.2.5 Association with response to infliximab treatment 44
5 SUMMARY 46
6 REFERENCES 48 |
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| index_date | 2024-07-02T13:24:45Z |
| indexdate | 2024-07-09T20:27:02Z |
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| language | English |
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| spelling | Schubert, Silvia 1978- Verfasser (DE-588)129463639 aut Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment vorgelegt von Silvia Schubert 2004 59 Bl. graph. Darst. txt rdacontent h rdamedia he rdacarrier Kiel, Univ., Diss., 2004 Mikroform-Ausgabe [2004 ?] 1 Mikrofiche : 24x Mikrofiche-Ausg.: [Mikrofiche-Ausg.] Signatur des reproduzierten Kulturobjekts: DBL_x001C_2004 MF 991 s2004 (DE-588)4113937-9 Hochschulschrift gnd-content Reproduktion von Schubert, Silvia, 1978- Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene 2004 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014188973&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schubert, Silvia 1978- Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment |
| subject_GND | (DE-588)4113937-9 |
| title | Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment |
| title_auth | Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment |
| title_exact_search | Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment |
| title_exact_search_txtP | Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment |
| title_full | Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment vorgelegt von Silvia Schubert |
| title_fullStr | Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment vorgelegt von Silvia Schubert |
| title_full_unstemmed | Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment vorgelegt von Silvia Schubert |
| title_short | Variant detection and single nucleotide polymorphism typing of lipopolysaccharide-induced transcription factor regulating tumor necrosis factor a [alpha] gene and caspase recruitment domain 15 gene |
| title_sort | variant detection and single nucleotide polymorphism typing of lipopolysaccharide induced transcription factor regulating tumor necrosis factor a alpha gene and caspase recruitment domain 15 gene association with inflammatory bowel disease and response to infliximab treatment |
| title_sub | association with inflammatory bowel disease and response to infliximab treatment |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014188973&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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