Kinetics and mechanics of non-equilibrium actin networks:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120802-1107744-1-5 Inhaltsverzeichnis |
| Beschreibung: | VII, 118 S. Ill., graph. Darst. |
Internformat
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| 100 | 1 | |a Schmoller, Kurt Michael |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Kinetics and mechanics of non-equilibrium actin networks |c Kurt Michael Schmoller |
| 264 | 1 | |c 2012 | |
| 300 | |a VII, 118 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a München, Techn. Univ., Diss., 2012 | ||
| 650 | 0 | 7 | |a Polymeres Netzwerk |0 (DE-588)4307122-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Nichtgleichgewicht |0 (DE-588)4171730-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Actin |0 (DE-588)4201876-6 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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Datensatz im Suchindex
| _version_ | 1804149418810671104 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
1 INTRODUCTION 1
2 MATERIALS A N D M E T H O D S 5
2.1 PROTEINS 5
2.1.1 ACTIN 5
2.1.1.1 COVALENTLY LABELED ACTIN 6
2.1.1.2 VISUALIZING ACTIN WITH LABELED PHALLOIDIN 6
2.1.2 CROSS-LINKING AND BUNDLING PROTEINS 7
2.1.2.1 HMM 7
2.1.2.2 FASCIN 8
2.1.2.3 FILAMIN 8
2.1.2.4 A-ACTININ 8
2.1.2.5 CORTEXILLIN-I 8
2.1.2.6 ANILLIN 9
2.1.3 OTHER ACTIN BINDING MOLECULES 9
2.1.3.1 MYOSIN-II 9
2.1.3.2 TROPOMYOSIN 9
2.1.3.3 COFILIN 9
2.1.3.4 GELSOLIN 10
2.1.3.5 LATRUNCULIN B 10
2.2 MICROSCOPY 10
2.2.1 FLUORESCENCE MICROSCOPY 10
2.2.2 CONFOCAL MICROSCOPY 11
2.3 MACRORHEOLOGY 11
2.3.1 CONFOCAL RHEOLOGY 12
2.3.2 SURFACE EFFECTS IN THE NON-LINEAR RHEOLOGY OF BIOPOLYMER NETWORKS
. 12
3 S T E A D Y S T A T E D Y N A M I C S O F A C T I N FILAMENTS:
FRAGMENTATION IS A CRUCIAL PROCESS 1 7
3.1 THEORETICAL BACKGROUND 18
3.1.1 SINGLE-STRANDED POLYMER IN THERMAL EQUILIBRIUM 18
3.1.1.1 LENGTH DISTRIBUTION 18
3.1.1.2 FRAGMENTATION AND ANNEALING 20
V
HTTP://D-NB.INFO/1029696373
IMAGE 2
CONTENTS
3.1.2 SINGLE-STRANDED POLAR POLYMER IN STEADY STATE 20
3.2 STEADY STATE DYNAMICS OF ACTIN FILAMENTS DIRECTLY VISUALIZED BY
FLUORESCENCE MICROSCOPY 22
3.3 PHOSPHATE RELEASE OF A STEADY STATE F-ACTIN ENSEMBLE 27
3.4 STEADY STATE DYNAMICS ARE EVEN SLOWER A T PHYSIOLOGICAL SALT
CONCENTRATIONS 29 3.5 DISCUSSION 31
4 SLOW D O W N O F A C T I N DEPOLYMERIZATION B Y CROSS-LINKING
MOLECULES 3 3
4.1 FASCIN AND HMM SLOW DOWN LATB INDUCED DEPOLYMERIZATION OF ACTIN . .
. 34 4.2 ABPS SLOW DOWN LATB INDUCED DEPOLYMERIZATION 37
4.3 ABPS SLOW DOWN DEPOLYMERIZATION INDUCED BY DILUTION 39
4.4 ABPS SLOW DOWN DISINTEGRATION OF ACTIN NETWORKS INDUCED BY COFILIN .
. . . 40 4.5 SIMULTANEOUS USE OF MOLECULAR MOTORS AND COFILIN DISRUPTS
BUNDLED ACTIN NETWORKS 40
4.6 STABILIZATION BY CROSS-LINKING MOLECULES IS A GENERIC EFFECT 42
4.7 OUTLOOK ON QUANTITATIVE MODELS 45
4.8 DISCUSSION 47
5 A C T I N / F I L A M I N N E T W O R K S 4 9
5.1 STRUCTURE OF ACTIN/FILAMIN NETWORKS 51
5.2 VISCOELASTIC RESPONSE OF ACTIN/FILAMIN NETWORKS 55
6 CYCLIC HARDENING I N A C T I N B U N D L E NETWORKS 6 1
6.1 MULLINS EFFECT 62
6.2 CYCLIC HARDENING IN ACTIN NETWORKS BUNDLED BY A-ACTININ 64
6.3 MEMORY EFFECT IN ACTIN NETWORKS BUNDLED BY A-ACTININ 65
6.4 STRUCTURAL REORGANIZATIONS ACCOUNT FOR CYCLIC HARDENING 65
6.5 STEPWISE SHEARING OF ACTIN NETWORKS BUNDLED BY A-ACTININ 68
6.6 CYCLIC HARDENING IS SENSITIVE TO NETWORK ARCHITECTURE 70
6.7 CYCLIC HARDENING IN ACTIN NETWORKS BUNDLED BY FILAMIN 73
6.8 CYCLIC HARDENING - A UNIQUE PROPERTY OF ACTIN BUNDLE NETWORKS 74
6.9 ANALOGY T O SHAPE MEMORY ALLOYS 75
6.9.1 SHAPE MEMORY ALLOYS 76
6.9.2 CYCLIC HARDENING IN ACTIN BUNDLE NETWORKS AND SHAPE MEMORY ALLOYS
78
7 P H M O D U L A T E S A C T I N NETWORK MECHANICS IN MULTIPLE W A Y S
8 1
7.1 ACTIN/FILAMIN NETWORKS EXHIBIT A COMPLEX PH DEPENDENCE 82
7.2 T H E BUNDLING ACTIVITY OF CORTEXILLIN IS PH DEPENDENT 84
7.3 FASCIN SUPPRESSES THE PH DEPENDENCE OF F-ACTIN SOLUTIONS 86
7.4 HMM SHOWS A PH DEPENDENT CROSS-LINKING ACTIVITY 87
7.5 CONTRACTILITY OF CROSS-LINKED ACTIVE ACTIN SYSTEMS CAN BE TUNED VIA
PH . . . 88
VI
IMAGE 3
CONTENTS
7.6 PH AS A POTENTIAL REGULATOR OF CROSS-LINKED ACTIN STRUCTURES IN
CELLS 91
8 O U T L O O K 9 3
BIBLIOGRAPHY 9 7
LIST O F FIGURES 1 1 3
VII
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| spelling | Schmoller, Kurt Michael Verfasser aut Kinetics and mechanics of non-equilibrium actin networks Kurt Michael Schmoller 2012 VII, 118 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2012 Polymeres Netzwerk (DE-588)4307122-3 gnd rswk-swf Nichtgleichgewicht (DE-588)4171730-2 gnd rswk-swf Actin (DE-588)4201876-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Actin (DE-588)4201876-6 s Polymeres Netzwerk (DE-588)4307122-3 s Nichtgleichgewicht (DE-588)4171730-2 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20120802-1107744-1-5 http://mediatum.ub.tum.de/node?id=1107744 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120802-1107744-1-5 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025225396&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schmoller, Kurt Michael Kinetics and mechanics of non-equilibrium actin networks Polymeres Netzwerk (DE-588)4307122-3 gnd Nichtgleichgewicht (DE-588)4171730-2 gnd Actin (DE-588)4201876-6 gnd |
| subject_GND | (DE-588)4307122-3 (DE-588)4171730-2 (DE-588)4201876-6 (DE-588)4113937-9 |
| title | Kinetics and mechanics of non-equilibrium actin networks |
| title_auth | Kinetics and mechanics of non-equilibrium actin networks |
| title_exact_search | Kinetics and mechanics of non-equilibrium actin networks |
| title_full | Kinetics and mechanics of non-equilibrium actin networks Kurt Michael Schmoller |
| title_fullStr | Kinetics and mechanics of non-equilibrium actin networks Kurt Michael Schmoller |
| title_full_unstemmed | Kinetics and mechanics of non-equilibrium actin networks Kurt Michael Schmoller |
| title_short | Kinetics and mechanics of non-equilibrium actin networks |
| title_sort | kinetics and mechanics of non equilibrium actin networks |
| topic | Polymeres Netzwerk (DE-588)4307122-3 gnd Nichtgleichgewicht (DE-588)4171730-2 gnd Actin (DE-588)4201876-6 gnd |
| topic_facet | Polymeres Netzwerk Nichtgleichgewicht Actin Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1107744 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20120802-1107744-1-5 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025225396&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT schmollerkurtmichael kineticsandmechanicsofnonequilibriumactinnetworks |