Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver: = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English German |
| Veröffentlicht: |
2000
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Erlangen-Nürnberg, Univ., Diss., 2000. - Enth. Zsfassung in dt. Sprache |
| Beschreibung: | [11], 110 S. Ill., graph. Darst. |
Internformat
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| 100 | 1 | |a Schümann, Jens |d 1971- |e Verfasser |0 (DE-588)122455614 |4 aut | |
| 245 | 1 | 0 | |a Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver |b = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen |c von Jens Schümann |
| 246 | 1 | 1 | |a Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen |
| 264 | 1 | |c 2000 | |
| 300 | |a [11], 110 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Erlangen-Nürnberg, Univ., Diss., 2000. - Enth. Zsfassung in dt. Sprache | ||
| 502 | |a Erlangen-Nürnberg, Univ., Diss., 2000 | ||
| 650 | 7 | |a Hochschulschrift |2 gtt | |
| 650 | 0 | 7 | |a Immunreaktion |0 (DE-588)4133841-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Leber |0 (DE-588)4034933-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Exotoxin |0 (DE-588)4388651-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Pseudomonas aeruginosa |0 (DE-588)4047651-0 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 689 | 0 | 0 | |a Pseudomonas aeruginosa |0 (DE-588)4047651-0 |D s |
| 689 | 0 | 1 | |a Exotoxin |0 (DE-588)4388651-6 |D s |
| 689 | 0 | 2 | |a Immunreaktion |0 (DE-588)4133841-8 |D s |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-009137146 | |
Datensatz im Suchindex
| _version_ | 1807322857897721856 |
|---|---|
| adam_text |
TABLE
OF
CONTENTS
TABLE
OF
CONTENTS
1
INTRODUCTION
1
1.1
PSEUDOMONAS
AERUGINOSA
1
1.2
PSEUDOMONAS
AERUGINOSA
AND
THE
LIVER
3
1.3
PEA
IS
MORE
THAN
AN
IRREVERSIBLE
INHIBITOR
OF
PROTEIN
SYNTHESIS
5
1.4
WHAT
IS
KNOWN
ABOUT
THE
T
CELL-STIMULATORY
PROPERTIES
OF
PEA?
6
1.5
THE
LIVER
AS
TARGET
OF
MISDIRECTED
OR
OVERSTIMULATED
T
CELLS
9
1.6
TNF
IS
THE
MOST
COMMON
CYTOKINE
MEDIATOR
OF
T
CELL-DEPENDENT
LIVER
INJURY
12
1.7
PHARMACOLOGICAL
TOOLS
TO
INFLUENCE
T
CELL-DEPENDENT
LIVER
INJURY
13
1.8
AIMS
OF
THIS
STUDY
14
2
MATERIALS
AND
METHODS
17
2.1
MICE
17
2.2
ANIMAL
TREATMENTS
18
2.3
GENERATION
OF
MOUSE
BONE
MARROW
CHIMERAS
19
2.4
FLOW
CYTOMETRY
OF
MOUSE
INTRAHEPATIC
MONONUCLEAR
CELLS
21
2.5
SAMPLING
OF
MATERIAL
22
2.6
DETERMINATION
OF
PLASMA
TNF
23
2.7
ANALYSIS
OF
PLASMA
TRANSAMINASES
23
2.8
CONVENTIONAL
RT-PCR
24
2.9
REAL-TIME
RT-PCR
25
2.10
IMMUNOFLUORESCENT
STAINING
AND
CONFOCAL
LASER
IMAGING
27
2.11
HEMATOXYLIN/EOSIN
STAINING
OF
LIVER
SECTIONS
28
2.12
STATISTICAL
ANALYSIS
28
TABLE
OF
CONTENTS
3
RESULTS
29
3.1
CHARACTERIZATION
OF
THE
PEA-INDUCED
TNF
RESPONSE
-
THE
IMPORTANCE
OF
T
CELLS
29
3.1.1
ACCUMULATION
OF
TNF
MRNA
WITHIN
LIVER
TISSUE
OF
PEA-TREATED
MICE
29
3.1.2
ACCUMULATION
OF
TNFPROTEIN
WITHIN
LIVER
TISSUE
OF
PEA-TREATED
MICE
30
3.1.3
IMPORTANCE
OF
T
CELLS
FOR
KUPFFER
CELL-PRODUCED
TNF
32
3.2
IMPORTANCE
OF
KUPFFER
CELLS
FOR
PEA-INDUCED
HEPATOTOXICITY
AND
TNF
PRODUCTION
33
3.2.1
IMPORTANCE
OF
KUPFFER
CELLS
FOR
PEA-INDUCED
LIVER
INJURY
33
3.2.2
IMPORTANCE
OF
KUPFFER
CELLS
FOR
PEA-INDUCED
INTRAHEPATIC
PRODUCTION
OF
TNF
36
3.2.3
"REPLACEMENT
"
OF
KUPFFER
CELLS
BY
RMUTNF
37
3.3
EXPRESSION
AND
ROLE
OF
TNFR2
DURING
INTOXICATION
WITH
PEA
38
3.3.1
PEA-INDUCED
CHANGES
IN
THE
INTRAHEPATIC
EXPRESSION
OFTNFR2
38
3.3.2
RELEVANCE
OFTNFR2
EXPRESSING
LEUKOCYTES
FOR
PEA-INDUCED
LIVER
INJURY
40
3.4
SYNERGISTIC
INTERACTIONS
BETWEEN
PEA
AND
LPS,
SEB,
OR
RMUTNF
42
3.4.
1
LIVER
INJURY
INDUCED
BY
PEA/LPS,
PEA/SEB,
OR
PEA/RMUTNF
43
3.4.2
PEA-INDUCED
AUGMENTATION
OF
LPS
OR
SEB-INDUCED
TNF
RELEASE
43
3.4.3
ROLE
OF
T
CELLS
IN
PEA/LPS
AND
PEA/SEB
SYNERGISMS
44
3.4.4
IMPORTANCE
OFTNFRL
AND
TNFR2FOR
PEA/LPS-,
PEA/SEB-,
OR
PEA/RMUTNF-INDUCED
LIVER
INJURY
46
3.5
CONTRIBUTION
OF
NK
CELLS
TO
PEA-INDUCED
LIVER
INJURY
47
3.5.1
PEA-INDUCED
LIVER
INJURY
IN
NK
CELL-DEFICIENT
MICE
47
3.5.2
IMPORTANCE
OF
PERFORIN
AND
FAS
FOR
PEA-INDUCED
LIVER
INJURY
49
4
DISCUSSION
51
4.1
THE
ROLE
OF
KUPFFER
CELLS
IN
PEA-INDUCED
LIVER
INJURY
52
4.1.1
PEA-INDUCED
RAPID
TNF
PRODUCTION
52
TABLE
OF
CONTENTS
4.1.2
IMPORTANCE
OF
KUPFFER
CELLS
FOR
PEA-INDUCED
LIVER
INJURY
53
4.1.3
THE
FATE
OF
KUPFFER
CELLS
AT
LATER
STAGES
OF
PEA
INTOXICATION
56
4.2
THE
ROLE
OF
T
CELLS
IN
PEA-INDUCED
LIVER
INJURY
57
4.3
THE
ROLE
OF
LEUKOCYTE
VS
LIVER
CELL
TNFR2
EXPRESSION
IN
PEA-INDUCED
LIVER
INJURY
59
4.4
THE
ROLES
OF
NK
CELLS,
PERFORIN,
AND
FAS
IN
PEA-INDUCED
LIVER
INJURY
63
4.4.1
IMPORTANCE
OF
NK
CELLS
FOR
PEA-INDUCED
LIVER
INJURY
63
4.4.2
ROLES
OF
PERFORIN
AND
FAS
IN
PEA-INDUCED
LIVER
INJURY
65
4.5
CONCLUDING
REMARKS
AND
PERSPECTIVES
FOR
THERAPY
67
5
SUMMARY
71
6
REFERENCES
75
7
DEUTSCHSPRACHIGE
ZUSAMMENFASSUNG
103
8
LEBENSLAUF
107 |
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| author | Schümann, Jens 1971- |
| author_GND | (DE-588)122455614 |
| author_facet | Schümann, Jens 1971- |
| author_role | aut |
| author_sort | Schümann, Jens 1971- |
| author_variant | j s js |
| building | Verbundindex |
| bvnumber | BV013393781 |
| classification_rvk | XD 3100 |
| ctrlnum | (OCoLC)48720320 (DE-599)BVBBV013393781 |
| discipline | Medizin |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV013393781 |
| illustrated | Illustrated |
| indexdate | 2024-08-14T01:03:08Z |
| institution | BVB |
| language | English German |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-009137146 |
| oclc_num | 48720320 |
| open_access_boolean | |
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| owner_facet | DE-29 DE-29T DE-355 DE-BY-UBR DE-12 DE-83 DE-188 |
| physical | [11], 110 S. Ill., graph. Darst. |
| publishDate | 2000 |
| publishDateSearch | 2000 |
| publishDateSort | 2000 |
| record_format | marc |
| spelling | Schümann, Jens 1971- Verfasser (DE-588)122455614 aut Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen von Jens Schümann Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen 2000 [11], 110 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Erlangen-Nürnberg, Univ., Diss., 2000. - Enth. Zsfassung in dt. Sprache Erlangen-Nürnberg, Univ., Diss., 2000 Hochschulschrift gtt Immunreaktion (DE-588)4133841-8 gnd rswk-swf Leber (DE-588)4034933-0 gnd rswk-swf Exotoxin (DE-588)4388651-6 gnd rswk-swf Pseudomonas aeruginosa (DE-588)4047651-0 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Pseudomonas aeruginosa (DE-588)4047651-0 s Exotoxin (DE-588)4388651-6 s Immunreaktion (DE-588)4133841-8 s Leber (DE-588)4034933-0 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009137146&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schümann, Jens 1971- Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen Hochschulschrift gtt Immunreaktion (DE-588)4133841-8 gnd Leber (DE-588)4034933-0 gnd Exotoxin (DE-588)4388651-6 gnd Pseudomonas aeruginosa (DE-588)4047651-0 gnd |
| subject_GND | (DE-588)4133841-8 (DE-588)4034933-0 (DE-588)4388651-6 (DE-588)4047651-0 (DE-588)4113937-9 |
| title | Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen |
| title_alt | Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen |
| title_auth | Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen |
| title_exact_search | Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen |
| title_full | Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen von Jens Schümann |
| title_fullStr | Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen von Jens Schümann |
| title_full_unstemmed | Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen von Jens Schümann |
| title_short | Pseudomonas aeruginosa exotoxin A-stimulated immune reactions in the mouse liver |
| title_sort | pseudomonas aeruginosa exotoxin a stimulated immune reactions in the mouse liver pseudomonas aeruginosa exotoxin a stimulierte immunreaktionen in der leber von mausen |
| title_sub | = Pseudomonas aeruginosa Exotoxin-A-stimulierte Immunreaktionen in der Leber von Mäusen |
| topic | Hochschulschrift gtt Immunreaktion (DE-588)4133841-8 gnd Leber (DE-588)4034933-0 gnd Exotoxin (DE-588)4388651-6 gnd Pseudomonas aeruginosa (DE-588)4047651-0 gnd |
| topic_facet | Hochschulschrift Immunreaktion Leber Exotoxin Pseudomonas aeruginosa |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=009137146&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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