Metabonomics in toxicity assessment:
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boca Raton ; London ; New York ; Singapore
CRC Press, Taylor & Francis Group
2005
|
| Schlagworte: | |
| Online-Zugang: | Table of contents Inhaltsverzeichnis |
| Beschreibung: | xii, 522 Seiten Diagramme |
| ISBN: | 0824726650 9780824726652 |
Internformat
MARC
| LEADER | 00000nam a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV021514619 | ||
| 003 | DE-604 | ||
| 005 | 20240326 | ||
| 007 | t | ||
| 008 | 060316s2005 xxu|||| |||| 00||| eng d | ||
| 010 | |a 2005276362 | ||
| 020 | |a 0824726650 |9 0-8247-2665-0 | ||
| 020 | |a 9780824726652 |9 978-0-8247-2665-2 | ||
| 035 | |a (OCoLC)635249428 | ||
| 035 | |a (DE-599)BVBBV021514619 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 044 | |a xxu |c US | ||
| 049 | |a DE-355 | ||
| 084 | |a WC 2600 |0 (DE-625)148071: |2 rvk | ||
| 245 | 1 | 0 | |a Metabonomics in toxicity assessment |c edited by Donald G. Robertson and John Lindon |
| 264 | 1 | |a Boca Raton ; London ; New York ; Singapore |b CRC Press, Taylor & Francis Group |c 2005 | |
| 300 | |a xii, 522 Seiten |b Diagramme | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Toxikologie |0 (DE-588)4060538-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Gift |0 (DE-588)4021007-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Stoffwechsel |0 (DE-588)4057699-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Biomarker |0 (DE-588)4425928-1 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a NMR-Spektroskopie |0 (DE-588)4075421-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Gift |0 (DE-588)4021007-8 |D s |
| 689 | 0 | 1 | |a Stoffwechsel |0 (DE-588)4057699-1 |D s |
| 689 | 0 | 2 | |a NMR-Spektroskopie |0 (DE-588)4075421-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Toxikologie |0 (DE-588)4060538-3 |D s |
| 689 | 1 | 1 | |a Biomarker |0 (DE-588)4425928-1 |D s |
| 689 | 1 | 2 | |a NMR-Spektroskopie |0 (DE-588)4075421-2 |D s |
| 689 | 1 | |C b |5 DE-604 | |
| 700 | 1 | |a Robertson, Donald G. |4 edt | |
| 700 | 1 | |a Lindon, John C. |0 (DE-588)1125662883 |4 edt | |
| 856 | 4 | |u http://www.loc.gov/catdir/toc/fy055/2005276362.html |3 Table of contents | |
| 856 | 4 | 2 | |m Digitalisierung UBRegensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014731193&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-014731193 | ||
Datensatz im Suchindex
| _version_ | 1804135252721926144 |
|---|---|
| adam_text | Contents
Preface
Contributors
1.
John C. Lindon, Elaine Holmes and Jeremy K. Nicholson
Introduction
The Metabolic Continuum
Biomarkers
Brief Overview of Metabonomics Techniques
Metabonomics Applications
Summary
2.
John Timbrell
Introduction
Biomarkers of Exposure
Biomarkers of Response
Biomarkers of Susceptibility
viii Contents
3.
Instrumentation
Michael D. Reily and John C. Lindon
Introduction
Principles of NMR Spectroscopy
Operational Methods
Realization of NMR Spectroscopy in a Metabonomics
Laboratory
Conclusions
4.
John C. Lindon, Jeremy K. Nicholson and Elaine Holmes
Introduction
Practicalities of ID
of Biofluids
Techniques for Resonance Assignment in NMR Spectra
of Biofluids
XH NMR Spectroscopy of Cerebrospinal
Fluid (CSF)
XH NMR Spectroscopy of Blood Plasma and Whole
Blood
XH NMR Spectroscopy of Human and Animal
Urine
XH NMR Spectroscopy of Seminal Fluids
^ NMR Spectroscopy of Bile
NMR Spectroscopy of Miscellaneous Body
Fluids
NMR Studies of Dynamic Interactions
Concluding Remarks
5.
of Tissues
Julian L. Griffin, Jeremy K. Nicholson, Elaine Holmes and
John C. Lindon
Introduction
Magic-angle-spinning (MAS) NMR Spectroscopy:
Principles and Practice
Applications of XH MAS NMR Spectroscopy
to Metabonomics
Contents ix
Future Directions and Challenges for XH MAS NMR
Spectroscopy
6.
In Vivo Toxicity Screen
Gregory J. Stevens, Alan J. Deese and Donald G. Robertson
Introduction
Experimental Considerations
Examples
Screening Models
Conclusion
7.
of Endogenous and Xenobiotic Metabolites Detected
in Metabonomic Studies
John Shockcor and Ian D. Wilson
Introduction
Xenobiotic and Endogenous Metabolite Identification
Directly from Biofluids
Low Resolution, Off-Line, Techniques for the
Isolation of Unknowns
Direct On-Line Methods of Identifying
Unknowns
Miniaturization
Conclusions
8.
Using Regularities in Metabonomics Data
Lennart Eriksson, Erik Johansson,
Elaine Holmes
Introduction
Data-Analytical Methods
Results for Example Data Set I
Investigation of Phospholipidosis
Results for Example Data Set II
Sequence of Biochemical Events Following the Onset
of Toxicity
Discussion
Concluding Remarks
x Contents
9.
Toxicity
Craig E. Thomas, Elaine Holmes and Donald G. Robertson
Introduction
Hepatic Toxicity
Renal Toxicity
Vascular Toxicity
10.
and Humans
M.E. Bollard, E.G. Stanley, Y. Wang, J.C. Lindon,
J.K. Nicholson and E. Holmes
Introduction
Physiological Variation in Laboratory
Animals
Physiological Variation in Humans
11.
Profiling
Jacob G. Bundy
Differences to Clinical Studies
Characterization of Baseline Data By NMR
Spectroscopy
Toxicological and Related Studies
Conclusions and Future Implications
12.
in Metabonomics Technology
Donald G. Robertson
Perspective
The Power of the Metabonomic Approach in
Toxicology
Metabonomics as an Omic Technology
Short Term Needs for Metabonomics as a
Science
Cautionary Note
Conclusion
Index
|
| adam_txt |
Contents
Preface
Contributors
1.
John C. Lindon, Elaine Holmes and Jeremy K. Nicholson
Introduction
The Metabolic Continuum
Biomarkers
Brief Overview of Metabonomics Techniques
Metabonomics Applications
Summary
2.
John Timbrell
Introduction
Biomarkers of Exposure
Biomarkers of Response
Biomarkers of Susceptibility
viii Contents
3.
Instrumentation
Michael D. Reily and John C. Lindon
Introduction
Principles of NMR Spectroscopy
Operational Methods
Realization of NMR Spectroscopy in a Metabonomics
Laboratory
Conclusions
4.
John C. Lindon, Jeremy K. Nicholson and Elaine Holmes
Introduction
Practicalities of ID
of Biofluids
Techniques for Resonance Assignment in NMR Spectra
of Biofluids
XH NMR Spectroscopy of Cerebrospinal
Fluid (CSF)
XH NMR Spectroscopy of Blood Plasma and Whole
Blood
XH NMR Spectroscopy of Human and Animal
Urine
XH NMR Spectroscopy of Seminal Fluids
^ NMR Spectroscopy of Bile
NMR Spectroscopy of Miscellaneous Body
Fluids
NMR Studies of Dynamic Interactions
Concluding Remarks
5.
of Tissues
Julian L. Griffin, Jeremy K. Nicholson, Elaine Holmes and
John C. Lindon
Introduction
Magic-angle-spinning (MAS) NMR Spectroscopy:
Principles and Practice
Applications of XH MAS NMR Spectroscopy
to Metabonomics
Contents ix
Future Directions and Challenges for XH MAS NMR
Spectroscopy
6.
In Vivo Toxicity Screen
Gregory J. Stevens, Alan J. Deese and Donald G. Robertson
Introduction
Experimental Considerations
Examples
Screening Models
Conclusion
7.
of Endogenous and Xenobiotic Metabolites Detected
in Metabonomic Studies
John Shockcor and Ian D. Wilson
Introduction
Xenobiotic and Endogenous Metabolite Identification
Directly from Biofluids
Low Resolution, Off-Line, Techniques for the
Isolation of Unknowns
Direct On-Line Methods of Identifying
Unknowns
Miniaturization
Conclusions
8.
Using Regularities in Metabonomics Data
Lennart Eriksson, Erik Johansson,
Elaine Holmes
Introduction
Data-Analytical Methods
Results for Example Data Set I
Investigation of Phospholipidosis
Results for Example Data Set II
Sequence of Biochemical Events Following the Onset
of Toxicity
Discussion
Concluding Remarks
x Contents
9.
Toxicity
Craig E. Thomas, Elaine Holmes and Donald G. Robertson
Introduction
Hepatic Toxicity
Renal Toxicity
Vascular Toxicity
10.
and Humans
M.E. Bollard, E.G. Stanley, Y. Wang, J.C. Lindon,
J.K. Nicholson and E. Holmes
Introduction
Physiological Variation in Laboratory
Animals
Physiological Variation in Humans
11.
Profiling
Jacob G. Bundy
Differences to Clinical Studies
Characterization of Baseline Data By NMR
Spectroscopy
Toxicological and Related Studies
Conclusions and Future Implications
12.
in Metabonomics Technology
Donald G. Robertson
Perspective
The Power of the Metabonomic Approach in
Toxicology
Metabonomics as an "Omic" Technology
Short Term Needs for Metabonomics as a
Science
Cautionary Note
Conclusion
Index |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author2 | Robertson, Donald G. Lindon, John C. |
| author2_role | edt edt |
| author2_variant | d g r dg dgr j c l jc jcl |
| author_GND | (DE-588)1125662883 |
| author_facet | Robertson, Donald G. Lindon, John C. |
| building | Verbundindex |
| bvnumber | BV021514619 |
| classification_rvk | WC 2600 |
| ctrlnum | (OCoLC)635249428 (DE-599)BVBBV021514619 |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01989nam a2200493zc 4500</leader><controlfield tag="001">BV021514619</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20240326 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">060316s2005 xxu|||| |||| 00||| eng d</controlfield><datafield tag="010" ind1=" " ind2=" "><subfield code="a">2005276362</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0824726650</subfield><subfield code="9">0-8247-2665-0</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780824726652</subfield><subfield code="9">978-0-8247-2665-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)635249428</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV021514619</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">xxu</subfield><subfield code="c">US</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WC 2600</subfield><subfield code="0">(DE-625)148071:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Metabonomics in toxicity assessment</subfield><subfield code="c">edited by Donald G. Robertson and John Lindon</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Boca Raton ; London ; New York ; Singapore</subfield><subfield code="b">CRC Press, Taylor & Francis Group</subfield><subfield code="c">2005</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xii, 522 Seiten</subfield><subfield code="b">Diagramme</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Toxikologie</subfield><subfield code="0">(DE-588)4060538-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Gift</subfield><subfield code="0">(DE-588)4021007-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Stoffwechsel</subfield><subfield code="0">(DE-588)4057699-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Biomarker</subfield><subfield code="0">(DE-588)4425928-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">NMR-Spektroskopie</subfield><subfield code="0">(DE-588)4075421-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Gift</subfield><subfield code="0">(DE-588)4021007-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Stoffwechsel</subfield><subfield code="0">(DE-588)4057699-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="2"><subfield code="a">NMR-Spektroskopie</subfield><subfield code="0">(DE-588)4075421-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Toxikologie</subfield><subfield code="0">(DE-588)4060538-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Biomarker</subfield><subfield code="0">(DE-588)4425928-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="2"><subfield code="a">NMR-Spektroskopie</subfield><subfield code="0">(DE-588)4075421-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="C">b</subfield><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Robertson, Donald G.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lindon, John C.</subfield><subfield code="0">(DE-588)1125662883</subfield><subfield code="4">edt</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">http://www.loc.gov/catdir/toc/fy055/2005276362.html</subfield><subfield code="3">Table of contents</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UBRegensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014731193&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-014731193</subfield></datafield></record></collection> |
| id | DE-604.BV021514619 |
| illustrated | Not Illustrated |
| index_date | 2024-07-02T14:20:05Z |
| indexdate | 2024-07-09T20:37:33Z |
| institution | BVB |
| isbn | 0824726650 9780824726652 |
| language | English |
| lccn | 2005276362 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-014731193 |
| oclc_num | 635249428 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | xii, 522 Seiten Diagramme |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | CRC Press, Taylor & Francis Group |
| record_format | marc |
| spelling | Metabonomics in toxicity assessment edited by Donald G. Robertson and John Lindon Boca Raton ; London ; New York ; Singapore CRC Press, Taylor & Francis Group 2005 xii, 522 Seiten Diagramme txt rdacontent n rdamedia nc rdacarrier Toxikologie (DE-588)4060538-3 gnd rswk-swf Gift (DE-588)4021007-8 gnd rswk-swf Stoffwechsel (DE-588)4057699-1 gnd rswk-swf Biomarker (DE-588)4425928-1 gnd rswk-swf NMR-Spektroskopie (DE-588)4075421-2 gnd rswk-swf Gift (DE-588)4021007-8 s Stoffwechsel (DE-588)4057699-1 s NMR-Spektroskopie (DE-588)4075421-2 s DE-604 Toxikologie (DE-588)4060538-3 s Biomarker (DE-588)4425928-1 s b DE-604 Robertson, Donald G. edt Lindon, John C. (DE-588)1125662883 edt http://www.loc.gov/catdir/toc/fy055/2005276362.html Table of contents Digitalisierung UBRegensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014731193&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Metabonomics in toxicity assessment Toxikologie (DE-588)4060538-3 gnd Gift (DE-588)4021007-8 gnd Stoffwechsel (DE-588)4057699-1 gnd Biomarker (DE-588)4425928-1 gnd NMR-Spektroskopie (DE-588)4075421-2 gnd |
| subject_GND | (DE-588)4060538-3 (DE-588)4021007-8 (DE-588)4057699-1 (DE-588)4425928-1 (DE-588)4075421-2 |
| title | Metabonomics in toxicity assessment |
| title_auth | Metabonomics in toxicity assessment |
| title_exact_search | Metabonomics in toxicity assessment |
| title_exact_search_txtP | Metabonomics in toxicity assessment |
| title_full | Metabonomics in toxicity assessment edited by Donald G. Robertson and John Lindon |
| title_fullStr | Metabonomics in toxicity assessment edited by Donald G. Robertson and John Lindon |
| title_full_unstemmed | Metabonomics in toxicity assessment edited by Donald G. Robertson and John Lindon |
| title_short | Metabonomics in toxicity assessment |
| title_sort | metabonomics in toxicity assessment |
| topic | Toxikologie (DE-588)4060538-3 gnd Gift (DE-588)4021007-8 gnd Stoffwechsel (DE-588)4057699-1 gnd Biomarker (DE-588)4425928-1 gnd NMR-Spektroskopie (DE-588)4075421-2 gnd |
| topic_facet | Toxikologie Gift Stoffwechsel Biomarker NMR-Spektroskopie |
| url | http://www.loc.gov/catdir/toc/fy055/2005276362.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=014731193&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT robertsondonaldg metabonomicsintoxicityassessment AT lindonjohnc metabonomicsintoxicityassessment |