Industrial biotechnology of vitamins, biopigments, and antioxidants:
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| Other Authors: | , |
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| Format: | Book |
| Language: | English |
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Weinheim
Wiley-VCH Verlag GmbH & Co. KGaA
[2016]
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXIX, 548 Seiten Illustrationen, Diagramme |
| ISBN: | 9783527337347 9783527681754 |
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| 245 | 1 | 0 | |a Industrial biotechnology of vitamins, biopigments, and antioxidants |c edited by Erick J. Vandamme and José Luis Revuelta |
| 264 | 1 | |a Weinheim |b Wiley-VCH Verlag GmbH & Co. KGaA |c [2016] | |
| 264 | 4 | |c © 2016 | |
| 300 | |a XXIX, 548 Seiten |b Illustrationen, Diagramme | ||
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| 700 | 1 | |a Vandamme, Erick J. |0 (DE-588)1095130498 |4 edt | |
| 700 | 1 | |a Revuelta, José Luis |0 (DE-588)1119266769 |4 edt | |
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Record in the Search Index
| _version_ | 1804176006233194496 |
|---|---|
| adam_text | 1
1.1
1.2
1.3
1.4
1.5
1.6
2
2.1
2.2
2.3
2.4
2.5
2.6
2
.
6.1
2
.
6.2
2.6.3
2.7
2.8
2.9
2.10
CONTENTS
LIST OF CONTRIBUTORS XIX
PREFACE XXVII
VITAMINS, BIOPIGMENTS, ANTIOXIDANTS AND RELATED COMPOUNDS:
A HISTORICAL, PHYSIOLOGICAL AND (BIO)TECHNOLOGICAL PERSPECTIVE 1
ERICK J. VANDAMME AND JOSE L REVUELTA
HISTORICAL ASPECTS OF THE SEARCH FOR VITAMINS 1
VITAMINS: WHAT S IN A NAME 3
PHYSIOLOGICAL FUNCTIONS OF VITAMINS AND RELATED COMPOUNDS 6
TECHNICAL FUNCTIONS OF VITAMINS AND RELATED COMPOUNDS 8
PRODUCTION AND APPLICATION OF VITAMINS AND RELATED
FACTORS 8
OUTLOOK 13
REFERENCES 13
PART I WATER-SOLUBLE VITAMINS 15
INDUSTRIAL PRODUCTION OF VITAMIN B2 BY MICROBIAL FERMENTATION 17
JOSE L REVUELTA, RODRIGO LEDESMA-AMARO, AND ALBERTO JIMENEZ
INTRODUCTION AND HISTORICAL OUTLINE 17
OCCURRENCE IN NATURAL/FOOD SOURCES 17
CHEMICAL AND PHYSICAL PROPERTIES; TECHNICAL FUNCTIONS 18
ASSAY METHODS AND UNITS 18
BIOLOGICAL ROLE OF FLAVINS AND FLAVOPROTEINS 19
BIOTECHNOLOGICAL SYNTHESIS OF RIBOFLAVIN 21
RIBOFLAVIN-PRODUCING MICROORGANISMS 21
BIOSYNTHESIS OF RIBOFLAVIN 22
REGULATION OF THE BIOSYNTHESIS OF RIBOFLAVIN 25
STRAIN DEVELOPMENT: GENETIC MODIFICATIONS, MOLECULAR GENETICS AND
METABOLIC ENGINEERING 26
FERMENTATION PROCESS 31
DOWNSTREAM PROCESSING 32
CHEMICAL SYNTHESIS 33
2.11 APPLICATION AND ECONOMICS 33
REFERENCES 33
3 VITAMIN B3, NIACIN 41
TEK CHAND BHALLA AND SAVITRI
3.1 INTRODUCTION 41
3.2 HISTORY 42
3.3 OCCURRENCE IN NATURE/FOOD SOURCES 43
3.4 CHEMICAL AND PHYSICAL PROPERTIES 44
3.4.1 CHEMICAL PROPERTIES 44
3.4.2 PHYSICAL PROPERTIES 44
3.5 VITAMIN B3 DEFICIENCY DISEASE (PELLAGRA) 45
3.6 METHODS USED FOR DETERMINATION OF VITAMIN B3 46
3.6.1 MICROBIOLOGICAL METHODS 46
3.6.2 CHEMICAL METHODS 46
3.7 SYNTHESIS 47
3.7.1 CHEMICAL PROCESS USED FOR NICOTINIC ACID PRODUCTION 47
3.7.2 BIOSYNTHESIS 49
3.7.2.1 BIOLOGICAL PROCESSES USED FOR NICOTINIC ACID PRODUCTION 49
3.8 DOWNSTREAM PROCESSING OF NICOTINIC ACID 52
3.9 REACTIVE EXTRACTION 53
3.10 PHYSIOLOGICAL ROLE OF VITAMIN B3 (NIACIN) 53
3.10.1 COENZYME IN METABOLIC REACTIONS 53
3.10.2 THERAPEUTIC MOLECULE 56
3.10.2.1 TREATMENT OF PELLAGRA 56
3.10.2.2 TREATMENT OF CARDIOVASCULAR DISEASES 57
3.10.2.3 ANTIHYPERLIPIDEMIC EFFECT 57
3.10.2.4 TREATMENT OF HYPERCHOLESTEROLEMIA 57
3.10.2.5 DIABETES 58
3.10.2.6 FIBRINOLYSIS 58
3.10.2.7 TREATMENT OF NEURODEGENERATIVE DISORDERS 58
3.11 SAFETY OF NIACIN 59
3.12 TOXICITY OF NIACIN 59
3.12.1 HEPATOTOXICITY 59
3.12.2 VASODILATION/NIACIN FLUSH 59
3.12.3 GLUCOSE INTOLERANCE 60
3.13 DERIVATIVES OF NIACIN 60
3.14 APPLICATION IN COSMETICS, FOOD AND FEED 61
3.15 FUTURE PROSPECTS 61
REFERENCES 61
4 PANTOTHENIC ACID 67
JESUS GONZALEZ-LOPEZ, LUIS AIIAGA, ALEJANDRO GONZALEZ-MARTINEZ, AND
MARIA V. MARTINEZ-TOLEDO
4.1 INTRODUCTION AND HISTORICAL OUTLINE 67
4.2 OCCURRENCE IN NATURAL FOOD SOURCES AND REQUIREMENTS 71
4.3 PHYSIOLOGICAL ROLE AS VITAMIN OR AS COENZYME 74
4.4 CHEMICAL AND PHYSICAL PROPERTIES 77
4.5 ASSAY METHODS 79
4.6 CHEMICAL AND BIOTECHNOLOGICAL SYNTHESIS 81
4.7 APPLICATION AND ECONOMICS 92
REFERENCES 98
5 FOLATE: RELEVANCE OF CHEMICAL AND MICROBIAL PRODUCTION 103
MADDALENA ROSSI, STEFANO RAIMONDI, LUCA COSTANTINO, AND ALBERTO AMARETTI
5.1 INTRODUCTION 103
5.2 FOLATES: CHEMICAL PROPERTIES AND OCCURRENCE IN FOOD 103
5.3 BIOSYNTHESIS 105
5.4 PHYSIOLOGICAL ROLE 106
5.5 BIOAVAILABILITY AND DIETARY SUPPLEMENTS 109
5.6 CHEMICAL AND CHEMOENZYMATIC SYNTHESIS OF FOLIC ACID AND
DERIVATIVES 110
5.7 INTESTINAL MICROBIOTA, PROBIOTICS AND VITAMINS 114
5.8 FOLATE PRODUCTION BY LACTIC ACID BACTERIA 115
5.9 FOLATE PRODUCTION BY BIFIDOBACTERIA 117
5.10 CONCLUSIONS 120
REFERENCES 124
6 VITAMIN B12 - PHYSIOLOGY, PRODUCTION AND APPLICATION 129
JANICE MARIE SYCH, CHRISTOPHE LACROIX, AND MARC J.A. STEVENS
6.1 INTRODUCTION AND HISTORICAL OUTLINE 129
6.2 OCCURRENCE IN FOOD AND OTHER NATURAL SOURCES 130
6.3 PHYSIOLOGICAL ROLE AS A VITAMIN OR COENZYME 131
6.3.1 ABSORPTION AND TRANSPORT 131
6.3.2 METABOLIC FUNCTIONS 132
6.3.3 MAIN CAUSES AND PREVALENCE OF DEFICIENCIES 133
6.3.4 DIAGNOSIS OF DEFICIENCIES 134
6.4 CHEMICAL AND PHYSICAL PROPERTIES 134
6.5 ASSAY METHODS 137
6.6 BIOTECHNOLOGICAL SYNTHESIS 140
6.6.1 PRODUCING MICROORGANISMS 140
6.6.1.1 PROPIONIBACTERIA (PAB) 142
6.6.1.2 PSEUDOMONADES 143
6.6.2 BIOSYNTHESIS AND METABOLIC REGULATION 144
6.6.3 ENGINEERING OF B12 PRODUCTION 145
6.6.3.1 PROPIONIBACTERIA 145
6.6.3.2 PSEUDOMONADES 146
6.6.4 FERMENTATION PROCESS 146
6.6.4.1 PROPIONIBACTERIA 146
6.6.4.2 PSEUDOMONADES 148
6.7 DOWNSTREAM PROCESSING; PURIFICATION AND FORMULATION 149
6.8 APPLICATION AND ECONOMICS ISO
6.9 CONCLUSIONS AND OUTLOOK 151
REFERENCES 151
7 INDUSTRIAL FERMENTATION OF VITAMIN C 161
WEICHAO YANG AND HUI XU
7.1 INTRODUCTION AND HISTORICAL OUTLINE 161
7.2 OCCURRENCE IN NATURAL/FOOD SOURCES 162
7.2.1 OCCURRENCE OF ASC IN FOODS 162
7.2.2 BIOSYNTHESIS OF ASC IN PLANTS AND MAMMALS 164
7.3 PHYSIOLOGICAL ROLE OF ASC 164
7.4 CHEMICAL AND PHYSICAL PROPERTIES 165
7.5 ASSAY METHODS 165
7.6 INDUSTRIAL FERMENTATION OF ASC 166
7.6.1 THE REICHSTEIN PROCESS: THE MAJOR INDUSTRIAL ASC PROCESS UNTIL THE
LATE 1990S 167
7.6.1.1 THE ESTABLISHMENT OF THE REICHSTEIN PROCESS 167
7.6.1.2 BIOCONVERSION OF D-SORBITOL TO L-SORBOSE BY GLUCONOBACTER 167
7.6.1.3 THE KEY ENZYME OF GLUCONOBACTER FOR L-SORBOSE PRODUCTION 168
7.6.1.4 OXIDATION OF L-SORBOSE TO 2-KLG AND REARRANGEMENT TO ASC 168
7.6.2 THE TWO-STEP FERMENTATION PROCESS FOR ASC PRODUCTION 168
7.6.2.1 THE FIRST STEP OF FERMENTATION: CONVERSION OF D-SORBITOL TO
L-SORBOSE 169
7.6.2.2 THE SECOND STEP OF FERMENTATION: CONVERSION OF L-SORBOSE TO
2-KETO-L-GULONIC ACID 170
7.6.2.3 STRAIN DEVELOPMENT: GENETIC MODIFICATION, MOLECULAR GENETICS AND
METABOLIC ENGINEERING 175
7.6.2.4 FERMENTATION PROCESS 177
7.6.2.5 UPSTREAM AND DOWNSTREAM PROCESSING 181
7.7 APPLICATION AND ECONOMICS 182
7.8 OUTLOOK 183
REFERENCES 185
8 DIRECT MICROBIAL ROUTES TO VITAMIN C PRODUCTION 193
GUENTER PAPPENBERGER AND HANS-PETER HOHMANN
8.1 INTRODUCTION AND SCOPE 193
8.2 PRINCIPLES OF DIRECT
L
-
ASCORBIC ACID FORMATION: THE MAJOR
CHALLENGES 195
8.2.1 STEREOCHEMISTRY OF
L-
ASCORBIC ACID 195
8.2.2 ENZYMES PRODUCING
L
-
ASCORBIC ACID AND THEIR BY-PRODUCT
SPECTRUM 196
8.3 DIRECT
L-
ASCORBIC ACID FORMATION VIA 1,4-LACTONES 197
8.3.1
L-
ASCORBIC ACID FORMING ENZYMES: 1,4-LACTONE
OXIDOREDUCTASES 198
8.3.2 DIRECT
L-
ASCORBIC ACID FORMATION IN HETEROTROPHIC MICROALGAE 200
8.3.3 DIRECT L-ASCORBIC ACID FORMATION IN RECOMBINANT YEAST 201
8.3.4 DIRECT L-ASCORBIC ACID FORMATION FROM ORANGE PROCESSING WASTE IN
RECOMBINANT
ASPERGILLUS NIGER 203
8.3.5 OVERALL CONCLUSION ON 1,4-LACTONE ROUTES 204
8.4 DIRECT L-ASCORBIC ACID FORMATION VIA 2-I ETO ALDOSES 206
8.4.1 L-ASCORBIC ACID FORMING ENZYMES: L-SORBOSONE
DEHYDROGENASES 208
8.4.1.1 SNDHALC 208
8.4.1.2 SNDHAI 211
8.4.1.3
PREVALENCE OF
L
-A
SC
FORMING SORBOSONE DEHYDROGENASES IN
NATURE 211
8.4.2
L
-A
SC
OR
2-KGA
FROM L-SORBOSONE: ONE SUBSTRATE, SEVERAL ISOMERS,
TWO PRODUCTS 212
8.4.3 L-SORBOSE DEHYDROGENASE, ACCUMULATING L-SORBOSONE 215
8.4.3.1 SSDH FROM
K. VULGARE 215
8.4.3.2 SORBOSE DEHYDROGENASE SDH FROM G. OXYDANS 217
8.4.4 GLUCONOBACTER AS HOST FOR DIRECT L-ASCORBIC ACID FORMATION 217
8.5 OUTLOOK 219
ACKNOWLEDGEMENT 220
REFERENCES 220
PART II FAT SOLUBLE VITAMINS 227
9 SYNTHESIS OF /3-CAROTENE AND OTHER IMPORTANT CAROTENOIDS WITH
BACTERIA 229
CHRISTOPH ALBERMANN AND HOLGER BEUTTLER
9.1 INTRODUCTION 229
9.2 CAROTENOIDS: CHEMICAL PROPERTIES, NOMENCLATURE AND
ANALYTICS 230
9.2.1 NOMENCLATURE 231
9.2.2 ANALYSIS OF CAROTENOIDS 231
9.2.2.1 HANDLING PRECAUTIONS 231
9.2.2.2 EXTRACTION 232
9.2.2.3 CHROMATOGRAPHY METHODS FOR ANALYSIS OF CAROTENOIDS 233
9.3 NATURAL OCCURRENCE IN BACTERIA 234
9.4 BIOSYNTHESIS OF CAROTENOIDS IN BACTERIA 236
9.5 BIOTECHNOLOGICAL SYNTHESIS OF CAROTENOIDS BY CAROTENOGENIC AND
NON-CAROTENOGENIC BACTERIA 239
9.5.1 HETEROLOGOUS EXPRESSION OF CAROTENOID BIOSYNTHESIS GENES 240
9.5.2 INCREASED ISOPRENOID PRECURSOR SUPPLY 243
9.5.3 GENOME-WIDE MODIFICATION OF E. COLI TO INCREASE CAROTENOID
FORMATION 244
9.5.4 BALANCING RECOMBINANT ENZYME ACTIVITIES FOR AN IMPROVED SYNTHESIS
OF CAROTENOIDS BY E. COLI 249
9.5.5 PRODUCTION OF INDUSTRIALLY IMPORTANT CAROTENOIDS BY OTHER
RECOMBINANT BACTERIA 252
9.5.6 CULTURE CONDITIONS OF IMPROVED FORMATION OF CAROTENOIDS BY
RECOMBINANT BACTERIA 252
9.6 CONCLUSION 253
REFERENCES 254
10 /1-CAROTENE AND OTHER CAROTENOIDS AND PIGMENTS FROM
MICROALGAE 265
BORHANE SAMIR GRAMA, ANTOINE DEIHAYE, SPIROS N. AGATHOS, AND
CLAYTON
JEFF RYES
10.1 INTRODUCTION AND HISTORICAL OUTLINE 265
10.2 OCCURRENCE IN NATURE AND FOOD SOURCES 266
10.3 PHYSIOLOGICAL ROLE AS A VITAMIN OR AS A COENZYME 267
10.4 CHEMICAL AND PHYSICAL PROPERTIES; TECHNICAL FUNCTIONS 268
10.5 ASSAY METHODS AND UNITS 270
10.6 BIOTECHNOLOGICAL SYNTHESIS 270
10.6.1 PRODUCING ORGANISMS 270
10.6.2 BIOSYNTHESIS AND METABOLIC REGULATION 273
10.6.3 STRAIN DEVELOPMENT: GENETIC MODIFICATION, MOLECULAR GENETICS AND
METABOLIC ENGINEERING 276
10.6.4 DOWNSTREAM PROCESSING, PURIFICATION AND FORMULATION 276
10.7 CHEMICAL SYNTHESIS OR EXTRACTION 279
10.8 PROCESS ECONOMICS 279
REFERENCES 280
11 MICROBIAL PRODUCTION OF VITAMIN F AND OTHER POLYUNSATURATED FATTY
ACIDS 287
COLIN RATLEDGE
LIPID NOMENCLATURE 287
11.1 INTRODUCTION: ESSENTIAL FATTY ACIDS 288
11.2 GENERAL PRINCIPLES FOR THE ACCUMULATION OF OILS AND FATS IN
MICROORGANISMS 294
11.3 PRODUCTION OF MICROBIAL OILS 297
11.3.1 PRODUCTION OF GAMMA-LINOLENIC ACID (GLA; 18:3 N-6) 297
11.3.2 PRODUCTIONS OF DOCOSAHEXAENOIC ACID (DHA) AND ARACHIDONIC ACID
(ARA) 300
11.3.3 ALTERNATIVE SOURCES OF DHA 302
11.3.4 PRODUCTION OF EICOSAPENTAENOIC ACID (EPA N-3) 305
11.3.5 PROSPECTS OF PHOTOSYNTHETIC MICROALGAE FOR PRODUCTION OF
PUFAS 307
11.4 SAFETY ISSUES 310
11.5 FUTURE PROSPECTS 312
ACKNOWLEDGEMENTS 315
REFERENCES 316
12 VITAMIN Q10: PROPERTY, PRODUCTION AND APPLICATION 321
JOONG K. KIM, EUN J. KIM, AND HYUN Y. JUNG
12.1 BACKGROUND OF VITAMIN Q10 321
12.1.1 HISTORICAL ASPECTS 321
12.1.2 DEFINITION 321
12.1.3 OCCURRENCE 322
12.1.3.1 IN NATURE 322
12.1.3.2 IN FOOD SOURCES 322
12.1.3.3 IN MICROORGANISMS 326
12.1.4 FUNCTIONS 326
12.2 CHEMICAL AND PHYSICAL PROPERTIES OF COQ10 326
12.2.1 CHEMICAL PROPERTIES 326
12.2.2 PHYSICAL PROPERTIES 327
12.3 BIOSYNTHESIS AND METABOLIE REGULATION OF COQ10 327
12.3.1 BIOSYNTHESIS OF COQ10 327
12.3.1.1 MICROORGANISMS 327
12.3.1.2 BIOSYNTHETIC PATHWAYS 329
12.3.2 METABOLIC REGULATION 334
12.3.3 STRAIN DEVELOPMENT 335
12.3.3.1 MUTAGENESIS 335
12.3.3.2 GENETIC MODIFICATION 335
12.3.3.3 METABOLIC ENGINEERING 337
12.3.4 FERMENTATION PROCESS 339
12.3.5 UPSTREAM AND DOWNSTREAM PROCESSING 340
12.3.5.1 UPSTREAM PROCESSING 340
12.3.5.2 DOWNSTREAM PROCESSING 343
12.4 CHEMICAL SYNTHESIS AND SEPARATION OF COQ10 345
12.4.1 CHEMICAL SYNTHESIS 345
12.4.2 SOLVENT EXTRACTION 346
12.4.3 PURIFICATION 350
12.5 APPLICATIONS AND ECONOMICS OF COQ10 351
12.5.1 APPLICATIONS 351
12.5.1.1 IN DISEASES 351
12.5.1.2 IN COSMETICS 352
12.5.1.3 IN FOODS AND OTHERS 353
12.5.2 ECONOMICS 354
REFERENCES 355
13 PYRROLOQUINOLINE QUINONE (PQQ) 367
HIROHIDE TOYAMA
13.1 INTRODUCTION AND HISTORICAL OUTLINE 367
13.2 OCCURRENCE IN NATURAL/FOOD SOURCES 367
13.3 PHYSIOLOGICAL ROLE AS VITAMIN OR AS BIOACTIVE SUBSTANCE 368
13.4 PHYSIOLOGICAL ROLE AS A COFACTOR 373
13.5 CHEMICAL AND PHYSICAL PROPERTIES; TECHNICAL FUNCTIONS 376
13.6
13.7
13.7.1
13.7.2
13.8
13.9
13.10
13.11
14
14.1
14.2
14.3
14.3.1
14.3.2
14.3.3
14.4
14.5
14.5.1
14.5.2
14.5.3
14.5.4
14.6
14.6.1
14.6.1.1
14.6.1.2
14.6.1.3
14.6.2
14.6.2.1
14.6.2.2
14.6.2.3
14.6.3
14.6.3.1
14.6.3.2
14.6.4
ASSAY METHODS 377
BIOTECHNOLOGICAL SYNTHESIS 377
PRODUCING MICROORGANISMS 377
BIOSYNTHESIS AND METABOLIC REGULATION 378
STRAIN DEVELOPMENT: GENETIC MODIFICATION, MOLECULAR GENETICS AND
METABOLIC ENGINEERING 378
UP- AND DOWN-STREAM PROCESSING; PURIFICATION AND
FORMULATION 380
CHEMICAL SYNTHESIS OR EXTRACTION TECHNOLOGY 380
APPLICATION AND ECONOMICS 380
REFERENCES 381
PART III OTHER GROWTH FACTORS, BIOPIGMENTS AND ANTIOXIDANTS 389
L-CARNITINE, THE VITAMIN BT: USES AND PRODUCTION BY THE SECONDARY
METABOLISM OF BACTERIA 391
VICENTE BERNAL PAULA ARENSE, AND MANUEL CANOVAS
INTRODUCTION AND HISTORICAL OUTLINE 391
OCCURRENCE IN NATURAL/FOOD SOURCES 392
PHYSIOLOGICAL ROLE AS VITAMIN OR AS COENZYME 393
PHYSIOLOGICAL ROLE OF CARNITINE IN THE MITOCHONDRIA 393
PHYSIOLOGICAL ROLE OF CARNITINE IN THE PEROXISOMES 394
OTHER FUNCTIONS OF CARNITINE 394
CHEMICAL AND PHYSICAL PROPERTIES 394
ASSAY METHODS AND UNITS 395
CHROMATOGRAPHIC METHODS 395
MS-BASED METHODS 395
ENZYMATIC METHODS 398
AUTOMATED METHODS 399
BIOTECHNOLOGICAL SYNTHESIS OF L-CARNITINE MICROBIAL METABOLISM OF
L-CARNITINE AND ITS REGULATION 399
BIOTECHNOLOGICAL METHODS FOR L-CARNITINE PRODUCTION 399
DE NOVO BIOSYNTHESIS OF L-CARNITINE 399
BIOLOGICAL RESOLUTION OF RACEMIC MIXTURES 399
BIOTRANSFORMATION FROM NON-CHIRAL SUBSTRATES 400
ROLES OF L-CARNITINE IN MICROORGANISMS 401
PROTECTANT AGENT 401
CARBON AND NITROGEN SOURCE 401
ELECTRON ACCEPTOR: CARNITINE RESPIRATION 402
L-CARNITINE METABOLISM IN ENTEROBACTERIA AND ITS REGULATION 403
METABOLISM OF L-CARNITINE IN E. COLI 403
METABOLISM OF L-CARNITINE IN PROTEUS SP. 405
EXPRESSION OF METABOLISING ACTIVITIES: EFFECT OF INDUCERS, OXYGEN AND
SUBSTRATES 406
14.6.5
14.6.6
14.6.6.1
14.6.6.2
14.6.6.3
14.6.7
14.6.7.1
14.6.7.2
14.7
14.7.1
14.7.2
15
15.1
15.2
15.2.1
15.2.2
15.2.3
15.3
15.3.1
15.3.2
15.4
15.4.1
15.4.2
15.4.2.1
15.4.2.2
15.4.2.3
15.4.3
15.5
BIOTRANSFORMATION WITH D-CARNITINE OR CROTONOBETAINE AS
SUBSTRATES 406
TRANSPORT PHENOMENA FOR L-CARNITINE PRODUCTION 407
MEMBRANE PERMEABILISATION 407
OSMOTIC STRESS INDUCTION OF TRANSPORTERS 408
OVEREXPRESSION OF THE TRANSPORTER CAIT 408
METABOLIC ENGINEERING FOR HIGH-YIELDING L-CARNITINE PRODUCING
STRAINS 408
LINK BETWEEN CENTRAL AND SECONDARY METABOLISM DURING
BIOTRANSFORMATION 408
METABOLIC ENGINEERING FOR STRAIN ENGINEERING: FEEDBACK
BETWEEN MODELLING AND EXPERIMENTAL ANALYSIS OF CELL
METABOLISM 409
OTHER METHODS FOR L-CARNITINE PRODUCTION: EXTRACTION FROM NATURAL
SOURCES AND CHEMICAL SYNTHESIS 411
ISOLATION OF L-CARNITINE FROM NATURAL SOURCES 411
CHEMICAL SYNTHESIS 411
ACKNOWLEDGEMENT 412
REFERENCES 412
APPLICATION OF CARNOSINE AND ITS FUNCTIONALISED DERIVATIVES 421
ISABELLE CHEVALOT, ELMIRA ARAB-TEHRANY, EDOUARD HUSSON, AND CHRISTINE
GERARDIN
INTRODUCTION AND HISTORICAL OUTLINE 421
SOURCES AND SYNTHESIS 422
OCCURRENCE IN NATURAL/FOOD SOURCES 422
CHEMICAL SYNTHESIS OF CARNOSINE 422
ENZYMATIC SYNTHESIS OF CARNOSINE 423
PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES OF
CARNOSINE 425
PHYSICO-CHEMICAL PROPERTIES 425
PHYSIOLOGICAL PROPERTIES 426
BIOTECHNOLOGICAL SYNTHESIS OF CARNOSINE DERIVATIVES: MODIFICATION,
VECTORISATION AND FUNCTIONALISATION 427
CHEMICAL FUNCTIONALISATION 427
ENZYMATIC FUNCTIONALISATION: ENZYMATIC N-ACYLATION OF
CARNOSINE 430
LIPASE-CATALYSED N-ACYLATION OF CARNOSINE IN NON-AQUEOUS
MEDIUM 431
ACYLTRANSFERASE-CATALYSED N-ACYLATION OF CARNOSINE IN AQUEOUS
MEDIUM 432
IMPACT OF ENZYMATIC OLEYLATION OF CARNOSINE ON SOME BIOLOGICAL
PROPERTIES 434
VECTORISATION 434
APPLICATIONS OF CARNOSINE AND ITS DERIVATIVES 435
15.5.1 NUTRACEUTICS AND FOOD SUPPLEMENTATION 435
15.5.2 COSMETICS 436
15.5.3 PHARMACEUTICALS 436
REFERENCES 438
16 METABOLISM AND BIOTECHNOLOGICAL PRODUCTION OF
GAMMA-AMINOBUTYRIC ACID (GABA) 445
FENG SHI, YALAN NI, AND NANNAN WANG
16.1 INTRODUCTION 445
16.2 PROPERTIES AND OCCURRENCE OF GABA IN NATURAL SOURCES 446
16.3 METABOLISM OF GABA 447
16.3.1 BIOSYNTHESIS AND EXPORT OF GABA 450
16.3.1.1 BIOSYNTHESIS OF GABA 450
16.3.1.2 ESSENTIAL ENZYME FOR GABA BIOSYNTHESIS - GAD 451
16.3.1.3 EXPORT OF GABA 452
16.3.2 UPTAKE AND CATABOLISM OF GABA 454
16.3.2.1 THE UPTAKE SYSTEM OF GABA 454
16.3.2.2 THE CATABOLISM OF GABA 455
16.4 REGULATION OF GABA BIOSYNTHESIS 456
16.5 BIOTECHNOLOGICAL PRODUCTION OF GABA 457
16.5.1 FERMENTATIVE PRODUCTION OF GABA BY LAB 458
16.5.2 PRODUCTION OF GABA BY ENZYMATIC CONVERSION 459
16.5.2.1 PRODUCTION OF GABA BY IMMOBILISED GAD 459
16.5.2.2 IMPROVING GAD ACTIVITY BY RATIONAL AND IRRATIONAL DESIGNS 459
16.5.3 FERMENTATION OF GABA BY RECOMBINANT C. GLUTAMICUM 460
16.6 PHYSIOLOGICAL FUNCTIONS AND APPLICATIONS OF GABA 461
16.6.1 PHYSIOLOGICAL FUNCTIONS OF GABA 461
16.6.2 APPLICATIONS OF GABA 462
16.7 CONCLUSION 462
ACKNOWLEDGEMENT 462
REFERENCES 463
17 FLAVONOIDS: FUNCTIONS, METABOLISM AND BIOTECHNOLOGY 469
CELESTINO SANTOS-BUELGA AND ANA M. GONZDLEZ-PARAMAS
17.1 INTRODUCTION 469
17.2 STRUCTURE AND OCCURRENCE IN FOOD 471
17.3 ACTIVITY AND METABOLISM 476
17.4 BIOSYNTHESIS OF FLAVONOIDS IN PLANTS 481
17.5 BIOTECHNOLOGICAL PRODUCTION 484
17.5.1 RECONSTRUCTION OF FLAVONOID PATHWAYS IN PLANT SYSTEMS 485
17.5.2 RECONSTRUCTION OF FLAVONOID PATHWAYS IN MICROBIAL SYSTEMS 487
17.5.2.1 . COLI PLATFORM 487
17.5.2.2 SACCHAROMYCES CEREVISIAE PLATFORM 489
17.6 CONCLUDING REMARKS 489
REFERENCES 490
18
MONASCUS PIGMENTS 497
YANLI FENG, YANCHUN SHAO, YOUXIANG ZHOU, WANPING CHEN, AND
FUSHENG CHEN
18.1
INTRODUCTION AND HISTORY OF MONASCUS PIGMENTS 497
18.2
CATEGORIES OF MPS 497
18.3
PHYSIOLOGICAL FUNCTIONS OF MPS 498
18.3.1 ANTI-CANCER ACTIVITIES
498
18.3.2
ANTIMICROBIAL ACTIVITIES 508
18.3.3
ANTI-OBESITY ACTIVITIES 509
18.3.4
ANTI-INFLAMMATION ACTIVITIES 510
18.3.5 REGULATION OF CHOLESTEROL LEVELS 510
18.3.6 ANTI-DIABETES ACTIVITIES 511
18.4
CHEMICAL AND PHYSICAL PROPERTIES OF MPS 511
18.4.1
SOLUBILITY 511
18.4.2 STABILITY 511
18.4.2.1 EFFECTS OF TEMPERATURE, PH AND SOLVENT ON STABILITY OF MPS
511
18.4.2.2 EFFECT OF LIGHT ON STABILITY OF MPS 512
18.4.2.3
EFFECT OF METAL ION ON STABILITY OF MPS 513
18.4.3 SAFETY 513
18.5 ASSAY METHODS AND UNITS OF MPS 513
18.5.1
EXTRACTION AND DETECTION OF MPS 513
18.5.2
ISOLATION AND PURIFICATION OF MPS COMPONENTS 514
18.5.2.1 CC AND TLC 514
18.5.2.2
HPLC 515
18.5.2.3
CE AND THE OTHERS 515
18.5.3
IDENTIFICATION OF MPS COMPONENTS 515
18.6
MPS PRODUCER - MONASCUS SPP. 520
18.6.1 BRIEF INTRODUCTION OF
MONASCUS SPECIES AND THEIR APPLICATIONS 520
18.6.2
PRODUCING METHODS OF MPS 520
18.6.3
PROGRESS OF MONASCUS SPP. AT THE GENETIC LEVEL 521
18.6.3.1
DNA TRANSFORMATION 521
18.6.3.2
CITRININ SYNTHESIS AND ITS REGULATIONS 521
18.6.3.3
MK SYNTHESIS AND ITS REGULATIONS 522
18.6.3.4
MPS SYNTHESIS AND ITS REGULATION 522
18.6.3.5
THE REGULATION OF SECONDARY METABOLISM IN MONASCUS SPP. 523
18.6.4
MONASCUS GENOMICS 524
18.7
APPLICATION AND ECONOMICS OF MPS 524
ACKNOWLEDGEMENTS 524
REFERENCES 526
INDEX 537
|
| any_adam_object | 1 |
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| author2_role | edt edt |
| author2_variant | e j v ej ejv j l r jl jlr |
| author_GND | (DE-588)1095130498 (DE-588)1119266769 |
| author_facet | Vandamme, Erick J. Revuelta, José Luis |
| building | Verbundindex |
| bvnumber | BV043415358 |
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| ctrlnum | (OCoLC)951491378 (DE-599)DNB1078034990 |
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| dewey-ones | 540 - Chemistry and allied sciences |
| dewey-raw | 540 |
| dewey-search | 540 |
| dewey-sort | 3540 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie Biologie |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV043415358 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:25:19Z |
| institution | BVB |
| isbn | 9783527337347 9783527681754 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-028833494 |
| oclc_num | 951491378 |
| open_access_boolean | |
| owner | DE-11 DE-83 DE-29T DE-634 |
| owner_facet | DE-11 DE-83 DE-29T DE-634 |
| physical | XXIX, 548 Seiten Illustrationen, Diagramme |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| publisher | Wiley-VCH Verlag GmbH & Co. KGaA |
| record_format | marc |
| spelling | Industrial biotechnology of vitamins, biopigments, and antioxidants edited by Erick J. Vandamme and José Luis Revuelta Weinheim Wiley-VCH Verlag GmbH & Co. KGaA [2016] © 2016 XXIX, 548 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Fermentation (DE-588)4129537-7 gnd rswk-swf Antioxidans (DE-588)4142729-4 gnd rswk-swf Vitamin (DE-588)4063635-5 gnd rswk-swf Wachstumsfaktor (DE-588)4188802-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Vitamin (DE-588)4063635-5 s Wachstumsfaktor (DE-588)4188802-9 s Antioxidans (DE-588)4142729-4 s Fermentation (DE-588)4129537-7 s DE-604 Vandamme, Erick J. (DE-588)1095130498 edt Revuelta, José Luis (DE-588)1119266769 edt Erscheint auch als Online-Ausgabe, EPUB 978-3-527-68177-8 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-68178-5 Erscheint auch als Online-Ausgabe, PDF 978-3-527-68176-1 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028833494&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Industrial biotechnology of vitamins, biopigments, and antioxidants Fermentation (DE-588)4129537-7 gnd Antioxidans (DE-588)4142729-4 gnd Vitamin (DE-588)4063635-5 gnd Wachstumsfaktor (DE-588)4188802-9 gnd |
| subject_GND | (DE-588)4129537-7 (DE-588)4142729-4 (DE-588)4063635-5 (DE-588)4188802-9 (DE-588)4143413-4 |
| title | Industrial biotechnology of vitamins, biopigments, and antioxidants |
| title_auth | Industrial biotechnology of vitamins, biopigments, and antioxidants |
| title_exact_search | Industrial biotechnology of vitamins, biopigments, and antioxidants |
| title_full | Industrial biotechnology of vitamins, biopigments, and antioxidants edited by Erick J. Vandamme and José Luis Revuelta |
| title_fullStr | Industrial biotechnology of vitamins, biopigments, and antioxidants edited by Erick J. Vandamme and José Luis Revuelta |
| title_full_unstemmed | Industrial biotechnology of vitamins, biopigments, and antioxidants edited by Erick J. Vandamme and José Luis Revuelta |
| title_short | Industrial biotechnology of vitamins, biopigments, and antioxidants |
| title_sort | industrial biotechnology of vitamins biopigments and antioxidants |
| topic | Fermentation (DE-588)4129537-7 gnd Antioxidans (DE-588)4142729-4 gnd Vitamin (DE-588)4063635-5 gnd Wachstumsfaktor (DE-588)4188802-9 gnd |
| topic_facet | Fermentation Antioxidans Vitamin Wachstumsfaktor Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028833494&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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