Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
München
Verl. Dr. Hut
2008
|
| Ausgabe: | 1. Aufl. |
| Schriftenreihe: | Pharmazeutische Biologie
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VI, 125 S. Ill., graph. Darst. |
| ISBN: | 9783899638653 |
Internformat
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Datensatz im Suchindex
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| adam_text | 3.7.4 CANCER CHEMOPREVENTIVE ACTIVITY 32 TABLE OF CONTENTS TABLE OF
CONTENTS PAGE 1. INTRODUCTION 1 1.1 DRUG DISCOVERY FROM MARINE-DERIVED
FIINGI 1 1.2 XANTHONES AND THEIR PHARMACOLOGICAL RELEVANCE 4 1.2.1
CHEMISTRY AND BIOACTIVITY OF XANTHONES 4 1.2.2 XANTHONES WITH PROMINENT
PHARMACOLOGICAL ACTIVITIES 13 2. SCOPE OF THE PRESENT STUDY 19 3.
MATERIALS AND METHODS 20 3.1 ORIGIN, ISOLATION AND TAXONOMYOF THE FUNGI
20 3.2 CULTIVATION OF THE FUNGAL STRAINS 21 3.3 EXTRACTIONOF THE FUNGAL
MATERIAL 21 3.4 CHROMATOGRAPHY 21 3.4.1 THIN LAYER CHROMATOGRAPHY (TLC)
21 3.4.2 VACUUM LIQUID CHROMATOGRAPHY (VLC) 22 3.4.3 HIGH PERFORMANCE
LIQUID CHROMATOGRAPHY (HPLC) 22 3.5 STRUCTURE ELUCIDATION 23 3.5.1 NMR
SPECTROSCOPY 23 3.5.2 MASS SPECTROMETRY 23 3.5.3 UV MEASUREMENTS 24
3.5.4 IR SPECTROSCOPY 24 3.5.5 OPTICAL ROTATION 25 3.5.6 CD SPECTROSCOPY
25 3.5.7 MOLECULAR MODELING 26 3.5.8 KARPLUS CALCULATIONS 26 3.6
CHEMICAL DERIVATIZATION 27 3.6.1 PREPARATION OF THE ACID CHLORIDES OF
(AE)- AND (S)-MPA 27 3.6.2 PREPARATION OF THE (AE)- AND (5)-MPA ESTERS OF
THE ISOLATED COMPOUNDS 28 3.7 BIOLOGICAL SCREENING 28 3.7.1 AGAR
DIFFUSION ASSAY 28 3.7.2 CYTOTOXICITY ASSAY AGAINST HUMAN CANCER CELL
LINES 29 3.7.3 ANTIPROTOZOAL ACTIVITY 31 BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/992163099 DIGITALISIERT DURCH TABLE OFCONTENTS 3.8
CHEMICALS 35 3.8.1 CHEMICALS AND SOLVENTS 35 3.8.2 MEDIA 36 4. RESULTS
AND DISCUSSION 38 4.1 ANTIPROTOZOAL ACTIVITIES OF NEW CHAETOXANTHONES A,
B AND C FROM CHAETOMIUM SP... 38 4.1.1 INTRODUCTION 38 4.1.2
CULTIVATION, EXTRACTION AND ISOLATION 39 4.1.3 RESULTS AND DISCUSSION 41
4.2 MONODICTYOCHROME A AND B, NEW DIMERIC XANTHONE DERIVATIVES FROM
MONODICTYS PUTREDINIS WITH CANCER CHEMOPREVENTIVE POTENTIAL 58 4.2.1
INTRODUCTION 58 4.2.2 CULTIVATION, EXTRACTION AND ISOLATION 59 4.2.3
RESULTS AND DISCUSSION 60 4.3 NODULIPREVENONE, A NOVEL HETERODIMERIC
CHROMANONE FROM NODULISPORIUM SP. WITH CANCER CHEMOPREVENTIVE POTENTIAL
75 4.3.1 INTRODUCTION 75 4.3.2 CULTIVATION, EXTRACTION AND ISOLATION 76
4.3.3 RESULTS AND DISCUSSION 77 4.4 NEW AROMATIC POLYKERIDES FROM
ACREMONIUM SP. AND NODULISPORIUM SP 88 4.4.1 INTRODUCTION 88 4.4.2
CULTIVATION, EXTRACTION AND ISOLATION 88 4.4.3 RESULTS AND DISCUSSION 89
4.5 CYTOTOXIC METABOLITES FROM ALTERNARIA SP 94 4.6 CYTOTOXIC OPHIOBOLIN
FROM ACREMONIUM SP 97 5. SIIMMARY 100 6. REFERENCES 103 7
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| spelling | Pontius, Alexander Verfasser (DE-588)136946224 aut Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance Alexander Pontius 1. Aufl. München Verl. Dr. Hut 2008 VI, 125 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Pharmazeutische Biologie Zugl.: Bonn, Univ., Diss.,, 2008 Marine Pilze - Xanthon - Pharmazeutische Analyse Pharmazeutische Analyse (DE-588)4174139-0 gnd rswk-swf Xanthon (DE-588)4332380-7 gnd rswk-swf Marine Pilze (DE-588)4348359-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Marine Pilze (DE-588)4348359-8 s Xanthon (DE-588)4332380-7 s Pharmazeutische Analyse (DE-588)4174139-0 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017025129&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pontius, Alexander Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance Marine Pilze - Xanthon - Pharmazeutische Analyse Pharmazeutische Analyse (DE-588)4174139-0 gnd Xanthon (DE-588)4332380-7 gnd Marine Pilze (DE-588)4348359-8 gnd |
| subject_GND | (DE-588)4174139-0 (DE-588)4332380-7 (DE-588)4348359-8 (DE-588)4113937-9 |
| title | Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance |
| title_auth | Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance |
| title_exact_search | Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance |
| title_full | Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance Alexander Pontius |
| title_fullStr | Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance Alexander Pontius |
| title_full_unstemmed | Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance Alexander Pontius |
| title_short | Structurally unprecedented xanthones from marine-derived fungi and their pharmacological relevance |
| title_sort | structurally unprecedented xanthones from marine derived fungi and their pharmacological relevance |
| topic | Marine Pilze - Xanthon - Pharmazeutische Analyse Pharmazeutische Analyse (DE-588)4174139-0 gnd Xanthon (DE-588)4332380-7 gnd Marine Pilze (DE-588)4348359-8 gnd |
| topic_facet | Marine Pilze - Xanthon - Pharmazeutische Analyse Pharmazeutische Analyse Xanthon Marine Pilze Hochschulschrift |
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