Verfügbarkeit: Tumors of the pancreas

Tumors of the pancreas:

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Bibliographische Detailangaben
Hauptverfasser:	Hruban, Ralph H. (VerfasserIn), Pitman, Martha B. (VerfasserIn), Klimstra, David S. (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Washington, DC American Registry of Pathology 2007
Schriftenreihe:	AFIP atlas of tumor pathology Fourth series ; 6
Schlagworte:	Pancreas > Cancer > Atlases Pancreas > Cancer > Diagnosis > Atlases Pancreas > Diseases > Atlases Pancreas > Diseases > Diagnosis > Atlases Pancreatic Neoplasms > diagnosis > Atlases Pancreatic Neoplasms > pathology > Atlases
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XVIII, 422 S. zahlr. Ill., graph. Darst.
ISBN:	1933477024 9781933477022

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adam_text	CONTENTS 1. The Normal Pancreas ..................................................... 1 Embryology .......................................................... 1 Gross Anatomy ....................................................... 3 Anatomic Relationships .............................................. 4 The Vascular Supply ................................................. 5 The Lymphatic System ............................................... 7 Innervation of the Pancreas ........................................... 9 Histology, Cytology, and Function ........................................ 9 The Exocrine Pancreas ................................................ 10 The Endocrine Pancreas .............................................. 13 Minor Architectural Variations ........................................... 16 Acinar Cell Nodule .................................................. 16 Acinar Ectasia ....................................................... 17 Metaplasia of Ductal Epithelium ....................................... 17 Congenital and Developmental Anomalies ................................. 18 Agenesis and Hypoplasia .............................................. 18 Pancreas Divisum ................................................... 19 Annular Pancreas .................................................... 20 Congenital Lipomatosis .............................................. 20 2. Classification of Pancreatic Tumors ......................................... 23 3. Staging ............................................................... 27 Anatomic Subsites ..................................................... 27 Τ Classification ....................................................... 28 N Classification ....................................................... 29 M Classification ....................................................... 29 Extent of Resection .................................................... 29 Prefixes Applied to the TNM Classification ................................. 29 Staging .............................................................. 30 Histopathologic Grading ................................................ 30 Comparison to the Japanese Staging System ................................ 30 4. Serous Cystic Neoplasms .................................................. 33 Microcystic Serous Cystadenoma ......................................... 33 Serous Cystadenocarcinoma ............................................. 45 5. Mucinous Cystic Neoplasms ............................................... 51 Definition ............................................................ 51 General Features ...................................................... 51 xiii Tumors of the Pancreas Clinical Features ...................................................... 51 Pathologic Features .................................................... 52 Gross Findings ...................................................... 52 Microscopic Findings ................................................. 54 Histologie Types of Invasive Carcinoma .................................. 59 Frozen Section ...................................................... 60 Immunohistochemical Findings ........................................ 60 Ultrastructural Findings .............................................. 61 Cytologie Findings .................................................. 61 Molecular and Other Special Techniques ................................. 64 Differential Diagnosis .................................................. 65 Pathogenesis ......................................................... 68 Spread and Métastases .................................................. 68 Staging .............................................................. 69 Treatment ............................................................ 69 Prognosis ............................................................ 69 6. Intraductal Neoplasms .................................................... 75 Intraductal Papillary Mucinous Neoplasm .................................. 75 Intraductal Oncocytic Papillary Neoplasm .................................. 100 Intraductal Tubular Neoplasm ............................................ 103 7. Ductal Adenocarcinoma .................................................. Ill Definition ............................................................ Ill General Features ..................................................... . Ill Familial Pancreatic Cancer .............................................. 114 Clinical Features ...................................................... 115 Pathologic Features .................................................... 118 Gross Findings ...................................................... 118 Microscopic Findings ................................................. 120 Histologie Types ..................................................... 127 Frozen Section ...................................................... 128 Immunohistochemical Findings ........................................ 129 Ultrastructural Findings .............................................. 132 Cytologie Findings .................................................. 132 Molecular and Other Special Techniques ................................. 137 Differential Diagnosis .................................................. 141 Spread and Métastases .................................................. 143 Staging, Treatment, and Prognosis ........................................ 146 Staging ............................................................ 146 xiv Contents Treatment .......................................................... 146 Prognosis .......................................................... 146 Pancreatic Intraepithelial Neoplasia ....................................... 148 8. Adenocarcinoma Variants ................................................. 165 Adenosquamous Carcinoma ............................................. 165 Colloid Carcinoma (Mucinous Noncystic Carcinoma) ........................ 168 Hepatoid Carcinoma ................................................... 172 Medullary Carcinoma .................................................. 174 Signet Ring Cell Carcinoma ............................................. 176 Undifferentiated Carcinoma ............................................. 177 Undifferentiated Carcinoma with Osteoclast-Like Giant Cells .................. 181 9. Acinar Neoplasms ....................................................... 191 Acinar Cell Cystadenoma ............................................... 191 Acinar Cell Carcinoma ................................................. 194 Acinar Cell Cystadenocarcinoma ......................................... 209 Mixed Acinar Carcinomas ............................................... 211 Mixed Acinar-Endocrine Carcinoma .................................... 211 Mixed Acinar-Ductal Carcinoma ....................................... 212 Mixed Acinar-Endocrine-Ductal Carcinoma ............................... 214 10. Pancreatoblastoma ....................................................... 219 Definition ............................................................ 219 General Features ...................................................... 219 Clinical Features ...................................................... 220 Pathologic Features .................................................... 220 Gross Findings ...................................................... 220 Microscopic Findings ................................................. 220 Frozen Section ...................................................... 224 Immunohistochemical Findings ........................................ 224 Ultrastructural Findings .............................................. 225 Cytologie Findings .................................................. 225 Molecular and Other Special Techniques ................................. 225 Differential Diagnosis .................................................. 226 Spread and Métastases .................................................. 227 Staging, Treatment, and Prognosis ........................................ 227 11. Solid-Pseudopapillary Neoplasms ........................................... 231 Definition ............................................................ 231 General Features ...................................................... 231 Clinical Features ...................................................... 231 xv Tumors of the Pancreas Pathologic Features .................................................... 232 Gross Findings ...................................................... 232 Microscopic Findings ................................................. 233 Histologie Types ..................................................... 240 Frozen Section ...................................................... 240 Immunohistochemical Findings ........................................ 241 Ultrastructural Findings .............................................. 241 Cytologie Findings .................................................. 242 Molecular and Other Special Techniques ................................. 244 Differential Diagnosis .................................................. 245 Spread and Métastases .................................................. 246 Staging, Treatment, and Prognosis ........................................ 247 12. Endocrine Neoplasms .................................................... 251 Endocrine Microadenomas .............................................. 252 Well-Differentiated Pancreatic Endocrine Neoplasms ......................... 254 General Features and Nonfunctional Pancreatic Endocrine Neoplasms ......... 254 Clinicopathic Features of Functional Pancreatic Endocrine Neoplasms ......... 276 Insulinoma ......................................................... 276 Glucagonoma ...................................................... 280 Somatostatinoma .................................................... 281 Gastrinoma ........................................................ 282 VIPoma ........................................................... 284 Pancreatic Polypeptide-Cell Pancreatic Endocrine Neoplasm ................. 286 Serotonin-Secreting Pancreatic Endocrine Neoplasm ....................... 287 Pancreatic Endocrine Neoplasm Producing Other Ectopie Syndromes .......... 288 Pancreatic Endocrine Neoplasms Producing Mixed Syndromes ............... 288 Poorly Differentiated Endocrine Carcinoma ................................. 289 Mixed Ductal-Endocrine Carcinoma ....................................... 291 13. Nonepithelial and Miscellaneous Neoplasms .................................. 305 Primary Nonepithelial Neoplasms ......................................... 305 Benign Nonepithelial Neoplasms ......................................... 305 Lymphangioma ..................................................... 305 Hemangioma ....................................................... 306 Kaposiform Hemangioendothelioma .................................... 307 Schwannoma ....................................................... 307 Neurofibroma ...................................................... 307 Granular Cell Tumors ................................................ 307 Leiomyoma ........................................................ 308 XVI Contents Lipoma ............................................................ 308 Perivascular Epithelioid Cell Neoplasm (PEComa) .......................... 309 Nonepithelial Neoplasms of Uncertain Malignant Potential .................... 309 Inflammatory Myofibroblastic Tumor ................................... 309 Solitary Fibrous Tumor ............................................... 311 Extragastrointestinal Stromal Tumor .................................... 312 Malignant Nonepithelial Neoplasms ...................................... 313 Leiomyosarcoma and Other Sarcomas ................................... 313 Primitive Neuroectodermal Tumor ...................................... 314 Desmoplastic Small Round Cell Tumor .................................. 316 Non-Hodgkin s Lymphoma ............................................ 317 Miscellaneous Neoplasms ............................................... 319 Mature Cystic Teratoma .............................................. 319 Adenomatoid Tumor ................................................. 320 Extraadrenal Paraganglioma ........................................... 320 14. Secondary Neoplasms .................................................... 325 Metastatic Renal Cell Carcinoma ......................................... 327 Hematopoietic Malignancies ............................................. 329 Metastatic Melanoma .................................................. 330 15. Non-Neoplastic Tumors and Tumor-Like Lesions ............................... 335 Solid Lesions of the Exocrine Pancreas ..................................... 335 Chronic Pancreatitis ................................................. 336 Lymphoplasmacytic Sclerosing Pancreatitis (Autoimmune Pancreatitis) ........ 343 Reactive Fibroinflammatory Pseudotumor ................................ 348 Heterotopic Pancreas ................................................. 349 Heterotopic Spleen .................................................. 351 Hamartoma ........................................................ 351 Miscellaneous Solid Lesions ........................................... 352 Cystic Lesions of the Exocrine Pancreas .................................... 353 Pseudocyst ......................................................... 354 Paraampullary Duodenal Wall Cyst (Groove Pancreatitis) .................... 356 Ductal Retention Cyst and Mucinous Non-neoplastic Cyst .................. 358 Congenital Cyst ..................................................... 360 Lymphoepithelial Cyst ............................................... 361 Epidermoid Cyst in Intrapancreatic Heterotopic Spleen ..................... 363 Miscellaneous Cystic Lesions .......................................... 364 Lesions of the Endocrine Pancreas ........................................ 364 Islet Hyperplasia .................................................... 364 xvii Tumors of the Pancreas Islet Aggregation .................................................... 364 Nesidioblastosis ..................................................... 367 Islet Dysplasia ...................................................... 369 16. Dissection and Reporting of Pancreatic Resection Specimens ..................... 377 Dissection ............................................................ 377 Pancreatoduodenectomy (Whipple) Specimen ............................ 377 Distal Pancreatectomy ................................................ 381 The Pathology Report .................................................. 385 17. Diagnostic Evaluation of Pancreatic Neoplasms ................................ 387 Diagnosis of Ductal Adenocarcinoma ...................................... 387 Biopsy Interpretation ................................................ 387 Liver and Peritoneal Biopsies .......................................... 394 Diagnosis of the Solid Cellular Pancreatic Neoplasm .......................... 396 Diagnosis of the Cystic Pancreatic Neoplasm ................................ 399 Cytologie Evaluation of Pancreatic Neoplasms .............................. 403 Specimen Preparation ................................................ 403 Bile Duct Brushing Cytology ........................................... 403 Fine Needle Aspiration Biopsy ......................................... 403 Gastrointestinal Contamination ........................................ 404 Solid Masses ........................................................ 405 Cystic Lesions ...................................................... 408 Index .............................................................. 413 xviii
adam_txt	CONTENTS 1. The Normal Pancreas . 1 Embryology . 1 Gross Anatomy . 3 Anatomic Relationships . 4 The Vascular Supply . 5 The Lymphatic System . 7 Innervation of the Pancreas . 9 Histology, Cytology, and Function . 9 The Exocrine Pancreas . 10 The Endocrine Pancreas . 13 Minor Architectural Variations . 16 Acinar Cell Nodule . 16 Acinar Ectasia . 17 Metaplasia of Ductal Epithelium . 17 Congenital and Developmental Anomalies . 18 Agenesis and Hypoplasia . 18 Pancreas Divisum . 19 Annular Pancreas . 20 Congenital Lipomatosis . 20 2. Classification of Pancreatic Tumors . 23 3. Staging . 27 Anatomic Subsites . 27 Τ Classification . 28 N Classification . 29 M Classification . 29 Extent of Resection . 29 Prefixes Applied to the TNM Classification . 29 Staging . 30 Histopathologic Grading . 30 Comparison to the Japanese Staging System . 30 4. Serous Cystic Neoplasms . 33 Microcystic Serous Cystadenoma . 33 Serous Cystadenocarcinoma . 45 5. Mucinous Cystic Neoplasms . 51 Definition . 51 General Features . 51 xiii Tumors of the Pancreas Clinical Features . 51 Pathologic Features . 52 Gross Findings . 52 Microscopic Findings . 54 Histologie Types of Invasive Carcinoma . 59 Frozen Section . 60 Immunohistochemical Findings . 60 Ultrastructural Findings . 61 Cytologie Findings . 61 Molecular and Other Special Techniques . 64 Differential Diagnosis . 65 Pathogenesis . 68 Spread and Métastases . 68 Staging . 69 Treatment . 69 Prognosis . 69 6. Intraductal Neoplasms . 75 Intraductal Papillary Mucinous Neoplasm . 75 Intraductal Oncocytic Papillary Neoplasm . 100 Intraductal Tubular Neoplasm . 103 7. Ductal Adenocarcinoma . Ill Definition . Ill General Features .". Ill Familial Pancreatic Cancer . 114 Clinical Features . 115 Pathologic Features . 118 Gross Findings . 118 Microscopic Findings . 120 Histologie Types . 127 Frozen Section . 128 Immunohistochemical Findings . 129 Ultrastructural Findings . 132 Cytologie Findings . 132 Molecular and Other Special Techniques . 137 Differential Diagnosis . 141 Spread and Métastases . 143 Staging, Treatment, and Prognosis . 146 Staging . 146 xiv Contents Treatment . 146 Prognosis . 146 Pancreatic Intraepithelial Neoplasia . 148 8. Adenocarcinoma Variants . 165 Adenosquamous Carcinoma . 165 Colloid Carcinoma (Mucinous Noncystic Carcinoma) . 168 Hepatoid Carcinoma . 172 Medullary Carcinoma . 174 Signet Ring Cell Carcinoma . 176 Undifferentiated Carcinoma . 177 Undifferentiated Carcinoma with Osteoclast-Like Giant Cells . 181 9. Acinar Neoplasms . 191 Acinar Cell Cystadenoma . 191 Acinar Cell Carcinoma . 194 Acinar Cell Cystadenocarcinoma . 209 Mixed Acinar Carcinomas . 211 Mixed Acinar-Endocrine Carcinoma . 211 Mixed Acinar-Ductal Carcinoma . 212 Mixed Acinar-Endocrine-Ductal Carcinoma . 214 10. Pancreatoblastoma . 219 Definition . 219 General Features . 219 Clinical Features . 220 Pathologic Features . 220 Gross Findings . 220 Microscopic Findings . 220 Frozen Section . 224 Immunohistochemical Findings . 224 Ultrastructural Findings . 225 Cytologie Findings . 225 Molecular and Other Special Techniques . 225 Differential Diagnosis . 226 Spread and Métastases . 227 Staging, Treatment, and Prognosis . 227 11. Solid-Pseudopapillary Neoplasms . 231 Definition . 231 General Features . 231 Clinical Features . 231 xv Tumors of the Pancreas Pathologic Features . 232 Gross Findings . 232 Microscopic Findings . 233 Histologie Types . 240 Frozen Section . 240 Immunohistochemical Findings . 241 Ultrastructural Findings . 241 Cytologie Findings . 242 Molecular and Other Special Techniques . 244 Differential Diagnosis . 245 Spread and Métastases . 246 Staging, Treatment, and Prognosis . 247 12. Endocrine Neoplasms . 251 Endocrine Microadenomas . 252 Well-Differentiated Pancreatic Endocrine Neoplasms . 254 General Features and Nonfunctional Pancreatic Endocrine Neoplasms . 254 Clinicopathic Features of Functional Pancreatic Endocrine Neoplasms . 276 Insulinoma . 276 Glucagonoma . 280 Somatostatinoma . 281 Gastrinoma . 282 VIPoma . 284 Pancreatic Polypeptide-Cell Pancreatic Endocrine Neoplasm . 286 Serotonin-Secreting Pancreatic Endocrine Neoplasm . 287 Pancreatic Endocrine Neoplasm Producing Other Ectopie Syndromes . 288 Pancreatic Endocrine Neoplasms Producing Mixed Syndromes . 288 Poorly Differentiated Endocrine Carcinoma . 289 Mixed Ductal-Endocrine Carcinoma . 291 13. Nonepithelial and Miscellaneous Neoplasms . 305 Primary Nonepithelial Neoplasms . 305 Benign Nonepithelial Neoplasms . 305 Lymphangioma . 305 Hemangioma . 306 Kaposiform Hemangioendothelioma . 307 Schwannoma . 307 Neurofibroma . 307 Granular Cell Tumors . 307 Leiomyoma . 308 XVI Contents Lipoma . 308 Perivascular Epithelioid Cell Neoplasm (PEComa) . 309 Nonepithelial Neoplasms of Uncertain Malignant Potential . 309 Inflammatory Myofibroblastic Tumor . 309 Solitary Fibrous Tumor . 311 Extragastrointestinal Stromal Tumor . 312 Malignant Nonepithelial Neoplasms . 313 Leiomyosarcoma and Other Sarcomas . 313 Primitive Neuroectodermal Tumor . 314 Desmoplastic Small Round Cell Tumor . 316 Non-Hodgkin's Lymphoma . 317 Miscellaneous Neoplasms . 319 Mature Cystic Teratoma . 319 Adenomatoid Tumor . 320 Extraadrenal Paraganglioma . 320 14. Secondary Neoplasms . 325 Metastatic Renal Cell Carcinoma . 327 Hematopoietic Malignancies . 329 Metastatic Melanoma . 330 15. Non-Neoplastic Tumors and Tumor-Like Lesions . 335 Solid Lesions of the Exocrine Pancreas . 335 Chronic Pancreatitis . 336 Lymphoplasmacytic Sclerosing Pancreatitis (Autoimmune Pancreatitis) . 343 Reactive Fibroinflammatory Pseudotumor . 348 Heterotopic Pancreas . 349 Heterotopic Spleen . 351 Hamartoma . 351 Miscellaneous Solid Lesions . 352 Cystic Lesions of the Exocrine Pancreas . 353 Pseudocyst . 354 Paraampullary Duodenal Wall Cyst (Groove Pancreatitis) . 356 Ductal Retention Cyst and Mucinous Non-neoplastic Cyst . 358 Congenital Cyst . 360 Lymphoepithelial Cyst . 361 Epidermoid Cyst in Intrapancreatic Heterotopic Spleen . 363 Miscellaneous Cystic Lesions . 364 Lesions of the Endocrine Pancreas . 364 Islet Hyperplasia . 364 xvii Tumors of the Pancreas Islet Aggregation . 364 Nesidioblastosis . 367 Islet Dysplasia . 369 16. Dissection and Reporting of Pancreatic Resection Specimens . 377 Dissection . 377 Pancreatoduodenectomy (Whipple) Specimen . 377 Distal Pancreatectomy . 381 The Pathology Report . 385 17. Diagnostic Evaluation of Pancreatic Neoplasms . 387 Diagnosis of Ductal Adenocarcinoma . 387 Biopsy Interpretation . 387 Liver and Peritoneal Biopsies . 394 Diagnosis of the Solid Cellular Pancreatic Neoplasm . 396 Diagnosis of the Cystic Pancreatic Neoplasm . 399 Cytologie Evaluation of Pancreatic Neoplasms . 403 Specimen Preparation . 403 Bile Duct Brushing Cytology . 403 Fine Needle Aspiration Biopsy . 403 Gastrointestinal Contamination . 404 Solid Masses . 405 Cystic Lesions . 408 Index . 413 xviii
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spelling	Hruban, Ralph H. Verfasser (DE-588)173034411 aut Tumors of the pancreas by Ralph H. Hruban ; Martha Bishop Pitman ; David S. Klimstra Washington, DC American Registry of Pathology 2007 XVIII, 422 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier AFIP atlas of tumor pathology : Fourth series 6 Pancreas Cancer Atlases Pancreas Cancer Diagnosis Atlases Pancreas Diseases Atlases Pancreas Diseases Diagnosis Atlases Pancreatic Neoplasms diagnosis Atlases Pancreatic Neoplasms pathology Atlases Pitman, Martha B. Verfasser aut Klimstra, David S. Verfasser aut AFIP atlas of tumor pathology Fourth series ; 6 (DE-604)BV019661402 6 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015647624&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Hruban, Ralph H. Pitman, Martha B. Klimstra, David S. Tumors of the pancreas AFIP atlas of tumor pathology Pancreas Cancer Atlases Pancreas Cancer Diagnosis Atlases Pancreas Diseases Atlases Pancreas Diseases Diagnosis Atlases Pancreatic Neoplasms diagnosis Atlases Pancreatic Neoplasms pathology Atlases
title	Tumors of the pancreas
title_auth	Tumors of the pancreas
title_exact_search	Tumors of the pancreas
title_exact_search_txtP	Tumors of the pancreas
title_full	Tumors of the pancreas by Ralph H. Hruban ; Martha Bishop Pitman ; David S. Klimstra
title_fullStr	Tumors of the pancreas by Ralph H. Hruban ; Martha Bishop Pitman ; David S. Klimstra
title_full_unstemmed	Tumors of the pancreas by Ralph H. Hruban ; Martha Bishop Pitman ; David S. Klimstra
title_short	Tumors of the pancreas
title_sort	tumors of the pancreas
topic	Pancreas Cancer Atlases Pancreas Cancer Diagnosis Atlases Pancreas Diseases Atlases Pancreas Diseases Diagnosis Atlases Pancreatic Neoplasms diagnosis Atlases Pancreatic Neoplasms pathology Atlases
topic_facet	Pancreas Cancer Atlases Pancreas Cancer Diagnosis Atlases Pancreas Diseases Atlases Pancreas Diseases Diagnosis Atlases Pancreatic Neoplasms diagnosis Atlases Pancreatic Neoplasms pathology Atlases
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015647624&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
volume_link	(DE-604)BV019661402
work_keys_str_mv	AT hrubanralphh tumorsofthepancreas AT pitmanmarthab tumorsofthepancreas AT klimstradavids tumorsofthepancreas

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