The role of TNFR2 in experimentally induced glomerulonephritis:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-253105 Inhaltsverzeichnis |
| Beschreibung: | VI, 70 Bl. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a The role of TNFR2 in experimentally induced glomerulonephritis |c vorgelegt von Eva Elisabeth Pfeifer |
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Datensatz im Suchindex
| _version_ | 1804149348931469312 |
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| adam_text | IMAGE 1
TABLE OF CONTENTS
TABLE OF CONTENTS A
TABLE OF CONTENTS I
LIST OF FIGURES ILL
ABBREVIATIONS V
1 INTRODUCTION 1
1.1 GLOMERULONEPHRITIS 1
1.1.1 RENAL PHYSIOLOGY 1
1.1.2 PATHOPHYSIOLOGY OF GLOMERULONEPHRITIS 4
1.1.3 CLINICAL SYMPTOMS OF GLOMERULONEPHRITIS 5
1.2 TUMOR NECROSIS FACTOR 6
1.2.1 STRUCTURE OF TNF 6
1.2.2 DISCOVERY OF TNF 6
1.2.3 TNF-RECEPTORS AND SIGNALING PATHWAYS 7
1.2.4 FUNCTIONS OF TNF 9
1.2.5 ANTI-TNF-THERAPIES 10
1.3 ROLE OF TNF IN RENAL DISEASES 11
1.3.1 ROLE OF TNF AND TNF-RECEPTORS IN GLOMERULONEPHRITIS 12
1.4 AIM OF THE STUDY 13
2 MATERIALS AND METHODS 15
2.1 METHODS 15
2.1.1 INDUCTION OF GLOMERULONEPHRITIS 15
2.1.2 MEASUREMENT OF PROTEINURIA 16
2.1.3 ELISAS FOR MEASURING THE SOLUBLE MOUSE TNFRII, HUMAN TNFRII AND
MOUSE TNF
IN URINE AND SERUM 17
2.1.4 PHENOTYPING OF MICE TRANSGENIC FOR HTNFR2 19
2.1.5 MEASUREMENT OF CREATININE IN SERUM AND URINE 20
2.1.6 FIXATION AND STAINING OF MOUSE KIDNEY TISSUE 21
2.1.7 STATISTICS 23
2.2 MATERIALS 24
2.2.1 CHEMICALS 24
2.2.2 CONSUMABLES -. 24
2.2.3 INSTRUMENTS 25
2.2.4 BUFFER SOLUTIONS 25
2.2.5 ASSAY KITS 26
2.2.6 ANTIBODIES 26
HTTP://D-NB.INFO/1025761235
IMAGE 2
TABLE OF CONTENTS II
2.2.7 ANIMALS 26
2.2.8 OTHERS 27
3 RESULTS 28
3.1 GLOMERULONEPHRITIS INDUCTION IN TNFR2-/- MICE AND CONTROL ANIMALS 28
3.1.1 PROTEINURIA 28
3.1.2 CREATININE CONCENTRATION 29
3.1.3 RELATION OF PROTEINURIA TO CREATININE 30
3.1.4 HISTOLOGICAL FINDINGS 31
3.2 GLOMERULONEPHRITIS INDUCTION IN HTNFR2TG MICE AND CONTROL ANIMALS 34
3.2.1 PROTEINURIA 34
3.2.2 CREATININE CONCENTRATION 35
3.2.3 RELATION OF PROTEINURIA TO CREATININE 37
3.2.4 HISTOLOGICAL FINDINGS 38
3.3 GLOMERULONEPHRITIS INDUCTION IN HTNFR2TG MICE AND CONTROL ANIMALS -
PART 2 39
3.3.1 PROTEINURIA 39
3.3.2 CREATININE CONCENTRATION 40
3.3.3 RELATION OF PROTEINURIA TO CREATININE 41
3.3.4 MTNFR2 CONCENTRATION 42
3.3.5 HTNFR2 CONCENTRATION 43
3.3.6 HISTOLOGICAL FINDINGS 45
3.4 MTNFR2 CONCENTRATION IN URINE WITH AND WITHOUT INDUCTION OF
GLOMERULONEPHRITIS ...46
3.5 TITRATION OF ANTI-GBM-SERUM IN INDUCTION OF GLOMERULONEPHRITIS 48
3.6 PHENOTYPING OF HTNFR2TG MICE 51
4 DISCUSSION 52
4.1 DEVELOPMENT OF GLOMERULONEPHRITIS IN TNFR2-DEFICIENT MICE 52
4.2 DEVELOPMENT OF GLOMERULONEPHRITIS IN HTNFR2-TRANSGENIC MICE 54
4.3 PHENOTYPING OF HTNFR2-TRANSGENIC MICE 57
4.4 DETECTION OF SOLUBLE TNFR2 IN URINE 58
4.5 CONCLUSION 59
5 REFERENCES 61
6 ACKNOWLEDGMENTS 68
7 CURRICULUM VITAE 70
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| indexdate | 2024-07-10T00:21:36Z |
| institution | BVB |
| language | English |
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| spelling | Pfeifer, Eva Elisabeth 1986- Verfasser (DE-588)1024380785 aut The role of TNFR2 in experimentally induced glomerulonephritis vorgelegt von Eva Elisabeth Pfeifer 2012 VI, 70 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Regensburg, Univ., Diss., 2012 Glomerulonephritis (DE-588)4128949-3 gnd rswk-swf Rezeptor (DE-588)4049722-7 gnd rswk-swf Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Tumor-Nekrose-Faktor (DE-588)4202932-6 s Rezeptor (DE-588)4049722-7 s Glomerulonephritis (DE-588)4128949-3 s b DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:355-epub-253105 http://epub.uni-regensburg.de/25310/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-253105 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025175939&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pfeifer, Eva Elisabeth 1986- The role of TNFR2 in experimentally induced glomerulonephritis Glomerulonephritis (DE-588)4128949-3 gnd Rezeptor (DE-588)4049722-7 gnd Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd |
| subject_GND | (DE-588)4128949-3 (DE-588)4049722-7 (DE-588)4202932-6 (DE-588)4113937-9 |
| title | The role of TNFR2 in experimentally induced glomerulonephritis |
| title_auth | The role of TNFR2 in experimentally induced glomerulonephritis |
| title_exact_search | The role of TNFR2 in experimentally induced glomerulonephritis |
| title_full | The role of TNFR2 in experimentally induced glomerulonephritis vorgelegt von Eva Elisabeth Pfeifer |
| title_fullStr | The role of TNFR2 in experimentally induced glomerulonephritis vorgelegt von Eva Elisabeth Pfeifer |
| title_full_unstemmed | The role of TNFR2 in experimentally induced glomerulonephritis vorgelegt von Eva Elisabeth Pfeifer |
| title_short | The role of TNFR2 in experimentally induced glomerulonephritis |
| title_sort | the role of tnfr2 in experimentally induced glomerulonephritis |
| topic | Glomerulonephritis (DE-588)4128949-3 gnd Rezeptor (DE-588)4049722-7 gnd Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd |
| topic_facet | Glomerulonephritis Rezeptor Tumor-Nekrose-Faktor Hochschulschrift |
| url | http://epub.uni-regensburg.de/25310/ https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-253105 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025175939&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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