Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Giessen
VVB Laufersweiler Verlag
2019
|
| Edition: | 1. Auflage |
| Series: | Edition scientifique
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Im Titel ist "1" hochgestellt |
| Physical Description: | 95 Seiten Illustrationen, Diagramme |
| ISBN: | 9783835967656 |
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| 245 | 1 | 0 | |a Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy |c eingerichtet von Agnieszka Olszewska |
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Record in the Search Index
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|---|---|
| adam_text | Aus dem Klinikum Veterinärmedizin
Klinik für Kleintiere, Chirurgie,
Neurologie und Neurochirurgie
der Justus-Liebig-Universität Gießen
Betreuer: Prof Dr Martin J Schmidt
Interictal single-voxel ^-proton magnetic
resonance spectroscopy of the temporal lobe
in dogs with idiopathic epilepsy
INAUGURAL-DISSERTATION
zur Erlangung des Grades eines
Dr med vet
beim Fachbereich Veterinärmedizin
der Justus-Liebig-Universität Gießen
eingerichtet von
Agnieszka Olszewska
Tierärztin aus Olsztyn (Polen)
Gießen 2019
Contents
Abbreviations 7
List of figures 10
1 Introduction 14
2 Literature review 15
2 1 Definition of primary epilepsy 15
2 2 Breed predisposition in idiopathic epilepsy 16
2 3 Pathophysiology of primary epilepsy 17
2 4 Morphology of the hippocampus 18
2 5 The role of the hippocampus in epilepsy 24
2 6 Refractory epilepsy 26
2 7 MRI abnormalities in dogs with seizures 27
2 8 Magnetic resonance spectroscopy 29
281 Physical principles of MR-spectroscopy 29
282 Quantification of MR Spectra 32
283 Major metabolites 32
2831 N-acetyl aspartate (NAA) - the neuronal marker 3®
2832 Choline (Cho) ^2
2833 Creatine 1,2
284 Internal metabolite referencing 44
285 MRS methodology on animal models of epileptogenesis 4^
3 Research study 47
3 1 Aim of the study 47
3 2 Materials and Methods 47
321 Study population 47
48
322 Neurodiagnostic investigation
5
49
323 Anaesthesia protocol
323 Magnetic Resonance Imaging (MRI) 49
324 Magnetic Resonance Spectroscopy (MRS) 49
326 Data processing and quantification 50
327 Statistical analysis 53
4 Results 54
4 1 Comparison of the metabolite ratios between the control and diseased group 61
4 2 Correlation between the metabolite ratios and the age and sex 63
4 3 Correlation between the metabolite ratios and the time from the last seizure in the
group of the diseased dogs 65
5 Discussion 66
5 1 Limitations of the study 68
6 Conclusion 71
7 Summary 71
8 Zusammenfassung 71
9 Acknowledgments 72
8 References 73
9 Ethics 94
|
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| indexdate | 2024-07-10T08:31:07Z |
| institution | BVB |
| isbn | 9783835967656 |
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| physical | 95 Seiten Illustrationen, Diagramme |
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| spelling | Olszewska, Agnieszka Verfasser (DE-588)1182368832 aut Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy eingerichtet von Agnieszka Olszewska 1. Auflage Giessen VVB Laufersweiler Verlag 2019 95 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Edition scientifique Im Titel ist "1" hochgestellt Dissertation Justus-Liebig-Universität Gießen 2019 dogs cabt epilepsy cabt magnetic resonance cabt imaging cabt contrast agents cabt veterinary medicine cabt (DE-588)4113937-9 Hochschulschrift gnd-content HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031325940&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Olszewska, Agnieszka Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy dogs cabt epilepsy cabt magnetic resonance cabt imaging cabt contrast agents cabt veterinary medicine cabt |
| subject_GND | (DE-588)4113937-9 |
| title | Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy |
| title_auth | Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy |
| title_exact_search | Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy |
| title_full | Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy eingerichtet von Agnieszka Olszewska |
| title_fullStr | Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy eingerichtet von Agnieszka Olszewska |
| title_full_unstemmed | Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy eingerichtet von Agnieszka Olszewska |
| title_short | Interictal single-voxel 1H-proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy |
| title_sort | interictal single voxel 1h proton magnetic resonance spectroscopy of the temporal lobe in dogs with idiopathic epilepsy |
| topic | dogs cabt epilepsy cabt magnetic resonance cabt imaging cabt contrast agents cabt veterinary medicine cabt |
| topic_facet | dogs epilepsy magnetic resonance imaging contrast agents veterinary medicine Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=031325940&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT olszewskaagnieszka interictalsinglevoxel1hprotonmagneticresonancespectroscopyofthetemporallobeindogswithidiopathicepilepsy |