Polymeric carriers as pulmonary gene and siRNA delivery systems:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 167 S. Ill., graph. Darst. 21 cm |
Internformat
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-021197729 | |
Datensatz im Suchindex
| _version_ | 1807682839519428608 |
|---|---|
| adam_text |
TABLE
OF
CONTENTS
CHAPTER
1
INTRODUCTION
1
GENE
THERAPY
AND
RNA
INTERFERENCE
THERAPY
2
NUCLEIC
ACID
DELIVERY
VEHICLES
3
PULMONARY
GENE
AND
RNAI
THERAPY
4
EXTRACELLULAR
BARRIERS
TO
PULMONARY
GENE
AND
RNAI
THERAPY
5
INTRACELLULAR
BARRIERS
TO
GENE
AND
RNAI
THERAPY
8
NON-BIODEGRADABLE
POLYMERIC
VECTORS
FOR
PULMONARY
GENE
AND
RNAI
THERAPY
10
BIODEGRADABLE
POLYMERIC
VECTORS
FOR
PULMONARY
GENE
AND
RNAI
THERAPY
12
NEBULIZATION
14
DELIVERY
FORMULATIONS
FOR
PDNA
AND
SIRNA
15
AIMSAND
SCOPE
18
REFERENCES
20
CHAPTER
2
EFFECTS
OF
CELL-PENETRATING
PEPTIDES
AND
PEGYLATION
ON
TRANSFECTION
EFFICIENCY
OF
POLYETHYLENIMINE
IN
MOUSE
LUNGS
27
ABSTRACT
28
INTRODUCTION
29
METHODS
AND
MATERIALS
30
RESULTS
36
DISCUSSION
49
CONCLUSIONS
51
REFERENCES
52
CHAPTER
3
NANOCOMPOSITES
OF
LUNG
SURFACTANT
AND
BIODEGRADABLE
CATIONIC
NANOPARTICLES
IMPROVE
TRANSFECTION
EFFICIENCY
TO
LUNG
CELLS
56
ABSTRACT
57
INTRODUCTION
58
METHODS
AND
MATERIALS
60
RESULTS
66
DISCUSSION
79
CONCLUSIONS
82
REFERENCES
83
CHAPTER
4
FAST
DEGRADING
POLYESTERS
AS
SIRNA
NANO-CARRIERS
FOR
PULMONARY
GENE
THERAPY
87
ABSTRACT
88
INTRODUCTION
89
METHODS
AND
MATERIALS
90
RESULTS
AND
DISCUSSION
96
CONCLUSION
109
REFERENCES
110
CHAPTER
5
STRUCTURE-ACTIVITY
RELATIONSHIPS
OF
AMINE-MODIFIED
POLY(VINYL
ALCOHOL)S:
EFFECTS
OF
AMINE
DENSITY
ON
PHYSICOCHEMICAL
PROPERTIES
AND
KNOCKDOWN
EFFICIENCY
115
ABSTRACT
116
INTRODUCTION
117
METHODS
AND
MATERIALS
118
RESULTS
124
DISCUSSION
139
CONCLUSIONS
142
REFERENCES
143
CHAPTER
6
SUMMARY
AND
PERSPECTIVES
146
SUMMARY
147
PERSPECTIVES
150
ZUSAMMENFASSUNG
154
AUSBLICK
157
APPENDICES
162
ABBREVIATION
163
LIST
OF
PUBLICATIONS
165
CURRICULUM
VITAE
167 |
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| author | Nguyen, Juliane 1980- |
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| author_facet | Nguyen, Juliane 1980- |
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-search | 615.37 |
| dewey-sort | 3615.37 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| indexdate | 2024-08-18T00:24:53Z |
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| language | English |
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| spelling | Nguyen, Juliane 1980- Verfasser (DE-588)140093192 aut Polymeric carriers as pulmonary gene and siRNA delivery systems vorgelegt von Juliane Nguyen 2009 167 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Marburg, Univ., Diss., 2009 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021197729&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nguyen, Juliane 1980- Polymeric carriers as pulmonary gene and siRNA delivery systems |
| subject_GND | (DE-588)4113937-9 |
| title | Polymeric carriers as pulmonary gene and siRNA delivery systems |
| title_auth | Polymeric carriers as pulmonary gene and siRNA delivery systems |
| title_exact_search | Polymeric carriers as pulmonary gene and siRNA delivery systems |
| title_full | Polymeric carriers as pulmonary gene and siRNA delivery systems vorgelegt von Juliane Nguyen |
| title_fullStr | Polymeric carriers as pulmonary gene and siRNA delivery systems vorgelegt von Juliane Nguyen |
| title_full_unstemmed | Polymeric carriers as pulmonary gene and siRNA delivery systems vorgelegt von Juliane Nguyen |
| title_short | Polymeric carriers as pulmonary gene and siRNA delivery systems |
| title_sort | polymeric carriers as pulmonary gene and sirna delivery systems |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021197729&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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