The role of model integration in complex systems modelling: an example from cancer biology
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2010
|
| Schriftenreihe: | Understanding complex systems
Springer complexity |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 168 S. graph. Darst. |
| ISBN: | 9783642156021 |
Internformat
MARC
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Datensatz im Suchindex
| _version_ | 1804143423520768000 |
|---|---|
| adam_text | CONTENTS 1 INTRODUCTION 1 1.1 COMPLEX BIOLOGICAL SYSTEMS, MODELLING AND
MODEL INTEGRATION 1 2 NATURE TO NUMBERS: COMPLEX SYSTEMS MODELLING OF
CANCER 5 2.1 MATHEMATICAL MODELLING IN TUMOUR SYSTEMS BIOLOGY 5 2.1.1
GROWTH MODELS 7 2.1.2 ANGIOGENESIS MODELS 16 2.1.3 TREATMENT RESPONSE
MODELS 21 2.1.4 MODELLING METHODOLOGIES 23 2.1.5 DYNAMIC PATHWAY MODELS
27 2.1.6 OTHER MODELS 31 2.2 SUMMARY 32 2.3 CONCLUSION 32 3 COPING WITH
COMPLEXITY: MODELLING OF COMPLEX SYSTEMS 33 3.1 PREAMBLE 33 3.2 DYNAMIC
COMPLEX SYSTEMS 35 3.2.1 PROPERTIES OF COMPLEX SYSTEMS 37 3.3 A
SYSTEMS-THEORETIC APPROACH IN BIOLOGY: SYSTEM BIOLOGY 43 3.4 COPING WITH
COMPLEXITY: MODELLING OF COMPLEX SYSTEMS ... 46 3.4.1 INDIVIDUAL-BASED
MODELLING METHODS 48 3.4.2 SIMULATION SOFTWARE 51 3.5 SUMMARY 54 3.6
CONCLUSION 55 BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/1005454264
DIGITALISIERT DURCH VI CONTENTS 4 COMPLEXITY AND MODEL INTEGRATION:
FORMALISATIONS 57 4.1 PREAMBLE 57 4.2 THE NATURE OF MODELS 58 4.2.1
ABSTRACT VIEWS OF MODELS 59 4.3 MODEL INTEGRATION: PREVIOUS WORK 71
4.3.1 MODEL INTEGRATION IN MANAGEMENT AND ENVIRONMENTAL SCIENCES 71
4.3.2 MODEL INTEGRATION IN SYSTEMS BIOLOGY 74 4.4 SUMMARY 76 4.5
CONCLUSION 76 5 NOVEL STRATEGIES FOR INTEGRATING MODELS INTO
SYSTEMS-LEVEL SIMULATIONS 77 5.1 MOTIVATION 77 5.2 NOVEL MODEL
INTEGRATION FORMALISATIONS 79 5.2.1 LINEAR INTEGRATION STRATEGY 79 5.2.2
AGENT-BASED INTEGRATION 81 5.2.3 A KNOWLEDGE-DRIVEN APPROACH (KDA) FOR
ADDRESSING MODEL FOCUS AND SCOPE 86 5.2.4 KNOWLEDGE-DRIVEN ABI: A NOVEL
FORMAL PROTOCOL FOR MODEL INTEGRATION 90 5.2.5 EXPECTED RESULTS AND
VALIDATION 94 5.3 SUMMARY 94 5.4 CONCLUSION 95 6 EXPERIMENTS IN MODEL
INTEGRATION 97 6.1 MODEL INTEGRATION EXPERIMENTS 97 6.2 KNOWLEDGE DRIVEN
APPROACH: BIT-BUILDING 98 6.2.1 CHEN (2004) 99 6.2.2 DE PILLIS (2005) 99
6.2.3 MALLET (2006) 100 6.2.4 MARKUS (1999) 101 6.2.5 ZHANG (2007) 102
6.3 ABI: MODEL DECOMPOSITIONS 104 6.3.1 DECOMPOSITION OF THE DIFFUSION
MODEL 104 6.3.2 DECOMPOSITION OF THE GOMPERTZ MODEL 107 6.4 KDA+ABI:
FORMAL MODEL INTEGRATIONS ILL 6.4.1 GOMPERTZ MODEL INTEGRATION WITH ODES
AND DISCRET CONTENTS VII 7 DISCUSSION 127 7.1 KDA/ABI PERFORMANCE 127
7.1.1 THE KNOWLEDGE-DRIVEN APPROACH 127 7.1.2 AGENT-BASED INTEGRATION
135 7.2 CONCLUSION 152 REFERENCES 153 INDEX 165
|
| any_adam_object | 1 |
| author | Patel, Manish Nagl, Sylvia |
| author_GND | (DE-588)131984195 |
| author_facet | Patel, Manish Nagl, Sylvia |
| author_role | aut aut |
| author_sort | Patel, Manish |
| author_variant | m p mp s n sn |
| building | Verbundindex |
| bvnumber | BV036757476 |
| classification_rvk | WD 9200 XH 1500 |
| classification_tum | MAT 032f BIO 105f |
| ctrlnum | (OCoLC)700478507 (DE-599)BVBBV036757476 |
| dewey-full | 616.9940011 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.9940011 |
| dewey-search | 616.9940011 |
| dewey-sort | 3616.9940011 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Mathematik Medizin |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T22:47:26Z |
| institution | BVB |
| isbn | 9783642156021 |
| language | English |
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| series2 | Understanding complex systems Springer complexity |
| spelling | Patel, Manish Verfasser aut The role of model integration in complex systems modelling an example from cancer biology Manish Patel and Sylvia Nagl Berlin [u.a.] Springer 2010 X, 168 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Understanding complex systems Springer complexity Komplexes System (DE-588)4114261-5 gnd rswk-swf Mathematisches Modell (DE-588)4114528-8 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Biologisches System (DE-588)4122930-7 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Biologisches System (DE-588)4122930-7 s Komplexes System (DE-588)4114261-5 s Mathematisches Modell (DE-588)4114528-8 s DE-604 Nagl, Sylvia Verfasser (DE-588)131984195 aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020674624&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Patel, Manish Nagl, Sylvia The role of model integration in complex systems modelling an example from cancer biology Komplexes System (DE-588)4114261-5 gnd Mathematisches Modell (DE-588)4114528-8 gnd Krebs Medizin (DE-588)4073781-0 gnd Biologisches System (DE-588)4122930-7 gnd |
| subject_GND | (DE-588)4114261-5 (DE-588)4114528-8 (DE-588)4073781-0 (DE-588)4122930-7 |
| title | The role of model integration in complex systems modelling an example from cancer biology |
| title_auth | The role of model integration in complex systems modelling an example from cancer biology |
| title_exact_search | The role of model integration in complex systems modelling an example from cancer biology |
| title_full | The role of model integration in complex systems modelling an example from cancer biology Manish Patel and Sylvia Nagl |
| title_fullStr | The role of model integration in complex systems modelling an example from cancer biology Manish Patel and Sylvia Nagl |
| title_full_unstemmed | The role of model integration in complex systems modelling an example from cancer biology Manish Patel and Sylvia Nagl |
| title_short | The role of model integration in complex systems modelling |
| title_sort | the role of model integration in complex systems modelling an example from cancer biology |
| title_sub | an example from cancer biology |
| topic | Komplexes System (DE-588)4114261-5 gnd Mathematisches Modell (DE-588)4114528-8 gnd Krebs Medizin (DE-588)4073781-0 gnd Biologisches System (DE-588)4122930-7 gnd |
| topic_facet | Komplexes System Mathematisches Modell Krebs Medizin Biologisches System |
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