P53 suppressor gene:
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York u.a.
Springer u.a.
1995
|
| Series: | Molecular biology intelligence unit
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 129 S. graph. Darst. |
| ISBN: | 1570592128 354059082X |
Staff View
MARC
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| 245 | 1 | 0 | |a P53 suppressor gene |c Tapas Mukhopadhyay ; Steven A. Maxwell ; Jack A. Roth |
| 264 | 1 | |a New York u.a. |b Springer u.a. |c 1995 | |
| 300 | |a 129 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Molecular biology intelligence unit | |
| 650 | 2 | |a Gènes p53 | |
| 650 | 7 | |a Neoplasias |2 larpcal | |
| 650 | 2 | |a Transformation cellulaire néoplasique - Génétique | |
| 650 | 4 | |a Cell Transformation, Neoplastic |x genetics | |
| 650 | 4 | |a Genes, p53 | |
| 650 | 4 | |a p53 antioncogene | |
| 650 | 0 | 7 | |a Protein p53 |0 (DE-588)4176550-3 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Tumorsuppressor-Gen |0 (DE-588)4326903-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Suppressorgen |0 (DE-588)4278851-1 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Protein p53 |0 (DE-588)4176550-3 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Suppressorgen |0 (DE-588)4278851-1 |D s |
| 689 | 1 | |5 DE-604 | |
| 689 | 2 | 0 | |a Protein p53 |0 (DE-588)4176550-3 |D s |
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| 700 | 1 | |a Maxwell, Steven A. |e Verfasser |4 aut | |
| 700 | 1 | |a Roth, Jack A. |e Verfasser |4 aut | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-006782751 | |
Record in the Search Index
| _version_ | 1808046626720186368 |
|---|---|
| adam_text |
CONTENTS
1.
THE
ROLE
OF
P53
IN
CANCER
.
1
FROM
ONCOGENE
TO
TUMOR
SUPPRESSOR
GENE
.
1
INTERACTIONS
WITH
DNA
TUMOR
VIRUS-TRANSFORMING
PROTEINS
.
2
2.
GENE
STRUCTURE
.
13
INTRODUCTION
.
13
STRUCTURE
OF
P53
GENE
.
13
3.
WILD-TYPE
VERSUS
MUTANT
P53
.
19
INTRODUCTION
.
19
STRUCTURE
AND
FUNCTION
OF
WILD-TYPE
P53
PROTEIN
.
20
MUTATIONAL
INACTIVATION
OF
P53
.
24
METHODS
OF
ASSAYING
P53
GENE
MUTATION
IN
HUMAN
CANCERS
.
30
MUTANT
P53
PROTEINS
.33
P53
MUTATIONS
IN
HUMAN
CANCER
.
36
4.
BIOPHYSICAL
AND
BIOCHEMICAL
PROPERTIES
OF
THE
P53
PROTEIN
.
55
INTRODUCTION
.
55
MISSENSE
MUTATIONS
WITHIN
A
CONSERVED
REGION
OF
P53
ALTER
ITS
BIOLOGICAL
ACTIVITY
.
59
THE
CENTRAL
CONSERVED
REGION
IS
A
CONFORMATIONAL
DOMAIN
OF
P53
.
60
THE
CONFORMATION
OF
P53
DETERMINES
ITS
BIOLOGICAL
ACTIVITY
.
61
CONCLUSION
.
64
5.
REGULATION
AND
MODULATION
OF
THE
FUNCTION
OF
P53
.
73
INTRODUCTION
.73
PROTEIN
INTERACTIONS
CAN
REGULATE
P53
.
73
REGULATION
OF
P53
BY
PHOSPHORYLATION
.
79
REDOX
MECHANISMS
.
81
ALLOSTERIC
REGULATION
MODEL
.
81
REGULATION
OF
INTRACELLULAR
P53
LEVELS
.84
REGULATION
OF
SUBCELLULAR
LOCALIZATION
OF
P53
.
86
CONTROL
OVER
THE
POTENTIAL
ROLE
OF
P53
IN
DNA
REPLICATION
.
87
CELL
CYCLE
REGULATION
OF
P53
FUNCTION
.89
TISSUE
AND
CELL
TYPE-SPECIFIC
REGULATION
OF
P53
ACTIVITY
.
90
CONCLUSIONS
.93
6.
POTENTIAL
CLINICAL
SIGNIFICANCE
OF
THE
P53
TUMOR
SUPPRESSOR
GENE
IN
CANCER
PATIENTS
.
113
SECOND
PRIMARY
CANCERS
.
114
THE
ROLE
OF
P53
IN
PREMALIGNANCY
.
115
PROGNOSTIC
STUDIES
IN
CANCER
PATIENTS
.
116
GENE
REPLACEMENT
CLINICAL
TRIALS
.
116
RETROVIRAL
VECTORS
FOR
GENE
DELIVERY
.
118
ADENOVIRAL
VECTORS
FOR
GENE
DELIVERY
.
120
CLINICAL
APPLICATIONS
.
122
INDEX
.
127 |
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| author | Mukhopadhyay, Tapas Maxwell, Steven A. Roth, Jack A. |
| author_facet | Mukhopadhyay, Tapas Maxwell, Steven A. Roth, Jack A. |
| author_role | aut aut aut |
| author_sort | Mukhopadhyay, Tapas |
| author_variant | t m tm s a m sa sam j a r ja jar |
| building | Verbundindex |
| bvnumber | BV010207751 |
| callnumber-first | R - Medicine |
| callnumber-label | RC268 |
| callnumber-raw | RC268.44.P16 |
| callnumber-search | RC268.44.P16 |
| callnumber-sort | RC 3268.44 P16 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | WG 3290 XH 5200 |
| ctrlnum | (OCoLC)32051331 (DE-599)BVBBV010207751 |
| dewey-full | 616.99/4042 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.99/4042 |
| dewey-search | 616.99/4042 |
| dewey-sort | 3616.99 44042 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
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| id | DE-604.BV010207751 |
| illustrated | Illustrated |
| indexdate | 2024-08-22T00:47:08Z |
| institution | BVB |
| isbn | 1570592128 354059082X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-006782751 |
| oclc_num | 32051331 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 129 S. graph. Darst. |
| publishDate | 1995 |
| publishDateSearch | 1995 |
| publishDateSort | 1995 |
| publisher | Springer u.a. |
| record_format | marc |
| series2 | Molecular biology intelligence unit |
| spelling | Mukhopadhyay, Tapas Verfasser aut P53 suppressor gene Tapas Mukhopadhyay ; Steven A. Maxwell ; Jack A. Roth New York u.a. Springer u.a. 1995 129 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular biology intelligence unit Gènes p53 Neoplasias larpcal Transformation cellulaire néoplasique - Génétique Cell Transformation, Neoplastic genetics Genes, p53 p53 antioncogene Protein p53 (DE-588)4176550-3 gnd rswk-swf Tumorsuppressor-Gen (DE-588)4326903-5 gnd rswk-swf Suppressorgen (DE-588)4278851-1 gnd rswk-swf Protein p53 (DE-588)4176550-3 s DE-604 Suppressorgen (DE-588)4278851-1 s Tumorsuppressor-Gen (DE-588)4326903-5 s Maxwell, Steven A. Verfasser aut Roth, Jack A. Verfasser aut DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006782751&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mukhopadhyay, Tapas Maxwell, Steven A. Roth, Jack A. P53 suppressor gene Gènes p53 Neoplasias larpcal Transformation cellulaire néoplasique - Génétique Cell Transformation, Neoplastic genetics Genes, p53 p53 antioncogene Protein p53 (DE-588)4176550-3 gnd Tumorsuppressor-Gen (DE-588)4326903-5 gnd Suppressorgen (DE-588)4278851-1 gnd |
| subject_GND | (DE-588)4176550-3 (DE-588)4326903-5 (DE-588)4278851-1 |
| title | P53 suppressor gene |
| title_auth | P53 suppressor gene |
| title_exact_search | P53 suppressor gene |
| title_full | P53 suppressor gene Tapas Mukhopadhyay ; Steven A. Maxwell ; Jack A. Roth |
| title_fullStr | P53 suppressor gene Tapas Mukhopadhyay ; Steven A. Maxwell ; Jack A. Roth |
| title_full_unstemmed | P53 suppressor gene Tapas Mukhopadhyay ; Steven A. Maxwell ; Jack A. Roth |
| title_short | P53 suppressor gene |
| title_sort | p53 suppressor gene |
| topic | Gènes p53 Neoplasias larpcal Transformation cellulaire néoplasique - Génétique Cell Transformation, Neoplastic genetics Genes, p53 p53 antioncogene Protein p53 (DE-588)4176550-3 gnd Tumorsuppressor-Gen (DE-588)4326903-5 gnd Suppressorgen (DE-588)4278851-1 gnd |
| topic_facet | Gènes p53 Neoplasias Transformation cellulaire néoplasique - Génétique Cell Transformation, Neoplastic genetics Genes, p53 p53 antioncogene Protein p53 Tumorsuppressor-Gen Suppressorgen |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=006782751&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mukhopadhyaytapas p53suppressorgene AT maxwellstevena p53suppressorgene AT rothjacka p53suppressorgene |