Molecular and cell biology of type 2 diabetes and its complications
Molecular and cell biology of type 2 diabetes and its complications:

The present volume summarizes current research on type 2 diabetes, its etiology, pathogenesis and long-term vascular and neurological consequences, with special emphasis on molecular and biochemical mechanisms. Alterations in insulin secretion are comprehensively treated, focusing on the role of glu...

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Bibliographische Detailangaben
Weitere Verfasser: Belfiore, Francesco (HerausgeberIn), Lorenzi, Mara (HerausgeberIn), Molinatti, Gian Michele (HerausgeberIn), Porta, Massimo 1953- (HerausgeberIn)
Format: Elektronisch Tagungsbericht E-Book
Sprache:English
Veröffentlicht: Basel Karger 1998
Schriftenreihe:Frontiers in diabetes Vol. 14
Schlagworte:
Endocrinology
Metabolism
Clinical Nutrition
Diabetes
Diabetes mellitus Typ 2
Sekundärkrankheit
Molekularbiologie
Konferenzschrift > 1997 > Turin
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Zusammenfassung:The present volume summarizes current research on type 2 diabetes, its etiology, pathogenesis and long-term vascular and neurological consequences, with special emphasis on molecular and biochemical mechanisms. Alterations in insulin secretion are comprehensively treated, focusing on the role of glucokinase as glucose sensor. Moreover, insulin action is analyzed with regard to both nonoxidative glucose utilization and glucose oxidation. Concerning the complications in chronic diabetes, topics covered include the effects of high glucose concentration on cellular and endothelial functions and on the glucose phosphorylation rate in non-insulin-sensitive tissues. Furthermore, the role of oxidative stress and advanced glycation end products as well as the significance of alterations in lipoprotein structure are considered. Finally, the pericyte loss in retinopathy and microalbuminuria as related to cardiovascular risk are discussed. Taken as a whole, the contributions included in this book represent a large body of information that will be of great interest to diabetologists, endocrinologists and internists interested in both the basic and clinical aspects of diabetes and its complications
Beschreibung:5th International Diabetes Conference, Turin, April 1998
Beschreibung:1 Online-Ressource (X, 260 Seiten) Illustrationen, Diagramme
ISBN:9783318002720
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